Izumoring: a strategy for bioproduction of all hexoses.

Abstract:

:Izumoring is a new concept for the bioproduction of all hexose sugars - 16 aldohexoses, eight ketohexoses and 10 hexitols -- using enzymatic and microbiological reactions. The biocatalysts necessary for the strategy were (i) d-tagatose 3-epimerase [which epimerizes all ketohexoses at C-3 of the sugar], (ii) polyol dehydrogenases [which catalyze oxidation-reduction reactions between ketohexoses and the corresponding hexitols], and (iii) aldose isomerases [which catalyze isomerization reactions between aldohexoses and corresponding aldoketoses]. All ketohexoses, aldohexoses and hexitols may be arranged in a symmetric ring connected by the biochemical reactions, allowing the design for the bioproduction of all 34 hexose sugars. The ring shows there are four entrances to the l-hexose world from the natural d-hexoses. The Izumoring ring shows clearly the relationship and the position of all 34 six carbon sugars.

journal_name

J Biotechnol

journal_title

Journal of biotechnology

authors

Izumori K

doi

10.1016/j.jbiotec.2006.04.016

subject

Has Abstract

pub_date

2006-08-05 00:00:00

pages

717-22

issue

4

eissn

0168-1656

issn

1873-4863

pii

S0168-1656(06)00323-3

journal_volume

124

pub_type

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