Mice deficient for testis-brain RNA-binding protein exhibit a coordinate loss of TRAX, reduced fertility, altered gene expression in the brain, and behavioral changes.

abstract：:We cloned a 12.3-kilobase (kb) endogenous plasmid, Ddp1, found in several wild-type and laboratory strains of Dictyostelium discoideum into pBR322. The cloned plasmids have been used to cotransform D. discoideum cells with B10S, a transformation vector carrying a gene fusion conferring resistance to G418. Whereas B10S...

journal_title：Molecular and cellular biology

authors： Firtel RA,Silan C,Ward TE,Howard P,Metz BA,Nellen W,Jacobson A

更新日期：1985-11-01 00:00:00

abstract：:Previous work had identified a corepressor, NAB1, which represses transcriptional activation mediated by NGFI-A (also known as Egr-1, zif268, and Krox24) and Krox20. These zinc finger transcription factors are encoded by immediate-early genes and have been implicated in a wide variety of proliferative and differentiat...

journal_title：Molecular and cellular biology

authors： Svaren J,Sevetson BR,Apel ED,Zimonjic DB,Popescu NC,Milbrandt J

更新日期：1996-07-01 00:00:00

abstract：:Glucocorticoid production in the adrenal cortex is activated in response to an increase in cyclic AMP (cAMP) signaling. The nuclear protein p54(nrb)/NONO belongs to the Drosophila behavior/human splicing (DBHS) family and has been implicated in several nuclear processes, including transcription, splicing, and RNA expo...

journal_title：Molecular and cellular biology

authors： Lu JY,Sewer MB

更新日期：2015-04-01 00:00:00

abstract：:Cyclooxygenase (COX) catalyzes the first step in prostanoid biosynthesis and exists as two isoforms. COX-1 is a constitutive enzyme involved in physiological processes, whereas COX-2 is induced by a variety of stimuli. MicroRNAs (miRNAs) are noncoding RNAs that function as key posttranscriptional regulators of gene ex...

journal_title：Molecular and cellular biology

authors： Motiño O,Francés DE,Mayoral R,Castro-Sánchez L,Fernández-Velasco M,Boscá L,García-Monzón C,Brea R,Casado M,Agra N,Martín-Sanz P

更新日期：2015-07-01 00:00:00

abstract：:Tristetraprolin (TTP) regulates the expression of AU-rich element-containing mRNAs through promoting the degradation and repressing the translation of target mRNA. While the mechanism for promoting target mRNA degradation has been extensively studied, the mechanism underlying translational repression is not well estab...

journal_title：Molecular and cellular biology

authors： Tao X,Gao G

更新日期：2015-11-01 00:00:00

abstract：:The signal transducer and activator of transcription STAT5 plays a major role in the cellular response to cytokines, but the mechanism by which it activates transcription remains poorly understood. We show here that deacetylase inhibitors (trichostatin A, suberoylanilide hydroxamic acid, and sodium butyrate) prevent i...

journal_title：Molecular and cellular biology

authors： Rascle A,Johnston JA,Amati B

更新日期：2003-06-01 00:00:00

abstract：:In this report, we explored the mechanisms underlying keratinocyte-specific and differentiation-specific gene expression in the skin. We have identified five keratinocyte-specific, open chromatin regions that exist within the 6 kb of 5' upstream regulatory sequence known to faithfully recapitulate the strong endogenou...

journal_title：Molecular and cellular biology

authors： Kaufman CK,Sinha S,Bolotin D,Fan J,Fuchs E

更新日期：2002-06-01 00:00:00

abstract：:Glucocorticoids are stress hormones that maintain homeostasis through gene regulation mediated by nuclear receptors. We have discovered that other cellular stressors are integrated with glucocorticoid signaling through a new hormone-independent phosphorylation site, Ser134, on the human glucocorticoid receptor (GR). S...

journal_title：Molecular and cellular biology

authors： Galliher-Beckley AJ,Williams JG,Cidlowski JA

更新日期：2011-12-01 00:00:00

abstract：:In the acellular slime mold Physarum polycephalum, the several hundred genes coding for rRNA are located on linear extrachromosomal DNA molecules of a discrete size, 60 kilobases. Each molecule contains two genes that are arranged in a palindromic fashion and separated by a central spacer region. We investigated how r...

journal_title：Molecular and cellular biology

authors： Ferris PJ,Vogt VM,Truitt CL

更新日期：1983-04-01 00:00:00

abstract：:In both tissue sections and cell culture, the endothelial nature of a cell is most commonly determined by demonstration of its expression of von Willebrand factor (vWf) protein and/or mRNA. Thus, the mechanism of cell-type-specific transcriptional regulation of the vWf gene is central to studying the basis of endothel...

