Analysis of 3'-phosphoglycolaldehyde residues in oxidized DNA by gas chromatography/negative chemical ionization/mass spectrometry.

abstract：:Antineoplastic therapy with anthracyclines like doxorubicin (DOX) and daunorubicin (DNR) is limited by the possible development of a dose-related cardiomyopathy. Secondary alcohol metabolites like doxorubicinol (DOXol) and daunorubicinol (DNRol), formed by cytoplasmic two-electron reductases, have been implicated as p...

journal_title：Chemical research in toxicology

authors： Silvestrini A,Meucci E,Vitali A,Giardina B,Mordente A

更新日期：2006-11-01 00:00:00

abstract：:Aflatoxin Q1 8,9-oxide was synthesized and found to yield lower levels of N7-guanyl adducts than obtained from aflatoxin B1 8,9-oxide when mixed with calf thymus DNA or Salmonella typhimurium TA 98 cells. However, when S. typhimurium TA 98 was treated with the (analogous) epoxides of aflatoxin B1, aflatoxin G1, aflato...

journal_title：Chemical research in toxicology

authors： Raney KD,Shimada T,Kim DH,Groopman JD,Harris TM,Guengerich FP

更新日期：1992-03-01 00:00:00

abstract：:Hemoglobin adducts have been used to assess exposure to carcinogenic compounds in tobacco smoke. However, because of background levels in nonsmokers, most adducts that have been studied are not useful for monitoring low-level exposure. Bergmark [(1997) Chem. Res. Toxicol. 10, 78-84] showed that the level of adducts of...

journal_title：Chemical research in toxicology

authors： Pérez HL,Segerbäck D,Osterman-Golkar S

更新日期：1999-10-01 00:00:00

abstract：:Although many phenols and catechols found as polyphenol natural products are antioxidants and have putative disease-preventive properties, others have deleterious health effects. One possible route to toxicity is the bioactivation of the phenolic function to quinones that are electrophilic, redox-agents capable of mod...

journal_title：Chemical research in toxicology

authors： Tu T,Giblin D,Gross ML

更新日期：2011-09-19 00:00:00

abstract：:Premarin (Wyeth-Ayerst) is the estrogen replacement treatment of choice and continues to be one of the most widely dispensed prescriptions in the United States. In addition to endogenous estrogens, Premarin contains unsaturated estrogens including equilenin. We synthesized the catechol metabolite of equilenin, 4-hydro...

journal_title：Chemical research in toxicology

authors： Shen L,Qiu S,Chen Y,Zhang F,van Breemen RB,Nikolic D,Bolton JL

更新日期：1998-02-01 00:00:00

abstract：:Deferoxamine is an inhibitor of iron-dependent free radical reactions. Despite the antioxidant roles, prolonged clinical use of the chelator is far from benign, and paradoxically, deferoxamine has been shown to promote lipid peroxidation. The possible toxicity of the drug's metabolites, such as deferoxamine nitroxide ...

journal_title：Chemical research in toxicology

authors： Kiyose M,Lee CI,Okabe E

更新日期：1999-02-01 00:00:00

abstract：:Catechol estrogens (CE) are among the major metabolites of estrone (E1) and 17 beta-estradiol (E2). Oxidation of these metabolites to semiquinones and quinones could generate ultimate carcinogenic forms of E1 and E2. The 2,3- and 3,4-quinones of E1 and E2 were synthesized by MnO2 oxidation of the corresponding CE, fol...

journal_title：Chemical research in toxicology

authors： Dwivedy I,Devanesan P,Cremonesi P,Rogan E,Cavalieri E

更新日期：1992-11-01 00:00:00

abstract：:Cytochrome P-450 enzymes have been postulated to oxidize amines through a variety of mechanisms. One of the means of distinguishing among potential pathways involves the use of kinetic hydrogen isotope effects: low isotope effects are characteristic of aminium radical mechanisms while high values are consistent with h...

journal_title：Chemical research in toxicology

authors： Guengerich FP

更新日期：1990-01-01 00:00:00

abstract：:Copper is a physiologically important, redox-active metal that may be involved in endogenous DNA damage and mutagenesis. To understand the factors that affect the location and quantity of copper-induced oxidative DNA damage in cells, we used the 5S rDNA nucleosome as a model to assess the effect of chromatin structure...

journal_title：Chemical research in toxicology

authors： Liang Q,Dedon PC

更新日期：2001-04-01 00:00:00

abstract：:Contact allergy is caused by a wide range of chemicals after skin contact. Its clinical manifestation, allergic contact dermatitis (ACD), is developed upon repeated contact with the allergen. This perspective focuses on two areas that have yielded new useful information during the last 20 years: (i) structure-activity...

