Short term effects of valproate on infantile spasms.

Abstract:

:Although valproic acid (VPA) is used to treat infantile spasms, VPA's efficacy in infantile spasms has not been determined in a controlled study. This study evaluated the effect of VPA on infantile spasms in patients who had not responded to adrenocorticotropin (ACTH) and corticosteroid therapy. The hypotheses were tested using a double-blind, randomized controlled crossover design. Twenty-one patients were randomly assigned to either the baseline-valproate-placebo treatment or the baseline-placebo-valproate treatment groups. Based on a repeated measures analysis of variance test, the valproate group had lower total mean spasm frequency levels than the placebo group. However, this difference did not remain after the crossover; the difference was due to the initial administration of valproate and placebo. When the spasm index was analyzed, the valproate treatment was found to have lower mean spasm index scores than the baseline treatments (p less than 0.03). No short-term toxic effects were observed in any patient. We conclude that short-term VPA therapy has a beneficial effect even on chronic infantile spasm patients who have failed to respond to ACTH/corticosteroid therapy.

journal_name

Pediatr Neurol

journal_title

Pediatric neurology

authors

Dyken PR,DuRant RH,Minden DB,King DW

doi

10.1016/0887-8994(85)90006-2

subject

Has Abstract

pub_date

1985-01-01 00:00:00

pages

34-7

issue

1

eissn

0887-8994

issn

1873-5150

pii

0887-8994(85)90006-2

journal_volume

1

pub_type

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