Hashimoto's encephalopathy in children and adolescents.

Abstract:

:Hashimoto's encephalopathy is an underdiagnosed, steroid-responsive, progressive or relapsing encephalopathy associated with high titers of serum antithyroid antibodies. Although Hashimoto's encephalopathy is well documented in adults, it is rarely observed or studied in children and adolescents. We describe the clinical and laboratory findings of four children (aged 9-15 years) with Hashimoto's encephalopathy. The clinical features of two patients at presentation included epileptic seizures and confusion. The other presenting signs included breath-holding spells, behavioral problems, psychosis, and ataxia (one patient each). During their presentation, three patients were euthyroid, and one was hyperthyroid. All patients manifested increased antithyroid antibodies, and all improved with steroid treatment. Hashimoto's encephalopathy is rarely suspected at presentation. Therefore, greater awareness of its signs by clinicians is necessary for proper diagnoses.

journal_name

Pediatr Neurol

journal_title

Pediatric neurology

authors

Erol I,Saygi S,Alehan F

doi

10.1016/j.pediatrneurol.2011.09.010

subject

Has Abstract

pub_date

2011-12-01 00:00:00

pages

420-2

issue

6

eissn

0887-8994

issn

1873-5150

pii

S0887-8994(11)00413-9

journal_volume

45

pub_type

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