Abstract：
:Macrophages (MPs) produce increased levels of proinflammatory cytokines in Crohn's disease; these cytokines are thought to play a central role in the occurrence of the disease. Biologics are currently available for anti-cytokine therapy, but treating intestinal inflammation through direct suppression of proinflammatory cytokine production could be more effective. P-ATPase inhibitors have been reported to be anti-inflammatory, and these inhibitors might suppress the production of MP proinflammatory cytokines. In this study, we examined the effect of two types of ATPase inhibitors on the expression patterns of typical proinflammatory cytokines. Peritoneal MPs from 6- to 8-week-old mice were cultured for 48 h in the presence of lansoprazole (P-ATPase inhibitor), bafilomycin A(1) (V-ATPase inhibitor), or the control solvent dimethylsulfoxide. The MPs were then examined for cytokine expression by quantitative real-time polymerase chain reaction (PCR), and culture supernatants were examined for cytokine production with a multiplex assay in a suspension array system. The possible existence of P-ATPase mRNA in MPs was explored using reverse-transcriptase PCR. P-ATPase mRNA was not detected in MP cells. However, all examined proinflammatory cytokines decreased significantly in their mRNA and protein expression in the lansoprazole-treated group. Conversely, bafilomycin A(1) increased the levels of these cytokines. Lansoprazole might be useful for the treatment of inflammatory bowel diseases (IBDs), including Crohn's disease, as it suppresses the production of relevant MP proinflammatory cytokines. However, because P-ATPase was not detected in MPs, the mechanism is unclear and remains to be studied further in an IBD animal model.
journal_name
Pediatr Surg Intjournal_title
Pediatric surgery internationalauthors
Hinoki A,Yoshimura K,Fujita K,Akita M,Ikeda R,Nagashima M,Nomura M,Satomi Adoi
10.1007/s00383-006-1767-8subject
Has Abstractpub_date
2006-11-01 00:00:00pages
915-23issue
11eissn
0179-0358issn
1437-9813journal_volume
22pub_type
杂志文章abstract：UNLABELLED:Anorectal malformation (ARM) is a group of significant birth defects with geographic variation in incidence, individual phenotypes and regional geographic subtypes occurring in approximately 1:5,000 live births. Anorectal atresia with gross terminal colonic distension in the presence of an absent anal canal ...
journal_title：Pediatric surgery international
pub_type： 杂志文章,多中心研究
doi：10.1007/s00383-013-3346-0
更新日期：2013-12-01 00:00:00
abstract：:This article describes five cases of congenital epulis, a rare and benign swelling in the mouth of a newborn, which is not widely known. We present five cases: four cases presented as single pedunculated nodules of the gingiva and in one case two nodules were present. Of all, 50% were located at the maxilla. Excision ...
journal_title：Pediatric surgery international
pub_type： 杂志文章,评审
doi：10.1007/s00383-008-2304-8
更新日期：2009-02-01 00:00:00
abstract：BACKGROUND:Vitamin D deficiency is associated with intestinal barrier dysfunction, which contributes to pathogenesis of acute intestinal injury in children. We aim to investigate the effects of vitamin D on intestinal injury in intestinal epithelial cells and organoids. METHODS:Lipopolysaccharide (LPS) was used to ind...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-019-04586-y
更新日期：2019-12-01 00:00:00
abstract：PURPOSE:The Mac-2-binding protein glycosylation-modified isomer (M2BPGi) is a new marker for progression of hepatic fibrosis. We examined the relationship between serum M2BPGi levels and liver histological findings in patients with biliary atresia (BA) who were not transplant candidates. METHODS:Patients with BA who w...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-018-4317-2
更新日期：2018-10-01 00:00:00
abstract：:A reproducible technique was developed experimentally in pigs for construction of a 'composite bowel tube' (CBT) made up of ileal mucosa that was grafted to a mucosally denuded colonic muscle surface vascularised by the colonic mesentery. Macroscopic and microscopic studies at terminal laparotomy revealed a viable, mu...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/BF00178430
更新日期：1996-04-01 00:00:00
abstract：:To determine the long-term outcome of congenital cystic adenomatoid malformation (CCAM), the records of all patients with CCAM treated in three Hungarian paediatric surgical centers between 1977 and 1996 were reviewed. Patients were followed for up to 20 years following diagnosis and treatment. In 20 patients CCAM was...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s003830050593
更新日期：1999-07-01 00:00:00
abstract：:Modern plastic and reconstructive surgery continues to significantly improve the functional and aesthetic post-burn sequelae in children. It has become a major factor in restoring mobility, aesthetic appearance, self-esteem, and quality of life. The entire spectrum of plastic reconstructive procedures should be availa...
