Time course evaluation of reparative cartilage with MR imaging after autologous chondrocyte implantation.

abstract：:Bone marrow-derived mesenchymal stem cells (MSCs) are multipotent cells characterized by their self-renewal and differentiation potential. Accumulating clinical and preclinical evidence indicate MSCs are a promising cell source for regenerative medical therapies. However, undesirable immortalization, spontaneous trans...

journal_title：Cell transplantation

authors： Furlani D,Li W,Pittermann E,Klopsch C,Wang L,Knopp A,Jungebluth P,Thedinga E,Havenstein C,Westien I,Ugurlucan M,Li RK,Ma N,Steinhoff G

更新日期：2009-01-01 00:00:00

abstract：:Rare cells are present in human umbilical cord blood that do not express the hematopoietic marker CD45 and in culture do not produce cells of hematopoietic lineage. These umbilical cord multipotent stem cells (UC-MC) behave as multilineage progenitor cells (stem cells) and can be expanded in tissue culture. Exposure t...

journal_title：Cell transplantation

authors： Bicknese AR,Goodwin HS,Quinn CO,Henderson VCD,Chien SN,Wall DA

更新日期：2002-04-01 00:00:00

abstract：:Stroke is one of the most devastating diseases worldwide. In recent years, a great number of studies have focused on the effects of microRNAs (miRNAs) on stroke and the results demonstrated that the expressions of miRNAs are associated with the prognosis of stroke. In the present study, we review relevant articles reg...

journal_title：Cell transplantation

authors： Xu W,Gao L,Zheng J,Li T,Shao A,Reis C,Chen S,Zhang J

更新日期：2018-12-01 00:00:00

abstract：:The purpose of this study was to investigate the clinical efficacy of neural stem/progenitor cell (NS/PC) transplantation to treat severe cortical visual impairment (CVI), a sequela of neonatal brain injury. Fifty-two patients with cerebral injury and CVI were randomly divided into two groups: the treatment group (n =...

journal_title：Cell transplantation

authors： Luan Z,Qu S,Du K,Liu W,Yang Y,Wang Z,Cui Y,Du Q

更新日期：2013-01-01 00:00:00

abstract：:Persistent corneal wounds result from numerous eye disorders, and to date, available treatments often fail to accelerate reepithelialization, the key initial step in wound healing. To speed reepithelialization, we explored a cell-transfer transplant method utilizing polydimethylsiloxane (PDMS) contact lenses to delive...

journal_title：Cell transplantation

authors： Pino CJ,Haselton FR,Chang MS

更新日期：2005-01-01 00:00:00

abstract：:Successful repair of damage in cerebral palsy (CP) needs effective clinical interventions other than simply symptomatic treatments. To elucidate the feasibility of using olfactory ensheathing cells (OECs) to treat CP in children and adolescents, we conducted a randomized controlled clinical trial (RCT) on 33 patients....

journal_title：Cell transplantation

authors： Chen L,Huang H,Xi H,Xie Z,Liu R,Jiang Z,Zhang F,Liu Y,Chen D,Wang Q,Wang H,Ren Y,Zhou C

更新日期：2010-01-01 00:00:00

abstract：:Achieving good islet isolation is one of the most important factors for successful islet transplantation. Porcine pancreas is suitable for islet isolation research due to its anatomical and physiological similarities to human pancreas. In this study, we evaluated a new porcine islet isolation method designed to maximi...

journal_title：Cell transplantation

authors： Yonekawa Y,Matsumoto S,Okitsu T,Arata T,Iwanaga Y,Noguchi H,Nagata H,O'Neil JJ,Tanaka K

更新日期：2005-01-01 00:00:00

abstract：:In cartilage tissue engineering using stem cells, it is important to stimulate proliferation and control the differentiation of stem cells to specific lineages. Here we reported a combined technique for articular cartilage repair, consisting of bone marrow mesenchymal stem cells (BMMSCs) transfected with connective ti...

