Effect of vitamin E and polyphenols on ochratoxin A-induced cytotoxicity in liver (HepG2) cells.

Abstract:

:It has been shown that oxidative damage contributes to the wide range of toxic effects of the mycotoxin ochratoxin A (OTA). Therefore, we examined the effects of alpha-tocopherol (alpha-TOC) and different polyphenols--catechin (CAT), daidzein (DAI), epicatechin (EC), epigallocatechin gallate (EGCG), genistein (GEN), and quercetin (QUE)--on OTA-induced cytotoxicity in HepG2 liver cells. Incubation of HepG2 cells with increasing concentrations of OTA resulted in a dose- and time-dependent cytotoxicity as measured by the neutral red assay. Half lethal concentrations (LC50) of OTA were 35 and 10 microM after 48 and 72 h incubation, respectively. Incubation of HepG2 cells with alpha-TOC as well as with different polyphenols (exhibiting different antioxidant potency as determined by the FRAP, TEAC and DPPH assays) did not counteract OTA-induced cytotoxicity. These findings indicate that OTA may exert its toxic effects by affecting other hepatic mechanisms than those directly modulated by alpha-TOC and polyphenols.

journal_name

J Plant Physiol

authors

Hundhausen C,Bösch-Saadatmandi C,Augustin K,Blank R,Wolffram S,Rimbach G

doi

10.1016/j.jplph.2005.04.021

subject

Has Abstract

pub_date

2005-07-01 00:00:00

pages

818-22

issue

7

eissn

0176-1617

issn

1618-1328

pii

S0176-1617(05)00142-2

journal_volume

162

pub_type

杂志文章
  • Multiplication végétative in vitro de Gardenia jasminoïdes Ellis: In vitro Vegetative Multiplication of Gardenia jasminoïdes Ellis.

    abstract::The vegetative propagation in vitro of Gardenia jasminoides Ellis, an ornamental shrub producing secondary metabolites useful in perfumery and pharmacy, has been investigated. In the presence of benzylaminopurine (0.3 to 1 mg l(-1)) and indoleacetic acid (1 mg l(-1)), axillary shoots arose from nodes of greenhause pla...

    journal_title:Journal of plant physiology

    pub_type: 杂志文章

    doi:10.1016/S0176-1617(84)80131-5

    authors: Dumanois C,Godin B,Bigot C

    更新日期:1984-11-01 00:00:00

  • Characterization of expressed sequence tags from Lilium longiflorum in vernalized and non-vernalized bulbs.

    abstract::In Lilium longiflorum, vernalization is both an obligatory requirement and the major factor affecting flowering time, however, little is known about the molecular regulation of this mechanism in Lilium and other flowering bulbs. Exposure of L. longiflorum bulbs to 9 weeks at 4°C greatly promoted stem elongation within...

    journal_title:Journal of plant physiology

    pub_type: 杂志文章

    doi:10.1016/j.jplph.2014.09.015

    authors: Lugassi-Ben Hamo M,Martin CV,Zaccai M

    更新日期:2015-01-15 00:00:00

  • Characterization of starch phosphorylase from the marine green microalga (Chlorophyta) Tetraselmis subcordiformis reveals its potential role in starch biosynthesis.

    abstract::In a marine green starch-producing microalga Tetraselmis subcordiformis, the role of starch phosphorylase (SP) in the starch biosynthesis was disclosed by characterizing the enzyme properties and activity variations during the starch accumulation process. TsSP4, a SP isoform accounting for the major SP activity in T. ...

    journal_title:Journal of plant physiology

    pub_type: 杂志文章

    doi:10.1016/j.jplph.2017.07.019

    authors: Jiang J,Yao C,Cao X,Liu Y,Xue S

    更新日期:2017-11-01 00:00:00

  • Light is a positive regulator of strigolactone levels in tomato roots.

    abstract::Strigolactones (SLs) or closely related molecules were recently identified as phytohormones, acting as long-distance branching factors that suppress growth of pre-formed axillary buds in the shoot. The SL signaling pathways and light appear to be connected, as SLs were shown to induce light-regulated pathways and to m...

    journal_title:Journal of plant physiology

    pub_type: 杂志文章

    doi:10.1016/j.jplph.2011.05.022

    authors: Koltai H,Cohen M,Chesin O,Mayzlish-Gati E,Bécard G,Puech V,Ben Dor B,Resnick N,Wininger S,Kapulnik Y

