Abstract:
BACKGROUND:Rifampin has been used for the eradication of Staphylococcus aureus (S. aureus) colonization in various populations of healthy and sick people. METHODS:We performed a systematic review of the evidence from randomized and nonrandomized controlled trials that compared the effectiveness and safety of a rifampin-based regimen with another regimen in eradicating S. aureus colonization from healthy and sick people. RESULTS:Nine comparative trials (6 of which were randomized controlled trials) were included in our analysis. S. aureus was eradicated more commonly in patients receiving rifampin-containing regimens compared to monotherapy with other systemic agents (ciprofloxacin, cloxacillin, minocycline, or vancomycin), both during early and late (>1 month after therapy) post treatment evaluations (odds ratio [OR] 46.2, 95% confidence interval [CI] 14.4-148, and OR 8.8, 95% CI 3.4-22.5 respectively, 4 studies included). There was no statistically significant difference between rifampin monotherapy and combinations of rifampin with other topical (bacitracin) or systemic (cloxacillin and minocycline) antibiotics in eradicating S. aureus both in early and late evaluations (OR 1.5, 95% CI 0.5-4.4, and OR 1.6, 95% CI 0.7-3.7, respectively, 3 studies included). Eradication of methicillin-resistant S. aureus (MRSA) varied according to the type and duration of the rifampin-containing regimen. It ranged from 25% for the combination of rifampin with trimethoprim/sulfamethoxazole for 5 days to 100% for the combination of oral rifampin and minocycline for 14 days. Discontinuation of rifampin due to drug-related toxicity was necessary in 2% of 282 studied patients. Development of resistance of S. aureus to rifampin during and after treatment with a regimen containing rifampin ranged from 0% to 40% (7 studies) and overall 17% of the 236 patients for whom relevant data was reported. CONCLUSION:The available evidence suggests that oral rifampin is an effective agent for the eradication of S. aureus carriage. However, development of antimicrobial resistance during and after treatment with rifampin occurs in a considerable proportion of patients; using rifampin in combination with another antimicrobial agent may decrease this resistance.
journal_name
Am J Infect Controljournal_title
American journal of infection controlauthors
Falagas ME,Bliziotis IA,Fragoulis KNdoi
10.1016/j.ajic.2006.09.005subject
Has Abstractpub_date
2007-03-01 00:00:00pages
106-14issue
2eissn
0196-6553issn
1527-3296pii
S0196-6553(06)01239-9journal_volume
35pub_type
杂志文章,评审abstract:BACKGROUND:Compliance with cleaning of flexible endoscope channels cannot be verified using visual inspection. Adenosine triphosphate (ATP) has been suggested as a possible rapid cleaning monitor for flexible endoscope channels. There have not been published validation studies to specify the level of ATP that indicates...
journal_title:American journal of infection control
pub_type: 杂志文章
doi:10.1016/j.ajic.2012.03.018
更新日期:2013-03-01 00:00:00
abstract::We illustrate how genotyping of mycobacterial strains contributed to the discovery of an undetected outbreak of tuberculosis in a hospital ward, ruling out misleading assumptions of transmission chains. Genotyping should be taken into account in routine tests for the control of tuberculosis. ...
journal_title:American journal of infection control
pub_type: 杂志文章
doi:10.1016/j.ajic.2011.03.003
更新日期:2012-02-01 00:00:00
abstract::Endoscope auditing is unique from other types of auditing normally completed as part of ongoing quality initiatives. When auditors walk into an endoscopy processing area, they are confronted with a variety of complex processes generally packed into a small space. Auditors are challenged to become experts on the proces...
journal_title:American journal of infection control
pub_type: 杂志文章
doi:10.1016/j.ajic.2019.06.029
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:We used workers' compensation data to identify health care workers at risk of tuberculosis exposure in the hospital and nonhospital environment. METHODS:We identified State Fund workers' compensation claims having a documented tuberculin skin test (TST) conversion (size >or=10 mm) with a previous negative s...
