Synthesis and 32P-postlabeling/high-performance liquid chromatography separation of diastereomeric 1,N2-(1,3-propano)-2'-deoxyguanosine 3'-phosphate adducts formed from 4-hydroxy-2-nonenal.

abstract：:Nuclei from human lymphoblast cells grown in culture were treated with [7-14C]-(+/-)-r-7,t-8-dihydroxy-t-9,t-10-epoxy-7,8,9,10- tetrahydrobenzo[a]pyrene (anti-BPDE), and the nucleosomal core histones were isolated for adduct studies by cryogenic fluorescence line narrowing spectroscopy. The four core histones H2A, H2B...

journal_title：Chemical research in toxicology

authors： SooHoo CK,Singh K,Skipper PL,Tannenbaum SR,Dasari RR

更新日期：1994-03-01 00:00:00

abstract：:The term class effect has gained in use to describe a side effect including toxicity common to a series of drugs. There is no definition of what constitutes a class effect, and it is not applied against a rigid set of criteria.Thus, the finding of toxicity in one of a series of drugs can raise the concern of a class e...

journal_title：Chemical research in toxicology

authors： Smith DA,Harrison A,Morgan P

更新日期：2011-04-18 00:00:00

abstract：:Allyl alcohol (AA) is one of the environmental pollutants used as a herbicide and industrial chemical. AA undergoes enzymatic oxidation in vivo to form Acrolein (Acr), a highly reactive and ubiquitous environmental toxicant. The exposure to AA/Acr has detrimental effects on cells and is highly fatal. In corroboration ...

journal_title：Chemical research in toxicology

authors： Golla U,Bandi G,Tomar RS

更新日期：2015-06-15 00:00:00

abstract：:Chemically reactive species formed from the metabolism of carboxylic acid-containing compounds have been proposed as mediators of their toxic side-effects. Two alternative metabolic pathways known to be involved in the generation of reactive acylating metabolites of carboxylic acids are acyl glucuronidation and acyl-C...

journal_title：Chemical research in toxicology

authors： Li C,Benet LZ,Grillo MP

更新日期：2002-10-01 00:00:00

abstract：:The hepatotoxicity of Troglitazone (TGZ) has been ascribed to the formation of reactive metabolites, and the primary reactive metabolite of TGZ has been confirmed to be an o-quinone methide. Oxidation of the chromane moiety is also known to produce quinone containing metabolites. Quantum chemical studies have been per...

journal_title：Chemical research in toxicology

authors： Dixit VA,Bharatam PV

更新日期：2011-07-18 00:00:00

abstract：:For decades, many studies have linked maternal smoking to an increased risk of preterm birth. As a result, the scientific community has long hypothesized that exposure to environmental tobacco smoke (ETS), commonly referred to as second-hand smoke, is also associated with an increased risk of preterm birth. Multiple s...

journal_title：Chemical research in toxicology

authors： Elkin ER,O'Neill MS

更新日期：2017-07-17 00:00:00

abstract：:Metabolic bioactivation, glutathione depletion, and covalent binding are the early hallmark events after acetaminophen (APAP) overdose. However, the subsequent metabolic consequences contributing to APAP-induced hepatic necrosis and apoptosis have not been fully elucidated. In this study, serum metabolomes of control ...

journal_title：Chemical research in toxicology

authors： Chen C,Krausz KW,Shah YM,Idle JR,Gonzalez FJ

更新日期：2009-04-01 00:00:00

abstract：:Toxicological studies assessing the safety of compounds for humans frequently use in vitro systems to characterize toxic responses in combination with transcriptomic analyses. Thus far, changes have mostly been investigated at the mRNA level. Recently, microRNAs have attracted attention because they are powerful negat...

journal_title：Chemical research in toxicology

authors： Lizarraga D,Gaj S,Brauers KJ,Timmermans L,Kleinjans JC,van Delft JH

更新日期：2012-04-16 00:00:00

abstract：:Induction of Phase II enzymes of the [Ah] gene battery by L-buthionine (S,R)-sulfoximine (BSO) and other agents was examined in mouse hepatoma Hepa-1c1c7 cells. BSO, a nonelectrophilic inhibitor of gamma-glutamylcysteine synthetase (GCS), is routinely used to examine the toxicological implications of GSH depletion. Ex...

journal_title：Chemical research in toxicology

authors： Shertzer HG,Vasiliou V,Liu RM,Tabor MW,Nebert DW

更新日期：1995-04-01 00:00:00

abstract：:While xenobiotic carboxylic acids (XCAs) have been studied extensively with respect to their enzymatic conversion to potentially reactive acyl glucuronides with implications to drug induced hepatotoxicity, the formation of xenobiotic-S-acyl-CoA thioesters (xenobiotic-CoAs) have been much less studied in spite of data ...

