Intravenous mesenchymal stem cell therapy early after reperfused acute myocardial infarction improves left ventricular function and alters electrophysiologic properties.


UNLABELLED:Direct intramyocardial injection of mesenchymal stem cells (MSCs) improves left ventricular ejection fraction (LVEF) and may increase ventricular arrhythmia in hearts with myocardial infarction (MI). We hypothesized that intravenous MSCs given early after acute MI would engraft in injured myocardium, improve LV function, and result in pro-arrhythmic electrical remodeling. We created an apical infarction in swine by balloon occlusion/reperfusion, administered diI-labeled allogeneic bone marrow derived MSCs intravenously 30 min post-reperfusion and measured LVEF and wall thickness at baseline, 1 month, and 3 months. Epicardial effective refractory periods (ERPs) were determined before sacrifice. At 3 months, treated pigs [n=7] had significantly higher LVEF than controls [n=8] (49+/-2% vs. 44+/-3%, P=0.015) and significantly less wall thickening of non-infarcted myocardium. ERPs were significantly shorter than controls at all pacing cycle lengths (P


Int J Cardiol


Price MJ,Chou CC,Frantzen M,Miyamoto T,Kar S,Lee S,Shah PK,Martin BJ,Lill M,Forrester JS,Chen PS,Makkar RR




Has Abstract


2006-08-10 00:00:00














  • Association of the body mass index with outcomes in elderly patients (≥80 years) undergoing percutaneous coronary intervention.

    abstract:BACKGROUND:The obesity paradox has been recognized in patients with cardiovascular disease. The association between obesity and outcomes in elderly patients undergoing percutaneous coronary intervention (PCI) has not been investigated, yet. METHODS:A total of 990 elderly (≥80 years) patients undergoing PCI at our inst...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Leistner DM,Bazara S,Münch C,Steiner J,Erbay A,Siegrist PT,Skurk C,Lauten A,Müller-Werdan U,Landmesser U,Stähli BE

    更新日期:2019-10-01 00:00:00

  • Plasmin and thrombin inhibitors in essentially untreated patients with coronary artery spasm.

    abstract::We examined activities or levels of plasmin and thrombin inhibitors in essentially untreated patients with angiographically documented coronary artery spasm. The patients received the ergonovine malate provocation test and were classified into two groups: (a) those with significant coronary artery spasm that produced ...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Handa K,Kimoto K,Kawaguchi H,Mori T,Matsunaga A,Sasaki J,Arakawa K

    更新日期:1993-12-31 00:00:00

  • Sex-related differences in cardiomyopathies.

    abstract::Cardiomyopathies (CMPs) are a heterogeneous group of heart muscle diseases with several different phenotypes defined as myocardial disorders in which the heart muscle is structurally and functionally abnormal in the absence of coronary artery disease, hypertension, valvular heart disease and congenital heart disease s...

    journal_title:International journal of cardiology

    pub_type: 杂志文章,评审


    authors: Pelliccia F,Limongelli G,Autore C,Gimeno-Blanes JR,Basso C,Elliott P

    更新日期:2019-07-01 00:00:00

  • Evolution and prognosis of intramural aortic hematoma. Insights from a midterm cohort study.

    abstract:BACKGROUND:Although several hypotheses have been proposed, the true origin and pathogenesis of aortic intramural hematoma (IMH) remain unclear. Evolution of patients with aortic IMH is highly variable. Progression to classic aortic dissection, aneurysm or to complete resolution have been described. Our purpose was to a...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Ferrera C,Vilacosta I,Gómez-Polo JC,Villanueva-Medina S,Cabeza B,Ortega L,Cañadas V,Carnero-Alcázar M,Martínez-López I,Maroto-Castellanos L,Serrano-Hernando FJ

    更新日期:2017-12-15 00:00:00

  • Detection of myosin gene expression in the developing heart using probes derived by polymerase chain reaction.