journal_title:American journal of infection control
pub_type: 杂志文章
doi:10.1016/j.ajic.2006.02.005
更新日期:2006-08-01 00:00:00
abstract::Six hundred twenty-two isolates from 554 samples taken from hands of 103 hospital personnel and 50 controls were obtained over a mean period of 35 days. Eighty-five were obtained immediately before and after handwashing (HW), the remainder after HW only. The relationship of HW agent used, clinical area and job, and fr...
journal_title:American journal of infection control
pub_type: 杂志文章
doi:10.1016/0196-6553(84)90020-8
更新日期:1984-04-01 00:00:00
abstract:BACKGROUND:Improperly cleaned, disinfected, or sterilized reusable medical devices are a critical cause of health care-associated infections. More effective studies are required to address the improvement of cleaning and disinfection instructions, as well as selection of cleaning and disinfecting agents, for surfaces o...
journal_title:American journal of infection control
pub_type: 杂志文章
doi:10.1016/j.ajic.2013.01.029
更新日期:2013-10-01 00:00:00
abstract:BACKGROUND:Debate remains over the core activities of infection control (IC) programs. Differences in stakeholder opinions must be considered if consensus panel guidelines and recommendations are to be broadly applied. This article describes a survey of administrators and clinicians employed in hospitals in New South W...
journal_title:American journal of infection control
pub_type: 杂志文章
doi:10.1067/mic.2001.117037
更新日期:2001-08-01 00:00:00
abstract:BACKGROUND:Methicillin-resistant Staphylococcus aureus (MRSA) isolated from frequently touched dental school clinic surfaces were compared with MRSA isolated nasal cultures of dental students. METHOD:Sixty-one dental students and 95 environmental surfaces from 7 clinics were sampled using SANICULT (Starplex Scientific...
journal_title:American journal of infection control
pub_type: 杂志文章
doi:10.1016/j.ajic.2010.11.007
更新日期:2011-10-01 00:00:00
abstract::Urinary tract infections are one of the most common hospital-acquired infections, with 70%-80% resulting from catheter-associated urinary tract infections (CAUTIs). We undertook a qualitative study to assess patient perspectives of indwelling urinary catheters using a semistructured interview. We found that patient aw...
journal_title:American journal of infection control
pub_type: 杂志文章
doi:10.1016/j.ajic.2015.10.011
更新日期:2016-03-01 00:00:00
abstract::In an investigation of microbial contamination of enteral feeding solutions, all 22 residual solutions obtained immediately after administration were contaminated at concentrations of 10(3) to 10(6) viable counts/ml. Major contaminants were glucose-nonfermenting gram-negative bacilli such as Pseudomonas aeruginosa and...
journal_title:American journal of infection control
pub_type: 杂志文章
doi:10.1016/0196-6553(93)90205-i
更新日期:1993-02-01 00:00:00
abstract:BACKGROUND:Hand hygiene (HH) in health care facilities is a key component to reduce pathogen transmission and nosocomial infections. However, most HH interventions (HHI) have not been sustainable. AIMS:This review aims to provide a comprehensive summary of recently published evidence-based HHI designed to improve HH c...
journal_title:American journal of infection control
pub_type: 杂志文章,评审
doi:10.1016/j.ajic.2015.11.034
更新日期:2016-06-01 00:00:00
abstract:BACKGROUND:Although hand hygiene (HH) is key to reducing health care-associated infections, it is well documented that health care worker (HCW) adherence to appropriate HH protocols is relatively low. METHODS:This was a collaborative quality improvement project with multiple interventions conducted in a 570-bed academ...
journal_title:American journal of infection control
pub_type: 杂志文章
doi:10.1016/j.ajic.2014.07.003
更新日期:2014-11-01 00:00:00
abstract:BACKGROUND:Infection preventionists (IPs) play key roles in preventing health care-associated infections and ensuring quality of care. To develop strategies to support comprehensive infection prevention practice, it is critical to understand key aspects of their practice. METHODS:A task force of expert IPs, staff repr...
