Nonisothermal denaturation kinetics of human hair and the effects of oxidation.

abstract：:The interaction of an RGD-containing epitope from the hepatitis A virus VP3 capsid protein and its RGA-analogue with lipid membranes was studied by biophysical methods. Two types of model membrane were used: vesicles and monolayers spread at the air/water interface, with a composition that closely resembles the lipid ...

journal_title：Biopolymers

authors： Chávez A,Pujol M,Haro I,Alsina MA,Cajal Y

更新日期：2001-01-01 00:00:00

abstract：:While end capping in alpha-helices is well understood, the concept of capping a beta-hairpin is a relatively recent development; to date, favorable Coulombic interactions are the only example of sidechains at the termini influencing the overall stability of a beta-hairpin. While cross-strand hydrophobic residues gener...

journal_title：Biopolymers

authors： Eidenschink L,Crabbe E,Andersen NH

更新日期：2009-07-01 00:00:00

abstract：:The pressure-induced structural changes of a de novo designed four-helix bundle protein, (alpha-l-alpha)(2), in aqueous solution have been investigated by FTIR spectroscopy. Changes in the amide I' band intensity show that pressure induces disruption of tertiary interactions and stabilizes the solvated alpha-helical f...

journal_title：Biopolymers

authors： Takekiyo T,Takeda N,Isogai Y,Kato M,Taniguchi Y

更新日期：2007-02-05 00:00:00

abstract：:We present a method for analysis of a fitness landscape of a biopolymer with significantly epistatic sites. The analysis is based on a quasi-additive fitness model. The fitness model is constructed with additive terms conducted by "site-fitness" and epistatic terms conducted by "pair-fitness," where the site-fitness i...

journal_title：Biopolymers

authors： Aita T,Hamamatsu N,Nomiya Y,Uchiyama H,Shibanaka Y,Husimi Y

更新日期：2002-07-05 00:00:00

abstract：:For the controlled synthesis of even the simplest dipeptide, the N(alpha)-amino group of one of the amino acids and the C-terminal carboxyl group of the other should both be blocked with suitable protecting groups. Formation of the desired amide bond can now occur upon activation of the free carboxyl group. After coup...

journal_title：Biopolymers

authors： Albericio F

更新日期：2000-01-01 00:00:00

abstract：:Three new polyoxaalkyl esters of lasalocid are synthesized. Their ability to form complexes with Li(+) and Na(+) cations is studied using multinuclear NMR methods, FTIR spectroscopy in the middle and far IR regions, and mass spectrometry. It is found that lasalocid esters form only 1:1 complexes with the metal cations...

journal_title：Biopolymers

authors： Pankiewicz R,Schroeder G,Gierczyk B,Brzezinski B,Bartl F

更新日期：2002-10-15 00:00:00

abstract：:The aim of this study was to develop a nondestructive method to quantitate relative amounts of n-3 and n-6 polyunsaturated fatty acid (PUFA) species in vegetable oils and oil seeds using Fourier transform IR spectroscopy (FTIR). The alkene Cbond;H stretching vibrations of unsaturated fatty acids in oils showed IR abso...

journal_title：Biopolymers

authors： Yoshida S,Yoshida H

更新日期：2003-12-01 00:00:00

abstract：:We report on the conformation of a tetrasaccharide fragment in the repeating subunit of the cell wall polysaccharide of Streptococcus mitis J22, a receptor for the lectin of Actinomyces viscosus T14V in a bacterial coaggregation that is important in the ecological interactions of oral bacteria. Although there is consi...

journal_title：Biopolymers

authors： Xu Q,Mohan S,Bush CA

更新日期：1996-03-01 00:00:00

abstract：:Individual ethidium-stained DNA molecules, embedded in an agarose gel made with electrophoresis buffer (0.05 molar salt), are observed using a fluorescence microscope. In the first experiment, open circular 66 kilobase pair (kbp) plasmids, immobilized by agarose fibers threaded through their centers, display entropic ...

journal_title：Biopolymers

authors： Smith SB,Bendich AJ

更新日期：1990-07-01 00:00:00

abstract：:We prepared the water soluble model peptide, (E)(8) GGLGGQGAG(A)(6) GGAGQGGYGG, to throw light on the local structure of spidroin 1 (MaSpl) protein in spider dragline silk of Nephila clavipes before and after spinning. Solution (13) C NMR showed that the conformation of the peptide in aqueous solution was essentially ...

