A controlled trial of prednisolone treatment in primary biliary cirrhosis. Three-year results.


:The results of a 3-year, placebo-controlled trial of prednisolone treatment in primary biliary cirrhosis (PBC) are presented. The active (n = 19) and placebo (n = 17) arms were initially well matched for age, menopausal status and disease severity. At 3 years hepatic symptoms were relatively improved in the prednisolone group. Hepatic mortality was 3/19 (prednisolone), 5/17 (placebo) (p = n.s.). For all liver blood tests the trend favoured prednisolone treatment, though the differences were only significant for alkaline phosphatase and protein. All immunoglobulins fell significantly. Quantitative ELISA determination of antimitochondrial antibody showed a significant fall in the prednisolone group compared with placebo (p less than 0.001 at 1 year, p less than 0.05 at 3 years). Deterioration in histology (appearance of cirrhosis) was more common in the placebo group. Overall hepatic function (hepatic mortality, doubling in bilirubin, 6 milligrams fall in albumin, de novo appearance of cirrhosis or symptoms of portal hypertension) was significantly worse in the placebo group (p less than 0.01). After 3 years no significant differences could be detected in bone mineral content (single photon absorptiometry of radius and femur) between the two groups or in comparison with other PBC patients. Thus, after 3 years, prednisolone treatment was associated with a better overall hepatic outcome and little evidence of increased bone loss.


J Hepatol


Journal of hepatology


Mitchison HC,Palmer JM,Bassendine MF,Watson AJ,Record CO,James OF




Has Abstract


1992-07-01 00:00:00














  • Hepatitis B virus reinfection after orthotopic liver transplantation. Serological and clinical implications.

    abstract::The implications of hepatitis B virus (HBV) reinfection after liver transplantation were studied in 29 patients followed for 1.7-15 years. Of 20 patients with HBV infection alone, nine were HBeAg and HBV DNA seronegative and 11 had evidence of HBV replication as measured by HBeAg or HBV DNA seropositivity. Nine patien...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: O'Grady JG,Smith HM,Davies SE,Daniels HM,Donaldson PT,Tan KC,Portmann B,Alexander GJ,Williams R

    更新日期:1992-01-01 00:00:00

  • Lysophosphatidylcholine acyltransferase 1 altered phospholipid composition and regulated hepatoma progression.

    abstract:BACKGROUND & AIMS:Several lipid synthesis pathways play important roles in the development and progression of hepatocellular carcinoma (HCC), although the precise molecular mechanisms remain to be elucidated. Here, we show the relationship between HCC progression and alteration of phospholipid composition regulated by ...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Morita Y,Sakaguchi T,Ikegami K,Goto-Inoue N,Hayasaka T,Hang VT,Tanaka H,Harada T,Shibasaki Y,Suzuki A,Fukumoto K,Inaba K,Murakami M,Setou M,Konno H

    更新日期:2013-08-01 00:00:00

  • Blunted postprandial reaction of portal venous flow in chronic liver disease, assessed with duplex Doppler: significance for prognosis.

    abstract::To establish the effects of a meal on portal venous flow and the prognostic value of this parameter, 46 patients with chronic liver disease and 28 healthy subjects were examined with duplex Doppler before and after a meal. The measurements were completed in 40 patients and 21 healthy subjects. Postprandial portal veno...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: de Vries PJ,de Hooge P,Hoekstra JB,van Hattum J

    更新日期:1994-12-01 00:00:00

  • Retrorsine: a kinetic study of its influence on rat liver regeneration in the portal branch ligation model.

    abstract:BACKGROUND:Retrorsine, a naturally occurring pyrrolizidine alkaloid, impairs liver regeneration after partial hepatectomy by mechanisms that are still unclear. AIM:The aim of the study was to clarify the influence of retrorsine on cell cycle progression in the regenerating liver lobes of rats after portal branch ligat...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Picard C,Lambotte L,Starkel P,Sempoux C,Saliez A,Van Den Berge V,de Saeger C,Horsmans Y

    更新日期:2003-07-01 00:00:00

  • Plasma somatostatin response to an oral mixed test meal in cirrhotic patients.

