Abstract:
:A randomized, double-blind, placebo-controlled, multicenter clinical trial was conducted in five centers to assess safety, ocular tolerance, and efficacy of an ophthalmic solution of epidermal growth factor (EGF) for the treatment of traumatic corneal epithelial defects. One hundred four patients completed the study: 47 received EGF and 57 placebo (the drug vehicle). Mean epithelial healing time was significantly enhanced in the EGF-treated group (44.17 h) compared with the placebo-treated treated group (61.05 h) (p < 0.01). The number of epithelial defects completely healed at 24, 48, and 72 h after the onset of treatment was significantly greater in the EGF-treated group. Local tolerance was adequate in both groups. These results indicated that topical EGF is well tolerated and may be a significant addition to the ophthalmologist's armamentarium for treating corneal epithelial defects.
journal_name
Corneajournal_title
Corneaauthors
Pastor JC,Calonge Mdoi
10.1097/00003226-199207000-00007subject
Has Abstractpub_date
1992-07-01 00:00:00pages
311-4issue
4eissn
0277-3740issn
1536-4798journal_volume
11pub_type
临床试验,杂志文章,多中心研究,随机对照试验相关文献
CORNEA文献大全abstract:PURPOSE:To report the outcomes of repeat endothelial keratoplasty (EK) in patients with previous failed deep lamellar endothelial keratoplasty (DLEK). METHODS:This retrospective interventional case series involved the review of clinical records of patients with failed DLEK surgery who underwent repeat EK surgery. RES...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e31821522b4
更新日期:2011-11-01 00:00:00
abstract:PURPOSE:To report 5-year outcomes of ultrathin Descemet stripping automated endothelial keratoplasty (UT-DSAEK) with a central graft thickness intended to be <100 μm. METHODS:This retrospective, consecutive, interventional case series included 354 eyes with endothelial decompensation due to various causes (Fuchs endot...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000001999
更新日期:2019-09-01 00:00:00
abstract:PURPOSE:Patients undergoing primary pterygium excision with autologous conjunctival autograft and human tissue adhesive in New Zealand, currently receive subconjunctival anesthesia with oral postoperative analgesia for pain. Our aim was to investigate the potential added benefit of intraoperative subtenon bupivacaine t...
journal_title:Cornea
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1097/ICO.0000000000001973
更新日期:2019-08-01 00:00:00
abstract:PURPOSE:To evaluate if donor corneas obtained from deaths occurring because of septicemia can be used for corneal transplantation. STUDY DESIGN:Prospective study. METHODS:Eleven septicemic donor corneas were used in the study and 10 donor corneas from deaths because of causes other than septicemia were used as contro...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000000858
更新日期:2016-08-01 00:00:00
abstract:PURPOSE:To present a new treatment modality for recurrent corneal melting in a patient with a Boston type I keratoprosthesis (B-KPro) including in situ corneal cross-linking (CXL) and lamellar keratoplasty (LKP) as combined treatment. METHODS:Case report. RESULTS:Our report concerns a 27-year-old man whose case histo...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000000830
更新日期:2016-06-01 00:00:00
abstract:PURPOSE:Subepithelial amyloidosis of the cornea, or gelatinous drop-like corneal dystrophy (GDD), is a severe form of corneal stromal amyloidosis predominantly found in the Japanese population. GDD causes severe visual disturbances with irritating symptoms, and keratoplasty is inevitably complicated by early recurrence...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/00003226-200203000-00010
更新日期:2002-03-01 00:00:00
abstract:PURPOSE:This report describes a case of multiple myeloma that presented as bilateral eyelid ecchymoses and corneal crystals in the absence of widespread signs of systemic disease. METHODS:A 55-year-old man was found to have the sudden appearance of bilateral eyelid ecchymoses after he flexed 90 degrees at the waist. O...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/01.ico.0000154381.13237.a3
更新日期:2005-08-01 00:00:00
abstract::Fresh and organ-culture preserved human corneas were examined for HLA-A,B,C (class I) and HLA-DR (class II) histocompatibility antigens using mouse monoclonal antibodies and an indirect immunofluorescence technique. HLA-A,B,C antigens were detected on epithelial cells and on keratocytes, but not on endothelial cells i...