journal_title:American journal of infection control
pub_type: 杂志文章
doi:10.1016/j.ajic.2016.12.012
更新日期:2017-06-01 00:00:00
abstract::Central line-associated bloodstream infection (CLABSI) event data reported to the National Healthcare Safety Network from 2014, the first year of required use of the mucosal barrier injury laboratory-confirmed bloodstream infection (MBI-LCBI) definition, were analyzed to assess the impact of removing MBI-LCBI events f...
journal_title:American journal of infection control
pub_type: 杂志文章
doi:10.1016/j.ajic.2016.10.015
更新日期:2017-03-01 00:00:00
abstract:BACKGROUND:Antimicrobial stewardship programs (ASPs) are dedicated to improving antimicrobial use. Although clinical practice guidelines (CPGs) are available for the development of ASPs, it is unclear what the quality of these guidelines are. We therefore systematically reviewed published CPGs for the development of ac...
journal_title:American journal of infection control
pub_type: 杂志文章
doi:10.1016/j.ajic.2019.02.010
更新日期:2019-08-01 00:00:00
abstract:BACKGROUND:Central line-associated bloodstream infections (CLABSI) carry serious risks for patients and financial consequences for hospitals. Avoiding unnecessary temporary central venous catheters (CVC) can reduce CLABSI. Critical Care Medicine (CCM) is often consulted to insert CVC when alternatives are unavailable. ...
journal_title:American journal of infection control
pub_type: 杂志文章
doi:10.1016/j.ajic.2020.10.006
更新日期:2020-10-17 00:00:00
abstract:BACKGROUND:This study assessed reporting behavior and satisfaction with postexposure prophylaxis (PEP) systems among health care workers (HCWs) at risk for occupational bloodborne pathogen exposure (BPE) in 3 public hospitals in Botswana. METHODS:A cross-sectional survey among HCWs provided information on perceptions,...
journal_title:American journal of infection control
pub_type: 杂志文章
doi:10.1016/j.ajic.2016.01.027
更新日期:2016-08-01 00:00:00
abstract:OBJECTIVE:Recent research has suggested that episodes of gram-negative (GN) bloodstream infection (BSI) are more common in the population during summer months. Our objective was to determine if the same phenomenon could be observed in patients with health care-associated (HCA) BSI, and if so, whether a summer peak was ...
journal_title:American journal of infection control
pub_type: 杂志文章
doi:10.1016/j.ajic.2013.05.019
更新日期:2013-12-01 00:00:00
abstract::An antimicrobial stewardship program was implemented throughout 2012 at a tertiary pediatric institution with guideline development preceding prospective audit and feedback starting in 2013. Meropenem use decreased over 62% during the next 5 years. Non-cystic fibrosis Pseudomonas aeruginosa isolate susceptibility to m...
journal_title:American journal of infection control
pub_type: 杂志文章
doi:10.1016/j.ajic.2019.05.001
更新日期:2019-12-01 00:00:00
abstract:BACKGROUND:Iranian were advice to wear a mask and not touch their face during COVID-19 restrictions in Iran. METHODS:One-thousand people were observed for 15-30 minutes in public places between April 22 and May 9, 2020. The average number of touches to the mucosal zone was calculated per hour and mask wearers (N = 568...
journal_title:American journal of infection control
pub_type: 杂志文章
doi:10.1016/j.ajic.2020.08.009
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND:Clostridioides difficile is a major cause of infectious antibiotic resistant diarrhea. C. difficile spores are shed in patient stool, are hearty and difficult to kill. Bedpans are often used by patients with C. difficile infections and require proper handling and cleaning or disposal to prevent the transmiss...