    abstract::Ten patients with non-alcoholic cirrhosis and ten control subjects were studied in basal conditions and after ingestion of a standard mixed test meal. Plasma somatostatin, blood glucose, plasma insulin, C-peptide and glucagon were determined before and 15, 30, 45, 60, 90, 120 and 180 min after the start of the meal. B...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Barreca T,Franceschini R,Cataldi A,Rolandi E

    更新日期:1991-01-01 00:00:00

  • Schistosomiasis mansoni and viral B hepatitis in woodchucks.

    abstract:BACKGROUND/AIMS:An interaction between human schistosomiasis and viral hepatitis B has often been suggested, but never established. The experimental investigation has been hampered by the lack of a suitable model. Only woodchucks are susceptible to both Schistosoma mansoni and a B-like hepatitis virus (WHV) infections....

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Andrade ZA,Berthillon P,Paraná R,Grimaud JA,Trépo C

    更新日期:2001-01-01 00:00:00

  • Neurally-mediated vasodilatation in normal and portal hypertensive rats: role of nitric oxide and calcitonin gene-related peptide.

    abstract:BACKGROUND/AIMS:Portal hypertension is associated with systemic vasodilatation and vascular hyporeactivity, and is reversed by inhibiting nitric oxide biosynthesis. Nitric oxide and calcitonin gene-related peptide are neurotransmitters of non-adrenergic non-cholinergic nerves. The role of nitric oxide and calcitonin ge...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Moll-Kaufmann C,Sumanovski LT,Sieber CC

    更新日期:1998-06-01 00:00:00

  • Fatty acid composition of adipose tissue in patients with chronic liver disease.

    abstract::In this study plasma free fatty acids and adipose tissue fatty acid composition in 10 cirrhotic patients, 5 patients with non-cirrhotic chronic liver disease and in 5 controls have been investigated. Fatty acid composition of adipose tissue in cirrhotic patients demonstrated a significant increase of 16:1 and a decrea...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Merli M,Iapichino S,Bolognese A,Bruni A,Cantafora A,Riggio O,Capocaccia L

    更新日期:1986-01-01 00:00:00

  • Interleukins in chronic active hepatitis B. Relationship with viral markers.

    abstract::Interleukin-2, a product of helper T cells, is essentially involved in the regulation of cell-mediated immunity. Two monocyte-derived factors, interleukin-1 and prostaglandin E2, influence interleukin-2 synthesis with opposite actions. To analyse immunoregulatory function in HBsAg-positive chronic active hepatitis, T ...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Civeira M,Prieto J,Morte S,Riñon M,Serrano M

    更新日期:1987-08-01 00:00:00

  • The mitogenic activity of the liver growth factor is mediated by tumor necrosis factor alpha in rat liver.

    abstract:BACKGROUND/AIMS:Liver growth factor (LGF) is a hepatic mitogen, however, the hepatic stimulation pathway remains to be characterized. The aim of this study was to determine whether tumor necrosis factor alpha (TNF-alpha) stimulation constitutes a step in the mitogenic pathway of LGF. METHODS:Rats were injected with 4....

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Díaz-Gil JJ,Majano PL,López-Cabrera M,Sánchez-López V,Rúa C,Machín C,Trilla C,García-Cañero R,Moreno-Otero R

    更新日期:2003-05-01 00:00:00

  • Putrescine decreases cytochrome P450 3A4 levels during liver regeneration in the rat.

    abstract:BACKGROUND/AIMS:The mechanism by which many cytochrome P450 (CYP) isozymes decrease during liver regeneration is unclear. Peptides and growth factors are thought to be involved. Putrescine, the first polyamine synthesised by ornithine decarboxylase, peaks early following partial hepatectomy and is known to play an esse...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Favre C,Monti JA,Scapini C,Pellegrino J,Carnovale CE,Carrillo MC

    更新日期:1998-04-01 00:00:00

  • Liver transplantation for hepatic arteriovenous malformation in hereditary haemorrhagic telangiectasia.