    abstract::The polymerase chain reaction provides a rapid method for the molecular cloning of DNA probes suitable for the detection of specific messenger RNA. We have used this approach to prepare probes specific for human cardiac myosin messenger RNA and demonstrate here the use of such probes in the analysis of human cardiac d...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Barton PJ,Moscoso G,Thompson RP

    更新日期:1991-01-01 00:00:00

  • Effects of dilazep in evolving myocardial infarction in dogs: a biochemical study.

    abstract::Mongrel dogs of either sex with ligation of their left anterior descending coronary artery were employed for the present study to investigate the biochemical basis of the cardioprotective action of dilazep. Dilazep (0.2 mg/kg intravenous) was administered 20 minutes after coronary arterial occlusion. Ligation of the a...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Gupta JB,Seth SD,Singh U,Vyas DS

    更新日期:1989-05-01 00:00:00

  • Impact of left atrial volume in prediction of outcome after cardiac resynchronization therapy.

    abstract:UNLABELLED:Left atrial volume index (LAVI) as a predictor of mortality has not been well investigated in patients with cardiac resynchronization therapy (CRT). The purpose of this study is to evaluate the impact of LAVI in predicting mortality in CRT patients. METHODS:We studied 100 consecutive patients who received C...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Shen X,Nair CK,Holmberg MJ,Mooss AN,Koruth J,Wang F,Maciejewski S,Esterbrooks DJ

    更新日期:2011-10-06 00:00:00

  • A comparison of early versus delayed elective electrical cardioversion for recurrent episodes of persistent atrial fibrillation: A multi-center study.

    abstract:BACKGROUND:Due to barriers to accessing timely elective electrical cardioversion (CV) for persistent AF (PeAF), we adopted a policy of instructing patients to present directly to the Emergency Department (ED) for CV. OBJECTIVE:We compare a strategy of Emergency CV (ED-CV) versus Elective CV (EL-CV) for treatment of sy...

    journal_title:International journal of cardiology

    pub_type: 杂志文章,多中心研究


    authors: Voskoboinik A,Kalman E,Plunkett G,Knott J,Moskovitch J,Sanders P,Kistler PM,Kalman JM

    更新日期:2019-06-01 00:00:00

  • Clinicopathological characterization of cardiac free wall rupture in patients with acute myocardial infarction: difference between early and late phase rupture.

    abstract::Differences in morphological characteristics have been described in early phase and late phase post-infarction cardiac rupture. In this study, the clinicopathological characteristics of early and late phase rupture have been clarified by reviewing the clinical records of 1450 consecutive patients with acute myocardial...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Nakatsuchi Y,Minamino T,Fujii K,Negoro S

    更新日期:1994-12-01 00:00:00

  • Real-world procedural and 30-day outcome using the Portico transcatheter aortic valve prosthesis: A large single center cohort.

    abstract:BACKGROUND:Published procedural and short-term outcome of the Portico valve for Transcatheter Aortic Valve Implantation (TAVI) is limited. We report a single-center patient series assessing procedural and 30-day outcome of this device. METHODS AND RESULTS:Procedural and 30-day follow-up data were prospectively collect...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Denegri A,Nietlispach F,Kottwitz J,Suetsch G,Haager P,Rodriguez H,Taramasso M,Obeid S,Maisano F

    更新日期:2018-02-15 00:00:00

  • Prevalence of M4 macrophages within human coronary atherosclerotic plaques is associated with features of plaque instability.

    abstract:BACKGROUND:The platelet chemokine CXCL4 induces monocyte differentiation resulting in a macrophage phenotype called "M4", which co-expresses CD68, MMP7, and S100A8. We hypothesized that M4 macrophages are associated with plaque destabilization. METHODS:Atherosclerotic arteries were obtained from explanted hearts of pa...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Erbel C,Wolf A,Lasitschka F,Linden F,Domschke G,Akhavanpoor M,Doesch AO,Katus HA,Gleissner CA