journal_title：Chemical research in toxicology

authors： Darnell M,Weidolf L

更新日期：2013-08-19 00:00:00

abstract：:Benzo[a]pyrene diol epoxides (BPDEs) are the ultimate carcinogenic species of benzo[a]pyrene, a prototype polycyclic aromatic hydrocarbon (PAH). BPDE-modified DNA duplexes can adopt multiple conformations depending on the nature of the modified bases, the stereochemistry at the location of the covalent linkage, and th...

journal_title：Chemical research in toxicology

authors： Yang T,Huang Y,Cho BP

更新日期：2006-02-01 00:00:00

abstract：:Five major products (adducts A(1a), A(1b), A(2), A(3,) and B) from the reaction of guanosine (Guo) with 4-oxo-2(E)-nonenal (ONE) were detected by liquid chromatography-mass spectrometry (LC-MS). Tandem MS (MS/MS) analysis of these compounds suggested that modifications to the nucleoside had been introduced. Adducts A(...

journal_title：Chemical research in toxicology

authors： Zhu P,Lee SH,Wehrli S,Blair IA

更新日期：2006-06-01 00:00:00

abstract：:Anxiolytic kava products have been associated with rare but severe hepatotoxicity in humans. This adverse potential has never been captured in animal models, and the responsible compound(s) remains to be determined. The lack of such knowledge greatly hinders the preparation of a safer kava product and limits its benef...

journal_title：Chemical research in toxicology

authors： Narayanapillai SC,Leitzman P,O'Sullivan MG,Xing C

更新日期：2014-10-20 00:00:00

abstract：:Inhalation of environmental particulate matter (PM) is correlated with adverse health effects in humans, but gene products that couple detection with cellular responses, and the specific properties of PM that target different pathways, have not been fully elucidated. TRPA1 and V1 are two cation channels expressed by s...

journal_title：Chemical research in toxicology

authors： Deering-Rice CE,Romero EG,Shapiro D,Hughen RW,Light AR,Yost GS,Veranth JM,Reilly CA

更新日期：2011-06-20 00:00:00

abstract：:The measurement of metabolites constitutes a useful tool for detection of exposure and in pharmacokinetic studies. Epoxidation with subsequent glutathione conjugation and mercapturic acid formation is an important deactivation pathway for naphthalene, a toxin which presumably causes lung disease. The mercapturic acid ...

journal_title：Chemical research in toxicology

authors： Marco MP,Nasiri M,Kurth MJ,Hammock BD

更新日期：1993-05-01 00:00:00

abstract：:Nitric oxide can be introduced slowly and steadily into aqueous solutions, including cell culture media, over extended periods of time via semipermeable Silastic (a registered trademark of the Dow Corning Corp.) polymer membranes. The rates of introduction are predictable and reproducible and can approach rates of nit...

journal_title：Chemical research in toxicology

authors： Tamir S,Lewis RS,de Rojas Walker T,Deen WM,Wishnok JS,Tannenbaum SR

更新日期：1993-11-01 00:00:00

abstract：:The use of powerful analytical technologies to detect endogenous carbonyls formed as byproducts of oxidative cell injury has revealed that these species contribute to many human diseases. As electrophiles, they are attacked by reactive centers in cell macromolecules to form adducts, the levels of which serve as useful...

journal_title：Chemical research in toxicology

authors： Burcham PC

更新日期：2008-04-01 00:00:00

abstract：:Acrolein is a highly toxic environmental pollutant that readily alkylates the epsilon-amino group of lysine residues in proteins. In model systems, such chemistry involves sequential addition of two acrolein molecules to a given nitrogen, forming bis-Michael-adducted species that undergo aldol condensation and dehydra...

journal_title：Chemical research in toxicology

authors： Kaminskas LM,Pyke SM,Burcham PC

更新日期：2005-11-01 00:00:00

abstract：:Enzyme-linked immunosorbent assays (ELISAs) are reported for the detection of atrazine and its principle metabolite in human urine. The ELISAs can be used with crude urine or following extraction and partial purification by methods described in this report. GC, MS, and HPLC techniques were used to confirm and compleme...

journal_title：Chemical research in toxicology

authors： Lucas AD,Jones AD,Goodrow MH,Saiz SG,Blewett C,Seiber JN,Hammock BD

更新日期：1993-01-01 00:00:00

abstract：:A transient energy impairment with resultant release and subsequent reuptake of 5-hydroxytryptamine (5-HT) and NMDA receptor activation with consequent cytoplasmic superoxide (O(2)(-)(*)), nitric oxide (NO(*)), and peroxynitrite (ONOO(-)) generation have all been implicated in a neurotoxic cascade which ultimately lea...

journal_title：Chemical research in toxicology

authors： Jiang XR,Dryhurst G

更新日期：2002-10-01 00:00:00

abstract：:Many herbal medicines such as epimedium have been reported to cause adverse effects, and icaritin is the common aglycone of many glucosides in epimedium. Our present work aimed at the clarification of the metabolic activation of icaritin possibly responsible for the adverse effects of epimedium. A quinone methide meta...