    abstract::Symptomatic hepatic involvement is a rare complication of hereditary hemorrhagic telangiectasia and most commonly consists of fibrosis or cirrhosis. We describe a 33-year-old woman in whom multiple hepatic arteriovenous malformations led to high output cardiac failure and liver failure due to biliary necrosis with ref...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Bauer T,Britton P,Lomas D,Wight DG,Friend PJ,Alexander GJ

    更新日期:1995-05-01 00:00:00

  • Interferon induces insulin resistance in patients with chronic active hepatitis C.

    abstract:AIM/METHODS:To elucidate the metabolic effect of interferon alpha, the following tests were performed on 14 patients with chronic active hepatitis C before and after interferon therapy (6 million units/day for 2 weeks): (1) oral glucose tolerance tests to measure insulin secretion; (2) euglycemic hyperinsulinemic clamp...

    journal_title:Journal of hepatology

    pub_type: 临床试验,杂志文章


    authors: Imano E,Kanda T,Ishigami Y,Kubota M,Ikeda M,Matsuhisa M,Kawamori R,Yamasaki Y

    更新日期:1998-02-01 00:00:00

  • The apoptosis protector, bcl-2 protein, is downregulated in bile duct epithelial cells of human liver allografts.

    abstract:BACKGROUND/AIMS:Apoptosis of bile duct cells occurs in hepatic allografts and is correlated with acute rejection. bcl-2 protein counteracts apoptosis and prolongs cell survival. We therefore tested the expression of bcl-2 protein in bile ducts of liver grafts in comparison with those of liver cirrhosis. METHODS:115 bi...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Gapany C,Zhao M,Zimmermann A

    更新日期:1997-03-01 00:00:00

  • The bidirectional impacts of alcohol consumption and the metabolic syndrome: Cofactors for progressive fatty liver disease.

    abstract::Current medical practice artificially dichotomises a diagnosis of fatty liver disease into one of two common forms: alcoholic liver disease (ALD) and non-alcoholic fatty liver disease (NAFLD). Together, these account for the majority of chronic liver diseases worldwide. In recent years, there has been a dramatic incre...

    journal_title:Journal of hepatology

    pub_type: 杂志文章,评审


    authors: Boyle M,Masson S,Anstee QM

    更新日期:2018-02-01 00:00:00

  • Gene expression of interstitial collagenase in both progressive and recovery phase of rat liver fibrosis induced by carbon tetrachloride.

    abstract:BACKGROUND/AIMS:Liver fibrosis is a dynamic state between matrix production and degradation. Since our report in 1974, many studies have examined collagenase and liver fibrosis, but not the identification of cells responsible for collagenase production in vivo. The aim of this study was to investigate the gene expressi...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Watanabe T,Niioka M,Hozawa S,Kameyama K,Hayashi T,Arai M,Ishikawa A,Maruyama K,Okazaki I

    更新日期:2000-08-01 00:00:00

  • Genetic profile of hepatocellular carcinoma revealed by array-based comparative genomic hybridization: identification of genetic indicators to predict patient outcome.

    abstract:BACKGROUND/AIMS:We conducted an analysis of chromosomal numerical aberrations and their clinical significance in hepatocellular carcinoma. METHODS:We analyzed 87 hepatocellular carcinomas by array-based comparative genomic hybridization with an array containing 800 bacterial artificial chromosome clones. RESULTS:Freq...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Katoh H,Shibata T,Kokubu A,Ojima H,Loukopoulos P,Kanai Y,Kosuge T,Fukayama M,Kondo T,Sakamoto M,Hosoda F,Ohki M,Imoto I,Inazawa J,Hirohashi S

    更新日期:2005-11-01 00:00:00

  • The Hippo pathway effector YAP controls mouse hepatic stellate cell activation.

    abstract:BACKGROUND & AIMS:Hepatic stellate cell activation is a wound-healing response to liver injury. However, continued activation of stellate cells during chronic liver damage causes excessive matrix deposition and the formation of pathological scar tissue leading to fibrosis and ultimately cirrhosis. The importance of sus...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Mannaerts I,Leite SB,Verhulst S,Claerhout S,Eysackers N,Thoen LF,Hoorens A,Reynaert H,Halder G,van Grunsven LA

