Abstract:
:Stimulants may provide short-term performance and alertness enhancement during sleep loss. Caffeine 600 mg, d-amphetamine 20 mg, and modafinil 400 mg were compared during 85 h of total sleep deprivation to determine the extent to which the three agents restored performance on simple psychomotor tasks, objective alertness and tasks of executive functions. Forty-eight healthy young adults remained awake for 85 h. Performance and alertness tests were administered bi-hourly from 8:00 hours day 2 to 19:00 hours day 5. At 23:50 hours on day 4 (after 64 h awake), subjects ingested placebo, caffeine 600 mg, dextroamphetamine 20 mg, or modafinil 400 mg (n=12 per group). Performance and alertness testing continued, and probe tasks of executive function were administered intermittently until the recovery sleep period (20:00 hours day 5 to 8:00 hours day 5). Bi-hourly postrecovery sleep testing occurred from 10:00 hours to 16:00 hours day 6. All three agents improved psychomotor vigilance speed and objectively measured alertness relative to placebo. Drugs did not affect recovery sleep, and postrecovery sleep performance for all drug groups was at presleep deprivation levels. Effects on executive function tasks were mixed, with improvement on some tasks with caffeine and modafinil, and apparent decrements with dextroamphetamine on others. At the doses tested, caffeine, dextroamphetamine, and modafinil are equally effective for approximately 2-4 h in restoring simple psychomotor performance and objective alertness. The duration of these benefits vary in accordance with the different elimination rates of the drugs. Whether caffeine, dextroamphetamine, and modafinil differentially restore executive functions during sleep deprivation remains unclear.
journal_name
J Sleep Resjournal_title
Journal of sleep researchauthors
Wesensten NJ,Killgore WD,Balkin TJdoi
10.1111/j.1365-2869.2005.00468.xsubject
Has Abstractpub_date
2005-09-01 00:00:00pages
255-66issue
3eissn
0962-1105issn
1365-2869pii
JSR468journal_volume
14pub_type
杂志文章abstract::Very low energy diets (VLED) appear to be the most efficacious dietary-based obesity reduction treatments in obstructive sleep apnea (OSA); however, effective weight loss maintenance strategies remain untested in this condition. Our study aimed to assess the feasibility, tolerability and efficacy of two common mainten...
journal_title:Journal of sleep research
pub_type: 临床试验,杂志文章
doi:10.1111/jsr.12572
更新日期:2018-04-01 00:00:00
abstract::Ponto-geniculo-occipital (PGO) waves are spontaneously-occurring macropotential waveforms recorded in the pons, lateral geniculate body (LGB) and occipital cortex. PGO waves mark the onset and course of rapid eye movement sleep (REM). PGO-like waves can be recorded in several brain areas including the thalamic central...
journal_title:Journal of sleep research
pub_type: 杂志文章
doi:10.1111/j.1365-2869.1992.tb00048.x
更新日期:1992-12-01 00:00:00
abstract::It has been hypothesized that insufficient sleep may compromise neuronal function and contribute to neurodegenerative processes. While sleep loss by itself may not lead to cell death directly, it may affect the sensitivity to a subsequent neurodegenerative insult. Here we examined the effects of chronic sleep restrict...
journal_title:Journal of sleep research
pub_type: 杂志文章
doi:10.1111/j.1365-2869.2011.00932.x
更新日期:2012-02-01 00:00:00
abstract::Stimulus factors known to influence the amplitude of the well known endogenous event-related potential (ERP) component P300 were manipulated to determine whether they have the same, or a different, influence on the amplitude of positivities of the sleep ERPs identified as P220, P450, and P900. Behavioral responsivenes...
journal_title:Journal of sleep research
pub_type: 临床试验,杂志文章
doi:10.1046/j.1365-2869.2001.00238.x
更新日期:2001-03-01 00:00:00
abstract::Self-reported short or long sleep duration has been repeatedly found to be associated with increased mortality and health risks. However, there is still an insufficient amount of detailed knowledge available to characterize the short and long sleep duration groups in general population. Consequently, the underlying me...
journal_title:Journal of sleep research
pub_type: 杂志文章
doi:10.1111/j.1365-2869.2006.00543.x
更新日期:2006-09-01 00:00:00
abstract::Vestibular dysfunction was linked to moderate-to-severe obstructive sleep apnea syndrome (OSAS) patients in literature. However, due to a lack of knowledge among valid and recent implementations conceived to study postural control on static posturography (SP) and vestibulo-ocular reflex (VOR) gain under physiological ...
journal_title:Journal of sleep research
pub_type: 杂志文章
doi:10.1111/jsr.12516
更新日期:2017-08-01 00:00:00
abstract::The aim of this study was to explore the mediating role of sleep characteristics in the relationship between morningness-eveningness and three different aspects of daytime functioning: daytime sleepiness, depressive mood and substance use in university students. A multiple mediator model was proposed with sleep debt, ...
