Abstract：
:A dynamic compartmental model is developed to describe the redistribution of fluid and albumin between the circulation and the intact and injured interstitia following burn injury in humans. Transcapillary fluid and albumin exchange is described by a coupled Starling mechanism, while the effect of the burn is represented by time-dependent perturbations to all three compartments. The unknown model parameters are determined for two groups of patients, having less than and greater than 25% total body surface area burns, by statistical fitting of model predictions to patient data from two sources. The parameters include the perturbations to the fluid filtration coefficients in uninjured and injured tissue, GkF,Tl and GkF,BT, respectively, the relaxation coefficient, r, which describes the exponential decay of the perturbations, and the exudation factor, EXFAC, which relates the protein concentration in the exudate to that in the injured tissue. Perturbations to other parameters, including the membrane permeability-surface area product and the albumin reflection coefficient in the injured and uninjured tissues, are determined based on interrelationships with GkF,Tl and GkF,BT. The values of GkF,BT, when corrected for tissue destruction and decreased post-injury perfusion, are in reasonable agreement with the limited experimental data available from the literature. The model and its parameters are further validated by comparing the simulated patient responses to the clinical data used in the parameter estimation as well as to data available from two additional sources.
journal_name
Comput Methods Programs Biomedjournal_title
Computer methods and programs in biomedicineauthors
Ampratwum RT,Bowen BD,Lund T,Reed RK,Bert JLdoi
10.1016/0169-2607(95)01637-9subject
Has Abstractpub_date
1995-06-01 00:00:00pages
1-19issue
1eissn
0169-2607issn
1872-7565pii
0169260795016379journal_volume
47pub_type
杂志文章abstract：BACKGROUND AND OBJECTIVE:Frozen-thawed embryo transfer (FET) is now widely used for the treatment of infertility. For many couples and clinicians, concerns over the probability and how to increase the chance of a successful birth are very common. Currently, there is not a single model to predict the live birth outcomes...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2020.105780
更新日期：2021-01-01 00:00:00
abstract：:A novel methodology of electrophoretic gel image analysis has been proposed that is based on two-dimensional image processing methods instead of previously used one-dimensional Gaussian deconvolution. The crucial problem of the analysis of imperfect gels, that consists in band detection, is solved using the algorithms...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2004.09.007
更新日期：2005-03-01 00:00:00
abstract：:The paper describes a software method to extend ITK (Insight ToolKit, supported by the National Library of Medicine), leading to ITK++. This method, which is based on the extension of the iterator design pattern, allows the processing of regions of interest with arbitrary shapes, without modifying the existing ITK cod...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2005.09.006
更新日期：2006-01-01 00:00:00
abstract：:A current trend in genomics is the investigation of the cell mechanism using different technologies, in order to explain the relationship among genes, molecular processes and diseases. For instance, the combined use of gene-expression arrays and genomic arrays has been demonstrated as an effective instrument in clinic...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2013.04.006
更新日期：2013-08-01 00:00:00
abstract：:The successful implementation of PACS (or IMACS) depends on the integration of image and image related data handling systems in an overall hospital information system (HIS) and other departmental information systems (DIS), one of which is radiology information system (RIS). With respect to standardization in the medic...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/0169-2607(94)90181-3
更新日期：1994-05-01 00:00:00
abstract：:The increasing use of computer systems for storing patient information in different hospitals, in different departments within the same hospital, in clinics and even in doctors' surgeries, is creating a problem in terms of the fragmentation of the patient record. The lack of any coordination or standardization in the ...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/0169-2607(94)90080-9
更新日期：1994-06-01 00:00:00
abstract：:Telemedicine provides a new way of delivering medical services. The good quality of the picture is, however, essential for a proper and reliable teleconsultation, especially in the cases when visual information about the patient's physical condition is of great importance as in ophthalmology and dermatology. Therefore...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/s0169-2607(00)00120-6
更新日期：2001-05-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:In oral and maxillofacial surgery, conventional radiographic cephalometry is one of the standard auxiliary tools for diagnosis and surgical planning. While contemporary computer-assisted cephalometric systems and methodologies support cephalometric analysis, they tend neither to be practical no...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2016.03.014
更新日期：2016-07-01 00:00:00
abstract：:This paper describes the results of a controlled multicenter study on the effect of the computer assistance in the intensive insulin therapy. The patient collective consisted of 50 diabetics, randomly divided in two groups with 25 patients per group. The Multiple Subcutaneous Injection (MSI) group was treated with the...
