Abstract:
:Izumoring is a new concept for the bioproduction of all hexose sugars - 16 aldohexoses, eight ketohexoses and 10 hexitols -- using enzymatic and microbiological reactions. The biocatalysts necessary for the strategy were (i) d-tagatose 3-epimerase [which epimerizes all ketohexoses at C-3 of the sugar], (ii) polyol dehydrogenases [which catalyze oxidation-reduction reactions between ketohexoses and the corresponding hexitols], and (iii) aldose isomerases [which catalyze isomerization reactions between aldohexoses and corresponding aldoketoses]. All ketohexoses, aldohexoses and hexitols may be arranged in a symmetric ring connected by the biochemical reactions, allowing the design for the bioproduction of all 34 hexose sugars. The ring shows there are four entrances to the l-hexose world from the natural d-hexoses. The Izumoring ring shows clearly the relationship and the position of all 34 six carbon sugars.
journal_name
J Biotechnoljournal_title
Journal of biotechnologyauthors
Izumori Kdoi
10.1016/j.jbiotec.2006.04.016subject
Has Abstractpub_date
2006-08-05 00:00:00pages
717-22issue
4eissn
0168-1656issn
1873-4863pii
S0168-1656(06)00323-3journal_volume
124pub_type
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