journal_title：Molecular and cellular biology

authors： Jahroudi N,Lynch DC

更新日期：1994-02-01 00:00:00

abstract：:Heterochromatin protein 1 (HP1) is a conserved chromosomal protein with important roles in chromatin packaging and gene silencing. In fission yeast, two HP1 family proteins, Swi6 and Chp2, are involved in transcriptional silencing at heterochromatic regions, but how they function and whether they act cooperatively or ...

journal_title：Molecular and cellular biology

authors： Sadaie M,Kawaguchi R,Ohtani Y,Arisaka F,Tanaka K,Shirahige K,Nakayama J

更新日期：2008-12-01 00:00:00

abstract：:The death domain-containing receptor superfamily and their respective downstream mediators control whether or not cells initiate apoptosis or activate NF-kappaB, events critical for proper immune system function. A screen for upstream activators of NF-kappaB identified a novel serine-threonine kinase capable of activa...

journal_title：Molecular and cellular biology

authors： Pazdernik NJ,Donner DB,Goebl MG,Harrington MA

更新日期：1999-10-01 00:00:00

abstract：:The steroid hormone progesterone acts via high-affinity nuclear receptors that interact with specific DNA sequences located near the promoter of the hormone-responsive gene. Recent studies suggested that the hormone-occupied progesterone receptor (PR) mediates gene activation by recruiting a cellular coregulatory fact...

journal_title：Molecular and cellular biology

authors： Xu Y,Klein-Hitpass L,Bagchi MK

更新日期：2000-03-01 00:00:00

abstract：:XPC is responsible for DNA damage sensing in nucleotide excision repair (NER). Mutations in XPC lead to a defect in NER and to xeroderma pigmentosum (XP-C). Here, we analyzed the biochemical properties behind mutations found within three patients: one amino acid substitution (P334H, XP1MI, and GM02096), one amino acid...

journal_title：Molecular and cellular biology

authors： Bernardes de Jesus BM,Bjørås M,Coin F,Egly JM

更新日期：2008-12-01 00:00:00

abstract：:The Son of sevenless proteins (Sos) are guanine nucleotide exchange factors involved in the activation of Ras by cytoplasmic and receptor tyrosine kinases. Growth factor stimulation rapidly induces the phosphorylation of Sos on multiple serine and threonine sites. Previous studies have demonstrated that growth factor-...

journal_title：Molecular and cellular biology

authors： Corbalan-Garcia S,Yang SS,Degenhardt KR,Bar-Sagi D

更新日期：1996-10-01 00:00:00

abstract：:G(1)-specific transcription in the budding yeast Saccharomyces cerevisiae depends upon SBF and MBF. Whereas inactivation of SBF-regulated genes during the G(1)/S transition depends upon mitotic B-type cyclins, inactivation of MBF has been reported to involve multiple regulators, Nrm1 and Stb1. Nrm1 is a transcriptiona...

journal_title：Molecular and cellular biology

authors： de Bruin RA,Kalashnikova TI,Wittenberg C

更新日期：2008-11-01 00:00:00

abstract：:The fgr proto-oncogene encodes a nonreceptor protein-tyrosine kinase, designated p55c-fgr. In this study, we have isolated human fgr cDNA molecules from normal monocyte mRNA templates. Nucleotide sequence analysis of the longest fgr cDNA revealed a 5' untranslated region of 927 bp which included two Alu-like repeats a...

journal_title：Molecular and cellular biology

authors： Gutkind JS,Link DC,Katamine S,Lacal P,Miki T,Ley TJ,Robbins KC

更新日期：1991-03-01 00:00:00

abstract：:Cryptococcus neoformans is a fungal pathogen that causes meningitis in patients immunocompromised by AIDS, chemotherapy, organ transplantation, or high-dose steroids. Current antifungal drug therapies are limited and suffer from toxic side effects and drug resistance. Here, we defined the targets and mechanisms of ant...

journal_title：Molecular and cellular biology

authors： Cruz MC,Cavallo LM,Görlach JM,Cox G,Perfect JR,Cardenas ME,Heitman J

更新日期：1999-06-01 00:00:00

abstract：:The human serine protease inhibitor (serpin) gene cluster at 14q32.1 contains a number of genes that are specifically expressed in hepatic cells. Cell-specific enhancers have been identified in several of these genes, but elements involved in locus-wide gene and chromatin control have yet to be defined. To identify re...

journal_title：Molecular and cellular biology

authors： Marsden MD,Fournier RE

更新日期：2003-05-01 00:00:00

abstract：:Determining the functions of novel genes implicated in cell survival is directly relevant to our understanding of mammalian development and carcinogenesis. ARS2 is an evolutionarily conserved gene that confers arsenite resistance on arsenite-sensitive Chinese hamster ovary cells. Little is known regarding the function...

journal_title：Molecular and cellular biology

authors： Wilson MD,Wang D,Wagner R,Breyssens H,Gertsenstein M,Lobe C,Lu X,Nagy A,Burke RD,Koop BF,Howard PL