journal_title：Biopolymers

authors： Yazawa K,Yamaguchi E,Knight D,Asakura T

更新日期：2012-06-01 00:00:00

abstract：:Molecular dynamics simulation, with backbone constraints for 20 ps of equilibration and simulation, of a repeating polypeptide segment, Gln-Pro-His-Gln-Pro-Leu-Gln-Pro-His-Gln-Pro-Leu-Gln-Pro-Met-(Gln-Pro-Leu )4, constituting residues 112-138 of bovine amelolgenin, a 19.35 kD hydrophobic protein, are discussed. It is ...

journal_title：Biopolymers

authors： Renugopalakrishnan V,Pattabiraman N,Prabhakaran M,Strawich E,Glimcher MJ

更新日期：1989-01-01 00:00:00

abstract：:The comprehensive structural analysis reported herein of eight N-glycopeptides, in three different solvents, is based on quantitative CD experiments, homonuclear nuclear Overhauser effect measurements, and molecular dynamics (MD) calculations. Although several orientations of the two amide planes attached to the carbo...

journal_title：Biopolymers

authors： Perczel A,Kollát E,Hollósi M,Fasman GD

更新日期：1993-04-01 00:00:00

abstract：:The existence of an "RNA world" as an early step in the history of life increases the interest for the characterization of these biomolecules. The hairpin ribozyme studied here is a self-cleaving/ligating motif found in the minus strand of the satellite RNA associated with Tobacco ringspot virus. Surface-enhanced Rama...

journal_title：Biopolymers

authors： Percot A,Lecomte S,Vergne J,Maurel MC

更新日期：2009-05-01 00:00:00

abstract：:We have studied the use of a new Monte Carlo (MC) chain generation algorithm, introduced by T. Garel and H. Orland [(1990) Journal of Physics A, Vol. 23, pp. L621-L626], for examining the thermodynamics of protein folding transitions and for generating candidate C(alpha) backbone structures as starting points for a de...

journal_title：Biopolymers

authors： Solomon JE,Liney D

更新日期：1995-11-01 00:00:00

abstract：:RADA-16-I is a self-assembling peptide which forms biocompatible fibrils and hydrogels. We used molecular dynamics simulations, atomic-force microscopy, NMR spectroscopy, and thioflavin T binding assay to examine size, structure, and morphology of RADA-16-I aggregates. We used the native form of RADA-16-I (H-(ArgAlaAs...

journal_title：Biopolymers

authors： Bagrov D,Gazizova Y,Podgorsky V,Udovichenko I,Danilkovich A,Prusakov K,Klinov D

更新日期：2016-01-01 00:00:00

abstract：:The synthetic peptide Gly-L-Ala-L-Phe (C14H19N3O4.2H2O; GAF) crystallizes in the monoclinic space group P2I1), with a = 5.879(1), b = 7.966(1), c = 17.754(2) A, beta = 95.14(2) degrees, Dx = 1.321 g cm-3, and Z = 2. The crystal structure was solved by direct methods using the program SHELXS-86 and refined to an R valu...

journal_title：Biopolymers

authors： Ramasubbu N,Parthasarathy R

更新日期：1989-07-01 00:00:00

abstract：:Nocistatin, a new heptadecapeptide encoded in the bPNP-3 gene, has a powerful biological activity connected with the mechanisms of pain transmission. It does not bind to the opioid receptors but to another brain receptor with high affinity. In order to substantiate these novel biological data with a structural basis, ...

journal_title：Biopolymers

authors： Crescenzi O,Guerrini R,Picone D,Salvadori S,Tancredi T,Temussi PA

更新日期：2000-03-01 00:00:00

abstract：:In the first two papers of this series, the tools necessary to evaluate substrate ring deformations were developed, and then the modeling of short amylose fragments (maltotriose and maltopentaose) inside the catalytic site of barley alpha-amylase was performed. In this third paper, this docking has been extended to th...

journal_title：Biopolymers

authors： André G,Buléon A,Haser R,Tran V

更新日期：1999-12-01 00:00:00

abstract：:The physicochemical characteristics of the green fluorescent protein (GFP), including the thermodynamic properties (entropy, enthalpy, Gibbs' free energy, heat capacity), normal mode vibrations, and atomic fluctuations, were investigated. The Gaussian 03 computational chemistry program was employed for normal mode ana...

