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Synthesis and antitumor activity of 20-O-linked nitrogen-based camptothecin ester derivatives.

Abstract：

:A series of nitrogen-based 20S-hydroxyl camptothecin ester derivatives were prepared. 3-Aminopropionate of camptothecin was found more cytotoxic in vitro on several human tumor cell lines than 3-amidopropionate of camptothecin. Ester 16 showed best antitumor activity in vivo and in vitro in all esters we prepared.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Wang CY,Pan XD,Liu HY,Fu ZD,Wei XY,Yang LX

doi

10.1016/j.bmc.2004.04.023

subject

Has Abstract

pub_date

2004-07-01 00:00:00

pages

3657-62

issue

13

eissn

0968-0896

issn

1464-3391

pii

S0968089604003128

journal_volume

12

pub_type

杂志文章

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