Neutrophil--mediated cytotoxicity against tumour cells: state of art.

Abstract:

:When activated by a variety of stimuli, human neutrophils become capable of lysing tumour cells. The main physiologic cytotoxic trigger in neutrophils is represented by the surface receptor for the Fc domain of IgG (FcR). This receptor confers specificity to the target recognition by neutrophils and cooperates with adhesion glycoproteins (CD11-CD18) in the neutrophil-target conjugate formation. Although the FcR-dependent pathways of signal transduction remain to be clarified, the neutrophil responses involve both the production of oxidants and the release of granule constituents. These molecules are responsible for the target lysis, whose extent also depends on the target structural and metabolic characteristics. The use of monoclonal antibodies specific for tumour cell antigens, coupled with appropriate cytokines, may provide rational basis for designing trials to employ the neutrophil cytotoxic potential as adjuvant therapy in cancer patients.

authors

Dallegri F,Ottonello L

subject

Has Abstract

pub_date

1992-01-01 00:00:00

pages

39-42

issue

1

eissn

0004-069X

issn

1661-4917

journal_volume

40

pub_type

杂志文章,评审
  • Studies on mitogen activity of the dextrans.

    abstract::The influence of dextrans of various molecule sizes on blastic transformation induced by Con A and PHA lectins was studied. It was found that particularly dextran of smaller molecule inhibits blastogenesis induced by Con A. The dextran of greater molecule is less so inhibitory. On the other hand, in the effect of dext...

    journal_title:Archivum immunologiae et therapiae experimentalis

    pub_type: 杂志文章

    doi:

    authors: Giełdanowski J,Doskocz W

    更新日期:1980-01-01 00:00:00

  • Protection of mice against vaccinia and herpes simplex virus infection by Propionibacterium acnes.

    abstract::Heat-killed cell suspension of several Propionibacterium acnes strains were prepared and studied for their protective activity in viral infection of mice and immunomodulating properties. Majority of the strains caused marked spleen enlargement in the treated mice. These changes persisted for several weeks. Only some o...

    journal_title:Archivum immunologiae et therapiae experimentalis

    pub_type: 杂志文章

    doi:

    authors: Zgórniak-Nowosielska I,Cwik D,Sławińska B

    更新日期:1989-01-01 00:00:00

  • Storage of macrophages at -196 degrees C.

    abstract::Oil induced mice peritoneal cells were stored at -196 degrees C for 3 months, using dimethyl sulfoxide (DMSO) as a cryoprotective medium. Recovery counts upon thawing were about 90%. Macrophages retained their phagocytic activity of SRBC in 89% and there were no significant differences in spontaneous migration, expres...

    journal_title:Archivum immunologiae et therapiae experimentalis

    pub_type: 杂志文章

    doi:

    authors: Lukomska B,Olszewski WL,Pawtel B,Augustynowicz S,Szmurło W

    更新日期:1978-01-01 00:00:00

  • Nicotinic cholinergic signaling in adipose tissue and pancreatic islets biology: revisited function and therapeutic perspectives.

    abstract::Nicotinic acetylcholine receptors (nAChRs) are membrane ligand-gated cation channels whose activation is triggered by the binding of the endogenous neurotransmitter acetylcholine or other biologic compounds including nicotine. Their roles in synaptic transmission in the central and peripheral nervous system as well as...

    journal_title:Archivum immunologiae et therapiae experimentalis

    pub_type: 杂志文章,评审

    doi:10.1007/s00005-013-0266-6

    authors: Somm E

    更新日期:2014-04-01 00:00:00

  • Cellular immunity in asbestosis.

    abstract::A highly statistically significant correlation was found between asbestosis and impaired responsiveness in skin reaction to intermediate and second strength tuberculin and SK-SD. Considering ANA incidence these antibodies were found with higher frequency in asbestos workers who lacked a cutaneous response to the recal...

    journal_title:Archivum immunologiae et therapiae experimentalis

    pub_type: 杂志文章

    doi:

    authors: Lange A,Smolik R,Chmielarczyk W,Garncarek D,Gielgier Z

    更新日期:1978-01-01 00:00:00

  • Application of the NBT test in calves.

