Intravenous mesenchymal stem cell therapy early after reperfused acute myocardial infarction improves left ventricular function and alters electrophysiologic properties.

Abstract:

UNLABELLED:Direct intramyocardial injection of mesenchymal stem cells (MSCs) improves left ventricular ejection fraction (LVEF) and may increase ventricular arrhythmia in hearts with myocardial infarction (MI). We hypothesized that intravenous MSCs given early after acute MI would engraft in injured myocardium, improve LV function, and result in pro-arrhythmic electrical remodeling. We created an apical infarction in swine by balloon occlusion/reperfusion, administered diI-labeled allogeneic bone marrow derived MSCs intravenously 30 min post-reperfusion and measured LVEF and wall thickness at baseline, 1 month, and 3 months. Epicardial effective refractory periods (ERPs) were determined before sacrifice. At 3 months, treated pigs [n=7] had significantly higher LVEF than controls [n=8] (49+/-2% vs. 44+/-3%, P=0.015) and significantly less wall thickening of non-infarcted myocardium. ERPs were significantly shorter than controls at all pacing cycle lengths (P

journal_name

Int J Cardiol

authors

Price MJ,Chou CC,Frantzen M,Miyamoto T,Kar S,Lee S,Shah PK,Martin BJ,Lill M,Forrester JS,Chen PS,Makkar RR

doi

10.1016/j.ijcard.2005.07.036

subject

Has Abstract

pub_date

2006-08-10 00:00:00

pages

231-9

issue

2

eissn

0167-5273

issn

1874-1754

pii

S0167-5273(05)01042-9

journal_volume

111

pub_type

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