journal_title:Cornea
pub_type: 杂志文章
doi:
更新日期:1984-01-01 00:00:00
abstract:PURPOSE:Measurement of central corneal thickness (CCT) plays an essential role in the diagnosis and treatment of many ocular diseases. In this study, we aimed to compare the CCT measurements obtained using the Scheimpflug system (Pentacam; Oculus, Inc) with a retinal optical coherence tomography device (Stratus OCT; Ca...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e31820128a4
更新日期:2011-06-01 00:00:00
abstract:PURPOSE:To report the use of intracameral amphotericin B in the management of deep keratomycosis. METHODS:Four patients with deep keratomycosis unresponsive to conventional medical treatment underwent repeated intracameral injections of 5 microg amphotericin B in 0.1 mL 5% dextrose through a paracentesis. Three to 13 ...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/00003226-200210000-00004
更新日期:2002-10-01 00:00:00
abstract:PURPOSE:To describe a simple finding, consisting of a double-line reflection from the graft inside the anterior chamber, that can be used to determine the correct donor tissue orientation in Descemet membrane endothelial keratoplasty: which we would like to call Berrospi's sign. METHODS:Evaluation of the presence of l...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000001889
更新日期:2019-06-01 00:00:00
abstract::Corneal photorefractive surgery is currently performed by ablation of corneal stroma under the stromal flap. A stromal flap is created using a femtosecond (FS) laser or mechanical microkeratome, although the FS laser procedure is considered safer and more accurate. This review assesses and compares the use of FS laser...
journal_title:Cornea
pub_type: 杂志文章,评审
doi:10.1097/ICO.0000000000000251
更新日期:2014-11-01 00:00:00
abstract:PURPOSE:To evaluate tear osmolarity and tear film parameters in patients with vitiligo. METHODS:A total of 25 eyes of 25 patients with vitiligo with periocular involvement (group 1), 30 eyes of 30 patients with vitiligo without periocular involvement (group 2), and 20 eyes of 20 controls (group 3) were evaluated using...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000001469
更新日期:2018-04-01 00:00:00
abstract:PURPOSE:To report clinical outcome of treating ocular demodecosis by lid scrub with tea tree oil (TTO). METHODS:Retrospective review of clinical results in 11 patients with ocular Demodex who received weekly lid scrub with 50% TTO combined with daily lid hygiene with tea tree shampoo. RESULTS:These 11 patients also h...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/01.ico.0000244870.62384.79
更新日期:2007-02-01 00:00:00
abstract:PURPOSE:To report a case of insect corneal foreign body with in vivo confocal microscopy performed. METHODS:Clinical presentation, clinical pictures, and treatment are discussed. Confocal microscopy of the injured cornea was performed in areas showing foreign bodies with and without infiltrations seen under the slit-l...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/00003226-200301000-00013
更新日期:2003-01-01 00:00:00
abstract:PURPOSE:To determine the effect of intravitreal injection of ranibizumab on the corneal endothelium in patients with choroidal neovascularization in age-related macular degeneration. METHODS:Observational prospective case series study. Fifty-two eyes of 52 consecutive patients (29 men, 23 women; age range, 61-80 years...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e3181ca33d2
更新日期:2010-08-01 00:00:00
abstract:PURPOSE:We report a case of mycotic keratitis caused by a rare fungus Chaetomium atrobrunneum. METHODS:Clinical examination, slit-lamp examination, and microbiological evaluation of corneal ulcer were done, and its treatment outcome was studied. The fungal etiology was established by conventional microbiological techn...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e31821eeaed
更新日期:2012-01-01 00:00:00
abstract:PURPOSE:To evaluate the prevalence of undiagnosed and asymptomatic human immunodeficiency virus (HIV) infection in patients with ocular surface squamous neoplasia (OSSN) in a referral hospital in Karnataka, South India. METHODS:A consecutive series of patients presenting with OSSN were evaluated in an academic center ...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e3182479aed
更新日期:2012-11-01 00:00:00
abstract:PURPOSE:To provide insight into the mechanism by which epidermal growth factor (EGF) stimulates corneal epithelial migration, we investigated the possible interaction between EGF and cyclic AMP (cAMP) signaling pathways during epithelial migration with an organ culture system for the rabbit cornea. METHODS:Rabbit corn...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/00003226-200305000-00014
