Abstract:
BACKGROUND:Metabolic acidosis is highly prevalent in critically ill patients with acute renal failure. Little is known about the mechanisms by which renal replacement therapy intervenes in such cases. The objective of this study is to analyze the role of hemodialysis in acidosis correction in intensive care unit patients, with an emphasis on chloride levels in plasma and dialysate. METHODS:We studied 19 intermittent hemodialysis procedures in 17 acidotic patients. The patients were grouped by procedure type (conventional or sustained low-efficiency dialysis) and by predialysis plasma chloride level (higher or lower than the dialysate chloride concentration). Immediately before and after each procedure, blood samples were collected for biochemical analysis. The Stewart method was used to calculate the strong ion difference and strong ion gap. RESULTS:The patients presented acidosis related to hyperchloremia, hyperphosphatemia, and high unmeasured anions. Hypoalbuminemia had an alkalinizing effect. Hemodialysis corrected acidosis mainly by reducing phosphate and unmeasured anions. In the group as a whole, chloride levels did not change after dialysis. However, when analyzed according to predialysis plasma chloride, the high-chloride group presented a reduction in plasma chloride, resulting in better base excess improvement (Delta standard base excess) than in the low-chloride group. Among the determinants of acid-base status, the only factors correlating with Delta SBE were Delta strong ion gap and Delta chloride. CONCLUSION:The serum chloride/dialysate chloride relationship during hemodialysis has an important impact on acidosis control.
journal_name
J Crit Carejournal_title
Journal of critical careauthors
Libório AB,da Silva Alexandre C,Noritomi DT,Andrade L,Seguro ACdoi
10.1016/j.jcrc.2006.03.011subject
Has Abstractpub_date
2006-12-01 00:00:00pages
333-8issue
4eissn
0883-9441issn
1557-8615pii
S0883-9441(06)00050-5journal_volume
21pub_type
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pub_type: 杂志文章
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更新日期:2019-06-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.jcrc.2007.12.003
更新日期:2008-06-01 00:00:00
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journal_title:Journal of critical care
pub_type: 杂志文章,多中心研究
doi:10.1016/j.jcrc.2015.06.007
更新日期:2015-10-01 00:00:00
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journal_title:Journal of critical care
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更新日期:2010-03-01 00:00:00
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更新日期:2017-02-01 00:00:00
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pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2019-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.jcrc.2003.08.008
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pub_type: 杂志文章
doi:10.1053/jcrc.2003.YJCRC6
更新日期:2003-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.jcrc.2009.09.002
更新日期:2010-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.jcrc.2014.11.003
更新日期:2015-04-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:2010-03-01 00:00:00
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更新日期:2018-02-01 00:00:00
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更新日期:2018-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/s0883-9441(99)90004-7
更新日期:1999-03-01 00:00:00
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更新日期:2005-06-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2015-10-01 00:00:00
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更新日期:2014-04-01 00:00:00
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journal_title:Journal of critical care
pub_type: 临床试验,杂志文章
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更新日期:2004-09-01 00:00:00
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journal_title:Journal of critical care
pub_type: 杂志文章
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更新日期:2014-12-01 00:00:00
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journal_title:Journal of critical care
pub_type: 杂志文章
doi:10.1016/j.jcrc.2011.05.017
更新日期:2012-02-01 00:00:00
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journal_title:Journal of critical care
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.jcrc.2012.08.019
更新日期:2012-12-01 00:00:00
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journal_title:Journal of critical care
pub_type: 杂志文章
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更新日期:2014-02-01 00:00:00
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更新日期:2014-08-01 00:00:00
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pub_type: 杂志文章
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更新日期:1993-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:2018-12-01 00:00:00