Regulation of GABA Neurotransmission by Glutamic Acid Decarboxylase (GAD).

abstract：:Nonalcoholic fatty liver disease (NAFLD) is rapidly becoming the most common cause of chronic liver disease worldwide. This is primarily driven by the global epidemic of obesity and diabetes as well as the aging of the general population. Most of the epidemiology data of NAFLD for North America are published from stud...

journal_title：Current pharmaceutical design

authors： Arshad T,Golabi P,Henry L,Younossi ZM

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:A high dietary intake of polyphenols has been associated with a reduced cardiovascular mortality, due to their antioxidant properties. However, growing evidence suggests that counteracting oxidative stress in cardiovascular disease might also reduce sympathetic nervous system overactivity. METHODS:This arti...

journal_title：Current pharmaceutical design

authors： Bruno RM,Ghiadoni L

更新日期：2018-01-01 00:00:00

abstract：:The last decades have witnessed an explosion in studies of the role of amyloid-β (Aβ) in the progress of the neurodegenerative disorder Alzheimer's disease (AD) and it is now widely accepted that Aβ is related to the pathogenesis of AD. For example, studies have shown that Aβ is neurotoxic and that the neurotoxicity o...

journal_title：Current pharmaceutical design

authors： Portelius E,Mattsson N,Andreasson U,Blennow K,Zetterberg H

更新日期：2011-01-01 00:00:00

abstract：:Cumulative scientific evidence gathered over the past ten years has confirmed the role of platelet GP IIb/IIIa inhibitors in reducing ischemic complications of patients undergoing percutaneous coronary intervention (PCI). Recently, mortality data available on more than 20,000 patients enrolled in randomized clinical t...

journal_title：Current pharmaceutical design

authors： Dery JP,Harrington RA,Tcheng JE

更新日期：2004-01-01 00:00:00

abstract：:The cardiovascular system exhibits significant daily rhythms in physiologic processes (heart rate, blood pressure, cardiac contractility and function), and molecular gene and protein expression. An increasing number of clinical and experimental studies demonstrate the circadian system is an important underlying mechan...

journal_title：Current pharmaceutical design

authors： Reitz CJ,Martino TA

更新日期：2015-01-01 00:00:00

abstract：:Abnormal regulation of the ubiquitin-proteasome system (UPS) has been known to be involved in the pathogenesis of a variety of human diseases. A number of studies have focused on the identification of small modifiers for the UPS. Even though the proteasome inhibitor Bortezomib (Velcade®) has been approved for the ther...

journal_title：Current pharmaceutical design

authors： Lim KH,Baek KH

更新日期：2013-01-01 00:00:00

abstract：:Drug discovery is generally considered as a costly affair and it takes approximately 15 years to reach a new chemical entity into the market. Among the recent potent drug molecules with most effective pharmacological properties, very few reached for Phase I clinical trial in humans. Unfortunately, the historical avera...

journal_title：Current pharmaceutical design

authors： Paudwal G,Rawat N,Gupta R,Baldi A,Singh G,Gupta PN

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:The application of an ion selective technique for the determination of analyte concentrations is considered one of the most economical techniques for quality control purposes. OBJECTIVE:To elaborate and investigate the construction and general performance characteristics of potentiometric PVC membrane senso...

journal_title：Current pharmaceutical design

authors： Mansour MF,El-Moety MMA,El Kady EF,El Guindi NM,Schepdael AV,Aly SME

更新日期：2018-01-01 00:00:00

abstract：:MicroRNAs (miRNAs) play a vital role in the onset and development of many diseases, including cancers. Emerging evidence shows that numerous miRNAs have the potential to be used as diagnostic biomarkers for cancers, and miRNA-based therapy may be a promising therapy for the treatment of malignant neoplasm. MicroRNA-14...

journal_title：Current pharmaceutical design

authors： Ma Y,Cao X,Shi G,Shi T

更新日期：2020-10-28 00:00:00

abstract：:Cell therapy has been proposed to treat patients with end-stage heart failure. However, it has been suggested that the significant mechanical forces in an often ischaemic, inflamed, biochemically hostile environment may cause poor cell survival and retention. It is hypothesised that tissue engineering techniques could...

journal_title：Current pharmaceutical design

authors： Rao C,Barratt H,Prodromakis T,Terracciano CM

更新日期：2014-01-01 00:00:00

abstract：:Cancer disease is one of the leading causes of morbidity and mortality worldwide, with approximately 14 million new cases and around 8 million cancer-related deaths yearly. Estimates expect to increase these figures over the next few years. Therefore, it is very important to develop more effective and targeted therapi...

