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Glucose-insulin regulation model with subcutaneous insulin injection and evaluation using diabetic inpatients data.

Abstract：

:Closed-loop insulin delivery systems often implement glucose measurement and insulin administration in the subcutis. However some existing models for glucose-insulin system ignored the dynamics of subcutaneous glucose and subcutaneously-injected insulin. This paper reports a two-compartment model that includes glucose and insulin dynamics in subcutis, and its evaluation using patient data. Clinical information such as glucose level, insulin dosage, insulin injection time and meals of anonymous diabetes inpatients was collected. Measured glucose level of the diabetic inpatients agrees with that of computer simulation. Due to the lack of glucose-insulin model with subcutaneously-injected insulin for type 2 diabetic patients, our model was compared with existing model for type 1 subjects. The new glucose-insulin model can mimic dynamics of glucose and insulin under the disturbance of insulin injections and meals. Model parameters were estimated using nonlinear least square method and their effect on pathology and physiology of diabetes were analyzed.

journal_name

Comput Methods Programs Biomed

journal_title

Computer methods and programs in biomedicine

authors

Wu Z,Chui CK,Hong GS,Khoo E,Chang S

doi

10.1016/j.cmpb.2013.05.001

subject

Has Abstract

pub_date

2013-08-01 00:00:00

pages

347-56

issue

2

eissn

0169-2607

issn

1872-7565

pii

S0169-2607(13)00145-4

journal_volume

111

pub_type

杂志文章

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