更新日期：2008-03-01 00:00:00

abstract：:RBM4 promotes differentiation of neuronal progenitor cells and neurite outgrowth of cultured neurons via its role in splicing regulation. In this study, we further explored the role of RBM4 in neuronal differentiation. During neuronal differentiation, energy production shifts from glycolysis to oxidative phosphorylati...

journal_title：Molecular and cellular biology

authors： Su CH,Hung KY,Hung SC,Tarn WY

更新日期：2017-01-19 00:00:00

abstract：:Inactivation of gene expression by antisense mechanisms in general and by ribozymes in particular is a powerful technique for studying the function of a gene product. We have designed a strategy for expression of ribozymes, for selection of accessible cleavage sites in target RNAs, and for isolation of ribozymes from ...

journal_title：Molecular and cellular biology

authors： Lieber A,Strauss M

更新日期：1995-01-01 00:00:00

abstract：:SMAUG (SMG) is an RNA-binding protein that functions as a key component of a transcript degradation pathway that eliminates maternal mRNAs in the bulk cytoplasm of activated Drosophila melanogaster eggs. We previously showed that SMG destabilizes maternal Hsp83 mRNA by recruiting the CCR4-NOT deadenylase to trigger de...

journal_title：Molecular and cellular biology

authors： Semotok JL,Luo H,Cooperstock RL,Karaiskakis A,Vari HK,Smibert CA,Lipshitz HD

更新日期：2008-11-01 00:00:00

abstract：:c-jun is a member of the family of immediate-early genes whose expression is induced by factors such as serum stimulation, phorbol ester, and differentiation signals. Here we show that increased Jun synthesis after serum stimulation is accompanied by a concomitant increase in phosphorylation. Several serine-threonine ...

journal_title：Molecular and cellular biology

authors： Baker SJ,Kerppola TK,Luk D,Vandenberg MT,Marshak DR,Curran T,Abate C

更新日期：1992-10-01 00:00:00

abstract：:CAP, a protein from Saccharomyces cerevisiae that copurifies with adenylyl cyclase, appears to be required for yeast cells to be fully responsive to RAS proteins. CAP also appears to be required for normal cell morphology and responsiveness to nutrient deprivation and excess. We describe here a molecular and phenotypi...

journal_title：Molecular and cellular biology

authors： Gerst JE,Ferguson K,Vojtek A,Wigler M,Field J

更新日期：1991-03-01 00:00:00

abstract：:alpha 2u-Globulin is a rat protein of as yet unknown function whose synthesis can be induced by glucocorticoids and several other hormones. Induction by glucocorticoids is a secondary response to the hormone: protein synthesis is required before the hormone can exert its stimulatory effect on alpha 2u-globulin transcr...

journal_title：Molecular and cellular biology

authors： Addison WR,Kurtz DT

更新日期：1986-07-01 00:00:00

abstract：:The levels of the A, B, and C subunits of protein phosphatase 2A in extracts from synchronized embryonic bovine tracheal cells were determined by immunoblotting with subunit-specific antibodies. A constant amount of each subunit was found in resting cells as well as in growing cells from all stages of the cell cycle. ...

journal_title：Molecular and cellular biology

authors： Ruediger R,Van Wart Hood JE,Mumby M,Walter G

更新日期：1991-08-01 00:00:00

abstract：:We have isolated a gene, pmk1+, a third mitogen-activated protein kinase (MAPK) gene homolog from the fission yeast Schizosaccharomyces pombe. The predicted amino acid sequence shows the most homology (63 to 65% identity) to those of budding yeast Saccharomyces Mpk1 and Candida Mkc1. The Pmk1 protein contains phosphor...

journal_title：Molecular and cellular biology

authors： Toda T,Dhut S,Superti-Furga G,Gotoh Y,Nishida E,Sugiura R,Kuno T

更新日期：1996-12-01 00:00:00

abstract：:Eukaryotic translation initiation factor 4GI (eIF4GI) is an essential protein that is the target for translational regulation in many cellular processes and viral systems. It has been shown to function in both cap-dependent and cap-independent translation initiation by recruiting the 40S ribosomal subunit to the mRNA ...

journal_title：Molecular and cellular biology

authors： Byrd MP,Zamora M,Lloyd RE

更新日期：2002-07-01 00:00:00

abstract：:Insulin-like growth factor II (IGF-II) is a major fetal growth factor. The IGF-II gene generates multiple mRNAs with different 5' untranslated regions (5' UTRs) that are translated in a differential manner during development. We have identified a human family of three IGF-II mRNA-binding proteins (IMPs) that exhibit m...

journal_title：Molecular and cellular biology

authors： Nielsen J,Christiansen J,Lykke-Andersen J,Johnsen AH,Wewer UM,Nielsen FC

更新日期：1999-02-01 00:00:00