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Gallbladder disease is associated with insulin resistance in a high risk Hispanic population.

Abstract：

BACKGROUND/AIMS:We tested whether cholesterol gallstone disease (GS) is associated to insulin resistance and serum C-reactive protein (CRP) in a high risk population. METHODS:This was a nested case-control study on 881 Chilean subjects that included clinical examination, abdominal ultrasound and blood chemistries. Insulin resistance was determined by the homeostasis model assessment index (IR-HOMA). RESULTS:Compared to controls (n = 582), age and sex adjusted median IR-(HOMA) was significantly elevated in subjects with GS (n = 299) (P < 0.001). Risks of GS in subjects with insulin resistance and different body mass index (BMI) were: BMI < 25, 2.2 (1.1-4.7); BMI 25-30, 1.5 (0.9-2.5) and BMI > 30, 1.7 (1.0-2.9). Risk of GS in subjects with metabolic syndrome was 1.7 (CI, 1.2-2.5) and with fatty liver, 1.5 (1.1-2.2). Risk of GS in subjects with CRP > 1 mg/dL was 1.0 (0.7-1.7). CONCLUSIONS:GS is associated to insulin resistance, fatty liver and to metabolic syndrome, but not to serum CRP in a high risk Hispanic population. Insulin resistance could have a major role in the pathogenesis of GS favoring the production of cholesterol supersaturated bile and altering gallbladder function.

journal_name

J Hepatol

journal_title

Journal of hepatology

authors

Nervi F,Miquel JF,Alvarez M,Ferreccio C,García-Zattera MJ,González R,Pérez-Ayuso RM,Rigotti A,Villarroel L

doi

10.1016/j.jhep.2006.01.026

subject

Has Abstract

pub_date

2006-08-01 00:00:00

pages

299-305

issue

2

eissn

0168-8278

issn

1600-0641

pii

S0168-8278(06)00071-7

journal_volume

45

pub_type

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