Abstract：
:Sedation administration and agitation management are fundamental activities in any intensive care unit. A lack of objective measures of agitation and sedation, as well as poor understanding of the underlying dynamics, contribute to inefficient outcomes and expensive healthcare. Recent models of agitation-sedation dynamics have enhanced understanding of the underlying dynamics and enable development of advanced protocols for semi-automated sedation administration. In this research, the agitation-sedation model parameters are identified using an integral-based fitting method developed in this work. Parameter variance is then analysed over 37 intensive care unit patients. The parameter identification method is shown to be effective and computationally inexpensive, making it suited to real-time clinical control applications. Sedative sensitivity, an important model parameter, is found to be both patient-specific and time-varying. However, while the variation between patients is observed to be as large as a factor 10, the observed variation in time is smaller, and varies slowly over a period of days rather than hours. The high fitted model performance across all patients show that the agitation-sedation model presented captures the fundamental dynamics of the agitation-sedation system. Overall, these results provide additional insight into the system and clinical dynamics of sedation management.
journal_name
Comput Methods Programs Biomedjournal_title
Computer methods and programs in biomedicineauthors
Rudge AD,Chase JG,Shaw GM,Lee D,Hann CEdoi
10.1016/j.cmpb.2006.06.011subject
Has Abstractpub_date
2006-09-01 00:00:00pages
211-21issue
3eissn
0169-2607issn
1872-7565pii
S0169-2607(06)00161-1journal_volume
83pub_type
杂志文章abstract：BACKGROUND AND OBJECTIVE:Analysis of glomeruli geometry is important in histopathological evaluation of renal microscopic images. Due to the shape and size disparity of even glomeruli of same kidney, automatic detection of these renal objects is not an easy task. Although manual measurements are time consuming and at t...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2017.08.011
更新日期：2017-11-01 00:00:00
abstract：:A dynamic compartmental model is developed to describe the redistribution of fluid and albumin between the circulation and the intact and injured interstitia following burn injury in humans. Transcapillary fluid and albumin exchange is described by a coupled Starling mechanism, while the effect of the burn is represen...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/0169-2607(95)01637-9
更新日期：1995-06-01 00:00:00
abstract：:Closed-loop insulin delivery systems often implement glucose measurement and insulin administration in the subcutis. However some existing models for glucose-insulin system ignored the dynamics of subcutaneous glucose and subcutaneously-injected insulin. This paper reports a two-compartment model that includes glucose...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2013.05.001
更新日期：2013-08-01 00:00:00
abstract：:The quality of intraoral radiographs made in dental practices is too often not adequate for diagnostic purposes. This necessitates standardized measures for the quality of intraoral radiographs and controlled techniques for automatic image improvement. For the evaluation of the quality of digitized intraoral radiograp...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/0169-2607(94)01597-9
更新日期：1995-01-01 00:00:00
abstract：OBJECTIVES:Postoperative delirium is a common complication after major surgery among the elderly. Despite its potentially serious consequences, the complication often goes undetected and undiagnosed. In order to provide diagnosis support one could potentially exploit the information hidden in free text documents from e...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2017.09.014
更新日期：2017-12-01 00:00:00
abstract：:The continuing education is a challenge for health care professionals, considering the growing amount and variable quality of information in this field. In this context, we developed a method allowing clinicians to have a centralised access to the best current medical evidence supporting medical decision-making. Relev...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/s0169-2607(02)00055-x
更新日期：2003-05-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Frozen-thawed embryo transfer (FET) is now widely used for the treatment of infertility. For many couples and clinicians, concerns over the probability and how to increase the chance of a successful birth are very common. Currently, there is not a single model to predict the live birth outcomes...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2020.105780
更新日期：2021-01-01 00:00:00
abstract：:Analysis of longitudinal data is one of the most challenging tasks in statistical modeling. In the analysis, it is often necessary to take into account nonlinear response to a set of parameters of interest and correlation between measurements taken from the same individual. In addition, between- and within-subject var...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/s0169-2607(97)00066-7
更新日期：1998-03-01 00:00:00
abstract：BACKGROUND:Diabetic retinopathy (DR) is one of the leading causes of blindness globally. Earlier detection and timely treatment of DR are desirable to reduce the incidence and progression of vision loss. Currently, deep learning (DL) approaches have offered better performance in detecting DR from retinal fundus images....