    更新日期:2015-01-01 00:00:00

  • Acute pulmonary embolism in COVID-19 disease: Preliminary report on seven patients.

    abstract::There is some evidence that Covid 19 pneumonia is associated with prothrombotic status and increased risk of venous thromboembolic events (deep venous thrombosis and pulmonary embolism). Over a two-week period we admitted in our Unit 25 patients with Covid-19 pneumonia, of these pulmonary embolism was diagnosed using ...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Faggiano P,Bonelli A,Paris S,Milesi G,Bisegna S,Bernardi N,Curnis A,Agricola E,Maroldi R

    更新日期:2020-08-15 00:00:00

  • Congenital absence of the pericardium associated with atrial septal defect and sick sinus syndrome.

    abstract::We describe the case of a 42-year-old woman with a rare combination of congenital pericardial absence, atrial septal defect within the fossa ovalis and sick sinus syndrome. The features of the different examinations performed (chest X-ray, ECG, ambulatory ECG-monitoring, echocardiography, and cardiac catheterization) ...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Chiariello M,Indolfi C,Condorelli M

    更新日期:1984-04-01 00:00:00

  • Validation of the DAPT score in real-world patients undergoing coronary stent implantation.

    abstract:OBJECTIVES:To assess the external validity of the Dual Antiplatelet Therapy (DAPT) score decision tool in real world patients. METHODS AND RESULTS:Retrospective study using an all comers PCI registry. We compared the rates of myocardial infarction (MI) and actionable bleeding between 12 vs. 12+ months DAPT stratified ...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Witberg G,Zusman O,Bental T,Plakht I,Gabbay H,Gerber Y,Kornowski R

    更新日期:2020-02-01 00:00:00

  • Tako-tsubo cardiomyopathy induced by emotional stress leading to severe mitral regurgitation, cardiogenic shock and cardiopulmonary arrest.

    abstract::Tako-Tsubo cardiomyopathy (TTC) which is usually precipitated by profound emotional and physical stress has been widely reported in the past. In this case we report a young female patient who developed sudden dyspnea and palpitation after an profound stress (fierce argument).The patient had characteristic feature of p...

    journal_title:International journal of cardiology

    pub_type: 信件


    authors: Yaghoubi AR,Ansarin K,Hashemzadeh S,Azhough R,Faraji S,Bozorgi F

    更新日期:2009-07-10 00:00:00

  • Aortic dissection in the thrombolytic era: early recognition and optimal management is a prerequisite for increased survival.

    abstract::Based on two case reports, problems of diagnosis and treatment of aortic dissection are discussed. Thrombolytic treatment given to patients with aortic dissection presenting symptoms mimicking acute MI seems to have a fatal outcome. Indications, as well as contra-indications, for thrombolytic therapy are therefore of ...

    journal_title:International journal of cardiology

    pub_type: 杂志文章,评审


    authors: Melchior T,Hallam D,Johansen BE

    更新日期:1993-11-01 00:00:00

  • PPARβ/δ attenuates palmitate-induced endoplasmic reticulum stress and induces autophagic markers in human cardiac cells.

    abstract:BACKGROUND:Chronic endoplasmic reticulum (ER) stress contributes to the apoptotic cell death in the myocardium, thereby playing a critical role in the development of cardiomyopathy. ER stress has been reported to be induced after high-fat diet feeding in mice and also after saturated fatty acid treatment in vitro. Ther...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Palomer X,Capdevila-Busquets E,Botteri G,Salvadó L,Barroso E,Davidson MM,Michalik L,Wahli W,Vázquez-Carrera M

    更新日期:2014-06-01 00:00:00

  • Recurrent aortic valve prosthesis dehiscence secondary to aortoarteritis: three case reports and literature review.

    abstract::We report three young Chinese male patients who underwent aortic valve replacement for severe aortic regurgitation of subacute onset, complicated by recurrent dehiscence of the aortic valve prosthesis, due to aortitis. One of the three patients underwent aortic valve replacement three times and progression of the pros...