journal_title：Cell transplantation

authors： Zhu S,Zhang B,Man C,Ma Y,Liu X,Hu J

更新日期：2014-04-01 00:00:00

abstract：:Human skin contains keratinocytes in the epidermis. Such cells share their ectodermal origin with the central nervous system (CNS). Recent studies have demonstrated that terminally differentiated somatic cells can adopt a pluripotent state, or can directly convert its phenotype to neurons, after ectopic expression of ...

journal_title：Cell transplantation

authors： Tenorio-Mina A,Cortés D,Esquivel-Estudillo J,López-Ornelas A,Cabrera-Wrooman A,Lara-Rodarte R,Escobedo-Avila I,Vargas-Romero F,Toledo-Hernández D,Estudillo E,Acevedo-Fernández JJ,Tapia JS,Velasco I

更新日期：2021-01-01 00:00:00

abstract：:Xenotransplantation of porcine fetal ventral mesencephalic (pfVM) cells to overcome the dopamine shortage in the striatum of patients with Parkinson's disease seems a viable alternative to allotransplantion of human fetal donor tissue, especially because the latter is complicated by both practical and ethical issues. ...

journal_title：Cell transplantation

authors： Koopmans J,de Haan A,Bruin E,van der Gun I,van Dijk H,Rozing J,de Leij L,Staal M

更新日期：2006-01-01 00:00:00

abstract：:Multiple system atrophy (MSA) is a neurodegenerative disorder that occurs sporadically and causes parkinsonism, cerebellar, autonomic, urinary, and pyramidal dysfunction in many combinations. Progressive L-dopa-unresponsive parkinsonism due to underlying striatonigral degeneration dominates the clinical syndrome in th...

journal_title：Cell transplantation

authors： Wenning GK,Tison F,Scherfler C,Puschban Z,Waldner R,Granata R,Ghorayeb I,Poewe W

更新日期：2000-03-01 00:00:00

abstract：:In Alzheimer's disease cholinergic neurons degenerate, resulting in loss of hippocampal acetylcholine. The fimbria-fornix aspiration is a well-known animal model mimicking hippocampal cholinergic deficiency. The aim of the present study was to use in vivo lipid-mediated gene transfer to introduce an expression vector ...

journal_title：Cell transplantation

authors： Weis C,Kaufmann WA,Humpel C

更新日期：2001-01-01 00:00:00

abstract：:Prairie voles show strong pair bonding with their mating partners, and they demonstrate parental behavior toward their infants, indicating that the prairie vole is a unique animal model for analysis of molecular mechanisms of social behavior. Until a recent study, the signaling pathway of oxytocin was thought to be cr...

journal_title：Cell transplantation

authors： Katayama M,Hirayama T,Horie K,Kiyono T,Donai K,Takeda S,Nishimori K,Fukuda T

更新日期：2016-01-01 00:00:00

abstract：:Protocols of donor bone marrow infusion for tolerance induction are receiving increasing attention in clinical trials of organ allotransplantation. We report pulmonary embolism with bone fragments following vertebral body marrow infusion in a recipient of a liver and intestinal transplant. Even though pulmonary emboli...

journal_title：Cell transplantation

authors： Fernandez LA,Romaguera R,Viciana AL,Ruiz P,Tzakis AG,Ricordi C

更新日期：1996-07-01 00:00:00

abstract：:Human islet allografts are well known to induce full and sustained remission of hyperglycemia, with complete normalization of key metabolic parameters. Nevertheless, acquiring human islets, even from cadaveric human donor pancreases, remains a significant impediment to successful transplantation therapy for diabetes. ...

journal_title：Cell transplantation

authors： Luca G,Calvitti M,Nastruzzi C,Macchiarulo G,Becchetti E,Neri LM,Capitani S,Basta G,Brunetti P,Calafiore R,Cameron DF

