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A structured review of randomized controlled trials of weight loss showed little improvement in health-related quality of life.

Abstract：

OBJECTIVE:To estimate the effect of weight-loss interventions on health-related quality of life (HrQoL) in randomized controlled trials (RCTs); to conduct a meta-analysis of weight-loss treatment on depressive symptoms; and, to examine methodological and presentation issues that compromise study validity. STUDY DESIGN AND SETTING:We conducted a structured review of 34 RCTs with weight-loss interventions that reported the relationship between HrQoL and treatment at two or more time points. We also evaluated study quality. RESULTS:Trials lasted 6 weeks to 208 weeks and evaluated behavioral, surgical, or pharmacologic interventions. Nine of 34 trials showed HrQoL improvements in generic measures. Obesity-specific measures were more likely to show improvement in response to treatment than non-obesity-specific measures. Meta-analysis showed no treatment effect on depressive symptoms. Most trials tracked loss to follow-up and conducted intent-to-treat analysis, but only four trials concealed recruitment staff to randomization and 14 blinded the investigation team to randomization. CONCLUSION:HrQoL outcomes, including depression, were not consistently improved in RCTs of weight loss. The overall quality of these clinical trials was poor. Better-designed RCTs using standardized HrQoL measures are needed to determine the extent to which weight loss improves HrQoL.

journal_name

J Clin Epidemiol

journal_title

Journal of clinical epidemiology

authors

Maciejewski ML,Patrick DL,Williamson DF

doi

10.1016/j.jclinepi.2004.10.015

subject

Has Abstract

pub_date

2005-06-01 00:00:00

pages

568-78

issue

6

eissn

0895-4356

issn

1878-5921

pii

S0895-4356(04)00322-1

journal_volume

58

pub_type

杂志文章,meta分析,评审

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