Effect of treatment of obstructive sleep apnea on seizure outcomes in children with epilepsy.

Abstract:

:A retrospective review of children with epilepsy and obstructive sleep apnea, treated surgically for their obstructive sleep apnea from January 2008-October 2010, was performed for age, sex, type of epilepsy, antiseizure medications, sleep-study data, and changes in seizure frequency. Twenty-seven subjects (median age, 5 years) with no adjustment to their medications around their time of surgery were identified. Three months after surgery, 10 (37%) patients became seizure-free, three (11%) demonstrated >50% seizure-reduction, and six (22%) exhibited an amelioration of seizure frequency. Two (7%) demonstrated unchanged seizure-frequency, and six (22%) manifested a worsening of seizure frequency. Median seizure frequency before surgery was 8.5 (interquartile range, 2-90), and after surgery, three (interquartile range, 0-75), with a 53% median seizure reduction. Multivariate analysis demonstrated a trend toward seizure freedom with each percentile increase in body mass index and early age of surgery. We conclude that obstructive sleep apnea surgery may decrease seizure frequency, especially in children with elevated body mass index scores and younger age at time of surgery.

journal_name

Pediatr Neurol

journal_title

Pediatric neurology

authors

Segal E,Vendrame M,Gregas M,Loddenkemper T,Kothare SV

doi

10.1016/j.pediatrneurol.2012.03.005

subject

Has Abstract

pub_date

2012-06-01 00:00:00

pages

359-62

issue

6

eissn

0887-8994

issn

1873-5150

pii

S0887-8994(12)00092-6

journal_volume

46

pub_type

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