更新日期：2006-01-01 00:00:00

abstract：:Multipotent adult progenitor cells (MAPCs) are bone marrow-derived nonhematopoietic stem cells with a broad differentiation potential and extensive expansion capacity. A comparative study between human mesenchymal stem cells (hMSCs) and human MAPCs (hMAPCs) has shown that hMAPCs have clearly distinct phenotypical and ...

journal_title：Cell transplantation

authors： Jacobs SA,Pinxteren J,Roobrouck VD,Luyckx A,van't Hof W,Deans R,Verfaillie CM,Waer M,Billiau AD,Van Gool SW

更新日期：2013-01-01 00:00:00

abstract：:Cotransplantation of neural progenitors (NPs) with Schwann cells (SCs) might be a way to overcome low rate of neuronal differentiation of NPs following transplantation in spinal cord injury (SCI) and the improvement of locomotor recovery. In this study, we initially generated NPs from human embryonic stem cells (hESC...

journal_title：Cell transplantation

authors： Niapour A,Karamali F,Nemati S,Taghipour Z,Mardani M,Nasr-Esfahani MH,Baharvand H

更新日期：2012-01-01 00:00:00

abstract：:Liver cell transplantation into host organs like the spleen may possibly provide a temporary relief after extensive liver resection or severe liver disease or may enable treatment of an enzyme deficiency. With time, however, dedifferentiation or malignant transformation of the ectopically transplanted cells may be pos...

journal_title：Cell transplantation

authors： Lupp A,Danz M,Müller D

更新日期：2003-01-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) may be of value in regeneration of renal tissue after damage; however, lack of biological knowledge and variability of results in animal models limit their utilization. We studied the effects of MSCs on podocytes in vitro and in vivo utilizing adriamycin (ADR) as a model of renal toxicity...

journal_title：Cell transplantation

authors： Magnasco A,Corselli M,Bertelli R,Ibatici A,Peresi M,Gaggero G,Cappiello V,Chiavarina B,Mattioli G,Gusmano R,Ravetti JL,Frassoni F,Ghiggeri GM

更新日期：2008-01-01 00:00:00

abstract：:A new extracorporeal bioartificial liver using alginate-entrapped hepatocytes was developed and evaluated for its ability to correct the lack of bilirubin conjugation in the Gunn rat. Hepatocytes were harvested from Sprague-Dawley rats by the two-step collagenase perfusion method and then immobilized in Ca(++)-alginat...

journal_title：Cell transplantation

authors： Fremond B,Malandain C,Guyomard C,Chesne C,Guillouzo A,Campion JP

更新日期：1993-11-01 00:00:00

abstract：:Hepatocyte transplantation (HT) has become an effective therapy for patients with metabolic inborn errors. We report the clinical outcome of four children with metabolic inborn errors that underwent HT, describing the cell infusion protocol and the metabolic outcome of transplanted patients. Cryopreserved hepatocytes...

journal_title：Cell transplantation

authors： Ribes-Koninckx C,Ibars EP,Calzado Agrasot MÁ,Bonora-Centelles A,Miquel BP,Vila Carbó JJ,Aliaga ED,Pallardó JM,Gómez-Lechón MJ,Castell JV

更新日期：2012-01-01 00:00:00

abstract：:In order to fully characterize and determine the therapeutic potential of adult neural progenitor cells (NPCs), it is important to be able to isolate and study NPCs from animals such as rats, in which there are existing models of brain injury and disease. The focus of this study was to characterize the cultivation, di...

journal_title：Cell transplantation

authors： Chen K,Hughes SM,Connor B

更新日期：2007-01-01 00:00:00

abstract：:We transplanted adult whole bone marrow prelabeled with bromodeoxyuridine (BrdU) into the ischemic boundary zone of the adult rat brain at 1 day after 2 h of middle cerebral artery occlusion (MCAo). Approximately 3.3% of 10(6) transplanted bone marrow cells were BrdU reactive at 14 days after MCAo. BrdU-reactive cells...

