Abstract:
BACKGROUND:Anxious-retarded depression is a two-dimensionally defined subcategory of depression derived from DSM-IV melancholia. It is related to increased plasma vasopressin, correlative plasma vasopressin and cortisol levels, and a positive family history. We now explored its relation with outcome. METHODS:Seventy depressed patients were included to follow-up for two years. Outcome was defined by time until full-remission. Cox regression analyses were used to compare anxious-retarded and non-anxious-retarded patients, as well as melancholic and non-melancholic patients. RESULTS:Anxious-retarded depression had poor outcome. LIMITATIONS:The number of patients was relatively small. CONCLUSION:The poor outcome of anxious-retarded depression further supports its validity.
journal_name
J Affect Disordjournal_title
Journal of affective disordersauthors
de Winter RF,Zitman FG,van Houwelingen JC,Wolterbeek R,Goekoop JGdoi
10.1016/j.jad.2005.10.003subject
Has Abstractpub_date
2006-01-01 00:00:00pages
77-81issue
1eissn
0165-0327issn
1573-2517pii
S0165-0327(05)00293-4journal_volume
90pub_type
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