Cellular immunity in asbestosis.

Abstract:

:A highly statistically significant correlation was found between asbestosis and impaired responsiveness in skin reaction to intermediate and second strength tuberculin and SK-SD. Considering ANA incidence these antibodies were found with higher frequency in asbestos workers who lacked a cutaneous response to the recall antigens. In asbestosis cases peripheral blood lymphocyte profiles are also abnormal demonstrating low proportions of E-RFC. Moreover, MIF test results showed the impairment of this cytokine generation when lymphocytes were stimulated with SK-SD, PPD and PHA in asbestosis cases. The lymphocyte transformation study documents an impaired response mainly to a lower dose of PHA and ConA in asbestosis cases and in asbestos workers with ANA.

authors

Lange A,Smolik R,Chmielarczyk W,Garncarek D,Gielgier Z

subject

Has Abstract

pub_date

1978-01-01 00:00:00

pages

899-903

issue

1-6

eissn

0004-069X

issn

1661-4917

journal_volume

26

pub_type

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