journal_title：Pediatric surgery international
pub_type： 杂志文章,评审
doi：10.1007/BF01076930
更新日期：1997-07-01 00:00:00
abstract：:The confluence of the right and left hepatic ducts at the hepatic hilum frequently shows normal anatomic variations. Choledochal cysts (CC) are also accompanied by similar variations, and devices for free drainage of bile are occasionally required in biliary reconstruction. We present a CC that had an aberrant posteri...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/BF01371914
更新日期：1997-01-01 00:00:00
abstract：:Hirschsprung disease is the result of aganglionosis of a variable length of the terminal bowel, which arises from the incomplete colonisation of the embryonic gut by vagal neural crest-derived cells (NCC) that migrate caudally from the pharyngeal gut to the rectum. We have previously shown that a very small group of N...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-002-0868-2
更新日期：2002-10-01 00:00:00
abstract：:Bronchogenic cysts are congenital malformations of the tracheobronchial tree. We describe a 20-month-old male who presented with persistent non-bilious emesis; manometry and imaging were consistent with esophageal achalasia. During a planned laparoscopic Heller myotomy, an intramural bronchogenic cyst was discovered i...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-016-3994-y
更新日期：2017-01-01 00:00:00
abstract：AIM:Prepubertal testicular tumors are rare in children. We aim to present clinical and histological features of prepubertal testicular tumors through the analysis of the long-term experiences of a single medical center of China. MATERIALS AND METHODS:A total of 67 children (≤ 14 years) treated for testicular tumor at ...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-018-4366-6
更新日期：2018-12-01 00:00:00
abstract：:Anorectal malformations (ARM) remain a significant birth defect with geographic variation in incidence, individual phenotypes and regional geographic subtypes. Although early studies indicated a low incidence in Black patients, there is a great paucity of knowledge as to the types, frequency and incidence of ARMs enco...
journal_title：Pediatric surgery international
pub_type： 杂志文章,多中心研究
doi：10.1007/s00383-008-2131-y
更新日期：2008-06-01 00:00:00
abstract：:Management of stage IV rhabdomyosarcoma comprises systemic chemotherapy with local control by conservative surgery and radiotherapy. Abdominal radiotherapy may lead to radiation enteritis causing such serious morbidity as malabsorption, fistulae or stricture formation. The risk increases with the dose of radiation and...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-005-1490-x
更新日期：2005-09-01 00:00:00
abstract：:Recent studies of testicular descent suggest not only that the gubernaculum does not initially attach to the scrotum, but also that it must migrate from the groin. Two findings suggest that the gubernaculum may behave like an embryonic limb bud during this phase. First, the active growth centre is at the distal tip of...
journal_title：Pediatric surgery international
pub_type： 杂志文章,评审
doi：10.1007/s00383-007-1907-9
更新日期：2007-07-01 00:00:00
abstract：:Congenital pyloric atresia (CPA) is a very rare condition that was first described by Calder in 1749. Commonly, CPA occurs as an isolated lesion, which has an excellent prognosis, but it can also be seen in association with other malformations, which can have a negative impact on the final outcome. The medical records...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-007-1903-0
更新日期：2007-06-01 00:00:00
abstract：PURPOSE:Haemolytic uraemic syndrome (HUS) is the commonest childhood cause of acute renal failure. Peritoneal dialysis peritonitis (PDP) is a well-recognised complication, with some children requiring surgical intervention (SI). The aim of this study is to determine whether the presence of enteric organisms in cases of...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-015-3833-6
更新日期：2016-03-01 00:00:00
abstract：PURPOSE:We have retrospectively evaluated all patients who underwent endoscopic puncture (EP) of ureterocele over the last 26 years with special reference to the need in the second intervention and disease-free status. METHODS:78 (69%) of the 112 patients following EP and completed follow-up were included. 51 (65%) we...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-018-4258-9
更新日期：2018-05-01 00:00:00
abstract：PURPOSE:Pancreatic neoplasms are uncommon in children. This study sought to analyze the clinical and pathological features of surgically resected pancreatic tumors in children and discuss management strategies. METHODS:We conducted a retrospective review of patients ≤21 years with pancreatic neoplasms who underwent su...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-016-3925-y
更新日期：2016-08-01 00:00:00
