Cardio-protective effects of sodium-glucose co-transporter 2 inhibitors: focus on heart failure.

abstract：:Chloride channels play important roles in vital cellular signalling processes contributing to homeostasis in both excitable and non-excitable cells. Since 1987, more than ten ion channel genes have been identified as causing human hereditary diseases among them the genes for the voltage-dependent chloride channel ClC-...

journal_title：Current pharmaceutical design

authors： Becq F

更新日期：2006-01-01 00:00:00

abstract：:Regeneration of bone requires the coordinated processes of angiogenesis and osteogenesis. These repair mechanisms are closely linked through both direct cell-cell contact and indirect paracrine signaling among osteoblasts, endothelial cells, and other cell types. The vasculature provides a source of nutrients, oxygen,...

journal_title：Current pharmaceutical design

authors： Segar CE,Ogle ME,Botchwey EA

更新日期：2013-01-01 00:00:00

abstract：:Cardiovascular disease remains the number one killer in the United States and many other countries. Each year, there are enormous research efforts on its pathogenesis, prevention and treatment led by scientists worldwide. One of the most significant research areas is the impact and mechanisms of existing or new cardio...

journal_title：Current pharmaceutical design

authors： Jamaluddin MS,Liang Z,Lu JM,Yao Q,Chen C

更新日期：2014-01-01 00:00:00

abstract：:Advances in particle engineering techniques, such as spray drying, freeze drying and supercritical fluid precipitation, have greatly enhanced the ability to control the structure, morphology, and solid state phase of inhalable sized particles (1 - 5 µm) for formulation in pressurized metered dose inhalers (pMDI). To o...

journal_title：Current pharmaceutical design

authors： D'Sa D,Chan HK

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), termed coronavirus disease 2019 (COVID-19) by the World Health Organization, is a newly emerging zoonotic agent that emerged in China in December 2019. No specific treatment for COVID-19 is currently available. Usual palliative treatment includes ...

journal_title：Current pharmaceutical design

authors： Lovato ECW,Barboza LN,Wietzikoski S,de Souza ANV,Auth PA,Junior AG,Dos Reis Lívero FA

更新日期：2020-07-07 00:00:00

abstract：BACKGROUND:The HERC family contains six members from HERC1 to HERC6 that are featured with the HECT domains that exerts ubiquitin ligase activity and the RCC1-like domains that are involved in cell cycle regulation. Although identified as early as 1990s, their biological functions are extensively studied in recent year...

journal_title：Current pharmaceutical design

authors： Mao X,Sethi G,Zhang Z,Wang Q

更新日期：2018-01-01 00:00:00

abstract：:Insight is provided herein into the novel mechanisms of cardiometabolic risk. Previous reports, including the epidemiological work of the Turkish Adult Risk Factor study, indicated that proinflammatory state and oxidative stress are crucial for evaluating cardiometabolic risk. Autoimmune pathways in the course of oxid...

journal_title：Current pharmaceutical design

authors： Onat A,Can G

更新日期：2014-01-01 00:00:00

abstract：:Control of GABA neurotransmission at the pre-synaptic site occurs substantially through the activation of the glutamic acid decarboxylase (GAD) enzymes GAD65 and GAD67. Concentrations of GAD65 and GAD67 are controlled either by transcription or by mRNA splicing and importantly the activities of these key enzymes are r...

journal_title：Current pharmaceutical design

authors： Modi JP,Prentice H,Wu JY

更新日期：2015-01-01 00:00:00

abstract：:Arrhythmias in left ventricular hypertrabeculation/noncompaction (LVHT) comprise sustained or non-sustained ventricular tachycardia (VT) (n=135), atrial fibrillation (AF) (n=96) AV block (n=55) and QT prolongation (n=47). The prevalence differs between children and adults. In children most frequent are WPW-syndrome (n...

journal_title：Current pharmaceutical design

authors： Stöllberger C,Finsterer J

更新日期：2010-01-01 00:00:00

abstract：:Fibrate derivatives have a 40-year history in the management of dyslipidemia. Although this class of drugs is generally well tolerated, several safety issues have arisen from their use. In the present article we review the literature describing side effects associated with the use of fibrates except for those that are...