    更新日期:2011-11-01 00:00:00

  • Diurnal changes in CN metabolism and response of rice seedlings to UV-B radiation.

    abstract::Plants regulate a number of primary metabolites, including carbohydrates, organic acids, and amino acids, in response to UV-B radiation. Therefore, it is essential to understand the time-dependent response of rice plants to UV-B stress. This study focused on the response of plants to UV-B at different leaf development...

    journal_title:Journal of plant physiology

    pub_type: 杂志文章

    doi:10.1016/j.jplph.2018.02.007

    authors: Yun H,Lim S,Kim YX,Lee Y,Lee S,Lee D,Park K,Sung J

    更新日期:2018-09-01 00:00:00

  • Application of a genome walking method for the study of the spinach Lhcb1 multigene family.

    abstract::We describe the application of a novel genome walking (GW) strategy for the one-shot identification of members of multigene families. The method was used to study the spinach Lhcb1 family (encoding the light harvesting complex protein Lhcb1), for which three cDNAs were known. Two additional genes and regulatory region...

    journal_title:Journal of plant physiology

    pub_type: 杂志文章

    doi:10.1016/j.jplph.2009.06.020

    authors: Leoni C,Volpicella M,Placido A,Gallerani R,Ceci LR

    更新日期:2010-01-15 00:00:00

  • Involvement of reactive oxygen species and auxin in serotonin-induced inhibition of primary root elongation.

    abstract::The well-known neurotransmitter 5-hydroxytryptamine (serotonin) not only regulates sleep and mood in humans and animals but may also play important roles in modulating growth, development, and defense responses, such as seed germination, flowering, and abiotic stress tolerance, in plants. Serotonin inhibits primary ro...

    journal_title:Journal of plant physiology

    pub_type: 杂志文章

    doi:10.1016/j.jplph.2018.07.004

    authors: Wan J,Zhang P,Sun L,Li S,Wang R,Zhou H,Wang W,Xu J

    更新日期:2018-10-01 00:00:00

  • Differential expression of the ornithine decarboxylase gene during carposporogenesis in the thallus of the red seaweed Grateloupia imbricata (Halymeniaceae).

    abstract::This paper describes the cloning of the ornithine decarboxylase gene from a red seaweed, Grateloupia imbricata (Rhodophyta), the characterization of its expression throughout the reproductive process, and demonstrates how polyamines are involved in seaweed reproduction. In addition, the data indicate that the basal pe...

    journal_title:Journal of plant physiology

    pub_type: 杂志文章

    doi:10.1016/j.jplph.2009.04.018

    authors: García-Jiménez P,García-Maroto F,Garrido-Cárdenas JA,Ferrandiz C,Robaina RR

    更新日期:2009-11-01 00:00:00

  • Cloning and characterization of a type-A response regulator differentially expressed during adventitious shoot formation in Pinus pinea L.

    abstract::Type-A response regulators play an important role in cytokinin-induced adventitious shoot formation, acting as negative regulators of cytokinin signal transduction. In this work, we obtained the full-length cDNA clone of a type-A response regulator from the conifer Pinus pinea, designated PipiRR1. The derived peptide ...

    journal_title:Journal of plant physiology

    pub_type: 杂志文章

    doi:10.1016/j.jplph.2010.02.012

    authors: Cortizo M,Alvarez JM,Rodríguez A,Fernández B,Ordás RJ

    更新日期:2010-08-15 00:00:00

  • Brassinosteroid enhanced the level of abscisic acid in Chlorella vulgaris subjected to short-term heat stress.

    abstract::The present study was undertaken to test the influence of exogenously applied 10nM brassinolide (BL) on the abscisic acid (ABA) content in Chlorella vulgaris cultures subjected to short-term (3h) heat stress (30-40 degrees C). We found that BL enhanced the ABA content with increase in temperature. In parallel, under t...

    journal_title:Journal of plant physiology

    pub_type: 杂志文章

    doi:10.1016/j.jplph.2008.10.004

    authors: Bajguz A

    更新日期:2009-05-15 00:00:00

  • Salt tolerance and activity of antioxidative enzymes of transgenic finger millet overexpressing a vacuolar H(+)-pyrophosphatase gene (SbVPPase) from Sorghum bicolor.

    abstract::A vacuolar proton pyrophosphatase cDNA clone was isolated from Sorghum bicolor (SbVPPase) using end-to-end gene-specific primer amplification. It showed 80-90% homology at the nucleotide and 85-95% homology at the amino acid level with other VPPases. The gene was introduced into expression vector pCAMBIA1301 under the...

