Abstract:
BACKGROUND:Proton magnetic resonance spectroscopy can be used to assess brain integrity and maturation with age. OBJECTIVE:To compare regional cerebral magnetic resonance spectroscopy metabolite ratios in extremely low birth weight and healthy term control infants measured at term-equivalent age and to evaluate association between magnetic resonance spectroscopy metabolites and cognitive and language development at 18-22 months' corrected age. METHODS:Single-voxel point-resolved spectroscopy sequence was performed in a prospective cohort of 43 infants. Magnetic resonance spectroscopy metabolite ratios of N-acetylaspartate to choline-containing compounds and N-acetylaspartate to myo-inositiol in the hippocampus, cortex, and subventricular zone were associated with Bayley mental, cognitive, and language scores at 18-22 months' corrected age. RESULTS:The mean (±S.D.) gestation of the 31 extremely low birth weight population was 25 (±1.1) weeks and mean (±S.D.) birth weight was 749 (±133.9) g. Compared with healthy term control infants, extremely low birth weight infants exhibited consistently lower N-acetylaspartate-to-choline-containing compounds ratios in our three regions of interest, with differences reaching statistical significance for the subventricular zone and cortex regions. In multiple linear regression analyses, N-acetylaspartate-to-choline-containing compounds ratio in the subventricular zone, N-acetylaspartate-to-choline-containing compounds ratio in the cortex, and N-acetylaspartate-to-myo-inositiol ratio in the subventricular zone were significantly associated with Bayley mental scores at 18-22 months' corrected age. CONCLUSIONS:Magnetic resonance spectroscopy metabolite abnormalities at term-equivalent age appear to be significantly associated with cognitive and language development in extremely low birth weight infants.
journal_name
Pediatr Neuroljournal_title
Pediatric neurologyauthors
Bapat R,Narayana PA,Zhou Y,Parikh NAdoi
10.1016/j.pediatrneurol.2014.03.011subject
Has Abstractpub_date
2014-07-01 00:00:00pages
53-9issue
1eissn
0887-8994issn
1873-5150pii
S0887-8994(14)00162-3journal_volume
51pub_type
杂志文章abstract::Hashimoto encephalopathy is a rare, clinically heterogenous condition. Its treatment is based on corticosteroids. A previously normal 12-year-old boy was admitted to our pediatric emergency department with status epilepticus. He experienced a recurrence of status epilepticus after pentobarbital withdrawal, and require...
journal_title:Pediatric neurology
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journal_title:Pediatric neurology
pub_type: 临床试验,杂志文章
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journal_title:Pediatric neurology
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abstract::Occipital lobe epilepsy in children can present as an idiopathic form (i.e., childhood epilepsy with occipital paroxysms) or as a symptomatic form. Forty-three children (18 boys, 25 girls) were divided into the idiopathic group or symptomatic group, according to the classification for epileptic seizures of the Interna...
journal_title:Pediatric neurology
pub_type: 杂志文章
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journal_title:Pediatric neurology
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doi:10.1016/j.pediatrneurol.2017.01.033
更新日期:2017-05-01 00:00:00
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journal_title:Pediatric neurology
pub_type: 杂志文章
doi:10.1016/s0887-8994(02)00456-3
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journal_title:Pediatric neurology
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journal_title:Pediatric neurology
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journal_title:Pediatric neurology
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journal_title:Pediatric neurology
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journal_title:Pediatric neurology
pub_type: 杂志文章,评审
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更新日期:2015-01-01 00:00:00
abstract::Reversible posterior leukoencephalopathy syndrome is a recently recognized disorder with characteristic radiologic findings that mainly involve the white/gray matter of the parieto-occipital lobes. This complex syndrome is associated with cyclosporine A therapy or a variety of other conditions in which blood pressure ...
journal_title:Pediatric neurology
pub_type: 杂志文章
doi:10.1016/s0887-8994(01)00265-x
更新日期:2001-05-01 00:00:00
abstract::Brain plasticity refers to its ability to recover after damage. Visual field plasticity is not well recognized. We report a 12-year-old female who first presented with recurrent seizures and was subsequently found to have a large, right occipital cortical dysplasia on magnetic resonance imaging. Her visual field by Go...