    journal_title:International journal of cardiology

    pub_type: 杂志文章,评审


    authors: Chau EM,Cheung KL,Fu KH,Lee JW

    更新日期:1996-10-11 00:00:00

  • Performing diagnostic coronary angiography to evaluate high-risk cardiac donors: A French nationwide cohort study.

    abstract:BACKGROUND:Allograft shortage might be overcome by the use of hearts from expanded-criteria donors (ECD) but their estimated high-risk of coronary artery disease (CAD) results in a limited utilization of these hearts for transplantation. We aimed to determine if performing coronary angiography (CA) in ECD enhances card...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Ivanes F,Cantrelle C,Genet T,Le Feuvre C,Legeai C,Jasseron C,Pipien I,Epailly E,Bastien O,Angoulvant D,Dorent R

    更新日期:2019-02-15 00:00:00

  • Mid-term outcomes after percutaneous interventions in coronary bifurcations.

    abstract:BACKGROUND:The optimal treatment of patients undergoing percutaneous coronary interventions (PCI) for lesions located at coronary bifurcations is still debated. METHODS:Data on 5036 consecutive patients who underwent PCI on coronary bifurcation at 17 major coronary intervention centers between January 2012 and Decembe...

    journal_title:International journal of cardiology

    pub_type: 杂志文章,多中心研究


    authors: Zimarino M,Briguori C,Amat-Santos IJ,Radico F,Barbato E,Chieffo A,Cirillo P,Costa RA,Erglis A,Gamra H,Gil RJ,Kanic V,Kedev SA,Maddestra N,Nakamura S,Pellicano M,Petrov I,Strozzi M,Tesorio T,Vukcevic V,De Caterina

    更新日期:2019-05-15 00:00:00

  • Sex differences in left main coronary artery stenting: Different characteristics but similar outcomes for women compared with men.

    abstract:BACKGROUND:The clinical outcomes for women compared with men undergoing left main PCI were sparse. We compared the characteristics and long-term outcomes in women versus men after percutaneous coronary intervention (PCI) with drug-eluting stents (DES) for unprotected left main CAD. METHODS:We identified 2328 patients ...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Shin ES,Lee CW,Ahn JM,Lee PH,Chang M,Kim MJ,Yoon SH,Park DW,Kang SJ,Lee SW,Kim YH,Park SW,Park SJ

    更新日期:2018-02-15 00:00:00

  • Fiftieth anniversary of aldosterone: from discovery to cardiovascular therapy.

    abstract::Half a century after the elucidation of its molecular structure, aldosterone is generating the greatest interest, not in the fields of endocrinology or renal medicine but in cardiology-where aldosterone over-activation is now perceived as detrimental in heart failure (HF) and ischaemic heart disease. Clinically, exces...

    journal_title:International journal of cardiology

    pub_type: 杂志文章,评审


    authors: Tan LB,Schlosshan D,Barker D

    更新日期:2004-09-01 00:00:00

  • Stroke in coronary artery bypass graft surgery: an analysis of the CASS experience. The participants in the Coronary Artery Surgery Study.

    abstract::An analysis of the Coronary Artery Surgery Registry (CASS) was performed to determine the occurrence of stroke after coronary artery bypass surgery in patients entered into the Coronary Artery Surgery Study Registry. Of the 10,098 patients having coronary artery bypass surgery at the Coronary Artery Surgery Study part...

    journal_title:International journal of cardiology

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Frye RL,Kronmal R,Schaff HV,Myers WO,Gersh BJ

    更新日期:1992-08-01 00:00:00

  • Interaction between uric acid and endothelial dysfunction predicts new onset of diabetes in hypertensive patients.

    abstract:BACKGROUND:Both uric acid and endothelial dysfunction are associated with new occurrence of type-2 diabetes but, at this moment, there is no evidence about a possible interaction between them. We tested, in untreated hypertensive patients, without clinical evidence of vascular damage, the hypothesis that serum uric aci...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Perticone F,Maio R,Tassone JE,Perticone M,Pascale A,Sciacqua A,Sesti G

