[Normal pattern of intraepidermal nerve fibers in 30 healthy volunteers with PGP 9.5].

Abstract:

:Skin biopsy has become an attractive technique to evaluate the terminal regions of small nerve fibers. There is extensive innervation of the skin by both sensory and autonomic fibers as demonstrated by staining for the pan-axonal marker PGP 9,5. The normal pattern is fundamental before any study, since three different techniques described in the literature with different results. Skin biopsy specimens of 3-mm in diameter were obtained from the distal leg of 30 healthy controls. Median intraepidermal nerve fiber density was 5.3/mm. Skin biopsy may be a useful tool for assessing the topographic extent and degree of nerve fiber damage in sensory neuropathies and may be particularly useful in experimental treatment trials for peripheral neuropathies since, in contrast to standard nerve biopsy, the test can be repeated.

journal_name

Arq Neuropsiquiatr

authors

Moura L,Oliveira AS,Zanoteli E,Cardoso R,Schmidt B,Gabbai AA

doi

10.1590/s0004-282x2004000200015

subject

Has Abstract

pub_date

2004-06-01 00:00:00

pages

271-5

issue

2A

eissn

0004-282X

issn

1678-4227

pii

S0004-282X2004000200015

journal_volume

62

pub_type

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