Abstract：
PURPOSE:To observe the effects of exercise training on plasminogen activator inhibitor, type-1 (PAI-1), tissue plasminogen activator (tPA), and associated metabolic variables in sedentary men and women. METHODS:A randomized, controlled experimental design was used to examine the influence of 10 d of moderate-intensity exercise training on measures of fibrinolysis. Sixteen men and 16 women between the ages of 50 and 70 yr were randomly assigned to exercise (EX) and control groups (CON) that were balanced for gender and hormone replacement therapy. Blood samples were collected on days 1, 2, 11, and 12 for measurement of plasma PAI-1, tPA, insulin, glucose, and triglyceride. Subjects in EX performed 50 min of treadmill walking at an intensity corresponding to 65% of heart rate reserve each day for 10 consecutive days. RESULTS:There were no significant changes in PAI-1, tPA, or associated metabolic variables between EX and CON during the intervention period. Within EX subjects, those with higher body fatness had a significant decrease in insulin and triglyceride compared with those with lower body fatness. However, no changes in fibrinolytic measures were observed within these subgroups. CONCLUSIONS:Short-term exercise training does not change PAI-1 levels in normal, asymptomatic men and women. In addition, modest decreases in insulin and triglyceride in individuals with elevated body fatness do not result in changes in PAI-1 after short-term training. It appears likely that decreases in PAI-1 with exercise training require decreases in adiposity and/or marked changes in metabolic variables.
journal_name
Med Sci Sports Exercjournal_title
Medicine and science in sports and exerciseauthors
Bodary PF,Yasuda N,Watson DD,Brown AS,Davis JM,Pate RRdoi
10.1249/01.MSS.0000093751.82616.F0subject
Has Abstractpub_date
2003-11-01 00:00:00pages
1853-8issue
11eissn
0195-9131issn
1530-0315journal_volume
35pub_type
临床试验,杂志文章,随机对照试验abstract：PURPOSE:The study purpose was to determine the relationship: 1) of muscle metabolism to exercise performance and 2) of exercise performance to rate of weight gain. METHODS:Eighty-three black and white premenopausal women were evaluated for maximum oxygen uptake (VO2max ), isometric quadriceps and triceps surae strengt...
journal_title：Medicine and science in sports and exercise
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doi：10.1249/01.MSS.0000048641.47125.1C
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abstract：PURPOSE:The purpose of the study was to explore the utility of school- and county-level variables in explaining variability in children and adolescent body mass index (BMI). METHODS:BMI data from nearly 2.5 million of children and adolescents were aggregated at the school level from more than 5000 schools in Texas. Sc...
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abstract：PURPOSE:We examined the effect of regular physical activity on plasma ghrelin concentration after onset of puberty in girls. In addition, we also examined the association of fasting plasma ghrelin concentration with various plasma biochemical, body composition, and aerobic capacity variables in healthy adolescent girls...
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journal_title：Medicine and science in sports and exercise
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doi：10.1249/MSS.0b013e3181ca7e16
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abstract：INTRODUCTION:Strenuous exercise induces significant increases in cardiac biomarkers. However, it is still unclear whether this is caused by cardiomyocyte necrosis or secondary mechanisms such as ischemia, cardiac energy deficiency, increased inflammation, or renal dysfunction. METHODS:Therefore, we investigated cardia...
journal_title：Medicine and science in sports and exercise
pub_type： 临床试验,杂志文章
doi：10.1249/MSS.0b013e31821b12eb
更新日期：2011-10-01 00:00:00
abstract：PURPOSE:The extent to which the diaphragm is targeted during a bout of inspiratory muscle training (IMT) is unknown. The purpose of this study was to characterize the relative activation patterns of the diaphragm and extradiaphragmatic inspiratory muscles during a bout of IMT and to determine whether diaphragmatic recr...
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doi：10.1249/MSS.0b013e31825365f1
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abstract：PURPOSE:To evaluate long-term susceptibility to subsequent serious exertional heat illness (EHI) in military recruits who suffered exertional heat illness during basic training. METHODS:We identified Marine Corps members who completed at least 6 months of military service and suffered EHI treated as outpatients (N = 8...
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doi：10.1097/00005768-200109000-00004
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abstract：UNLABELLED:Closed rupture of the flexor tendon sheath has been known to occur in the elite rock climbing population. However, only one study has investigated the prevalence of this entity. PURPOSE:To examine an elite climbing group in this country for the prevalence of pulley rupture and report on other commonly occur...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1097/00005768-200008000-00002
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journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章,随机对照试验
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更新日期：2012-11-01 00:00:00
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journal_title：Medicine and science in sports and exercise
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doi：10.1097/00005768-199705000-00008
更新日期：1997-05-01 00:00:00
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doi：10.1249/MSS.0b013e3181de7a8a
更新日期：2010-11-01 00:00:00
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journal_title：Medicine and science in sports and exercise
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journal_title：Medicine and science in sports and exercise
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doi：10.1249/MSS.0b013e3181984fa8
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journal_title：Medicine and science in sports and exercise
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doi：
更新日期：1985-02-01 00:00:00
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journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
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journal_title：Medicine and science in sports and exercise
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doi：
更新日期：1987-08-01 00:00:00
