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The effect of atorvastatin on heart rate variability and lipoproteins in patients treated with coronary bypass surgery.

Abstract：

:Statins reduce mortality in patients with coronary heart disease (CHD). An antiarrhythmic effect of statins has been suggested and reported as a possible contributing mechanism. The aim of this study was to examine whether atorvastatin had any effect on heart rate variability (HRV), an important predictor of sudden cardiac death. Eighty patients previously treated with coronary artery bypass grafting (CABG) were studied. The study was designed as a randomized, placebo-controlled, double blinded crossover study. The patients were randomized in two groups, and were treated with 80 mg atorvastatin or placebo for 6 weeks before crossing over to the opposite treatment for another 6 weeks. There was no washout between treatments. Twenty-four-hour Holter recording and plasma lipids and lipoprotein measurements were performed at baseline and after each 6-week period. There was no change in HRV indices after treatment with 80 mg atorvastatin for 6 weeks. A significant reduction in total cholesterol (46%, p

journal_name

Int J Cardiol

journal_title

International journal of cardiology

authors

Riahi S,Schmidt EB,Amanavicius N,Karmisholt J,Jensen HS,Christoffersen RP,Niebuhr U,Christensen JH,Toft E

doi

10.1016/j.ijcard.2005.08.032

subject

Has Abstract

pub_date

2006-08-28 00:00:00

pages

436-41

issue

3

eissn

0167-5273

issn

1874-1754

pii

S0167-5273(05)01160-5

journal_volume

111

pub_type

杂志文章,随机对照试验

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