    abstract::A modified nitrobluetetrazolium test (NBT) was used to study 114 blood samples from calves, beginning from the birth to the 21-st day of life. The calves came from two farms with different breeding conditions. The absolute number of granulocytes with the ability to reduce NBT ranged between 0-9737. Comparison of mean ...

    journal_title:Archivum immunologiae et therapiae experimentalis

    pub_type: 杂志文章

    doi:

    authors: Nikołajczuk M

    更新日期:1978-01-01 00:00:00

  • Effect of cyclosporine A on the non-specific, innate antiviral immunity of mice.

    abstract::Different infections are the most common complication of immunosuppressive therapy. In this context, the effect of cyclosporine A (CsA) on the innate antiviral immunity of mice was studied. The presence of immunity was shown by infection of resident peritoneal cells (RPC) of BALB/c mice with herpes simplex virus type ...

    journal_title:Archivum immunologiae et therapiae experimentalis

    pub_type: 杂志文章

    doi:

    authors: Zaczyńska E,Olszewska ZB

    更新日期:2001-01-01 00:00:00

  • In vitro correction of a novel splicing alteration in the BTK gene by using antisense morpholino oligonucleotides.

    abstract::A novel sequence variant, c.240+109C>A, in the Bruton's tyrosine kinase (BTK) gene was identified in a patient with X-linked agammaglobulinemia. This alteration resulted in an incorporation of 106 nucleotides of BTK intron 3 into its mRNA. Administration of the 25-mer antisense morpholino oligonucleotide analog in the...

    journal_title:Archivum immunologiae et therapiae experimentalis

    pub_type: 杂志文章

    doi:10.1007/s00005-014-0283-0

    authors: Rattanachartnarong N,Tongkobpetch S,Chatchatee P,Daengsuwan T,Ittiwut C,Suphapeetiporn K,Shotelersuk V

    更新日期:2014-10-01 00:00:00

  • The MEK1/2-ERK1/2 pathway is activated in chronic rhinosinusitis with nasal polyps.

    abstract::Chronic rhinosinusitis with nasal polyps (CRSwNP) is a common disease that has a considerable impact on the quality of life. Alterations in signalling pathways may contribute to the ongoing inflammation and proliferation in CRSwNP. The MEK1/2-ERK1/2 pathway transmits signals from many extracellular molecules to regula...

    journal_title:Archivum immunologiae et therapiae experimentalis

    pub_type: 杂志文章

    doi:10.1007/s00005-014-0281-2

    authors: Linke R,Pries R,Könnecke M,Bruchhage KL,Böscke R,Gebhard M,Wollenberg B

    更新日期:2014-06-01 00:00:00

  • The murine Ly49 family: form and function.

    abstract::The activity of natural killer (NK) cells is regulated by surface receptors that recognize class I MHC. Murine NK cells express a large family of lectin-related receptors (Ly49s) to perform this function, while human NK cells utilize a separate group of proteins containing Ig-related domains (KIRs). Although these rec...

    journal_title:Archivum immunologiae et therapiae experimentalis

    pub_type: 杂志文章,评审

    doi:

    authors: Makrigiannis AP,Anderson SK

    更新日期:2001-01-01 00:00:00

  • Call for a dedicated European legal framework for bacteriophage therapy.

    abstract::The worldwide emergence of antibiotic resistances and the drying up of the antibiotic pipeline have spurred a search for alternative or complementary antibacterial therapies. Bacteriophages are bacterial viruses that have been used for almost a century to combat bacterial infections, particularly in Poland and the for...

    journal_title:Archivum immunologiae et therapiae experimentalis

    pub_type: 杂志文章,评审

    doi:10.1007/s00005-014-0269-y

    authors: Verbeken G,Pirnay JP,Lavigne R,Jennes S,De Vos D,Casteels M,Huys I

    更新日期:2014-04-01 00:00:00

  • Differential cell-cycle-dependent inhibition of DNA synthesis by hydroxyurea and cytosine arabinoside in cultured L5178Y mouse lymphoma cells.