    journal_title:Journal of plant physiology

    pub_type: 杂志文章

    doi:10.1016/j.jplph.2014.02.001

    authors: Anjaneyulu E,Reddy PS,Sunita MS,Kishor PB,Meriga B

    更新日期:2014-06-15 00:00:00

  • Light intensity-dependent retrograde signalling in higher plants.

    abstract::Plants are able to acclimate to highly fluctuating light environment and evolved a short- and long-term light acclimatory responses, that are dependent on chloroplasts retrograde signalling. In this review we summarise recent evidences suggesting that the chloroplasts act as key sensors of light intensity changes in a...

    journal_title:Journal of plant physiology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1016/j.jplph.2013.06.005

    authors: Szechyńska-Hebda M,Karpiński S

    更新日期:2013-11-15 00:00:00

  • Increases in jasmonic acid caused by indole-3-acetic acid and auxin herbicides in cleavers (Galium aparine).

    abstract::The effects of indole-3-acetic acid and auxin herbicides on endogenous jasmonic acid (JA) concentrations were studied in relation to changes in ethylene and abscisic acid (ABA) levels in cleavers (Galium aparine). When plants were root-treated with increasing concentrations of indole-3-acetic acid (IAA), ethylene bios...

    journal_title:Journal of plant physiology

    pub_type: 杂志文章

    doi:10.1016/j.jplph.2003.12.002

    authors: Grossmann K,Rosenthal C,Kwiatkowski J

    更新日期:2004-07-01 00:00:00

  • Suppression of tomato SlNAC1 transcription factor delays fruit ripening.

    abstract::Fruit ripening is a complex process involving many physiological and biochemical changes, including those for ethylene, carotenoid, and cell wall metabolism. Tomato (Solanum lycopersicum) serves as a research model for fruit development and ripening because it possesses numerous favorable genetic features. In this stu...

    journal_title:Journal of plant physiology

    pub_type: 杂志文章

    doi:10.1016/j.jplph.2016.01.014

    authors: Meng C,Yang D,Ma X,Zhao W,Liang X,Ma N,Meng Q

    更新日期:2016-04-01 00:00:00

  • Developmental changes in sub-plastidic distribution of chlorophyll biosynthetic intermediates in cucumber (Cucumis sativus L.).

    abstract::Four-day-old etiolated cucumber seedlings (Cucumis sativus L.) were transferred to cool-white-fluorescent light (15 mumol m-2 s-1) for 1 h and 24 hours and etiochloroplasts and chloroplasts were isolated from developing cotyledons. Plastids were fractionated to stroma, envelope and thylakoid or inner membranes and the...

    journal_title:Journal of plant physiology

    pub_type: 杂志文章

    doi:10.1078/0176-1617-00848

    authors: Mohapatra A,Tripathy BC

    更新日期:2003-01-01 00:00:00

  • Phospholipids profile in chloroplasts of Coffea spp. genotypes differing in cold acclimation ability.

    abstract::Environmental temperature change may induce modifications in membrane lipid properties and composition, which account for different physiological responses among plant species. Coffee plants, as many tropical species, are particularly sensitive to cold, but genotypes can present differences that can be exploited to im...

    journal_title:Journal of plant physiology

    pub_type: 杂志文章

    doi:10.1016/j.jplph.2013.07.007

    authors: Scotti-Campos P,Pais IP,Partelli FL,Batista-Santos P,Ramalho JC

    更新日期:2014-02-15 00:00:00

  • Tomato fruit development in the auxin-resistant dgt mutant is induced by pollination but not by auxin treatment.

    abstract::In tomato (Solanum lycopersicum Mill.), auxin is believed to play a pivotal role in controlling fruit-set and early ovary growth. In this paper we investigated the effect of the reduced auxin sensitivity exhibited by the diageotropica (dgt) tomato mutant on ovary growth during early stage of fruit development. Here we...

    journal_title:Journal of plant physiology

    pub_type: 杂志文章

    doi:10.1016/j.jplph.2012.04.005

    authors: Mignolli F,Mariotti L,Lombardi L,Vidoz ML,Ceccarelli N,Picciarelli P

    更新日期:2012-08-15 00:00:00

  • Involvements of H2O2 and metallothionein in NO-mediated tomato tolerance to copper toxicity.