journal_title:Journal of sleep research
pub_type: 杂志文章
doi:10.1111/jsr.12467
更新日期:2017-04-01 00:00:00
abstract::This consensus paper provides an overview of the state of the art in research on the aetiology and treatment of nightmare disorder and outlines further perspectives on these issues. It presents a definition of nightmares and nightmare disorder followed by epidemiological findings, and then explains existing models of ...
journal_title:Journal of sleep research
pub_type: 杂志文章,评审
doi:10.1111/jsr.12820
更新日期:2019-08-01 00:00:00
abstract::PAX6 gene mutations cause a variety of eye and central nervous system (CNS) abnormalities. Aniridia is often accompanied by CNS abnormalities such as pineal gland atrophy or hypoplasia, leading to disturbed circadian rhythm and sleep disorders. Less is known on the coincidence of narcolepsy in this patient group. We a...
journal_title:Journal of sleep research
pub_type: 杂志文章
doi:10.1111/jsr.12982
更新日期:2020-12-01 00:00:00
abstract::The aim of this work was to study the effects of bright light-induced circadian phase shifts on sleep propensity and sleep architecture while the timing of the sleep/wake cycle is kept constant. Twenty-three normal subjects underwent an 11-day study including: (i) baseline sleep and vigilance evaluation; (ii) baseline...
journal_title:Journal of sleep research
pub_type: 杂志文章
doi:10.1111/j.1365-2869.1995.tb00171.x
更新日期:1995-12-01 00:00:00
abstract::Slow-wave sleep is one of the most important restorative components of sleep and central for our health and cognitive functioning. Although the amount of slow-wave sleep depends on sleep drive, age and other factors, also the pre-sleep mental state might influence sleep depth. We had shown that a pre-sleep hypnotic su...
journal_title:Journal of sleep research
pub_type: 杂志文章
doi:10.1111/jsr.13168
更新日期:2020-08-17 00:00:00
abstract::Spatiotemporal activity patterns of neurones are organized by different types of coherent network oscillations. Frequency content and cross-frequency coupling of cortical oscillations are strongly state-dependent, indicating that different patterns of wakefulness or sleep, respectively, support different cognitive or ...
journal_title:Journal of sleep research
pub_type: 杂志文章
doi:10.1111/j.1365-2869.2012.01037.x
更新日期:2012-12-01 00:00:00
abstract::Patients with obstructive sleep apnoea (OSA) have an increased cardiovascular mortality and probably also an increased incidence of sudden cardiac death. Thus the question arises whether ventricular late potentials can constitute markers for an increased electric vulnerability in these patients. Signal-averaged electr...
journal_title:Journal of sleep research
pub_type: 杂志文章
doi:10.1111/j.1365-2869.1995.tb00213.x
更新日期:1995-06-01 00:00:00
abstract::The faces of people who are sleep deprived are perceived by others as looking paler, less healthy and less attractive compared to when well rested. However, there is little research using objective measures to investigate sleep-loss-related changes in facial appearance. We aimed to assess the effects of sleep deprivat...
journal_title:Journal of sleep research
pub_type: 杂志文章
doi:10.1111/jsr.12860
更新日期:2019-12-01 00:00:00
abstract::This study examined a two-dimensional approach to assessing affective states among good and poor sleepers using the self-assessment manikin (SAM), a brief non-verbal self-report measure of affective states with separate ratings of valence and arousal. A sample of 286 undergraduate students completed the Pittsburgh Sle...
journal_title:Journal of sleep research
pub_type: 杂志文章
doi:10.1111/j.1365-2869.2011.00907.x
更新日期:2011-12-01 00:00:00
abstract::Since rapid eye movement (REM) sleep deprivation has been reported to affect the neuronal excitability in the brain, it was hypothesized that a change in the neuronal membrane-bound Na-K ATPase activity might be at least one of the factors inducing such a change. Therefore, in this study rats were deprived of REM slee...
journal_title:Journal of sleep research
pub_type: 杂志文章
doi:10.1111/j.1365-2869.1993.tb00060.x
更新日期:1993-03-01 00:00:00
abstract::Excessive daytime sleepiness (EDS) is a frequent symptom of patients with obstructive sleep apnoea (OSA). EDS is a high-risk factor for accidents at work and on the road. Thirty untreated patients with different levels of severity of OSA were studied concerning night sleep and EDS. The criterion for severity was the r...
journal_title:Journal of sleep research
pub_type: 杂志文章
doi:10.1046/j.1365-2869.2000.00211.x
更新日期:2000-09-01 00:00:00
abstract::Whereas most people require more than 6 h of sleep to feel well rested, there appears to be a group of people who can function well on between 3 and 6 h of sleep. The aims of the present study were to compare 12 naturally short (3-6 h) sleepers (9 males 3 females, mean age 39.6 years, SD age 10.1 years) recruited by a...
journal_title:Journal of sleep research
pub_type: 杂志文章
doi:10.1046/j.1365-2869.2001.00254.x
更新日期:2001-09-01 00:00:00
abstract::Measuring sleep duration and early onset rapid eye movement sleep (REMS) is critical in the assessment of suspected central disorders of hypersomnolence (CDH). Current multi-sensor activity trackers that integrate accelerometry and heart rate are purported to accurately quantify sleep time and REMS; however, their uti...