journal_title：Computer methods and programs in biomedicine
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1016/s0169-2607(02)00034-2
更新日期：2002-08-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Shape prior models play a vital role for segmentation in medical image analysis. These models are most effective when shape variations can be captured by a parametric distribution, and sufficient training data is available. However, in the absence of these conditions, results are invariably muc...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2020.105760
更新日期：2020-09-24 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Automated segmentation with high accuracy and speed is a prerequisite for FEA-based quantitative assessment with a large population. However, hip joint segmentation has remained challenging due to a narrow articular cartilage and thin cortical bone with a marked interindividual variance. To ove...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2017.11.007
更新日期：2018-02-01 00:00:00
abstract：:Atrial fibrillation (AF) is the commonest arrhythmia, yet the mechanisms of its onset and persistence are incompletely known. Although techniques for quantitative assessment have been investigated, there have been few attempts to integrate this information to advance disease treatment protocols. In this review, key qu...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章,评审
doi：10.1016/j.cmpb.2019.06.017
更新日期：2019-09-01 00:00:00
abstract：:This article describes a computer program (HANOIPC3) based on the Tower of Hanoi game that, by analyzing a series of parameters during execution, allows a fast and accurate evaluation of data related to certain executive functions, especially planning, organizing and problem-solving. This computerized version has only...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2009.02.007
更新日期：2009-08-01 00:00:00
abstract：:The lower urinary tract is one of the most complex biological systems of the human body as it involved hydrodynamic properties of urine and muscle. Moreover, its complexity is increased to be managed by voluntary and involuntary neural systems. In this paper, a mathematical model of the lower urinary tract it is propo...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2012.09.005
更新日期：2013-03-01 00:00:00
abstract：:Several approaches, based on different assumptions and with various degree of theoretical sophistication and implementation complexity, have been developed for improving the measurement of evoked potentials (EP) performed by conventional averaging (CA). In many of these methods, one of the major challenges is the expl...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/s0169-2607(01)00175-4
更新日期：2002-06-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:The purpose of this study is to examine the reliability of the clinical use of the self-built decision support system, diagnosis-supported attention deficit hyperactivity disorder (DS-ADHD), in an effort to develop the DS-ADHD system, by probing into the development of indicating patterns of p...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2016.12.003
更新日期：2017-03-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Gallbladder polyp is a common disease with an overall population prevalence between 4 and 7%. It can be classified as neoplastic and non-neoplastic lesions. Surgical treatment is necessary for neoplastic polyps. Due to its easy accessibility and nonradioactive, ultrasonography is the mostly use...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2019.105118
更新日期：2020-03-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Deep learning enables tremendous progress in medical image analysis. One driving force of this progress are open-source frameworks like TensorFlow and PyTorch. However, these frameworks rarely address issues specific to the domain of medical image analysis, such as 3-D data handling and distanc...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2020.105796
更新日期：2021-01-01 00:00:00
abstract：:Role of hepatic insulin degradation in modulating insulin delivery to peripheral circulation, in insulin-resistant hypertensive patients, is not yet fully understood. This issue was investigated here by a novel application to hypertension of a previously proposed minimal modelling of insulin and C-peptide data, using ...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2009.08.007
更新日期：2010-02-01 00:00:00
abstract：:This paper presents an original interactive system for efficient medical image segmentation in computer aided diagnosis. The main originality concerns the method used to manage, according to an a priori topological-based structural model, regions of interest (ROIs) within which computations can be constrained. The goa...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2006.04.004
更新日期：2006-06-01 00:00:00
abstract：:A program for action potential waveform analysis based on a PC compatible computer is described. Single or averaged action potentials are analyzed by obtaining its first derivative and using criteria which allow automatic measurement of several action potential components, including: depolarization rate, repolarizatio...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/s0169-2607(00)00053-5
更新日期：2000-06-01 00:00:00
abstract：BACKGROUND:Glioblastoma multiforme (GBM) is the most frequent primary brain tumor in adults and Temozolomide (TMZ) is an effective chemotherapeutic agent for its treatment. In Silico models of GBM growth provide an appropriate foundation for analysis and comparison of different regimens. We propose a mathematical frame...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2020.105443
更新日期：2020-09-01 00:00:00
abstract：:A set of programs is described by which a consistent morphometry of bone sections can be performed. The programs are written in FORTRAN IV in a PDP 11/10 minicomputer, under the RT-11 operating system. The bone sections are run through the field of vision of the microscope using a scanning stage in one of several pres...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/0169-2607(85)90003-3
更新日期：1985-12-01 00:00:00
abstract：:In cardiology, ultrasound is often used to diagnose heart disease associated with myocardial infarction. This study aims to develop robust segmentation techniques for segmenting the left ventricle (LV) in ultrasound images to check myocardium movement during heartbeat. The proposed technique utilizes machine learning ...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2020.105914
更新日期：2020-12-17 00:00:00
abstract：:This research project sought to design and implement a computerized clinical decision support system (CDSS) that was able to identify patients who were at risk of pulmonary embolism (PE) and deep vein thrombosis (DVT), as well as produce reminders for prophylactic action for these diseases. The main purpose of the CDS...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2014.03.007
更新日期：2014-07-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Liver quality evaluation is one of the vital steps for predicting the success of liver transplantation. Current evaluation methods, such as biopsy and visual inspection, which are either invasive or lack of consistent standards, provide limited predictive value of long-term transplant viability...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2018.06.003
更新日期：2018-10-01 00:00:00
abstract：:Lung cancer is one of the most common forms of cancer resulting in over a million deaths per year worldwide. In this paper, the usage of support vector machine (SVM) classification for lung cancer is investigated, presenting a systematic quantitative evaluation against Boosting, Decision trees, k-nearest neighbor, LAS...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2013.04.016
更新日期：2013-08-01 00:00:00
abstract：:When underlying distributions are unknown and sample sizes are small, permutation tests may have superior features to parametric tests, such as smaller type I error and more accurate probability values when testing the null hypothesis. However, permutation tests are not widely used in clinical trials because of their ...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2005.03.010
更新日期：2005-08-01 00:00:00
abstract：:One of the critical functions of a tissue-engineered construct is to be able to provide adequate nutrient and oxygen supply into the interior of the construct. An insufficient supply will lead to slower cellular proliferation rates and eventual apoptosis. The supply of the nutrients is largely governed by the transpor...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2007.04.003
更新日期：2007-07-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Rotator cuff muscle tear is one of the most frequent reason of operations in orthopedic surgery. There are several clinical indicators such as Goutallier grade and occupation ratio in the diagnosis and surgery of these diseases, but subjective intervention of the diagnosis is an obstacle in acc...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2019.105063
更新日期：2019-12-01 00:00:00