    更新日期:2015-09-01 00:00:00

  • Targeted-bisulfite sequence analysis of the methylation of CpG islands in genes encoding PNPLA3, SAMM50, and PARVB of patients with non-alcoholic fatty liver disease.

    abstract:BACKGROUND & AIMS:The pathogenesis of non-alcoholic fatty liver disease (NAFLD) is affected by epigenetic factors as well as by genetic variation. METHODS:We performed targeted-bisulfite sequencing to determine the levels of DNA methylation of 4 CpG islands (CpG99, CpG71, CpG26, and CpG101) in the regulatory regions o...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Kitamoto T,Kitamoto A,Ogawa Y,Honda Y,Imajo K,Saito S,Yoneda M,Nakamura T,Nakajima A,Hotta K

    更新日期:2015-08-01 00:00:00

  • A comparison of fibrosis progression in chronic liver diseases.

    abstract:BACKGROUND/AIMS:No study has compared the liver fibrosis progression rates among chronic liver diseases and the risk factors in order to better organize screening strategies. METHODS:A total of 4852 patients were retrospectively studied (chronic hepatitis C (HCV) [n=2313], human immunodeficiency virus (HIV)-HCV co-inf...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Poynard T,Mathurin P,Lai CL,Guyader D,Poupon R,Tainturier MH,Myers RP,Muntenau M,Ratziu V,Manns M,Vogel A,Capron F,Chedid A,Bedossa P,PANFIBROSIS Group.

    更新日期:2003-03-01 00:00:00

  • Management of adverse events with tailored sorafenib dosing prolongs survival of hepatocellular carcinoma patients.

    abstract:BACKGROUND & AIMS:Sorafenib is associated with multiple adverse events (AEs), potentially causing its permanent interruption. It is unknown how physicians' experience has impacted on the management of these AEs and consequently on clinical outcomes. We aimed to assess whether AE management changed over time and if thes...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Tovoli F,Ielasi L,Casadei-Gardini A,Granito A,Foschi FG,Rovesti G,Negrini G,Orsi G,Renzulli M,Piscaglia F

    更新日期:2019-12-01 00:00:00

  • Hypolocomotion in rats with chronic liver failure is due to increased glutamate and activation of metabotropic glutamate receptors in substantia nigra.

    abstract:BACKGROUND/AIMS:Patients with hepatic encephalopathy show altered motor function, psychomotor slowing and hypokinesia. The underlying mechanisms remain unclear. This work's aims were: (1) to analyse in rats with chronic liver failure due to portacaval shunt (PCS) the neurochemical alterations in the basal ganglia-thala...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Cauli O,Llansola M,Erceg S,Felipo V

    更新日期:2006-11-01 00:00:00

  • Management of anemia induced by triple therapy in patients with chronic hepatitis C: challenges, opportunities and recommendations.

    abstract::The addition of protease inhibitors, boceprevir or telaprevir, to peginterferon+ribavirin (PegIFN/RBV) increases the frequency as well as the severity, and hence, clinical relevance of anemia, which has now become one of the major complications associated with triple therapy. Most significant factors associated with a...

    journal_title:Journal of hepatology

    pub_type: 杂志文章,评审


    authors: Romero-Gómez M,Berenguer M,Molina E,Calleja JL

    更新日期:2013-12-01 00:00:00

  • Predictive value of the IL28B polymorphism on the effect of interferon therapy in chronic hepatitis C patients with genotypes 2a and 2b.

    abstract:BACKGROUND & AIMS:Common IL28B locus polymorphisms (SNPs rs8099917 and rs12979860) have been reported to affect peg-interferon plus ribavirin combination therapy (PEG-RBV) for hepatitis C virus (HCV) genotype 1b, but few reports have examined their effect on other two common genotypes, 2a and 2b. METHODS:We analyzed p...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Kawaoka T,Hayes CN,Ohishi W,Ochi H,Maekawa T,Abe H,Tsuge M,Mitsui F,Hiraga N,Imamura M,Takahashi S,Kubo M,Tsunoda T,Nakamura Y,Kumada H,Chayama K