journal_title:Journal of sleep research
pub_type: 杂志文章
doi:10.1111/jsr.12789
更新日期:2019-08-01 00:00:00
abstract::It is believed that sexual activity increases the need to sleep in many species. However, the relationship between copulatory activity and sleep has been poorly studied. Several studies have observed variations in the sleep of female rats and women as a function of their reproductive state. These effects have been cor...
journal_title:Journal of sleep research
pub_type: 杂志文章
doi:10.1046/j.1365-2869.2002.00304.x
更新日期:2002-09-01 00:00:00
abstract::The present study sought to investigate the meaning of subjectively good sleep, using a longitudinal and intraindividual design. Eight subjects slept in an isolation unit according to an irregular schedule of 6 h sleeps and 1 h naps, designed to give normal amounts of time in bed (1/3 of total), but variable sleep qua...
journal_title:Journal of sleep research
pub_type: 杂志文章
doi:10.1111/j.1365-2869.1994.tb00122.x
更新日期:1994-09-01 00:00:00
abstract::Cetacean sleep phenomenology consists of a combination of unihemispheric slow wave sleep and a massive reduction in the amount of rapid eye movement sleep. Despite various proposals, the selection pressure driving the evolution of this combined sleep phenomenology is unknown. It was recently suggested that the need to...
journal_title:Journal of sleep research
pub_type: 杂志文章
doi:10.1111/j.1365-2869.2004.00419.x
更新日期:2004-12-01 00:00:00
abstract::The use of a short (< 1 h) nap in improving alertness during the early morning hours in the first night shift was examined under laboratory conditions. The study contained four experimental, non-consecutive night shifts with a nap of either 50 or 30 min at 01.00 or 04.00 hours. An experimental night shift without a na...
journal_title:Journal of sleep research
pub_type: 杂志文章
doi:10.1046/j.1365-2869.1998.00121.x
更新日期:1998-12-01 00:00:00
abstract::The effects of rate of presentation on the evoked K-Complex were examined. In different conditions, brief duration tone pips were presented every 5, 10 or 30 s. Trials were sorted into those on which a K-Complex was or was not elicited and averaged separately. The evoked K-Complex consisted of two different negative c...
journal_title:Journal of sleep research
pub_type: 杂志文章
doi:10.1111/j.1365-2869.1994.tb00109.x
更新日期:1994-06-01 00:00:00
abstract::Sleep loss, which affects about one-third of the US population, can severely impair physical and neurobehavioural performance. Although caffeine, the most widely used stimulant in the world, can mitigate these effects, currently there are no tools to guide the timing and amount of caffeine consumption to optimize its ...
journal_title:Journal of sleep research
pub_type: 杂志文章
doi:10.1111/jsr.12711
更新日期:2018-10-01 00:00:00
abstract::The beneficial effect of sleep on motor memory consolidation is well known for motor sequence memory, but remains unsettled for visuomotor adaptation in humans. The aim of this study was to characterize more clearly the influence of sleep on consolidation of visuomotor adaptation using a between-subjects functional ma...
journal_title:Journal of sleep research
pub_type: 杂志文章
doi:10.1111/j.1365-2869.2012.01059.x
更新日期:2013-04-01 00:00:00
abstract::An accurate home sleep study to assess electroencephalography (EEG)-based sleep stages and EEG power would be advantageous for both clinical and research purposes, such as for longitudinal studies measuring changes in sleep stages over time. The purpose of this study was to compare sleep scoring of a single-channel EE...
journal_title:Journal of sleep research
pub_type: 临床试验,杂志文章
doi:10.1111/jsr.12417
更新日期:2016-12-01 00:00:00
abstract::Sleep structure is highly stable within individuals but different between individuals. The present study investigated robustness of the individual sleep structure to extended total sleep deprivation. Seventeen healthy men spent a baseline night (23:00-07:00 hours), 58 h of sleep deprivation and a 14-h recovery night (...
journal_title:Journal of sleep research
pub_type: 杂志文章
doi:10.1111/jsr.12641
更新日期:2019-06-01 00:00:00
abstract::The Epworth Sleepiness Scale (ESS) is a widely used, validated questionnaire for effectively examining patients' sleepiness in a range of different situations. Test-retest reliability is an important aspect of a questionnaire, which, according to only a few studies, was found to be low in the case of the ESS. All thes...
journal_title:Journal of sleep research
pub_type: 杂志文章
doi:10.1111/jsr.13277
更新日期:2021-01-25 00:00:00
abstract::An intermediate phenotype of a disease is a trait in the path of pathogenesis from genetic predisposition to disease manifestation. Identifying intermediate phenotypes with high heritability is helpful in delineating the genetics of a disorder. In this study, we aimed to examine various traits with regards to obesity,...
journal_title:Journal of sleep research
pub_type: 杂志文章
doi:10.1111/jsr.13191
更新日期:2020-09-14 00:00:00