journal_title：Current pharmaceutical design

authors： Caro C,Pozo D

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:The objective of this study was to apply Quality by Design (QbD) principles on process parameter optimization for the development of hybrid delivery system (combination of (SLNs) and In-situ gelling system) for hydrophilic drug Moxifloxacin Hydrochloride (MOX) to achieve its controlled delivery, which otherw...

journal_title：Current pharmaceutical design

authors： Khurana LK,Singh R,Singh H,Sharma M

更新日期：2018-01-01 00:00:00

abstract：:Aspirin has been one of the most widely used medications since its first synthesis more than 100 years ago. In addition to short-term use for pain and fever relief, regular use of aspirin has been shown to reduce the risk of cardiovascular diseases and strokes. The issue of regular aspirin use in cancer prevention is ...

journal_title：Current pharmaceutical design

authors： Huang WK,Tu HT,See LC

更新日期：2015-01-01 00:00:00

abstract：:ABO-incompatible (ABO-I) liver transplantation (LT) has been limited due to the increased rate of complications, including severe cellular and antibody-mediated rejection, hepatic necrosis, hepatic artery thrombosis, and biliary complications. However, several strategies for reducing preformed anti-donor ABO antibodie...

journal_title：Current pharmaceutical design

authors： Cheng CH,Lee CF,Wang YC,Wu TH,Wu TJ,Chou HS,Chan KM,Lee WC

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Discovery and development of BCS class 1 drugs through high throughput screening is one of the biggest challenge faced by formulation scientist. METHODS:There are a number of approaches that have been exploited to enhance the solubility and permeability of drugs. Among them, development of nanosuspension ha...

journal_title：Current pharmaceutical design

authors： Arora D,Khurana B,Rath G,Nanda S,Goyal AK

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Polyphenols widely distributed in plants, fruits and vegetables have received considerable attention on account of their physiological functions, including their antioxidant and anti-inflammatory properties. Some antioxidant components of cacao liquor prepared from fermented and roasted cacao beans, which is...

journal_title：Current pharmaceutical design

authors： Natsume M

更新日期：2018-01-01 00:00:00

abstract：:The intestinal epithelium forms a barrier against the intestinal contents and the wider environment, allowing entry of selected molecules for nutrition and programming of the mucosal immune system, but excluding toxins and most microorganisms. Many receptors and signalling pathways are coupled and implicated in the ep...

journal_title：Current pharmaceutical design

authors： Talero E,Garcia-Maurino S,Motilva V

更新日期：2014-01-01 00:00:00

abstract：:Neuromuscular blocking agents are the leading drugs responsible for immediate hypersensitivity reactions during anaesthesia. Most hypersensitivity reactions represent IgE-mediated allergic reactions. Their incidence is estimated to be between 1 in 3,000 to 1 in 110,000 general anaesthetics. However striking variations...

journal_title：Current pharmaceutical design

authors： Mertes PM,Aimone-Gastin I,Guéant-Rodriguez RM,Mouton-Faivre C,Audibert G,O'Brien J,Frendt D,Brezeanu M,Bouaziz H,Guéant JL

更新日期：2008-01-01 00:00:00

abstract：:The CCN family of growth factors is composed of six structurally related proteins including the cysteine-rich 61 (Cyr61), connective tissue growth factor (CTGF), nephroblastoma overexpressed (NOV), Wnt-1 induced secreted protein-1 (WISP-1), WISP-2 and WISP-3. Each family member consists of four conserved cysteine rich...

journal_title：Current pharmaceutical design

authors： Desnoyers L

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:Spice and spice-derived compounds have been identified and explored for their health benefits since centuries. One of the spice long pepper has been traditionally used to treat chronic bronchitis, asthma, constipation, gonorrhea, paralysis of the tongue, diarrhea, cholera, malaria, viral hepatitis, respirato...

journal_title：Current pharmaceutical design

authors： Prasad S,Tyagi AK

更新日期：2016-01-01 00:00:00

abstract：:Pancreatic cancer is one of the most fatal human malignancies. Though a relatively rare malignancy, it remains one of the deadliest tumors, with an extremely high mortality rate. The prognosis of patients with pancreatic cancer remains poor; only patients with small tumors and complete resection have a chance of a com...

