Involvement of the transforming growth factor beta in the pathogenesis of hereditary hemorrhagic telangiectasia.

abstract：:The phenomenon of blood serum atherogenicity was described as the ability of human serum to induce lipid accumulation in cultured cells. The results of recent two-year prospective study in asymptomatic men provided the evidence for association between the changes in serum atherogenicity and dynamics of carotid intima-...

journal_title：Current pharmaceutical design

authors： Sobenin IA,Myasoedova VA,Anisimova EV,Pavlova XN,Möhlenkamp S,Schmermund A,Seibel R,Berenbein S,Lehmann N,Moebus S,Jöckel K,Orekhov AN,Erbel R

更新日期：2014-01-01 00:00:00

abstract：:The rise of multi-drug resistant and extensively drug resistant M. tuberculosis around the world poses a great threat to human health, and necessitates development of new, effective and inexpensive anti-tubercular agents. The availability of knowledge on molecular biology of M. tuberculosis infection coupled with whol...

journal_title：Current pharmaceutical design

authors： Chauhan RS,Chanumolu SK,Rout C,Shrivastava R

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:According to the World Health Organization (WHO), diabetes mellitus is considered the 7th leading cause of death as of 2016, while almost half of all deaths related to high blood glucose occur before the age of 70. According to the 2019 American Diabetes Association's (ADA) guidelines, metformin is the first...

journal_title：Current pharmaceutical design

authors： Gillani SW,Moosvi AF

更新日期：2020-01-01 00:00:00

abstract：:A new controlled delivery system has been developed for ropinirole (RP) for the treatment of Parkinson´s Disease (PD) consisting in PLGA microparticles (MPs) which exhibited in vitro constant release of RP (78.23 µg/day/10 mg MPs) for 19 days. The neuroprotective effects of RP released from MPs were evaluated in SKN-A...

journal_title：Current pharmaceutical design

authors： Negro S,Boeva L,Slowing K,Fernandez-Carballido A,Garcia-García L,Barcia E

更新日期：2017-01-01 00:00:00

abstract：:Advances in particle engineering techniques, such as spray drying, freeze drying and supercritical fluid precipitation, have greatly enhanced the ability to control the structure, morphology, and solid state phase of inhalable sized particles (1 - 5 µm) for formulation in pressurized metered dose inhalers (pMDI). To o...

journal_title：Current pharmaceutical design

authors： D'Sa D,Chan HK

更新日期：2015-01-01 00:00:00

abstract：:Somatostatin is a tetradeca peptide hormone produced by many different endocrine cells throughout the body. It is also present in both the central and peripheral nervous system. The peptide has many different moods of action including inhibition of hormone secretion and influence on gastrointestinal motility. Somatost...

journal_title：Current pharmaceutical design

authors： Janson ET,Oberg K

更新日期：1999-09-01 00:00:00

abstract：:Aneuploidy is a pathological condition that affects 35% of human spontaneous abortions and 0.3% of livebirths. In spite of the increasing knowledge about molecular mechanisms of meiosis and chromosome segregation, maternal age remains the only ascertained aetiological factor. Genetically modified mouse models have bee...

journal_title：Current pharmaceutical design

authors： Pacchierotti F,Ranaldi R

更新日期：2006-01-01 00:00:00

abstract：:Guanine-rich sequences found in telomeres and oncogene promoters have the ability to form G-quadruplex structures. In this paper we describe the use of a virtual screening assay to search a database of FDA-approved compounds for compounds with the potential to bind G-quadruplex DNA. More than 750 telomerase inhibitors...

journal_title：Current pharmaceutical design

authors： Castillo-González D,Pérez-Machado G,Guédin A,Mergny JL,Cabrera-Pérez MA

更新日期：2013-01-01 00:00:00

abstract：:The antifungal agents for systemic mycoses are only a few in number. Among them amphotericin-B is still the most widely used drug, but substantial side effects including nephrotoxicity limits its clinical usefulness. Efforts to lower the toxicity are synthesis of AMPH-B analogues such as AMPH-B esters and encapsulatio...

journal_title：Current pharmaceutical design

authors： Maesaki S

更新日期：2002-01-01 00:00:00

abstract：:In recent years, our understanding of the molecular interaction of collagens with their cognate integrin receptors has remarkably improved. Structural elucidations of both the integrin and the collagenous triple helix have contributed to this achievement. The structures of an entire integrin ectodomain and of an A-dom...