journal_title：Chemical research in toxicology

authors： Karlberg AT,Bergström MA,Börje A,Luthman K,Nilsson JL

更新日期：2008-01-01 00:00:00

abstract：:Fragrances are common causes of contact allergy. Geraniol (trans-3,7-dimethyl-2,6-octadiene-1-ol) is an important fragrance terpene. It is considered a weak contact allergen and is used for fragrance allergy screening among consecutive dermatitis patients. Analogous to other monoterpenes studied, such as limonene and ...

journal_title：Chemical research in toxicology

authors： Hagvall L,Bäcktorp C,Svensson S,Nyman G,Börje A,Karlberg AT

更新日期：2007-05-01 00:00:00

abstract：:DNA nucleobases are the prime targets for chemical modifications by endogenous and exogenous electrophiles. Alkylation of the N7 position of guanine and adenine in DNA triggers base-catalyzed imidazole ring opening and the formation of N5-substituted formamidopyrimidine (N5-R-FAPy) lesions. Me-FAPy-dG adducts induced ...

journal_title：Chemical research in toxicology

authors： Pujari SS,Tretyakova N

更新日期：2017-01-17 00:00:00

abstract：:Aminoglutethimide (AMG) is an aromatic amine aromatase inhibitor associated with a high incidence of idiosyncratic blood dyscrasias, especially agranulocytosis. Animal models of idiosyncratic drug reactions (IDRs) represent essential tools to study these reactions; however, there is currently no valid model of idiosyn...

journal_title：Chemical research in toxicology

authors： Ng W,Uetrecht J

更新日期：2013-08-19 00:00:00

abstract：:Two hemorrhagic proteases, Lachesis hemorrhagic toxins a and b (LHTa and LHTb), were isolated from the venom of Lachesis muta, which is distributed in Central and South America. One protease showed strong hemorrhagic action, while the other showed weak hemorrhagic activity even though the two enzymes are very similar ...

journal_title：Chemical research in toxicology

authors： Ran YL,Zheng SD,Tu AT

更新日期：1988-11-01 00:00:00

abstract：:A new method was developed to quantify the levels of 1,3-butadiene (BD), butadiene monoxide (BDO), and butadiene diepoxide (BDO2) in blood. The method was based on vacuum distillation of tissues followed by analysis of the distillates using multidimensional GC/MS. Metabolites isolated from blood by vacuum distillation...

journal_title：Chemical research in toxicology

authors： Bechtold WE,Strunk MR,Thornton-Manning JR,Henderson RF

更新日期：1995-03-01 00:00:00

abstract：:Oxidation of the tris(p-carboxyltetrathiaaryl)methyl (TAM) EPR radical probe, TAMa(•), by rat liver microsomes (RLM) + NADPH, or horseradish peroxidase (HRP) + H2O2, or K2IrCl6, led to an intermediate cation, TAMa(+), which was treated with glutathione (GSH), with formation of an adduct, TAMa-SG(•), resulting from the...

journal_title：Chemical research in toxicology

authors： Decroos C,Boucher JL,Mansuy D,Xu-Li Y

更新日期：2014-04-21 00:00:00

abstract：:The Salmonella typhimurium (TA100) mutagenic compound, mucochloric acid [3,4-dichloro-5-hydroxy-2(5H)-furanone (MCA)], was inactivated by in vitro N-acetylcysteine (NAC). The reaction of MCA with NAC at pH7 was second order and gave products 4, 5, and 6a that resulted from the displacement of chlorine from C-3 or C-4 ...

journal_title：Chemical research in toxicology

authors： LaLonde RT,Xie S

更新日期：1992-09-01 00:00:00

abstract：:Cyadox is a novel derivative of quinoxaline-1,4-dioxides (QdNOs) with the potential to be developed as a feed additive. However, the pharmacological and toxicological bioactive molecules of cyadox and the molecular mechanism of its pharmacological and toxic actions remain unclear. In the present study, cyadox and its ...

journal_title：Chemical research in toxicology

authors： Liu Q,Lei Z,Zhou K,Yu H,Liu S,Sun Q,Wang X,Dai M,Yuan Z

更新日期：2018-11-19 00:00:00

abstract：:Among the cellular components that can react directly with peroxynitrite in the presence of physiological CO(2) concentrations are sulfur-, selenium-, and metal-containing proteins, in particular hemoproteins. We have previously shown that the reactions of peroxynitrite with oxymyoglobin (MbFeO(2)) and oxyhemoglobin p...

journal_title：Chemical research in toxicology

authors： Herold S,Exner M,Boccini F

更新日期：2003-03-01 00:00:00

abstract：:A potentiometric and spectroscopic (UV/vis and CD) study of Cu(II) and Ni(II) binding to the N-terminal pentadecapeptide of human protamine HP2 (HP2(1-15)) was performed. The results indicate that the N-terminal tripeptide motif Arg-Thr-His is the exclusive binding site for both metal ions at a metal to HP2(1-15) mola...