    abstract::The effect of various concentrations of hydroxyurea and cytosine arabinoside on DNA synthesis, measured as 3H-thymidine incorporation, in exponentially growing and synchronized L5178Y cells in culture was investigated. The experiments revealed that each compound causes differential inhibition of DNA synthesis at vario...

    journal_title:Archivum immunologiae et therapiae experimentalis

    pub_type: 杂志文章

    doi:

    authors: Malec J,Kornacka L,Sawecka J

    更新日期:1979-01-01 00:00:00

  • The role of T cells in rheumatoid arthritis.

    abstract::In rheumatoid arthritis (RA), T cells infiltrate into the synovial membrane where they initiate and maintain activation of macrophages and synovial fibroblasts, transforming them into tissue-destructive effector cells. The diversity of the disease process and the formation of complex lymphoid microstructures indicate ...

    journal_title:Archivum immunologiae et therapiae experimentalis

    pub_type: 杂志文章,评审

    doi:

    authors: Weyand CM,Bryl E,Goronzy JJ

    更新日期:2000-01-01 00:00:00

  • The influence of trazodone on the circulatory system in patients with endogenous depression. I. Basic circulatory parameters.

    abstract::In patients with endogenous depression in remission, decline of systolic blood pressure and a statistically significant shortening of pulse time were found. ...

    journal_title:Archivum immunologiae et therapiae experimentalis

    pub_type: 杂志文章

    doi:

    authors: Mrozikiewicz A,Strzyzewski W,Kapelski Z,Sydor L

    更新日期:1976-01-01 00:00:00

  • Synthesis and biological properties of derivatives of 3-methyl-5-aminoisothiazolo-4-carboxylic acid.

    abstract::The reaction of 3-methyl-5-aminoisothiazolo-4-carboxylic acid with the chlorides of chloroacetaic acid and chloropropionic acid gave 3-methyl-5-chloroacetyl- and 5-chloropropionylisothiazolo-4-carboxylic acids, which upon heating in anhydrous ethanol with aliphatic and aromatic amines gave the respective 5-aminoacetyl...

    journal_title:Archivum immunologiae et therapiae experimentalis

    pub_type: 杂志文章

    doi:

    authors: Machón Z

    更新日期:1976-01-01 00:00:00

  • Capillary transport of immunoglobulins and complement proteins to the interstitial fluid and lymph.

    abstract::Low concentration of immunoglobulins G, A and M and complement component proteins were found in leg lymph of normal men. The lymph/serum ratios of different proteins ranged from 0.07 to 0.24 and depended on the molecular weight of the measured protein. Major variations in concentration were found dependent on the rate...

    journal_title:Archivum immunologiae et therapiae experimentalis

    pub_type: 杂志文章

    doi:

    authors: Olszewski WL,Engeset A

    更新日期:1978-01-01 00:00:00

  • Exhaled IL-8 in systemic lupus erythematosus with and without pulmonary fibrosis.

    abstract::The purpose of this study is to evaluate the relationship between the concentration of interleukin-8 (IL-8) in exhaled breath condensate (EBC) and bronchoalveolar lavage fluid (BALF) with the disease activity score and pulmonary function of systemic lupus erythematosus (SLE) patients with and without pulmonary fibrosi...

    journal_title:Archivum immunologiae et therapiae experimentalis

    pub_type: 杂志文章

    doi:10.1007/s00005-014-0270-5

    authors: Nielepkowicz-Goździńska A,Fendler W,Robak E,Kulczycka-Siennicka L,Górski P,Pietras T,Brzeziańska E,Antczak A

    更新日期:2014-06-01 00:00:00

  • Circulating immune complexes in uveitis.

    abstract::The occurrence of circulating immune complexes was studied in 28 patients suffering from uveitis. The presence of complexes was found in 18 patients including 6 out of 10 patients with iridocyclitis and in 12 out of 18 patients with chronic total uveitis. ...