    abstract::Both H(2)O(2) and NO are involved in multiple physiological responses in plants. Metallothionein (MT) can bind heavy metal ions and reduce metal toxicity. Copper toxicity has become a major problem with increasing agricultural and environmental pollution. Here, we investigated the possible roles of ROS, NO and metallo...

    journal_title:Journal of plant physiology

    pub_type: 杂志文章

    doi:10.1016/j.jplph.2010.04.007

    authors: Wang L,Yang L,Yang F,Li X,Song Y,Wang X,Hu X

    更新日期:2010-10-15 00:00:00

  • Antioxidative and proteolytic systems protect mitochondria from oxidative damage in S-deficient Arabidopsis thaliana.

    abstract::We examined the functioning of the antioxidative defense system in Arabidopsis thaliana under sulphur (S) deficiency with an emphasis on the role of mitochondria. In tissue extracts and in isolated mitochondria from S-deficient plants, the concentration of non-protein thiols declined but protein thiols did not change....

    journal_title:Journal of plant physiology

    pub_type: 杂志文章

    doi:10.1016/j.jplph.2015.07.011

    authors: Ostaszewska-Bugajska M,Rychter AM,Juszczuk IM

    更新日期:2015-08-15 00:00:00

  • Comparison of changes in water status and photosynthetic parameters in wild type and abscisic acid-deficient sitiens mutant of tomato (Solanum lycopersicum cv. Rheinlands Ruhm) exposed to sublethal and lethal salt stress.

    abstract::Abscisic acid (ABA) regulates many salt stress-related processes of plants such as water balance, osmotic stress tolerance and photosynthesis. In this study we investigated the responses of wild type (WT) and the ABA-deficient sitiens mutant of tomato (Solanum lycopersicum cv. Rheinlands Ruhm) to sublethal and lethal ...

    journal_title:Journal of plant physiology

    pub_type: 杂志文章

    doi:10.1016/j.jplph.2018.11.015

    authors: Poór P,Borbély P,Czékus Z,Takács Z,Ördög A,Popović B,Tari I

    更新日期:2019-01-01 00:00:00

  • Contribution of momilactone A and B to rice allelopathy.

    abstract::Eight cultivars of rice (Oryza sativa L.) inhibited shoot and root growth of Echinochloa crus-galli when co-cultured with rice seedlings in a bioassay medium. Momilactone A and B were found in the bioassay medium of all rice cultivars, and concentrations of momilactone A and B in the medium were 0.21-1.5 and 0.66-3.8 ...

    journal_title:Journal of plant physiology

    pub_type: 杂志文章

    doi:10.1016/j.jplph.2010.01.014

    authors: Kato-Noguchi H,Hasegawa M,Ino T,Ota K,Kujime H

    更新日期:2010-07-01 00:00:00

  • Synthesis of novel biomaterials in plants.

    abstract::Metabolic engineering of plants allows the possibility of using crops for the synthesis of novel polymers having useful material properties. Strong and flexible protein-based polymers, which are based on the structure of silk and elastin have been synthesized in transgenic plants. A wide range of polyhydroxyalkanoates...

    journal_title:Journal of plant physiology

    pub_type: 杂志文章,评审

    doi:10.1078/0176-1617-01030

    authors: Moire L,Rezzonico E,Poirier Y

    更新日期:2003-07-01 00:00:00

  • Higher concentration of Q(B)-nonreducing photosystem II centers in triazine-resistant Chenopodium album plants as revealed by analysis of chlorophyll fluorescence kinetics.

    abstract::Plants resistant to triazine-type herbicides are known to be altered in their photosystem II reaction center. Serine at site 264 in D1 protein is replaced by glycine. The measurements of chlorophyll a fluorescence excitations with a variable number of saturating flashes in Chenopodium album plants show characteristic ...

    journal_title:Journal of plant physiology

    pub_type: 杂志文章

    doi:10.1016/j.jplph.2009.04.011

    authors: Van Rensen JJ,Vredenberg WJ

    更新日期:2009-10-15 00:00:00

  • Nitric oxide production is associated with response to brown planthopper infestation in rice.

    abstract::Nilaparvata lugens Stål, the brown planthopper (BPH), is one of the most destructive phloem-feeding insects of rice (Oryza sativa L.) throughout Asia. Here, we show that BPH feeding increases the level of endogenous nitric oxide (NO) in the leaf and sheath tissue of both resistant and susceptible rice cultivars. Howev...

