Epidermal growth factor and corneal wound healing. A multicenter study.

Abstract:

:A randomized, double-blind, placebo-controlled, multicenter clinical trial was conducted in five centers to assess safety, ocular tolerance, and efficacy of an ophthalmic solution of epidermal growth factor (EGF) for the treatment of traumatic corneal epithelial defects. One hundred four patients completed the study: 47 received EGF and 57 placebo (the drug vehicle). Mean epithelial healing time was significantly enhanced in the EGF-treated group (44.17 h) compared with the placebo-treated treated group (61.05 h) (p < 0.01). The number of epithelial defects completely healed at 24, 48, and 72 h after the onset of treatment was significantly greater in the EGF-treated group. Local tolerance was adequate in both groups. These results indicated that topical EGF is well tolerated and may be a significant addition to the ophthalmologist's armamentarium for treating corneal epithelial defects.

journal_name

Cornea

journal_title

Cornea

authors

Pastor JC,Calonge M

doi

10.1097/00003226-199207000-00007

subject

Has Abstract

pub_date

1992-07-01 00:00:00

pages

311-4

issue

4

eissn

0277-3740

issn

1536-4798

journal_volume

11

pub_type

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