    journal_title:Archivum immunologiae et therapiae experimentalis

    pub_type: 杂志文章

    doi:

    authors: Hańczyc P,Prastowska E,Wieczorek E

    更新日期:1987-01-01 00:00:00

  • The sensitivity of guinea pig mesenteric and pulmonary mast cells to some histamine releasers.

    abstract::The mesenteric and pulmonary mast cells of guinea pigs were obtained by enzymatic dispersion of the tissues with the enzyme collagenase. The guinea pig mast cells obtained by this method were morphologically intact, as judged by light microscopy. The mast cells from lung and mesentery of actively sensitized guinea pig...

    journal_title:Archivum immunologiae et therapiae experimentalis

    pub_type: 杂志文章

    doi:

    authors: Brezezińska-Błaszczyk E,Czuwaj M,Wyczółkowska J

    更新日期:1987-01-01 00:00:00

  • Automatic Marsh method for detection and identification of erythrocyte antibodies in patients and blood donors.

    abstract::Using a Technicon autoanalyzer method of Marsh 752 sera of patients, Rh-negative subjects in the initial stage of immunization with Rh-positive blood, and healthy blood donors were investigated. In 56 sera (8.7%) positive reactions with standard erythrocytes were found. In 21 of these cases (36%) specificity of antibo...

    journal_title:Archivum immunologiae et therapiae experimentalis

    pub_type: 杂志文章

    doi:

    authors: Michael-Araszkiewicz P,Maślanka K,Kuśnierz G

    更新日期:1980-01-01 00:00:00

  • Effect of domperidone-induced hyperprolactinemia on selected immune parameters in healthy women.

    abstract::Domperidone, anti-emetic drug, given to healthy female volunteers, induced an elevation of plasma prolactin (PRL) concentration with the peak in 1-4 h. The release of prolactin had a transient stimulating effect on theophylline sensitive T lymphocytes and on concanavalin A induced mitogenic activity, suggesting an enh...

    journal_title:Archivum immunologiae et therapiae experimentalis

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Rovenský J,Buc M,Lojda Z,Ruzicková M,Blazícková S,Rauová L,Mistina T,Vigas M,Lackovic V

    更新日期:1995-01-01 00:00:00

  • Ludwik Hirszfeld Memorial Lecture: HIV-1 reservoirs: major molecular obstacles to viral eradication.

    abstract::Over the last 18 years of study in one of our laboratories, we have observed the development of residual disease and latent reservoirs as major problems in the long-term therapy of HIV-1-infected individuals on highly active antiretroviral therapy (HAART). It was shown in the early 1990 's that HAART, as it is present...

    journal_title:Archivum immunologiae et therapiae experimentalis

    pub_type: 杂志文章,评审

    doi:

    authors: Pomerantz RJ

    更新日期:2004-09-01 00:00:00

  • Aberrant function and differentiation of monocytes in end stage renal disease.

    abstract::Patients with end stage renal disease (ESRD) suffer from many disturbances of the immune system. These immunopathologies are related to the higher failure of vaccination, and increased prevalence of infections and neoplasms. In the presented article, we review the current data regarding the role of monocytes in immune...

    journal_title:Archivum immunologiae et therapiae experimentalis

    pub_type: 杂志文章,评审

    doi:10.1007/s00005-012-0191-0

    authors: Laudański K,Nowak Z

    更新日期:2012-12-01 00:00:00

  • Variant and Specific Forms of Autoimmune Cholestatic Liver Diseases.

    abstract::Primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC) are the main autoimmune cholestatic liver diseases. IgG4-associated sclerosing cholangitis is another distinct immune-mediated cholestatic disorder of unknown aetiology that is frequently associated with autoimmune pancreatitis or other IgG4-re...

    journal_title:Archivum immunologiae et therapiae experimentalis

    pub_type: 杂志文章,评审

    doi:10.1007/s00005-019-00550-9

    authors: Dalekos GN,Gatselis NK

    更新日期:2019-08-01 00:00:00

  • Microbial transformation of azacarbazoles. II. Conversion of methyl-substituted alpha-carbolines to corresponding alpha-iso-carbolines by Kitasatosporia setae strain.