journal_title：Current pharmaceutical design

authors： Eble JA

更新日期：2005-01-01 00:00:00

abstract：:The skin is often introduced as the largest organ of the human body which - being uniquely exposed to external stress - faces several types of challenges, from physical, chemical, biological, and immunological origin. Therefore, the skin is also a site where inflammation, oxidative stress and cellular damage occurs re...

journal_title：Current pharmaceutical design

authors： Szabo IL,Kenyeres A,Szegedi A,Szollosi AG

更新日期：2018-01-01 00:00:00

abstract：:Topiramate is one of the currently most promising compounds in the field of addiction medicine. This paper discusses its potential utility related to a phase model of addiction development, focusing on the assumption that addiction is a continuous process involving different neurobiological pathways, depending on the ...

journal_title：Current pharmaceutical design

authors： Thorens G,Billieux J,Manghi R,Khan R,Khazaal Y,Zullino DF

更新日期：2011-01-01 00:00:00

abstract：:Opioids constitute the basis for pharmacological treatment of moderate to severe pain in cancer pain and non-cancer pain patients. Their action is mediated by the activation of opioid receptors, which integrates the pain modulation system with other effects in the central nervous system including cognition resulting i...

journal_title：Current pharmaceutical design

authors： Højsted J,Kurita GP,Kendall S,Lundorff L,de Mattos Pimenta CA,Sjøgren P

更新日期：2012-01-01 00:00:00

abstract：:Cardiac ischemia, followed by reperfusion, often results in the development of cardiac contractile dysfunction that limits the recovery prognosis of patients. The current goal of pharmacological therapy in the course of ischemic heart disease is to improve the oxygen supply/demand ratio for the heart. Cardiac contract...

journal_title：Current pharmaceutical design

authors： Sawicki G

更新日期：2014-01-01 00:00:00

abstract：:Cardiovascular disease (CVD) is one of the major lifestyle associated disorders and leading causes of death worldwide. The incidence of CVD in diabetic patients has increased up to 3 folds and it became the major risk for diabetes associated morbidity and mortality. Insulin resistance and oxidative stress both play a ...

journal_title：Current pharmaceutical design

authors： Bagul PK,Banerjee SK

更新日期：2013-01-01 00:00:00

abstract：:Population studies have identified diabetes mellitus as a risk factor for cardiac and vascular events, with a common association with hypertension. Observational studies have consistently demonstrated blood glucose as a continuous cardiovascular risk factor. Experimental studies suggest that elevated blood glucose, th...

journal_title：Current pharmaceutical design

authors： Lim HS,MacFadyen RJ,Bakris G,Lip GY

更新日期：2006-01-01 00:00:00

abstract：:We have synthesized a novel series of N-substituted sarcosines, analogues of NFPS (N-[3-(biphenyl-4- yloxy)-3-(4-fluorophenyl)propyl]-N-methylglycine), as type-1 glycine transporter (GlyT-1) inhibitors. Several compounds incorporated a diazine ring inhibited recombinant hGlyT-1b expressed permanently in CHO cells and ...

journal_title：Current pharmaceutical design

authors： Harsing LG Jr,Timar J,Szabo G,Udvari S,Nagy KM,Marko B,Zsilla G,Czompa A,Tapolcsanyi P,Kocsis A,Matyus P

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Type 2 diabetes mellitus (DM) is associated with a considerable risk of cardiovascular and renal disease, including heart failure. Sodium-glucose cotransporter 2 (SGLT2) inhibitors have demonstrated unprecedented cardiorenal protective effects in large scale clinical trials of patients with or without diabet...

journal_title：Current pharmaceutical design

authors： Karangelis D,Mazer CD,Stakos D,Tzifa A,Loggos S,Verma S,Mitropoulos F

更新日期：2020-11-03 00:00:00

abstract：:Non-alcoholic fatty liver disease (NAFLD) includes liver diseases ranging from simple steatosis to progressive forms characterized by high rates of complications and mortality, namely fibrosis, cirrhosis and hepatocellular carcinoma. Identification of patients with simple steatosis who will evolve to a more severe liv...

journal_title：Current pharmaceutical design

authors： Lombardi R,Fargion S,Fracanzani AL

更新日期：2020-01-01 00:00:00

abstract：:Reactive oxygen species (ROS) are well recognized for playing a dual role as both deleterious and beneficial species. ROS are products of normal cellular metabolism and under physiological conditions, participate in maintenance of cellular 'redox homeostasis. Overproduction of ROS, results in oxidative stress. Oxidati...