    journal_title:Journal of plant physiology

    pub_type: 杂志文章

    doi:10.1016/j.jplph.2010.09.018

    authors: Liu Y,He J,Jiang L,Wu H,Xiao Y,Liu Y,Li G,Du Y,Liu C,Wan J

    更新日期:2011-05-15 00:00:00

  • Juvenile nitrogen uptake capacities and root architecture of two open-pollinated families of Picea abies. Effects of nitrogen source and ectomycorrhizal symbiosis.

    abstract::This study was carried out to find early physiological differences occurring in young seedlings between two contrasting Picea abies open-pollinated families (OPF), one with high- and one with low-growth performance in the field by, determining their N uptake capacities and their root architecture. We used three potent...

    journal_title:Journal of plant physiology

    pub_type: 杂志文章

    doi:10.1078/0176-1617-00973

    authors: Boukcim H,Plassard C

    更新日期:2003-10-01 00:00:00

  • Transformation of peanut using a modified bacterial mercuric ion reductase gene driven by an actin promoter from Arabidopsis thaliana.

    abstract::In order to test an alternative selectable marker system for the production of transgenic peanut plants (Arachis hypogaea), the bacterial mercuric ion reductase gene, merA, was introduced into embryogenic cultures via microprojectile bombardment. MerA reduces toxic Hg(II) to the volatile and less toxic metallic mercur...

    journal_title:Journal of plant physiology

    pub_type: 杂志文章

    doi:10.1078/0176-1617-01087

    authors: Yang H,Nairn J,Ozias-Akins P

    更新日期:2003-08-01 00:00:00

  • Plant cell proliferation and growth are altered by microgravity conditions in spaceflight.

    abstract::Seeds of Arabidopsis thaliana were sent to space and germinated in orbit. Seedlings grew for 4d and were then fixed in-flight with paraformaldehyde. The experiment was replicated on the ground in a Random Positioning Machine, an effective simulator of microgravity. In addition, samples from a different space experimen...

    journal_title:Journal of plant physiology

    pub_type: 杂志文章

    doi:10.1016/j.jplph.2009.08.012

    authors: Matía I,González-Camacho F,Herranz R,Kiss JZ,Gasset G,van Loon JJ,Marco R,Javier Medina F

    更新日期:2010-02-15 00:00:00

  • A novel bipartite nuclear localization signal with an atypically long linker in DOF transcription factors.

    abstract::Large molecules require a nuclear localization signal (NLS) for translocation into the nucleus. Classical NLSs are rich in basic amino acids and they represent three groups, based on their structural features: SV40 T-antigen-type, yeast mating factor Matalpha-2-type, and bipartite NLSs. DNA-binding-with-one-finger (DO...

    journal_title:Journal of plant physiology

    pub_type: 杂志文章

    doi:10.1016/j.jplph.2009.11.016

    authors: Krebs J,Mueller-Roeber B,Ruzicic S

    更新日期:2010-05-01 00:00:00

  • Recovery of maize (Zea mays L.) inbreds and hybrids from chilling stress of various duration: photosynthesis and antioxidant enzymes.

    abstract::The differences between two maize (Zea mays L.) inbred lines and their F1 hybrids in their response to chilling periods of various duration (1, 2, 3 or 4 weeks) and subsequent return to optimum temperatures were analysed by the measurement of the photosystem (PS) 1 and 2 activity, the photosynthetic pigments' content ...

    journal_title:Journal of plant physiology

    pub_type: 杂志文章

    doi:10.1016/j.jplph.2006.04.016

    authors: Holá D,Kocová M,Rothová O,Wilhelmová N,Benesová M

    更新日期:2007-07-01 00:00:00

  • Partial substitution of NO(3)(-) by NH(4)(+) fertilization increases ammonium assimilating enzyme activities and reduces the deleterious effects of salinity on the growth of barley.

    abstract::Productivity of cereal crops is restricted in saline soils but may be improved by nitrogen nutrition. In this study, the effect of ionic nitrogen form on growth, mineral content, protein content and ammonium assimilation enzyme activities of barley (Hordeum vulgare cv. Alexis L.) irrigated with saline water, was deter...

    journal_title:Journal of plant physiology

    pub_type: 杂志文章

    doi:10.1016/j.jplph.2005.12.011

    authors: Kant S,Kant P,Lips H,Barak S

    更新日期:2007-03-01 00:00:00