Abstract:
:Asymptomatic persons at risk for Huntington's disease (HD) (N = 28) were assessed with neuropsychological, psychiatric, and neurologic tests while undergoing genetic linkage studies to determine their probability of carrying the HD gene. Those participants who were subsequently identified as probable gene carriers did not differ on neurologic or psychiatric examination from those subsequently identified as probable noncarriers. Neuropsychological data are presented for a subset of participants free of other conditions (such as alcoholism) putting them at risk for cognitive deficits. Among these subjects, probable gene carriers were inferior to probable noncarriers on the neuropsychological battery as a whole and on several individual tests involving learning and memory. The results suggest the presence of cognitive decline prior to identifiable motor impairments in HD.
journal_name
J Clin Exp Neuropsycholjournal_title
Journal of clinical and experimental neuropsychologyauthors
Diamond R,White RF,Myers RH,Mastromauro C,Koroshetz WJ,Butters N,Rothstein DM,Moss MB,Vasterling Jdoi
10.1080/01688639208402547subject
Has Abstractpub_date
1992-11-01 00:00:00pages
961-75issue
6eissn
1380-3395issn
1744-411Xjournal_volume
14pub_type
杂志文章abstract::Fifty-one children who has sustained head injuries were divided into mildly, moderately and severely injured groups according to neurological criteria. The groups were matched for age, sex, and injury-test interval. Approximately 1 year after their injuries, patients were tested on speeded and nonspeeded measures of m...
journal_title:Journal of clinical and experimental neuropsychology
pub_type: 杂志文章
doi:10.1080/01688638508401241
更新日期:1985-02-01 00:00:00
abstract::We examined the prevalence and correlates of anomalous motor speed asymmetry in 104 right-handed patients with a diagnosis of probable Alzheimer's disease (AD). On the Halstead-Reitan Finger Tapping Test, over 60% of the AD patients exhibited notable departures from expected finger tapping asymmetry; 26% displayed an ...
journal_title:Journal of clinical and experimental neuropsychology
pub_type: 杂志文章
doi:10.1080/01688639608408267
更新日期:1996-02-01 00:00:00
abstract::Eight malingerers (MPs) were identified via significantly below-chance symptom validity testing (SVT) within a sample of 106 consecutive admissions for neuropsychological evaluation. The resulting incidence of 7.5% is seen as a minimal estimate of malingering within the sample. Eight individuals who "passed" SVT but p...
journal_title:Journal of clinical and experimental neuropsychology
pub_type: 杂志文章
doi:10.1080/01688639308402580
更新日期:1993-07-01 00:00:00
abstract::The ability to engage in instrumental activities of daily living (IADLs) is known to rely on cognitive abilities, primarily executive functioning and memory. There is also evidence that good self-awareness, which facilitates the use of compensatory strategies, may prolong functionality and delay the diagnosis of demen...
journal_title:Journal of clinical and experimental neuropsychology
pub_type: 杂志文章
doi:10.1080/13803395.2010.493148
更新日期:2011-01-01 00:00:00
abstract::We treated the cognitive impairments of a 69-year-old male, that persisted 7 months after an infarction in the distribution of the right posterior cerebral artery. The infarct produced a 20% reduction in right cerebral blood flow, established by positron emission tomography (PET). Neuropsychological status was charact...
journal_title:Journal of clinical and experimental neuropsychology
pub_type: 杂志文章
doi:10.1080/01688639208402836
更新日期:1992-07-01 00:00:00
abstract::Neuropsychological (NP) impairment is multiply determined among HIV-infected and HIV-uninfected individuals who are also dually diagnosed with depression and who use illicit substances. The purpose of the present study was to assess the impact of HIV status, depression, and problematic substance use on NP performance....
journal_title:Journal of clinical and experimental neuropsychology
pub_type: 杂志文章
doi:10.1080/13803390903313572
更新日期:2010-07-01 00:00:00
abstract::Tonic alertness was investigated in Alzheimer patients and normal elderly subjects. Sensitivity and criterion shifts were investigated across 45 min of continuous testing using a high event rate test with very low target probability. Alzheimer patients showed a significant sensitivity decrement over time that was unre...
journal_title:Journal of clinical and experimental neuropsychology
pub_type: 临床试验,杂志文章
doi:10.1080/01688639408402698
更新日期:1994-12-01 00:00:00
abstract::Two new short forms of the Boston Naming Test (BNT) were developed using item response theory (IRT) with data from 206 elderly outpatients. We evaluated the diagnostic ability of 12 short forms among the full sample and in a sub-sample of 69 patients diagnosed with mild Alzheimer's disease (AD) either alone or in comb...
journal_title:Journal of clinical and experimental neuropsychology
pub_type: 杂志文章
doi:10.1080/13803390490510716
更新日期:2004-10-01 00:00:00
abstract::This study determined whether the Vocabulary-Digit Span difference score and discriminant function based on subtests of the Wechsler Adult Intelligence Scale-Revised (WAIS-R) developed by Mittenberg et al. (1995) could differentiate patients with moderate and severe traumatic brain injuries (n = 50) from persons with ...