    更新日期:2013-07-15 00:00:00

  • General practice preventive health care in non-obstructive coronary artery disease determined by coronary computed tomography angiography.

    abstract:BACKGROUND:The aim of this study was to compare changes in health service utilization, preventive medical management, and cholesterol levels in patients without coronary artery disease (CAD) or with non-obstructive CAD as determined by coronary computed tomography angiography (CTA). METHODS:Single-center five-year obs...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Mols RE,Nørgaard BL,Vedsted P,Farkas DK,Bøtker HE,Jensen JM

    更新日期:2019-03-01 00:00:00

  • Advances in the diagnostic management of arrhythmogenic right ventricular dysplasia-cardiomyopathy.

    abstract::Latest advances in the diagnostic management of arrhythmogenic right ventricular dysplasia-cardiomyopathy (ARVD/C) confirm that ARVD/C is not a rare disease (one affected in 1000-1250 inhabitants) and is of familial origin in 50-80% of cases. Diagnostic criteria defined in 1994 lead to low rates in the diagnosis of AR...

    journal_title:International journal of cardiology

    pub_type: 杂志文章,评审


    authors: Peters S

    更新日期:2006-10-26 00:00:00

  • Chronic heart failure guidelines: do they adequately address patient need at the end-of-life?

    abstract:INTRODUCTION:A number of international guidelines have been developed to support primary care clinicians improve the quality of care for patients with chronic heart failure at the end of life. The objective of this study was to undertake a systematic evaluation of such guidelines in relation to end-of-life care. METHO...

    journal_title:International journal of cardiology

    pub_type: 杂志文章,评审


    authors: Irving G,Holden J,Edwards J,Reeve J,Dowrick C,Lloyd-Williams M

    更新日期:2013-10-03 00:00:00

  • Five-year clinical outcomes in patients with significant coronary artery spasm: A propensity score-matched analysis.

    abstract:BACKGROUND:Coronary artery spasm (CAS) is known to be a risk factor of acute coronary syndrome and angina pectoris. However, there is no currently available data with larger study population regarding long-term clinical outcomes of CAS in real world clinical practice. OBJECTIVES:We evaluated the prevalence of CAS and ...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Choi BG,Park SH,Rha SW,Park JY,Choi SY,Park Y,Xu S,Ngow HA,Ali J,Li H,Kim JB,Lee S,Na JO,Choi CU,Lim HE,Kim JW,Kim EJ,Park CG,Seo HS,Oh DJ

    更新日期:2015-04-01 00:00:00

  • Predictors of favorable and poor prognosis in unwitnessed out-of-hospital cardiac arrest with a non-shockable initial rhythm.

    abstract:BACKGROUND:Unwitnessed OHCA patients with non-shockable initial rhythms account for nearly half of all OHCA patients, and their prognosis is extremely poor. To date, no studies have focused on these patients. This study aimed to investigating the predictors of favorable and poor prognosis in these patients. METHODS:We...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Fukuda T,Matsubara T,Doi K,Fukuda-Ohashi N,Yahagi N

    更新日期:2014-10-20 00:00:00

  • Impact of chronic obstructive pulmonary disease on clinical course after an episode of acute heart failure. EAHFE-COPD study.

    abstract:OBJECTIVE:To study if the coexistence of chronic obstructive pulmonary disease (COPD) in patients diagnosed with acute heart failure (AHF) at the emergency department (ED) has an impact on short- and long-term outcomes. METHOD:The EAHFE-COPD study included patients who attended in 34 Spanish EDs for AHF. We compared p...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Jacob J,Tost J,Miró Ò,Herrero P,Martín-Sánchez FJ,Llorens P,ICA-SEMES Research Group.

    更新日期:2017-01-15 00:00:00