journal_title：Current pharmaceutical design

authors： Rosanna DP,Salvatore C

更新日期：2012-01-01 00:00:00

abstract：:The tumor cell growth inhibitory activities (log 1/GI(50)) of 166 anticancer agents studied at the National Cancer Institute (NCI) in vitro anticancer screening program have allowed us to analyze the relative importance of physicochemical parameters in influencing the inhibitory activities. Increased molecular weight,...

journal_title：Current pharmaceutical design

authors： Ren SS,Lien EJ

更新日期：2004-01-01 00:00:00

abstract：:Repurposing already approved drugs as new anticancer agents is a promising strategy considering the advantages such as low costs, low risks and less time-consumption. Disulfiram (DSF), as the first drug for antialcoholism, was approved by the U.S. Food and Drug Administration (FDA) over 60 years ago. Increasing eviden...

journal_title：Current pharmaceutical design

authors： Yang Q,Yao Y,Li K,Jiao L,Zhu J,Ni C,Li M,Dou QP,Yang H

更新日期：2019-01-01 00:00:00

abstract：:Estrogens are known as important modulators of development, growth and maintenance of primary sexual physiology. The medical field has also grown increasingly appreciative of the effects of estrogens on non-traditional target tissues such as bone, cardiovascular tissue and the CNS. Postmenopausal women have been the b...

journal_title：Current pharmaceutical design

authors： Miller CP

更新日期：2002-01-01 00:00:00

abstract：:Mitochondria fulfill a number of essential cellular functions, being recognized that the strict regulation of the structure, function and turnover of these organelles is an immutable control node for the maintenance of neuronal integrity and homeostasis. Many lines of evidence posit that mitochondria constitute a conv...

journal_title：Current pharmaceutical design

authors： Correia SC,Cardoso S,Santos RX,Carvalho C,Santos MS,Perry G,Smith MA,Moreira PI

更新日期：2011-01-01 00:00:00

abstract：:The activation of Corticotrophin Releasing-Factor (CRF) receptors in the brain is well established to coordinate the endocrine, behavioral, autonomic and visceral responses to stress. In addition, CRF receptors are also expressed within the gut where they exert biological actions and play a role in modulating stress-r...

journal_title：Current pharmaceutical design

authors： Czimmer J,Tache Y

更新日期：2017-01-01 00:00:00

abstract：:In 2007, the American Heart Association (AHA) recommended (class IIa, level of evidence B) in their guidelines on Perioperative Cardiovascular Evaluation and Care for Noncardiac Surgery volatile anesthetics as first choice for general anesthesia in hemodynamically stable patients at risk for myocardial ischemia. This ...

journal_title：Current pharmaceutical design

authors： Zaugg M,Lucchinetti E,Behmanesh S,Clanachan AS

更新日期：2014-01-01 00:00:00

abstract：:Naturally occurring and chemically modified ribonucleosides have interesting bioactive effects. Dietary ribonucleosides are ingested mainly as nucleoproteins and are converted in the course of intestinal digestion to monomeric compounds. Different bioactive effects of dietary ribonucleosides have been described, inclu...

journal_title：Current pharmaceutical design

authors： Martin D,Meisel H

更新日期：2007-01-01 00:00:00

abstract：:Catheter ablation for rhythm control in atrial fibrillation has been recognized as an established treatment. Patients with atrial fibrillation suffer from an increased risk of thromboembolic events. Long-term stroke risk and mortality have been shown to be reduced after catheter ablation, still the procedure per se is...

journal_title：Current pharmaceutical design

authors： Vrachatis DA,Giannopoulos G,Kossyvakis C,Panagopoulou V,Vavuranakis M,Papaioannou TG,Pagoni S,Pyrgakis VN,Cleman MW,Deftereos SG

更新日期：2017-01-01 00:00:00

abstract：:A small but increasing number of gene expression based biomarkers are becoming available for routine clinical use, principally in oncology and transplantation. These underscore the potential of gene expression arrays and RNA sequencing for biomarker development, but this potential has not yet been fully realized and m...

journal_title：Current pharmaceutical design

authors： Flint SM,McKinney EF,Lyons PA,Smith KG

更新日期：2015-01-01 00:00:00

abstract：:Thymulin is a thymic hormone exclusively produced by the epithelial cells of the thymus. After its discovery and initial characterization in the '70s, it was demonstrated that the production and secretion of thymulin are strongly influenced by the neuro-endocrine system. Conversely, a growing body of evidence, to be r...

journal_title：Current pharmaceutical design

authors： Reggiani PC,Schwerdt JI,Console GM,Roggero EA,Dardenne M,Goya RG

更新日期：2014-01-01 00:00:00