Evidence of presymptomatic cognitive decline in Huntington's disease.

Abstract:

:Asymptomatic persons at risk for Huntington's disease (HD) (N = 28) were assessed with neuropsychological, psychiatric, and neurologic tests while undergoing genetic linkage studies to determine their probability of carrying the HD gene. Those participants who were subsequently identified as probable gene carriers did not differ on neurologic or psychiatric examination from those subsequently identified as probable noncarriers. Neuropsychological data are presented for a subset of participants free of other conditions (such as alcoholism) putting them at risk for cognitive deficits. Among these subjects, probable gene carriers were inferior to probable noncarriers on the neuropsychological battery as a whole and on several individual tests involving learning and memory. The results suggest the presence of cognitive decline prior to identifiable motor impairments in HD.

authors

Diamond R,White RF,Myers RH,Mastromauro C,Koroshetz WJ,Butters N,Rothstein DM,Moss MB,Vasterling J

doi

10.1080/01688639208402547

subject

Has Abstract

pub_date

1992-11-01 00:00:00

pages

961-75

issue

6

eissn

1380-3395

issn

1744-411X

journal_volume

14

pub_type

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