journal_title：Current pharmaceutical design

authors： Liu H,Ma Q,Xu Q,Lei J,Li X,Wang Z,Wu E

更新日期：2012-01-01 00:00:00

abstract：:Adenosine A(2A)-dopamine D(2) receptor interactions play a very important role in striatal function. A(2A)-D(2) receptor interactions provide an example of the capabilities of information processing by just two different G protein-coupled receptors. Thus, there is evidence for the coexistence of two reciprocal antagon...

journal_title：Current pharmaceutical design

authors： Ferré S,Quiroz C,Woods AS,Cunha R,Popoli P,Ciruela F,Lluis C,Franco R,Azdad K,Schiffmann SN

更新日期：2008-01-01 00:00:00

abstract：:Post-traumatic stress disorder (PTSD) is an anxiety disorder that develops after experiencing trauma. Actual therapies do not help majority of patients with PTSD. Moreover, extinguished fear memories usually reappear in the individuals when exposed to trauma cues. New drugs to reduce the impact of conditioned cues in ...

journal_title：Current pharmaceutical design

authors： Barreto GE,Yarkov A,Avila-Rodriguez M,Aliev G,Echeverria V

更新日期：2015-01-01 00:00:00

abstract：:Gonadotropin Releasing Hormone (GnRH) is at the centre of the scientific debate for the treatment of hypogonadotropic hypogonadism. Sexual maturation and reproductive function depend on the pulsatile secretion of GnRH are mainly congenital and may or may not be associated with other genetic anomalies or syndromes. Cli...

journal_title：Current pharmaceutical design

authors： Bettocchi C,Rinaldi M,Sebastiani F

更新日期：2020-11-24 00:00:00

abstract：BACKGROUND:New Oral Anticoagulants (NOACs) are effective and widely used to prevent and treat thromboembolic diseases, but the response to NOACs differs according to ABCB1 genotypes. OBJECTIVE:We investigated the effects of ABCB1 genotypes on the pharmacokinetics and clinical outcomes of NOACs. METHODS:We searched Pu...

journal_title：Current pharmaceutical design

authors： Xie Q,Xiang Q,Mu G,Ma L,Chen S,Zhou S,Hu K,Zhang Z,Cui Y,Jiang J

更新日期：2018-01-01 00:00:00

abstract：:Histone lysine methylation can be modified by various writers and erasers. Different from other epigenetic modifications, mono-, di, and tri- methylation distinctly modulate chromatin structure and thereby contribute to the regulation of DNA-based nuclear processes such as transcription, replication and repair on thei...

journal_title：Current pharmaceutical design

authors： Zheng YC,Ma JL,Liu Y,Liu HM

更新日期：2016-01-01 00:00:00

abstract：:Molecular Mechanics (MM) force fields are the methods of choice for protein simulations, which are essential in the study of conformational flexibility. Given the importance of protein flexibility in drug binding, MM is involved in most if not all Computational Structure-Based Drug Discovery (CSBDD) projects. This pap...

journal_title：Current pharmaceutical design

authors： Vanommeslaeghe K,Guvench O,MacKerell AD Jr

更新日期：2014-01-01 00:00:00

abstract：:No-reflow, i.e., the lack of distal myocardial perfusion to fully recover following recanalization of an acutely occluded coronary artery, is not only a mere consequence of ischemic injury, as substantial microvascular alterations may also develop subsequently, after initial restoration of perfusion. Since part of per...

journal_title：Current pharmaceutical design

authors： Tritto I,Zuchi C,Vitale S,Ambrosio G

更新日期：2013-01-01 00:00:00

abstract：:Alcohol dependence is a major disease burden of adults in modern society worldwide. There is no cure for alcohol dependence. In this study, we have examined the molecular targets of ethanol-induced toxicity in humans based on a systematic review of literature data and then discussed current and potential therapeutic t...

journal_title：Current pharmaceutical design

authors： Wang LL,Yang AK,He SM,Liang J,Zhou ZW,Li Y,Zhou SF

更新日期：2010-01-01 00:00:00

abstract：:Severe sepsis leading to shock is the principal cause of death in intensive care units. It is a systemic inflammatory response caused by excessive secretion of pro-inflammatory mediators, such as tumor necrosis factor-alpha (TNFalpha) and reactive oxygen species (ROS), mainly induced by endotoxin (a major component of...

journal_title：Current pharmaceutical design

authors： Victor VM,Rocha M,Esplugues JV,De la Fuente M

更新日期：2005-01-01 00:00:00