    abstract::alpha-Carboline derivatives substituted with methyl groups at C-2, C-4, C-2,4, C-6 and C-8 position were subjected to N-1 methylation performed by Kitasatosporia setae. The yield of formed corresponding alpha-iso-carbolines varied, depending on the position of methyl substituent. It has been observed that the methyl g...

    journal_title:Archivum immunologiae et therapiae experimentalis

    pub_type: 杂志文章

    doi:

    authors: Peczyńska-Czoch W

    更新日期:1987-01-01 00:00:00

  • Antigenic characterization of urea-extractable crude burn toxin.

    abstract::Crude burn toxin was obtained from human skin scalded for 1 min at 90 degrees C in vitro. The toxin solubilized with 8 M urea was administered to rabbits to obtain antiserum. The antigenic analysis carried out by immunodiffusion and immunoelectrophoresis demonstrated that urea-extractable toxin solution differed from ...

    journal_title:Archivum immunologiae et therapiae experimentalis

    pub_type: 杂志文章

    doi:

    authors: Grzybowski J,Bogusławska-Kubin J

    更新日期:1981-01-01 00:00:00

  • Production of lymphokines by murine cortisone resistant thymocytes stimulated by concanavalin A. III. Effect of cytotoxic pretreatment with anti-Lyt antibodies on interleukin-2 and interferon producing cells.

    abstract::Lyt phenotypes of interleukin-2 and interferon producing Balb/c cortisone resistant thymocytes, stimulated by concanavalin A in vitro, were studied using cytotoxic anti-Lyt-1.2 and anti-Lyt-2.2 alloantisera and monoclonal antibodies. It was found that while interleukin-2 was produced by both Lyt1+ and Lyt2+ cells, the...

    journal_title:Archivum immunologiae et therapiae experimentalis

    pub_type: 杂志文章

    doi:

    authors: Pajtasz E,Kuśnierczyk P,Albin M,Kisielow P

    更新日期:1986-01-01 00:00:00

  • Labeling of ribosomal ribonucleic acid with iodine 125I.

    abstract::RNA was labeled with iodine in the reaction catalyzed with lactoperoxidase (LP). Labeling of RNA requires additional purification of LP on Sephadex G-100 and application of RNase inhibitors. Immobilized LP shows lower activity than a soluble enzyme but still it is sufficient to label RNA to 7% IC. Immobilized enzyme i...

    journal_title:Archivum immunologiae et therapiae experimentalis

    pub_type: 杂志文章

    doi:

    authors: Gładek A,Mordarski M

    更新日期:1983-01-01 00:00:00

  • Study of antibody dependent cellular cytotoxicity (ADCC). II. ADCC activity in renal graft recipients and acute accelerated graft rejection.

    abstract::ADCC activity in 27 cadaver renal allograft recipients was studied. All the patients were given standard immunosuppressive treatment. Significant positive correlation between high ADCC activity during first 5 days after grafting and accelerated rjection crisis was found. The high positive ADCC test may signalize the p...

    journal_title:Archivum immunologiae et therapiae experimentalis

    pub_type: 杂志文章

    doi:

    authors: Wasik M,Gradowska L,Lao M,Rowińska D,Orłowski T

    更新日期:1978-01-01 00:00:00

  • Evaluation of Endothelial Function by Flow-Mediated Dilation: a Comprehensive Review in Rheumatic Disease.

    abstract::Flow-mediated dilation (FMD) represents a non-invasive marker of endothelial function to evaluate vascular homeostasis, which reflects the effects of several mechanisms, including vessel tone regulation, cell proliferation, and inflammatory responses. Beyond classical atherosclerotic risk factors such as arterial hype...

    journal_title:Archivum immunologiae et therapiae experimentalis

    pub_type: 杂志文章,评审

    doi:10.1007/s00005-017-0465-7

    authors: Moroni L,Selmi C,Angelini C,Meroni PL

    更新日期:2017-12-01 00:00:00