journal_title:Pediatric neurology
pub_type: 杂志文章
doi:10.1016/s0887-8994(00)00171-5
更新日期:2000-09-01 00:00:00
abstract::Twelve patients with hereditary motor and sensory neuropathy with the absence of large myelinated fibers have been reported. All of these patients had central nervous system involvement. In this report, we describe the first patient with pure motor and sensory neuropathy with the absence of large myelinated fibers wit...
journal_title:Pediatric neurology
pub_type: 杂志文章
doi:10.1016/s0887-8994(00)00192-2
更新日期:2000-10-01 00:00:00
abstract::Magnetic resonance imaging (MRI) was used in high-risk infants to assess the myelination process and its relationship with neurologic outcome. The time period when delayed myelination is best detected by MRI was also studied. MRI was performed in 39 high-risk infants (i.e., preterm infants, infants with respiratory di...
journal_title:Pediatric neurology
pub_type: 杂志文章
doi:10.1016/0887-8994(93)90083-o
更新日期:1993-05-01 00:00:00
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journal_title:Pediatric neurology
pub_type: 杂志文章
doi:10.1016/j.pediatrneurol.2005.06.004
更新日期:2006-01-01 00:00:00
abstract::The clinical course and autopsy findings of 2 patients with measles encephalitis that occurred during the 1988-1989 Houston epidemic are reported. A previously healthy 25-month-old boy had serologically-proved measles, hemophagocytic syndrome, and acute disseminated demyelinating encephalitis. A 19-year-old male with ...
journal_title:Pediatric neurology
pub_type: 杂志文章
doi:10.1016/0887-8994(90)90046-4
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journal_title:Pediatric neurology
pub_type: 杂志文章
doi:10.1016/j.pediatrneurol.2019.04.009
更新日期:2019-09-01 00:00:00
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journal_title:Pediatric neurology
pub_type: 杂志文章
doi:10.1016/j.pediatrneurol.2015.01.009
更新日期:2015-05-01 00:00:00
abstract::The pathophysiologic mechanism for stereotypic, bilateral repetitive movements involving the arms and hands (complex motor stereotypies) is unknown. This study used volumetric magnetic resonance imaging to compare cerebral lobes and caudate nucleus in six males with complex stereotypies and average intelligence to age...
journal_title:Pediatric neurology
pub_type: 杂志文章
doi:10.1016/j.pediatrneurol.2004.09.005
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journal_title:Pediatric neurology
pub_type: 杂志文章
doi:10.1016/j.pediatrneurol.2006.05.005
更新日期:2006-11-01 00:00:00
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journal_title:Pediatric neurology
pub_type: 杂志文章
doi:10.1016/0887-8994(94)90054-x
更新日期:1994-03-01 00:00:00
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journal_title:Pediatric neurology
pub_type: 临床试验,杂志文章
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更新日期:2003-01-01 00:00:00
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journal_title:Pediatric neurology
pub_type: 杂志文章
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更新日期:2017-09-01 00:00:00
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journal_title:Pediatric neurology
pub_type: 杂志文章
doi:10.1016/s0887-8994(02)00379-x
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journal_title:Pediatric neurology
pub_type: 杂志文章
doi:10.1016/0887-8994(94)90111-2
更新日期:1994-10-01 00:00:00
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journal_title:Pediatric neurology
pub_type: 杂志文章
doi:10.1016/s0887-8994(01)00246-6
更新日期:2001-04-01 00:00:00
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journal_title:Pediatric neurology
pub_type: 杂志文章
doi:10.1016/s0887-8994(00)00206-x
更新日期:2000-11-01 00:00:00
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journal_title:Pediatric neurology
pub_type: 杂志文章
doi:10.1016/j.pediatrneurol.2014.01.028
更新日期:2014-06-01 00:00:00
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journal_title:Pediatric neurology
pub_type: 杂志文章
doi:10.1016/j.pediatrneurol.2013.01.008
更新日期:2013-07-01 00:00:00