更新日期:2003-05-01 00:00:00
abstract:PURPOSE:To review the indications and patient characteristics for penetrating keratoplasty (PKP). METHODS:Retrospective review of records at the Pathology Service, Department of Ophthalmology, University of Toronto from 1964 to 1997. RESULTS:The 6,222 records were reviewed. The leading indications for PKP were regraf...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/00003226-200001000-00002
更新日期:2000-01-01 00:00:00
abstract:PURPOSE:To evaluate the corneal topographic characteristics of first-degree relatives of patients with keratoconus with corneal topography to determine the incidence of clinical keratoconus and topographic abnormalities. METHODS:Between February and August 2006, Orbscan II analysis was done in 144 eyes of 72 cases who...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e318165d110
更新日期:2008-06-01 00:00:00
abstract:PURPOSE:To report 2 cases of cornea verticillata (CV) after vandetanib treatment for medullary thyroid carcinoma (MTC). METHODS:In this retrospective interventional, case-report study, 2 patients who under vandetanib treatment for MTC were referred to our ophthalmology department because of vision complaints. Both sub...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000001560
更新日期:2018-06-01 00:00:00
abstract::The mechanism of ocular surface allergy in the forms of atopic conjunctivitis and vernal keratoconjunctivitis has been highlighted by specific functions of chemokines. In the context of late-phase allergic responses, these molecules have key roles in recruitment and activation of leukocytes. Their interaction with lig...
journal_title:Cornea
pub_type: 杂志文章,评审
doi:10.1097/01.ico.0000136671.50777.fe
更新日期:2004-11-01 00:00:00
abstract:PURPOSE:The aim of this study was to estimate both the direct and indirect annual cost of managing dry eye disease (DED) in the United States from a societal and a payer's perspective. METHODS:A decision analytic model was developed to estimate the annual cost for managing a cohort of patients with dry eye with differ...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e3181f7f363
更新日期:2011-04-01 00:00:00
abstract:PURPOSE:To evaluate the surface characteristics of lenticules created by small-incision lenticule extraction (SMILE) with different cap thicknesses. METHODS:This prospective study included 20 consecutive patients who underwent bilateral SMILE. Surface regularity of the extracted corneal lenticule was analyzed using sc...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000001404
更新日期:2018-01-01 00:00:00
abstract:PURPOSE:To demonstrate the feasibility of Descemet membrane endothelial keratoplasty (DMEK) performed after previous penetrating keratoplasty (PK) failure and to describe primary outcomes. METHODS:Twenty-eight eyes of 28 patients who underwent DMEK after primary PK failure between January 2013 and November 2017 were i...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000001834
更新日期:2019-03-01 00:00:00
abstract:PURPOSE:To determine the stability of the laser in situ keratomileusis (LASIK) flap in a rabbit model when subjected to vertical acceleration at nine times the force of gravity (+9 Gz) in an aircraft cockpit ejection simulator. METHODS:Thirty-six eyes from 25 New Zealand white rabbits underwent LASIK flap creation wit...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/00003226-200303000-00013
更新日期:2003-03-01 00:00:00
abstract::Posterior polymorphous corneal dystrophy (PPD) is a rare bilateral, autosomal-dominant disease. The presence of the epitheliumlike endothelium and the thickening of Descemet's membrane by the posterior collagenous layer (PCL) has been reported in the majority of published cases. Reepithelialization of the posterior co...
journal_title:Cornea
pub_type: 杂志文章
doi:
更新日期:1994-11-01 00:00:00
abstract:PURPOSE:To evaluate the results of a combined approach of cicatrix lysis, intraoperative mitomycin C (MMC) application, oral mucosal transplantation (OMT), and amniotic membrane transplantation (AMT) for surgery of severe symblepharon. METHODS:This prospective study included 32 eyes with severe symblepharon in which a...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e318247983d
更新日期:2013-02-01 00:00:00
abstract:PURPOSE:In a Strampelli osteo-odonto-keratoprosthesis, a patch of oral mucosa is frequently used to cover the ocular surface after implantation of an osteodental lamina into the eye. In many cases, gross modifications in the eye covering become apparent a few years later. The aim of this study was to investigate the hi...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/01.ico.0000170695.98078.42
更新日期:2006-02-01 00:00:00