Abstract:
BACKGROUND:It is well known that febrile seizures are commonly occur in children with exanthem subitum. In this study, we compared the clinical features and backgrounds of patients with complex febrile seizures with and without primary human herpesvirus 6B infection. METHODS:Sixty-two patients were enrolled after experiencing their first febrile seizure. Primary human herpesvirus 6B infection was confirmed when human herpesvirus 6B DNA was detected and human herpesvirus 6B antibody was negative in serum obtained during the acute phase of infection. Patient age, gender, and features of seizures were evaluated between patients with and without human herpesvirus 6B infection. RESULTS:Thirty patients with complex febrile seizure were diagnosed with primary human herpesvirus 6B infection. Those with primary human herpesvirus 6B infection (median, 13 months; range, seven to 39 months) were significantly younger than those without primary human herpesvirus 6B infection (median, 19 months; range, 10 to 59 months) (P = 0.001), and the proportion of males was significantly higher in patients without primary human herpesvirus 6B infection (male/female, 25/7) than in those with the infection (male/female, 14/16) (P = 0.017). An interval between fever onset and seizures of more than 24 hours was significantly more common in patients with primary human herpesvirus 6B infection (15 of the 30 patients) than in those without primary HHV-6B infection (two of 32 patients) (P < 0.001). CONCLUSIONS:A younger age at onset, a different gender ratio compared with febrile seizure due to other causes, and the length of interval between fever and seizures were features of complex febrile seizure associated human herpesvirus 6B infection. These findings may suggest a mechanism of complex febrile seizure onset different from that due to other causes.
journal_name
Pediatr Neuroljournal_title
Pediatric neurologyauthors
Miyake M,Kawamura Y,Hattori F,Miura H,Ishihara N,Yoshikawa Tdoi
10.1016/j.pediatrneurol.2020.03.015subject
Has Abstractpub_date
2020-08-01 00:00:00pages
52-55eissn
0887-8994issn
1873-5150pii
S0887-8994(20)30109-0journal_volume
109pub_type
杂志文章abstract::Postictal psychosis is a state of psychosis following repeated or prolonged complex partial seizures with or without secondary generalization and is well described in adult epilepsy literature. It is sparsely reported in the pediatric literature. This report describes a 12-year-old male presenting with status epilepti...
journal_title:Pediatric neurology
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journal_title:Pediatric neurology
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journal_title:Pediatric neurology
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journal_title:Pediatric neurology
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abstract::The clinical course and autopsy findings of 2 patients with measles encephalitis that occurred during the 1988-1989 Houston epidemic are reported. A previously healthy 25-month-old boy had serologically-proved measles, hemophagocytic syndrome, and acute disseminated demyelinating encephalitis. A 19-year-old male with ...
journal_title:Pediatric neurology
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doi:10.1016/0887-8994(90)90046-4
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journal_title:Pediatric neurology
pub_type: 历史文章,杂志文章,评审
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journal_title:Pediatric neurology
pub_type: 杂志文章
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journal_title:Pediatric neurology
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Pediatric neurology
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journal_title:Pediatric neurology
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journal_title:Pediatric neurology
pub_type: 杂志文章
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journal_title:Pediatric neurology
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journal_title:Pediatric neurology
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journal_title:Pediatric neurology
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journal_title:Pediatric neurology
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journal_title:Pediatric neurology
pub_type: 杂志文章,评审
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更新日期:1991-03-01 00:00:00
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journal_title:Pediatric neurology
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journal_title:Pediatric neurology
pub_type: 杂志文章
doi:10.1016/s0887-8994(96)00229-9
更新日期:1996-11-01 00:00:00
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journal_title:Pediatric neurology
pub_type: 杂志文章,评审
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更新日期:2016-01-01 00:00:00
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journal_title:Pediatric neurology
pub_type: 杂志文章
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journal_title:Pediatric neurology
pub_type: 杂志文章
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journal_title:Pediatric neurology
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journal_title:Pediatric neurology
pub_type: 杂志文章
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