journal_title：Biopolymers

authors： Krasnenko V,Tkaczyk AH,Tkaczyk ER,Farkas O,Mauring K

更新日期：2005-06-15 00:00:00

abstract：:Because of its involvement in HIV entry, the chemokine receptor CXCR4 is an attractive target for antiretroviral drugs. Despite the large number of CXCR4 inhibitors studied, the 3D pharmacophore for binding to CXCR4 remains elusive, mainly as a result of conformational flexibility inherent in the identified ligands. I...

journal_title：Biopolymers

authors： Våbenø J,Nikiforovich GV,Marshall GR

更新日期：2006-01-01 00:00:00

abstract：:The experimental thermodynamic data for the dissolution of five simple hydrocarbon molecules in water were combined with the solute-solvent interaction energy from a computer simulation study to yield data on the enthalpy change of solvent reorganization. Similar data were generated for dissolving these same solute mo...

journal_title：Biopolymers

authors： Lee B

更新日期：1991-07-01 00:00:00

abstract：:Several new biocompatible and degradable materials were prepared by chemical modification of sodium hyaluronate. The method of activation of hyaluronate by cyanogen bromide was used and subsequent reaction with nucleophile led to the formation of carbamate. This modification of hydroxyl groups of glycosaminoglycans pr...

journal_title：Biopolymers

authors： Mlcochová P,Bystrický S,Steiner B,Machová E,Koós M,Velebný V,Krcmár M

更新日期：2006-05-01 00:00:00

abstract：:Sequence-specific optical signals are used to establish long-range sequence order and identification for fragments hundreds of kilo bases in length. ...

journal_title：Biopolymers

authors： Crothers DM

更新日期：2013-12-01 00:00:00

abstract：:This paper is a personal recollection of some of the events and research that surrounded the amino acid sequence determination of the hypothalamic releasing factor, TRF (now known as TRH), by mass spectrometry (MS), and the development of reverse phase high performance liquid chromatography (RP-HPLC) MS and tandem MS ...

journal_title：Biopolymers

authors： Desiderio DM

更新日期：1996-01-01 00:00:00

abstract：:Normal mode calculations have been done on a range of disulfide bridge conformations in order to determine how the SS stretch and CS stretch frequencies depend on structure. In addition to varying the C alpha C beta SS and NC alpha C beta S dihedral angles, we have varied the phi, psi of the adjoining peptide groups s...

journal_title：Biopolymers

authors： Qian W,Krimm S

更新日期：1992-08-01 00:00:00

abstract：:Side-chain lactam bridges linking amino acid residues that are spaced several residues apart in the linear sequence offer a convenient and flexible method for introducing conformational constraints into a peptide structure. The availability of a variety of selectively cleavable protecting groups for amines and carboxy...

journal_title：Biopolymers

authors： Taylor JW

更新日期：2002-01-01 00:00:00

abstract：:A theoretical method is proposed to identify structural domains in proteins of known structures. It is based on the distribution of the local axes of the polypeptide chain. In particular, a statistical analysis is applied to the contributions of the local axes to the absolute writhing number, a topological property of...

journal_title：Biopolymers

authors： Anselmi C,Bocchinfuso G,Scipioni A,De Santis P

更新日期：2001-02-01 00:00:00

abstract：:Elastin-like polypeptide (ELP) fusions have been designed to allow large-scale, nonchromatographic purification of many soluble proteins by using the inverse transition cycling (ITC) method; however, the sensitivity of the aqueous lower critical solubility phase transition temperature (T(t)) of ELPs to the addition of...

journal_title：Biopolymers

authors： Thapa A,Han W,Simons RH,Chilkoti A,Chi EY,López GP

更新日期：2013-01-01 00:00:00

abstract：:The use of alpha,alpha-disubstituted amino acids represents a valuable strategy to exercise conformational control in peptides. Incorporation of the nonstereogenic alpha-aminoisobutyryl-glycyl (Aib-Gly) dipeptidyl sequence into i+1 and i+2 positions of an acyclic peptide sequence, originally designed and investigated ...

journal_title：Biopolymers

authors： Masterson LR,Etienne MA,Porcelli F,Barany G,Hammer RP,Veglia G

更新日期：2007-01-01 00:00:00

abstract：:Cathelicidins are a numerous group of mammalian proteins that carry diverse antimicrobial peptides at the C-terminus of a highly conserved preproregion. These peptides, which become active when released from the proregion, display a remarkable variety of sizes, sequences, and structures, and in fact comprise represent...

journal_title：Biopolymers

authors： Gennaro R,Zanetti M

更新日期：2000-01-01 00:00:00