Comparison of the efficacy of oral midazolam alone versus midazolam and meperidine in the pediatric dental patient.

Abstract:

PURPOSE:The purpose of this study was to compare midazolam alone (Group A: 1 mg/kg) vs midazolam plus meperidine (Group B: 0.5 and 1 mg/kg, respectively) in regard to physiology and behavior of young children sedated for dental restorative care. METHODS:Twenty healthy children who met selection criteria were randomly assigned to 1 of 2 groups and subsequently treated in a prospective, crossover design. All sedative agents were administered orally, and all sedations included 50% nitrous oxide administered via a nasal hood. Heart rate, systolic and diastolic blood pressure, and behavior were recorded at 8 procedural or time periods during the visits. Chi-square and ANOVA were used to analyze the data. RESULTS:No difference in physiology or behavior was found between groups. However, higher heart rates and disruptive behaviors occurred more frequently during or after local anesthesia administration. CONCLUSIONS:Oral midazolam alone is just as effective as midazolam with meperidine. Disruptive behaviors accounted for increased heart rates.

journal_name

Pediatr Dent

journal_title

Pediatric dentistry

authors

Musial KM,Wilson S,Preisch J,Weaver J

subject

Has Abstract

pub_date

2003-09-01 00:00:00

pages

468-74

issue

5

eissn

0164-1263

issn

1942-5473

journal_volume

25

pub_type

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