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2020.105320
更新日期：2020-07-01 00:00:00
abstract：BACKGROUND:The aim of this articles is to investigate the entropy optimization in Darcy-Forchheimer hybrid nanofluids flow towards a stretchable surface. The flow is caused due to stretching of surface. Energy equation is discussed through heat generation/absorption, viscous dissipation and heat flux. Here molybdenum d...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2019.105152
更新日期：2020-03-01 00:00:00
abstract：OBJECTIVE:The present investigation is concerned with hybrid mediated blood flow model through atherosclerotic bifurcated artery with slip effects by considering the properties of compliant walls. DESIGN/APPROACH:In human body, the circulatory system is made up of a network of blood vessels that include the bifurcatio...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2019.07.008
更新日期：2019-10-01 00:00:00
abstract：:Rapid and accurate discrimination of single units from extracellular recordings is a fundamental process for the analysis and interpretation of electrophysiological recordings. We present an algorithm that performs detection, characterization, discrimination, and analysis of action potentials from extracellular record...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2004.07.001
更新日期：2004-12-01 00:00:00
abstract：:We propose a new algorithm for optimising sampling times for population pharmacokinetic experiments using D-optimality. The algorithm was used in conjunction with the population Fisher information matrix as implemented in MATLAB (PFIM 1.1 and 1.2) to evaluate population pharmacokinetic designs. The new algorithm based...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2005.07.001
更新日期：2005-11-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Attention deficit hyperactivity disorder (ADHD) is often presented with conduct disorder (CD). There is currently no objective laboratory test or diagnostic method to discern between ADHD and CD, and diagnosis is further made difficult as ADHD is a common neuro-developmental disorder often pre...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2021.105941
更新日期：2021-01-14 00:00:00
abstract：:This paper describes a framework, called QCMF (Qualitative Compartmental Modeling Framework), which assists the user in formulating models of a pathophysiological system and in analyzing their behaviors through the simulation of the effects of a variety of pathogenetic mechanisms and therapeutical treatments. QCMF has...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/0169-2607(94)90096-5
更新日期：1994-04-01 00:00:00
abstract：:Computer-assisted preoperative planning are particularly sought for enhancing surgical implantation and improving clinical outcome of ankle joint replacement arthroplasty. A planning tool was designed to enhance the surgical implantation of a novel ligament-compatible three-component prosthesis. The tool includes a ge...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/s0169-2607(01)00150-x
更新日期：2002-03-01 00:00:00
abstract：:A set of programs is described by which a consistent morphometry of bone sections can be performed. The programs are written in FORTRAN IV in a PDP 11/10 minicomputer, under the RT-11 operating system. The bone sections are run through the field of vision of the microscope using a scanning stage in one of several pres...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/0169-2607(85)90003-3
更新日期：1985-12-01 00:00:00
abstract：:This paper introduces temporal logics. Due to the eternal compromise between expressive adequacy and reasoning efficiency that must decided upon in any application, full (first order logic or modal logic based) temporal logics are frequently not suitable. This is especially true in real time expert systems, where a fi...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章,评审
doi：10.1016/0169-2607(96)01761-0
更新日期：1996-10-01 00:00:00
abstract：:A PC-based HIS/RIS/Modality/PACS coupling was developed and operated where hospital-wide PACS was closely cooperated with the HIS and RIS. Three workstations with a magneto-optical disk (MOD) juke-box for each one were used as PACS servers to collect images from eight computed radiography systems and three CT scanners...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/s0169-2607(98)00046-7
更新日期：1998-08-01 00:00:00
abstract：OBJECTIVE:To audit routine clinical practice in screening patients admitted to an accident and emergency department for deep venous thrombosis in the leg (DVT) and compare it with a computer algorithm. DESIGN:Retrospective study of case notes with data subsequently entered into a computer algorithm followed by a compa...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2019.105046
更新日期：2019-12-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Low-dose X-ray fluoroscopy has continually evolved to reduce radiation risk to patients during clinical diagnosis and surgery. However, the reduction in dose exposure causes quality degradation of the acquired images. In general, an X-ray device has a time-average pre-processor to remove the ge...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2017.09.010
更新日期：2017-12-01 00:00:00
abstract：:Traditional gait and fluoroscopy analysis of human movement are largely utilised but are still limited in registration, integration, synchronisation and visualisation capabilities. The present work exploits the features of a recently developed software tool based on multimodal display (Data Manager developed within th...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2005.04.007
更新日期：2005-09-01 00:00:00
abstract：:Accurate and fast approaches for automatic ECG data classification are vital for clinical diagnosis of heart disease. To this end, we propose a novel multistage algorithm that combines various procedures for dimensionality reduction, consensus clustering of randomized samples and fast supervised classification algorit...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2013.08.002
更新日期：2013-12-01 00:00:00
abstract：:Workplace description is an operation indispensable for the identification of professional risks and, in fulfillment of that objective, can best be accomplished by listing the constituent tasks associated with each job. This article presents a software in Visual-Basic to be run on a portable micro-computer, which faci...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/s0169-2607(97)01777-x
更新日期：1997-01-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Hepatocellular ballooning is an important histological parameter in the diagnosis of nonalcoholic steatohepatitis (NASH), and it is considered to be a morphological pattern that indicates the severity and the progression to cirrhosis and liver-related deaths. There remains uncertainty about the...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2020.105614
更新日期：2020-10-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:A new expert system is proposed to discriminate healthy people from people with Parkinson's Disease (PD) in early stages by using Diadochokinesis tests. METHODS:The system is based on temporal and spectral features extracted from the Voice Onset Time (VOT) segments of /ka/ syllables, whose bou...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2017.11.010
更新日期：2018-02-01 00:00:00
abstract：:Electroencephalogram (EEG) has established itself as an important means of identifying and analyzing epileptic seizure activity in humans. In most cases, identification of the epileptic EEG signal is done manually by skilled professionals, who are small in number. In this paper, we try to automate the detection proces...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2008.02.005
更新日期：2008-08-01 00:00:00
abstract：:An ion-selective electrode and microcomputer-based experimental setup for the study of ionic-exchange kinetics between a powdered solid and the solution is described. The equipment is composed of easily available commercial devices and a data acquisition and regularization computer program is presented. The system, es...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/0169-2607(90)90055-e
更新日期：1990-02-01 00:00:00
abstract：:Both sample entropy and approximate entropy are measurements of complexity. The two methods have received a great deal of attention in the last few years, and have been successfully verified and applied to biomedical applications and many others. However, the algorithms proposed in the literature require O(N(2)) execu...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2010.12.003
更新日期：2011-12-01 00:00:00
abstract：:Synchronous averaging over time locked single-trial of event-related potential (ERP) is known as the simplest scheme to extract P300 component. This method assumes the P300 features are invariant through the time while they are affected by factors like brain fatigue and habitation. In this study, a new scheme is propo...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2017.04.014
更新日期：2017-07-01 00:00:00