journal_title：Current pharmaceutical design

authors： Florentin M,Liberopoulos EN,Mikhailidis DP,Elisaf MS

更新日期：2008-01-01 00:00:00

abstract：:MicroRNA-34a (miR-34a) promotes apoptosis via down-regulating many anti-apoptotic proteins. Aldehyde dehydrogenase 2 (ALDH2) is an anti-apoptotic enzyme whose activity decline associates with myocardial injury. We tested hypothesis that miR-34a might play a pro-apoptotic role in myocardial infarction (MI) by down-regu...

journal_title：Current pharmaceutical design

authors： Fan F,Sun A,Zhao H,Liu X,Zhang W,Jin X,Wang C,Ma X,Shen C,Zou Y,Hu K,Ge J

更新日期：2013-01-01 00:00:00

abstract：:Viral infections are important causes of morbidity and mortality in hematopoietic stem cell transplant (HSCT) recipients. Some viruses, such as the respiratory and gastrointestinal viruses, are acquired from the healthcare or community in the midst of or after HSCT. Other viruses, such as the herpes-virus family, esta...

journal_title：Current pharmaceutical design

authors： Anderson EJ

更新日期：2008-01-01 00:00:00

abstract：:ATP-sensitive K+ channels, termed K(ATP) channels, provide a link between cellular metabolism and membrane electrical activity in a variety of tissues. Channel isoforms have been identified and are targets for compounds that both stimulate and inhibit their activity resulting in membrane hyperpolarization and depolari...

journal_title：Current pharmaceutical design

authors： Bryan J,Crane A,Vila-Carriles WH,Babenko AP,Aguilar-Bryan L

更新日期：2005-01-01 00:00:00

abstract：:Periodontal diseases are common inflammatory conditions of the supporting apparatus of the teeth which lead to early tooth loss. This review discusses the evidence for a role of reactive oxygen species in inducing periodontal tissue damage and focuses on recent evidence showing increased local and systemic alterations...

journal_title：Current pharmaceutical design

authors： Nibali L,Donos N

更新日期：2013-01-01 00:00:00

abstract：:With a 2030 projection of 23.6 million deaths per year the prevalence and severity of cardiovascular disease is at an astounding high. Thus, a definitive need for the identification of novel compounds with potential to prevent or treat the disease and associated states. Moreover, there is also an ever-increasing need ...

journal_title：Current pharmaceutical design

authors： Houacine C,Khan I,Yousaf SS

更新日期：2020-09-09 00:00:00

abstract：:The influence of mitochondrial dysfunction on pathological states involving inflammatory and/or oxidative stress in tissues that do not show frank cellular apoptosis or necrosis has been rather difficult to unravel, and the literature is replete with contradictory information. Although such discrepancies have many pot...

journal_title：Current pharmaceutical design

authors： Suliman HB,Piantadosi CA

更新日期：2014-01-01 00:00:00

abstract：:The acid-base balance of cells is related to the concentration of free H⁺ ions. These are highly reactive, and their intracellular concentration must be regulated to avoid detrimental effects to the cell. H⁺ ion dynamics are influenced by binding to chelator substances ('buffering'), and by the production, diffusion a...

journal_title：Current pharmaceutical design

authors： Hulikova A,Harris AL,Vaughan-Jones RD,Swietach P

更新日期：2012-01-01 00:00:00

abstract：:Multiple Sclerosis (MS) is the most common autoimmune demyelinating disorder in Western countries and can lead to permanent disability. Over the past decades remarkable progress has been made in providing new therapeutic strategies to tackle the burden of the disease. Oral drugs and monoclonal antibodies are the main ...

journal_title：Current pharmaceutical design

authors： Sanvito L,Constantinescu CS,Gran B

更新日期：2011-01-01 00:00:00

abstract：:In this review we discuss the role of protonation states in receptor-ligand interactions, providing experimental evidences and computational predictions that complex formation may involve titratable groups with unusual pKa's and that protonation states frequently change from unbound to bound states. These protonation ...

journal_title：Current pharmaceutical design

authors： Petukh M,Stefl S,Alexov E

更新日期：2013-01-01 00:00:00

abstract：:Tamoxifen is a selective oestrogen receptor modulator (SERM). SERMs act on oestrogen receptors to inhibit oestradiol mediated negative feedback on the hypothalamic-pituitary-gonadal (HPG) axis, thereby upregulating gonadotrophin secretion and release from the pituitary. Hence, Tamoxifen is used to upregulate activatio...

