Abstract：
:Epileptic activity, as a component of epileptic encephalopathies, can interfere with brain growth and development. Infantile spasms as a syndrome represent such epileptic activity during the period of spasms and hypsarrhythmia. The rate of head growth in infants with infantile spasms during the period of spasms has not been studied previously. A retrospective study of head growth in 38 infants with infantile spasms and no other cause of abnormal head growth is presented. Mental outcome was assessed at follow-up. The mean head circumference of infants with infantile spasms was not significantly smaller than in the normal population, but the proportion of head circumference below the tenth percentile in the infantile spasms group was higher (27%). Head circumference below the tenth percentile in the fourth and fifth month after the onset of infantile spasms was significantly associated with later mental retardation (P = 0.004). There was no correlation with specific treatment of infantile spasms. Transiently diminished head growth in infants with infantile spasms coincides temporally with the onset of infantile spasms and "catches up" during remission of infantile spasms in favorable cases. This pattern can reflect the negative influence of epileptic activity on brain growth during the sensitive period. Head circumference can provide a reliable predictive value of mental outcome in children with infantile spasms.
journal_name
Pediatr Neuroljournal_title
Pediatric neurologyauthors
Rener-Primec Z,Lozar-Krivec J,Krivec U,Neubauer Ddoi
10.1016/j.pediatrneurol.2006.03.009subject
Has Abstractpub_date
2006-09-01 00:00:00pages
197-203issue
3eissn
0887-8994issn
1873-5150pii
S0887-8994(06)00221-9journal_volume
35pub_type
杂志文章abstract：:A 16-year-old boy had a gradual onset of post-exercise myalgia with progressive fatigue and dizziness. He had bradycardia (37 beats/minute) with low supine and normal standing norepinephrine levels (56 and 311 pg/mL, respectively). He had absent sympathetically mediated vasoconstrictor responses during Valsalva maneuv...
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journal_title：Pediatric neurology
pub_type： 杂志文章,评审
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journal_title：Pediatric neurology
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journal_title：Pediatric neurology
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journal_title：Pediatric neurology
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journal_title：Pediatric neurology
pub_type： 杂志文章
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更新日期：2009-02-01 00:00:00
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journal_title：Pediatric neurology
pub_type： 杂志文章
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更新日期：2014-07-01 00:00:00
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journal_title：Pediatric neurology
pub_type： 杂志文章
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journal_title：Pediatric neurology
pub_type： 杂志文章,评审
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更新日期：2013-04-01 00:00:00
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journal_title：Pediatric neurology
pub_type： 杂志文章,评审
doi：10.1016/j.pediatrneurol.2007.09.013
更新日期：2008-04-01 00:00:00
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journal_title：Pediatric neurology
pub_type： 杂志文章
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更新日期：2016-08-01 00:00:00
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journal_title：Pediatric neurology
pub_type： 杂志文章
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journal_title：Pediatric neurology
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journal_title：Pediatric neurology
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pub_type： 杂志文章
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journal_title：Pediatric neurology
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更新日期：2013-10-01 00:00:00
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pub_type： 杂志文章
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更新日期：2019-05-01 00:00:00
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journal_title：Pediatric neurology
pub_type： 杂志文章
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更新日期：2018-08-01 00:00:00
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更新日期：2013-11-01 00:00:00