journal_title:American journal of infection control
pub_type: 杂志文章
doi:10.1016/j.ajic.2019.11.028
更新日期:2020-07-01 00:00:00
abstract:BACKGROUND:Studies conducted in the first decade of the AIDS epidemic indicated that, in general, dentists had suboptimal levels of compliance with standard infection control practices, including work practices designed to reduce exposure to bloodborne pathogens. This study was designed to assess current rates of compl...
journal_title:American journal of infection control
pub_type: 杂志文章
doi:10.1016/s0196-6553(98)70058-6
更新日期:1998-02-01 00:00:00
abstract:BACKGROUND:We were alerted to increased rates of Clostridium difficile-positive tests at all 3 hospitals in our health care system by MedMined Data Mining Surveillance Service, CareFusion (San Diego, CA). In response, an intervention of terminal room cleaning with dilute bleach was instituted to decrease the amount of ...
journal_title:American journal of infection control
pub_type: 杂志文章
doi:10.1016/j.ajic.2009.11.003
更新日期:2010-06-01 00:00:00
abstract::To assess the implementation of hepatitis B virus (HBV) vaccination programs for hospital workers, we mailed questionnaires to all 229 licensed Michigan hospitals. The response rate was 96% (221/229); of these, 68% (150/221) had vaccination programs. Although multiple hospital characteristics were associated with the ...
journal_title:American journal of infection control
pub_type: 杂志文章
doi:10.1016/0196-6553(88)90059-4
更新日期:1988-10-01 00:00:00
abstract:BACKGROUND:Many studies have examined hand hygiene (HH) frequency and adherence in response to various interventions. This study used 2 methods to determine HH frequency and adherence to see how well the outcomes correlated. METHODS:HH frequency was measured over 4, 1-month periods (phases 1-4), using 2 methods: an au...
journal_title:American journal of infection control
pub_type: 杂志文章
doi:10.1016/j.ajic.2005.07.006
更新日期:2006-04-01 00:00:00
abstract::The purpose of this study was to conduct a nationwide survey to determine the number of master's-prepared infection control practitioners (ICPs) and those eligible for admission to graduate programs. Continuing education needs also were assessed to determine whether they might best be met through formal education or i...
journal_title:American journal of infection control
pub_type: 杂志文章
doi:10.1016/0196-6553(90)90087-9
更新日期:1990-04-01 00:00:00
abstract:BACKGROUND:Health care workers (HCWs) use their mobile phones during working hours or medical care. There is evidence that the instruments are colonized with pathogenic microorganisms. Here, we describe levels of Enterobacteriaceae contamination (EC) in cell phones and the risk factors associated with EC in Peruvian in...
journal_title:American journal of infection control
pub_type: 杂志文章
doi:10.1016/j.ajic.2016.02.020
更新日期:2016-08-01 00:00:00
abstract::During a 17-month period (01/11/85-05/31/86) 225 cases of nosocomial diarrhea were identified in a children's hospital. Diarrhea was considered to be nosocomial if it began at least 72 hours after the patient's hospital admission or within 3 days after discharge. One or more routine diagnostic studies for identificati...
journal_title:American journal of infection control
pub_type: 杂志文章
doi:10.1016/0196-6553(89)90021-7
更新日期:1989-04-01 00:00:00
abstract:BACKGROUND:Health care-associated infections (HCAIs) are preventable with adoption of recognized preventive measures. The first step is to identify patients at higher risk of HCAI. This study aimed to identify patient risk factors (RFs) present on admission and acquired during inpatient stay which could be associated w...
journal_title:American journal of infection control
pub_type: 杂志文章
doi:10.1016/j.ajic.2017.03.036
更新日期:2017-10-01 00:00:00
abstract::In a series of experiments, the barrier integrity of single and double vinyl and latex examination gloves were tested for dye and water leaks after being placed under stress. A total of 886 examination gloves (385 vinyl: single, 199; double, 186; and 501 latex: single, 290; double, 211) were tested with a standardized...
journal_title:American journal of infection control
pub_type: 杂志文章
doi:10.1016/0196-6553(94)90085-x
更新日期:1994-02-01 00:00:00