当前位置： SCI文献检索 > AMERICAN HEART JOURNAL期刊下所有文献 > Incidence and characteristics of stroke during 90-day follow-up in patients stabilized after an acute coronary syndrome.

Incidence and characteristics of stroke during 90-day follow-up in patients stabilized after an acute coronary syndrome.

Abstract：

BACKGROUND:Stroke is a rare but serious event that complicates the course of patients with acute coronary syndromes (ACS). The type, outcome, and risk factors of stroke occurring in stabilized patients with ACS have not been previously reported. METHODS:We evaluated stroke incidence, subtypes, and outcomes, in addition to demographics and clinical risk characteristics associated with stroke among patients enrolled in the Sibrafiban versus Aspirin to Yield Maximum Protection from Ischemic Heart Events Post-acute Coronary Syndromes (SYMPHONY) and 2nd SYMPHONY trials. RESULTS:Of 15,904 stabilized patients with ACS, 113 (0.71%) had a stroke over a median follow-up of 90 days. The majority of strokes occurred within 30 days of presentation, and the time course for stroke occurrence paralleled that of myocardial (re)infarction. Most strokes were ischemic (78%), and 52% resulted in moderate or severe disability or death. Patients with stroke were older and more often had hypertension, diabetes, peripheral vascular disease, and atrial fibrillation. Among patients with stroke who had cardiac catheterization, percutaneous coronary intervention, or coronary artery bypass grafting, stroke occurred predominantly after the procedure. No difference in occurrence or type of stroke was observed in the assigned treatment groups. In multivariable modeling age, heart failure, prior stroke, left bundle branch block, and systolic blood pressure predicted the occurrence of stroke. CONCLUSIONS:In patients stabilized after presenting with a spectrum of ACS and treated with sibrafiban and/or aspirin, stroke occurred in fewer than 1% within 90 days but carried a significant mortality and morbidity risk.

journal_name

Am Heart J

journal_title

American heart journal

authors

Kassem-Moussa H,Mahaffey KW,Graffagnino C,Tasissa G,Sila CA,Simes RJ,White HD,Califf RM,Bhapkar MV,Newby LK,SYMPHONY and 2nd SYMPHONY Investigators.

doi

10.1016/j.ahj.2004.01.028

subject

Has Abstract

pub_date

2004-09-01 00:00:00

pages

439-46

issue

eissn

0002-8703

issn

1097-6744

pii

S0002870304001899

journal_volume

148

pub_type

临床试验,杂志文章,多中心研究,随机对照试验

在线工具

Incidence and characteristics of stroke during 90-day follow-up in patients stabilized after an acute coronary syndrome.