abstract：:A newborn case with cardiac rhabdomyoma is presented to discuss the differential diagnosis of mediastinal tumors around the heart in children. The diagnosis of rhabdomyoma can be suggested by modern visualization methods such as computerized tomography, magnetic resonance imaging and echocardiography. However, surgery...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-007-1875-0
更新日期：2007-08-01 00:00:00
abstract：PURPOSE:Controversy exists as regards the best non-invasive diagnostic tool for pediatric cervical lymphadenopathy. The current work aimed to evaluate the reliability, sensitivity, specificity, and accuracy of sonoelastography in diagnosing benign and/or malignant pediatric cervical lymphadenopathy. METHODS:Prospectiv...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-018-4301-x
更新日期：2018-08-01 00:00:00
abstract：PURPOSE:The use of general anesthesia in young children has come under increasing scrutiny due to its potential long-term neurotoxic effects. Meanwhile, regional anesthesia for surgical procedures in neonates has many advantages, including preservation of respiratory status and faster return to feeding. We describe the...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-016-4027-6
更新日期：2017-03-01 00:00:00
abstract：BACKGROUND:Subclinical varicocele is a relative rare condition. The aim of this study is to identify the role of bioflavonoids in the management of subclinical varicocele. MATERIALS AND METHODS:We analyzed the medical charts of patients treated for subclinical varicocele with bioflavonoids between 1999 and 2004; inclu...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-010-2574-9
更新日期：2010-05-01 00:00:00
abstract：PURPOSE:To show whether Alvarado, Eskelinen, Lintula and Ohmann scoring systems have predictive values in diagnosing acute appendicitis in children. METHODS:Sixty patients with suspected acute appendicitis were prospectively evaluated. Alvarado, Eskelinen, Lintula and Ohmann scores were calculated separately for each ...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-014-3467-0
更新日期：2014-03-01 00:00:00
abstract：:Aim was to describe the challenges faced in the management of bilateral multicystic kidney disease (MCKD). A case of antenatally detected bilateral polycystic disease was referred at 28 weeks of gestation. The patient was advised to continue pregnancy till term and be in regular follow-up. Postnatally, the male baby p...
journal_title：Pediatric surgery international
pub_type： 杂志文章,评审
doi：10.1007/s00383-007-1962-2
更新日期：2007-08-01 00:00:00
abstract：:Congenital/infantile fibrosarcoma (IFS) is a relatively rare form of fibrosarcoma diagnosed at birth or during early years of life and that differs from its adult counterpart because of a more favorable behavior. IFS is also known as cellular congenital mesoblastic nephroma, when it affects the kidney and is often but...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-015-3670-7
更新日期：2015-04-01 00:00:00
abstract：PURPOSE:Evaluate the management of hydrocephalus in pediatric patients in the Eastern Democratic Republic of Congo by a general surgeon. METHODS:Retrospective review of a single institution in the province of North Kivu. Patient charts and surgical notes were reviewed from 2003 to 2016. RESULTS:116 procedures were pe...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-018-4238-0
更新日期：2018-04-01 00:00:00
abstract：PURPOSE:The aim of this study is to identify the risk factors for esophageal anastomotic stricture (EAS) and/or anastomotic leakage (EAL) after primary repair of esophageal atresia with tracheoesophageal fistula (EA/TEF) in infants. METHODS:A retrospective chart review of 52 patients with congenital EA/TEF between Jan...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-016-3931-0
更新日期：2016-09-01 00:00:00
abstract：PURPOSE:The aim of the German Network for Congenital Uro-REctal malformations (CURE-Net) is to collect data of affected patients with anorectal malformation (ARM) to investigate molecular causes, clinical implications and psychosocial outcome. The current issue was to examine the transition to adulthood in adults with ...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-012-3120-8
更新日期：2012-08-01 00:00:00
abstract：:In contrast to adults, calcium carbonate gallstones are relatively common in children. Their pathogenesis is poorly understood. Cystic duct obstruction promotes calcium carbonate formation in bile and increases gallbladder mucin production. We tested the hypothesis that mucin producing epithelial cells would be increa...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-006-1867-5
更新日期：2007-03-01 00:00:00
abstract：:A total of four patients with communicating bronchopulmonary foregut malformation were treated surgically at Kobe Children's Hospital between 1993 and 2004. Of these, three patients displayed congenital tracheobronchial stenosis and developed life-threatening respiratory distress soon after birth. In each case, anomal...
journal_title：Pediatric surgery international
pub_type： 杂志文章
doi：10.1007/s00383-005-1520-8
更新日期：2005-11-01 00:00:00