journal_title:Journal of clinical and experimental neuropsychology
pub_type: 杂志文章
doi:10.1076/jcen.20.2.167.1171
更新日期:1998-04-01 00:00:00
abstract::Levels and rates of acquisition and amounts of forgetting of name-face associations and grocery list items were assessed in a sample of 1,921 normal participants that was divided into five age groups (i.e., 17-39, 40-49, 50-59, 60-69, and 70+). Retrieval was assessed via the consistent long-term retrieval score (CLTR)...
journal_title:Journal of clinical and experimental neuropsychology
pub_type: 杂志文章
doi:10.1080/01688639308402570
更新日期:1993-07-01 00:00:00
abstract::Memory tests may be predictive for cognitive decline. We investigated the sensitivity and change in performance over time of the Hopkins Verbal Learning Test (HVLT) and the Mini-Mental Status Examination (MMSE) for Mild Cognitive Impairment (MCI) and Alzheimer's Disease (AD) when compared to cognitively healthy contro...
journal_title:Journal of clinical and experimental neuropsychology
pub_type: 杂志文章
doi:10.1080/13803390590935462
更新日期:2006-04-01 00:00:00
abstract::Huntington disease (HD) is a neurodegenerative disease associated with cognitive, motor, and psychiatric deterioration over time. Although there is currently no cure for HD, there has been a surge of clinical trials available to patients with HD over the past 5 years. However, cognitive measures have generally been la...
journal_title:Journal of clinical and experimental neuropsychology
pub_type: 杂志文章
doi:10.1080/13803390903313564
更新日期:2010-07-01 00:00:00
abstract::The relationship of memory self-report to self-rated depression and to actual performance on computer-simulated everyday memory tasks was investigated in 125 normal adults. Canonical correlation analyses demonstrated that self-rated memory performance and objective computer-simulated everyday memory performance shared...
journal_title:Journal of clinical and experimental neuropsychology
pub_type: 杂志文章
doi:10.1080/01688639108401064
更新日期:1991-07-01 00:00:00
abstract::The present series of studies sought to examine how external factors influence behavioral decision making task performance. Utilizing the Iowa Gambling Task (IGT) to assess risky decision making, we examined the influence of a dual task paradigm (Study 1, Study 2), shifting task focus to decision making speed versus a...
journal_title:Journal of clinical and experimental neuropsychology
pub_type: 杂志文章,随机对照试验
doi:10.1080/13803395.2019.1662374
更新日期:2019-12-01 00:00:00
abstract::The aim was to study whether an inkblot technique can reveal differential deficits of ideation and memory related to the side and site of brain damage. Seventy-three patients with focal brain lesions and nine control patients were studied with a modified Holtzman Inkblot Technique. The results confirmed the previous R...
journal_title:Journal of clinical and experimental neuropsychology
pub_type: 杂志文章
doi:10.1080/01688638708405211
更新日期:1987-12-01 00:00:00
abstract:INTRODUCTION:Our study investigated the ability of nondemented Parkinson's disease (PD) patients to explicitly identify emotional words and to show implicit sensitivity to these emotions in a task that did not require emotional processing. METHODS:Twelve PD patients and 12 healthy controls, matched for age and educati...
journal_title:Journal of clinical and experimental neuropsychology
pub_type: 杂志文章
doi:10.1080/13803395.2011.639296
更新日期:2012-01-01 00:00:00
abstract::This study used an electrophysiological measurement operation to investigate lateralized processing deficits associated with academic learning-disability subtypes. Fast frequency EEG activity in the 36-44 hertz (Hz) band was recorded from reading-disabled (RLD), arithmetic-disabled (ALD), and nondisabled control child...
journal_title:Journal of clinical and experimental neuropsychology
pub_type: 杂志文章
doi:10.1080/01688639208402857
更新日期:1992-09-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to provide normative data for older and very old Czech adults on the Prague Stroop Test (PST) and to test its discriminative validity in individuals with Parkinson's disease mild cognitive impairment (PD-MCI). METHOD:The construction of the PST was modeled after the Victoria Stroop ...
journal_title:Journal of clinical and experimental neuropsychology
pub_type: 杂志文章
doi:10.1080/13803395.2015.1057106
更新日期:2015-01-01 00:00:00
abstract::Indices from the Minnesota Multiphasic Personality Inventory-2 (MMPI-2; Butcher, Dahlstrom, Graham, Tellegen, & Kaemmer, 1989) representing cognitive and emotional disturbance as well as incomplete effort on the Recognition Memory Test (RMT; Warrington, 1984) were examined as predictors of performance on the Halstead-...