journal_title：Current pharmaceutical design

authors： Dimakopoulou A,Foran D,Jayasena CN,Minhas S

更新日期：2020-02-12 00:00:00

abstract：:Many plant species and tissues have been investigated as production and delivery vehicles for recombinant pharmaceutical proteins. Examples include cultured cells, whole aquatic plants and transgenic plants expressing recombinant proteins in their leaves, seeds, fruits or tubers/roots. Each platform has unique propert...

journal_title：Current pharmaceutical design

authors： Hofbauer A,Stoger E

更新日期：2013-01-01 00:00:00

abstract：:This article reviews evidence that hyperpolarization-activated, cation nonselective (HCN) channels, the molecular basis of the Ih current, potentially represent valid targets for novel analgesic agents. Ih is a prominent current in many peripheral sensory nerves, with highest current density typically found in large d...

journal_title：Current pharmaceutical design

authors： Wickenden AD,Maher MP,Chaplan SR

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:A substantial part of literature has been centered on sex differences in the clinical aspects of ischemic heart disease (IHD). Many reports have documented differences in the presentation and risk profile between women and men. Such differences drive sex-related inequalities in the referral and treatment of ...

journal_title：Current pharmaceutical design

authors： Cenko E,Bugiardini R

更新日期：2016-01-01 00:00:00

abstract：:Obesity has become a serious epidemic and one of the leading global health problems. However, much of the current debate has been fractious, and etiologies of obesity have been attributed to eating behavior (i.e. fast food consumption), personality, depression, addiction or genetics. One of the interesting new hypothe...

journal_title：Current pharmaceutical design

authors： Zhang Y,von Deneen KM,Tian J,Gold MS,Liu Y

更新日期：2011-01-01 00:00:00

abstract：:An important goal of biomedical research is to translate basic research findings into practical clinical implementation. Despite the advances in the technology used in drug discovery, the development of drugs for central nervous system diseases remains challenging. The failure rate for new drugs targeting important ce...

journal_title：Current pharmaceutical design

authors： Morofuji Y,Nakagawa S

更新日期：2020-01-01 00:00:00

abstract：:Patients with diabetes mellitus (DM) type 2 have a high prevalence of coronary artery disease (CAD), as diabetes is implicated in the formation of atherosclerotic plaque. Hyperglycemia, elevated free fatty acid, increased amount of circulating end-glucosylated serum products and insulin resistance are the main mechani...

journal_title：Current pharmaceutical design

authors： Tousoulis D,Kampoli AM,Papageorgiou N,Papaoikonomou S,Antoniades C,Stefanadis C

更新日期：2009-01-01 00:00:00

abstract：:After years of pre-clinical and clinical testing monoclonal antibodies (mAbs) finally offer new therapeutic choices for patients with haematological and solid malignancies both as unconjugated antibody and as vectors to target radionuclides in radioimmunotherapy (RIT). In recent years some of the most exciting clinica...

journal_title：Current pharmaceutical design

authors： Illidge TM,Brock S

更新日期：2000-09-01 00:00:00

abstract：:Plasma concentrations of phytosterols and non-cholesterol sterol precursors of cholesterol synthesis have been used as markers of intestinal cholesterol absorption and synthesis in inherited and secondary dyslipidemias and in population-based investigations to evaluate the risk for cardiovascular disease, respectively...

journal_title：Current pharmaceutical design

authors： Quintão ECR

更新日期：2020-01-01 00:00:00

abstract：:Propofol (2, 6-diisopropylphenol) is a potent intravenous hypnotic agent which is widely used for the induction and maintenance of anesthesia and for sedation in the intensive care unit. Propofol is an oil at room temperature and insoluble in aqueous solution. Present formulations consists of 1% or 2% (w/v) propofol, ...

journal_title：Current pharmaceutical design

authors： Marik PE

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND & AIMS:Nowadays, the world is facing a common problem that the population aging process is accelerating. How to delay metabolic disorders in middle-aged and elderly people, has become a hot scientific and social issue worthy of attention. The liver plays an important role in lipid metabolism, and abnormal li...

journal_title：Current pharmaceutical design

authors： Su H,Liu D,Shao J,Li Y,Wang X,Gao Q

更新日期：2020-01-01 00:00:00