    更新日期:2011-03-01 00:00:00

  • Metabolic activity of microcarrier attached liver cells after intraperitoneal transplantation during severe liver insufficiency in the rat.

    abstract::Short- and long-term effects of intraperitoneally transplanted microcarrier attached liver cells (MAL) have been studied in two experimental models of severe liver insufficiency in the rat: subtotal hepatectomy (HX) and acute liver ischemia. Intraperitoneal transplantation of MAL immediately after subtotal hepatectomy...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Bosman DK,de Haan JG,Smit J,Jorning GG,Maas MA,Chamuleau RA

    更新日期:1989-07-01 00:00:00

  • TNF-α/IFN-γ profile of HBV-specific CD4 T cells is associated with liver damage and viral clearance in chronic HBV infection.

    abstract:BACKGROUND & AIMS:The role of hepatitis B virus (HBV)-specific CD4 T cells in patients with chronic HBV infection is not clear. Thus, we aimed to elucidate this in patients with chronic infection, and those with hepatitis B flares. METHODS:Through intracellular IFN-γ and TNF-α staining, HBV-specific CD4 T cells were a...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Wang H,Luo H,Wan X,Fu X,Mao Q,Xiang X,Zhou Y,He W,Zhang J,Guo Y,Tan W,Deng G

    更新日期:2020-01-01 00:00:00

  • Comparison of anti-HBe-positive and HBe-antigen-positive chronic hepatitis B in France. French Multicentre Group.

    abstract::Two groups of patients with HBV DNA-positive chronic active hepatitis B, from 20 French hospitals, separated according to HBe status, were prospectively subjected to a comparative analysis of various epidemiological, clinical, biochemical, serologic and histologic features. There were 61 patients with anti-HBe and 215...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Zarski JP,Marcellin P,Cohard M,Lutz JM,Bouche C,Rais A

    更新日期:1994-05-01 00:00:00

  • Effects of propranolol and sucralfate on ethanol-induced gastric mucosal damage in chronic portal hypertensive rats.

    abstract::In a rat model of chronic portal hypertension we studied ethanol-induced gastric mucosal damage and the effects of pretreatment by propranolol and sucralfate. Susceptibility to ethanol was increased in chronic portal hypertensive rats compared with sham-operated rats (55 +/- 8% vs. 25 +/- 4%). Both acute pretreatment ...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Geoffroy P,Duchateau A,Thiéfin G,Zeitoun P

    更新日期:1987-10-01 00:00:00

  • Stage-specific regulation of the WNT/β-catenin pathway enhances differentiation of hESCs into hepatocytes.

    abstract:BACKGROUND & AIMS:Hepatocytes differentiated from human embryonic stem cells (hESCs) have the potential to overcome the shortage of primary hepatocytes for clinical use and drug development. Many strategies for this process have been reported, but the functionality of the resulting cells is incomplete. We hypothesize t...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Touboul T,Chen S,To CC,Mora-Castilla S,Sabatini K,Tukey RH,Laurent LC

    更新日期:2016-06-01 00:00:00

  • Interferon-γ-dependent immune responses contribute to the pathogenesis of sclerosing cholangitis in mice.

    abstract:BACKGROUND AND AIMS:Primary sclerosing cholangitis (PSC) is an idiopathic, chronic cholestatic liver disorder characterized by biliary inflammation and fibrosis. Increased numbers of intrahepatic interferon-γ- (IFNγ) producing lymphocytes have been documented in patients with PSC, yet their functional role remains to b...

    journal_title:Journal of hepatology

    pub_type: 杂志文章


    authors: Ravichandran G,Neumann K,Berkhout LK,Weidemann S,Langeneckert AE,Schwinge D,Poch T,Huber S,Schiller B,Hess LU,Ziegler AE,Oldhafer KJ,Barikbin R,Schramm C,Altfeld M,Tiegs G

    更新日期:2019-10-01 00:00:00