journal_title：Chemical research in toxicology

authors： Chen Y,Guo X,Ma Y,Hu X,Peng Y,Zheng J

更新日期：2019-06-17 00:00:00

abstract：:Exposure to aristolochic acid I (AAI) is associated with aristolochic acid nephropathy, Balkan endemic nephropathy, and urothelial cancer. Individual differences in xenobiotic-metabolizing enzyme activities are likely to be a reason for interindividual susceptibility to AA-induced disease. We evaluated the reductive a...

journal_title：Chemical research in toxicology

authors： Arlt VM,Levová K,Bárta F,Shi Z,Evans JD,Frei E,Schmeiser HH,Nebert DW,Phillips DH,Stiborová M

更新日期：2011-10-17 00:00:00

abstract：:Little is known about the formation and disposition of benzene oxide (BO), the initial metabolite arising from oxidation of benzene by cytochrome P450. In this study, reactions of BO with hemoglobin (Hb) and albumin (Alb) were investigated in blood from B6C3F1 mice, F344 rats, and humans in vitro. The estimated half-l...

journal_title：Chemical research in toxicology

authors： Lindstrom AB,Yeowell-O'Connell K,Waidyanatha S,McDonald TA,Golding BT,Rappaport SM

更新日期：1998-04-01 00:00:00

abstract：:The synthesis, toxicity, neuroprotection, and human acetylcholinesterase (hAChE)/ human butyrylcholinesterase (hBuChE) inhibition properties of β-naphthotacrines1-14 as new drugs for Alzheimer's disease (AD) potential treatment, are reported. β-Naphthotacrines1-14 showed lower toxicity than tacrine; moreover, at the h...

journal_title：Chemical research in toxicology

authors： Esquivias-Pérez M,Maalej E,Romero A,Chabchoub F,Samadi A,Marco-Contelles J,Oset-Gasque MJ

更新日期：2013-06-17 00:00:00

abstract：:The polyphenolics in green tea are believed to be the bioactive components. However, poor bioavailability following ingestion limits their efficacy in vivo. In this study, polyphenon E (poly E), a standardized green tea extract, was administered by sustained-release polycaprolactone implants (two, 2-cm implants; 20% d...

journal_title：Chemical research in toxicology

authors： Cao P,Vadhanam MV,Spencer WA,Cai J,Gupta RC

更新日期：2011-06-20 00:00:00

abstract：:Differences in the metabolism of 1,3-butadiene (Bd) in rats and mice may account for the observed species difference in carcinogenicity. Previous studies of the metabolic fate of Bd have identified epoxide formation as a key metabolic transformation which gives 1, 2-epoxy-3-butene (BMO), although some evidence of alde...

journal_title：Chemical research in toxicology

authors： Richardson KA,Peters MM,Megens RH,van Elburg PA,Golding BT,Boogaard PJ,Watson WP,van Sittert NJ

更新日期：1998-12-01 00:00:00

abstract：:This paper reports on the analysis of the toxin content from Palythoa tuberculosa and Palythoa toxica samples collected off of the Hawaiian coast. Our work, based on in-depth high-resolution liquid chromatography-mass spectrometry analysis along with extensive NMR study, led us to structurally characterize 42-hydroxy-...

journal_title：Chemical research in toxicology

authors： Ciminiello P,Dell'aversano C,Dello Iacovo E,Fattorusso E,Forino M,Grauso L,Tartaglione L,Florio C,Lorenzon P,De Bortoli M,Tubaro A,Poli M,Bignami G

更新日期：2009-11-01 00:00:00

abstract：:n-Hexane is metabolized to the gamma-diketone 2,5-hexanedione (2,5-HD), a derivative that covalently binds to lysine residues in neurofilament (NF) protein to yield 2,5-dimethylpyrrole adducts. Studies comparing the pyrrole-forming potential and neurotoxic potency of gamma-diketones have demonstrated that pyrrolylatio...

journal_title：Chemical research in toxicology

authors： Zhu M,Spink DC,Yan B,Bank S,DeCaprio AP

更新日期：1995-07-01 00:00:00

abstract：:Drug induced liver injury (DILI) can require significant risk management in drug development and on occasion can cause morbidity or mortality, leading to drug attrition. Optimizing candidates preclinically can minimize hepatotoxicity risk, but it is difficult to predict due to multiple etiologies encompassing DILI, of...

journal_title：Chemical research in toxicology

authors： Williams DP,Lazic SE,Foster AJ,Semenova E,Morgan P

更新日期：2020-01-21 00:00:00

abstract：:8-Hydroxy-2'-deoxyguanosine (8-OHdG), a biomarker of oxidative DNA damage, has been extensively studied to assess human exposure to carcinogenic compounds. Previous studies have associated levels of human urinary hydroxylated polycyclic aromatic hydrocarbons (OH-PAHs) with those of 8-OHdG. However, measurements of OH-...

journal_title：Chemical research in toxicology

authors： Fan R,Wang D,Ramage R,She J

更新日期：2012-02-20 00:00:00