Abstract:
:Recombinant 15N-labeled human interleukin 2 (IL-2) has been studied by 2D and 3D NMR using uniformly 15N-labeled protein. Assignment of the backbone resonances has enabled the secondary structure of the protein to be defined. The secondary structure was found to consist of four alpha-helical regions and a short section of antiparallel beta-sheet. This structure is more similar to recent published structures of interleukin 4 and granulocyte-macrophage colony-stimulating factor than to a structure of IL-2 previously obtained from low-resolution X-ray diffraction data.
journal_name
Biochemistryjournal_title
Biochemistryauthors
Mott HR,Driscoll PC,Boyd J,Cooke RM,Weir MP,Campbell IDdoi
10.1021/bi00148a040subject
Has Abstractpub_date
1992-08-25 00:00:00pages
7741-4issue
33eissn
0006-2960issn
1520-4995journal_volume
31pub_type
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