journal_title:Journal of clinical and experimental neuropsychology
pub_type: 杂志文章
doi:10.1080/13803390590929270
更新日期:2006-01-01 00:00:00
abstract::Three experiments evaluating the rate of forgetting of pictorial stimuli in amnesic, demented, and normal control subjects are reported. When prolonged exposures of pictorial material were used to equate recognition performance after a 10-min delay, alcoholic Korsakoff (AK) patients and patients with Huntington's Dise...
journal_title:Journal of clinical and experimental neuropsychology
pub_type: 杂志文章
doi:10.1080/01688638608401309
更新日期:1986-06-01 00:00:00
abstract::Monocular occlusion has been posited to reduce activation of the contralateral hemisphere ("Sprague effect"), thus inducing a contralateral spatial bias (toward the viewing eye). Healthy right-handed participants bisected horizontal lines during monocular eye viewing. Although subjects tended to deviate away from the ...
journal_title:Journal of clinical and experimental neuropsychology
pub_type: 杂志文章
doi:10.1080/13803395.2013.770824
更新日期:2013-01-01 00:00:00
abstract::The performance of a group of 60 severely closed-head-injured patients in the subacute stage of recovery on a series of tests addressing focused, divided, and sustained attention, and supervisory attentional control was compared to the performance of a matched group of 60 healthy controls. Patients performed significa...
journal_title:Journal of clinical and experimental neuropsychology
pub_type: 临床试验,杂志文章
doi:10.1080/01688639608408298
更新日期:1996-10-01 00:00:00
abstract:INTRODUCTION:Previous studies have demonstrated that students with attention-deficit/hyperactivity disorder (ADHD) struggle particularly with grasping the implicit, inferential level of narratives that is crucial for story comprehension. However, these studies used offline tasks (i.e., after story presentation), used i...
journal_title:Journal of clinical and experimental neuropsychology
pub_type: 杂志文章
doi:10.1080/13803395.2016.1236906
更新日期:2017-06-01 00:00:00
abstract::What pattern of brain damage could completely obliterate the sense of olfaction in humans? We had an opportunity to address this intriguing question in Patient B., who has extensive bilateral damage to most of the limbic system, including the medial and lateral temporal lobes, orbital frontal cortex, insular cortex, a...
journal_title:Journal of clinical and experimental neuropsychology
pub_type: 杂志文章
doi:10.1080/13803395.2011.633897
更新日期:2012-01-01 00:00:00
abstract::Parkinsonism-Plus Syndrome (PPS) is a rare, degenerative disorder involving the subcortical structures of the brain. Little is known of the cognitive impairment, if any, that accompanies this syndrome. Initially PPS patients were thought to be cognitively intact; however, more recent research has suggested the presenc...
journal_title:Journal of clinical and experimental neuropsychology
pub_type: 杂志文章
doi:10.1080/01688639608408265
更新日期:1996-02-01 00:00:00
abstract::Tests of paced serial addition are used to detect diminished information-processing capacity. Nonetheless, performance might be influenced by modality-specific interference or by variables that specifically affect numerical processing. In a series of three experiments with normal adults, we manipulated, respectively, ...
journal_title:Journal of clinical and experimental neuropsychology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1076/jcen.20.4.463.1466
更新日期:1998-08-01 00:00:00
abstract::Although handedness as a measure of cerebral specialization has been linked to accident proneness, more direct measures of laterality are rarely considered. The present study aimed to fill that gap in the existing research. In addition, individual difference factors in accident proneness were further examined with the...
journal_title:Journal of clinical and experimental neuropsychology
pub_type: 杂志文章
doi:10.1080/13803395.2014.985191
更新日期:2015-01-01 00:00:00
abstract::The literature suggests that nondeclarative, or nonconscious, learning might be impaired among HIV-seropositive (HIV+) individuals compared with HIV-seronegative (HIV-) matched control groups, but these studies have included relatively few women. We administered measures of motor skill and probabilistic learning, task...
journal_title:Journal of clinical and experimental neuropsychology
pub_type: 杂志文章
doi:10.1080/13803395.2010.493150
更新日期:2011-01-01 00:00:00
abstract:INTRODUCTION:Functional magnetic resonance imaging studies have shown changes in the activity of medial prefrontal, medial temporal, and occipital regions in major depressive disorder patients during recall of autobiographical memories. Electrophysiological underpinning of these changes is not known. It is also not cle...
journal_title:Journal of clinical and experimental neuropsychology
pub_type: 杂志文章
doi:10.1080/13803395.2016.1219318
更新日期:2017-04-01 00:00:00
abstract::Neuropsychological impairment and the subjective symptoms of 21 patients with organic solvent intoxication were compared with those of patients with vertebrobasilar insufficiency (n = 16), cerebral trauma (n = 16), and headache (n = 15). The aim was to study the diagnostic efficiency of psychological methods in the ne...
journal_title:Journal of clinical and experimental neuropsychology
pub_type: 杂志文章
doi:10.1080/01688638608401316
更新日期:1986-06-01 00:00:00