journal_title：Cell transplantation

authors： Li Y,Chen J,Chopp M

更新日期：2001-01-01 00:00:00

abstract：:Despite the substantial efforts to elucidate the role of early brain injury in subarachnoid hemorrhage (SAH), an effective pharmaceutical therapy for patients with SAH continues to be unavailable. This study aims to reveal the role of necroptosis after SAH, and explore whether the disruption of the blood-brain barrier...

journal_title：Cell transplantation

authors： Chen J,Jin H,Xu H,Peng Y,Jie L,Xu D,Chen L,Li T,Fan L,He P,Ying G,Gu C,Wang C,Wang L,Chen G

更新日期：2019-11-01 00:00:00

abstract：:Mechanical thrombectomy (MT) is effective in managing patients with acute ischemic stroke (AIS) caused by large-vessel occlusions and allows for valuable histological analysis of thrombi. However, whether bridging therapy (pretreatment with intravenous thrombolysis before MT) provides additional benefits in patients w...

journal_title：Cell transplantation

authors： Gong L,Zheng X,Feng L,Zhang X,Dong Q,Zhou X,Wang H,Zhang X,Shu Z,Zhao Y,Liu X

更新日期：2019-06-01 00:00:00

abstract：:Cell therapy has attracted considerable interest as a promising therapeutic alternative for patients with Parkinson's disease (PD). Clinical studies have shown that grafted fetal neural tissue can achieve considerable biochemical and clinical improvements in PD. However, the source of fetal tissue grafts is limited an...

journal_title：Cell transplantation

authors： Gonzalez R,Garitaonandia I,Poustovoitov M,Abramihina T,McEntire C,Culp B,Attwood J,Noskov A,Christiansen-Weber T,Khater M,Mora-Castilla S,To C,Crain A,Sherman G,Semechkin A,Laurent LC,Elsworth JD,Sladek J,Snyder EY,

更新日期：2016-11-01 00:00:00

abstract：:Oligodendrocyte (OL) replacement can be a promising strategy for spinal cord injury (SCI) repair. However, the poor posttransplantation survival and inhibitory properties to axonal regeneration are two major challenges that limit their use as donor cells for repair of CNS injuries. Therefore, strategies aimed at enhan...

journal_title：Cell transplantation

authors： Hu JG,Wang XF,Deng LX,Liu NK,Gao X,Chen JH,Zhou FC,Xu XM

更新日期：2013-01-01 00:00:00

abstract：:The need for chronic immune suppression (IS) is one of the hurdles precluding widespread use of islet cell transplantation to restore glycemic control in patients with type 1 diabetes. We report the case of a healthy nonhuman primate (NHP) treated on and off for over 2.5 years with steroid-free IS, consisting of dacli...

journal_title：Cell transplantation

authors： Berman DM,Ruiz P Jr,Blandino-Rosano M,Bernal-Mizrachi E,Kenyon NS

更新日期：2019-03-01 00:00:00

abstract：:As an alternative to drug immunosuppression, attempts at inducing donor-specific tolerance by intrathymic (IT) inoculations to transplant recipient of donor origin alloantigenic products has proven very promising. Using fiber optic thoracoscopy, a technique for the study of this phenomena was developed for the dog. We...

journal_title：Cell transplantation

authors： Schachner RD,Qian T,Strasser S,Brendel MD,Alejandro R,Mintz DH

更新日期：1994-07-01 00:00:00

abstract：:During the isolation of human islets of Langerhans the digest has repeated direct contact with the ambient atmosphere. In order to fulfill GMP requirements in clinical applications, the entire cell preparation must be performed in clean room facilities. We hypothesized that the use of a closed system, which avoids the...

journal_title：Cell transplantation

authors： Klaffschenkel RA,Biesemeier A,Waidmann M,Northoff H,Steurer W,Königsrainer A,Lembert N

更新日期：2007-01-01 00:00:00