journal_title：Chemical research in toxicology

authors： Bal W,Jezowska-Bojczuk M,Kasprzak KS

更新日期：1997-08-01 00:00:00

abstract：:Drug induced liver injury (DILI) can require significant risk management in drug development and on occasion can cause morbidity or mortality, leading to drug attrition. Optimizing candidates preclinically can minimize hepatotoxicity risk, but it is difficult to predict due to multiple etiologies encompassing DILI, of...

journal_title：Chemical research in toxicology

authors： Williams DP,Lazic SE,Foster AJ,Semenova E,Morgan P

更新日期：2020-01-21 00:00:00

abstract：:Smokeless tobacco products, such as moist snuff or chewing tobacco, contain many of the same carcinogens as tobacco smoke; however, the impact on children of indirect exposure to tobacco constituents via parental smokeless tobacco use is unknown. As part of the California Childhood Leukemia Study, dust samples were co...

journal_title：Chemical research in toxicology

authors： Whitehead TP,Havel C,Metayer C,Benowitz NL,Jacob P 3rd

更新日期：2015-05-18 00:00:00

abstract：:4-Hydroxy-2-nonenal (HNE), a major electrophilic byproduct of lipid peroxidation, is mutagenic and cytotoxic. The two pairs of HNE-derived diastereomeric 1,N2-propanodeoxyguanosine 3'-monophosphate adducts were synthesized from reaction of HNE with 2'-deoxyguanosine 3'-monophosphate. After HPLC separation, these adduc...

journal_title：Chemical research in toxicology

authors： Yi P,Zhan D,Samokyszyn VM,Doerge DR,Fu PP

更新日期：1997-11-01 00:00:00

abstract：:Arsenic is a human carcinogen, causing skin, bladder, and lung cancers. Although arsenic in drinking water affects millions of people worldwide, the mechanism(s) of action by which arsenic causes cancers is not known. Arsenic probably exerts some toxic effects by binding with proteins. However, few experimental data a...

journal_title：Chemical research in toxicology

authors： Jiang G,Gong Z,Li XF,Cullen WR,Le XC

更新日期：2003-07-01 00:00:00

abstract：:Carcinogens induce complex transcriptional responses in cells that may hold key mechanistic information. Benzo(a)pyrene (BaP) modulation of transcription may occur through the activation of the aryl hydrocarbon receptor (AHR) or through responses to DNA damage. To characterize further the expression profiles induced b...

journal_title：Chemical research in toxicology

authors： Hockley SL,Arlt VM,Brewer D,Te Poele R,Workman P,Giddings I,Phillips DH

更新日期：2007-12-01 00:00:00

abstract：:Chromium(III) tris(picolinate) [Cr(pic)3] is currently a very popular nutritional supplement; however, its safety has recently been questioned, especially with regard to its ability to act as a clastogen. At physiologically relevant concentrations, Cr(pic)3 is reduced by biological reductants, including ascorbate and ...

journal_title：Chemical research in toxicology

authors： Speetjens JK,Collins RA,Vincent JB,Woski SA

更新日期：1999-06-01 00:00:00

abstract：:Acrolein is a highly toxic environmental pollutant that readily alkylates the epsilon-amino group of lysine residues in proteins. In model systems, such chemistry involves sequential addition of two acrolein molecules to a given nitrogen, forming bis-Michael-adducted species that undergo aldol condensation and dehydra...

journal_title：Chemical research in toxicology

authors： Kaminskas LM,Pyke SM,Burcham PC

更新日期：2005-11-01 00:00:00

abstract：:Cryogenic (4-10 K) laser-induced vibrationless ground state and vibronic excited state fluorescence emission spectra of the adducts resulting from reaction in vitro of human serum albumin and the carcinogen (+-)-r-7,t-8-dihydroxy-c-9,c-10-epoxy-7,8,9,10- tetrahydrobenzo[a]-pyrene were recorded in order to determine th...

journal_title：Chemical research in toxicology

authors： Day BW,Doxtader MM,Rich RH,Skipper PL,Singh K,Dasari RR,Tannenbaum SR

更新日期：1992-01-01 00:00:00

abstract：:The chlorofluorocarbon substitute 1,2-dichloro-1,1-difluoroethane (HCFC-132b) undergoes oxidative metabolism in rats to give a range of metabolites, including chlorodifluoroacetaldehyde [Harris and Anders (1991) Chem. Res. Toxicol. 4, 180]. The present experiments were undertaken after studies to characterize an unide...

journal_title：Chemical research in toxicology

authors： Yin H,Jones JP,Anders MW

更新日期：1993-09-01 00:00:00

abstract：:DNA conformational change and breakage induced by Cr(VI)-GSH interaction were characterized by the integrated tools of electrochemistry, atomic force microscopy (AFM), and DNA electrophoresis. While electrochemistry confirmed the formation of the active species generated from Cr(VI)-GSH reduction, which causes the DNA...

journal_title：Chemical research in toxicology

authors： Yang PH,Gao HY,Cai J,Chiu JF,Sun H,He QY

更新日期：2005-10-01 00:00:00