Inheritance of extrachromosomal rDNA in Physarum polycephalum.

abstract：:IkappaB alpha retains the transcription factor NF-kappaB in the cytoplasm, thus inhibiting its function. Various stimuli inactivate IkappaB alpha by triggering phosphorylation of the N-terminal residues Ser32 and Ser36. Phosphorylation of both serines is demonstrated directly by phosphopeptide mapping utilizing calpai...

journal_title：Molecular and cellular biology

authors： Brown K,Franzoso G,Baldi L,Carlson L,Mills L,Lin YC,Gerstberger S,Siebenlist U

更新日期：1997-06-01 00:00:00

abstract：:The mammalian target of rapamycin (mTOR) is a Ser/Thr (S/T) protein kinase, which controls mRNA translation initiation by modulating phosphorylation of the translational regulators PHAS-I and p70(S6K). Here we show that in vitro mTOR is able to phosphorylate these two regulators at comparable rates. Both (S/T)P sites,...

journal_title：Molecular and cellular biology

authors： McMahon LP,Choi KM,Lin TA,Abraham RT,Lawrence JC Jr

更新日期：2002-11-01 00:00:00

abstract：:Tristetraprolin (TTP) acts by binding to AU-rich elements in certain mRNAs, such as tumor necrosis factor (TNF) mRNA, and increasing their decay rates. TTP knockout mice exhibit a profound inflammatory syndrome that is largely due to increased TNF levels. Although TTP's effects on gene expression have been well studie...

journal_title：Molecular and cellular biology

authors： Patial S,Stumpo DJ,Young WS 3rd,Ward JM,Flake GP,Blackshear PJ

更新日期：2016-04-15 00:00:00

abstract：:The mitogen-activated protein (MAP) kinases represent one of the most important classes of signaling cascades that are used by eukaryotic cells to sense extracellular signals. One of the major responses to these cascades is a change in cellular gene expression profiles mediated through the direct targeting of transcri...

journal_title：Molecular and cellular biology

authors： Zhang L,Yang SH,Sharrocks AD

更新日期：2007-04-01 00:00:00

abstract：:The minimal muscle-specific dystrophin promoter contains the consensus sequence CC(A/T)6GG, or the CArG element, which can be found in serum-inducible or muscle-specific promoters. The serum response factor (SRF), which mediates the transcriptional activation of the c-fos gene in response to serum stimulation, can bin...

journal_title：Molecular and cellular biology

authors： Galvagni F,Lestingi M,Cartocci E,Oliviero S

更新日期：1997-03-01 00:00:00

abstract：:The mouse cytochrome P1450 (CYP1A1) gene is responsible for the metabolism of numerous carcinogens and toxic chemicals. Induction by the environmental contaminant tetrachlorodibenzo-p-dioxin (TCDD) requires a functional aromatic hydrocarbon (Ah) receptor. We examined the 5'-flanking region of the CYP1A1 gene in mouse ...

journal_title：Molecular and cellular biology

authors： Neuhold LA,Shirayoshi Y,Ozato K,Jones JE,Nebert DW

更新日期：1989-06-01 00:00:00

abstract：:A new dominant amplifiable selective system for use in bacterium-animal cell shuttle vectors was developed by the insertion of a 2-kilobase genomic fragment containing the cloned Escherichia coli gene for asparagine synthetase (AS) into the pBR322-simian virus 40 recombinant vector pSV2 so as to place the translationa...

journal_title：Molecular and cellular biology

authors： Cartier M,Chang MW,Stanners CP

更新日期：1987-05-01 00:00:00

abstract：:Cse4p is a variant of histone H3 that has an essential role in chromosome segregation and centromere chromatin structure in budding yeast. Cse4p has a unique 135-amino-acid N terminus and a C-terminal histone-fold domain that is more than 60% identical to histone H3 and the mammalian centromere protein CENP-A. Cse4p a...

journal_title：Molecular and cellular biology

authors： Keith KC,Baker RE,Chen Y,Harris K,Stoler S,Fitzgerald-Hayes M

更新日期：1999-09-01 00:00:00

abstract：:The gene encoding the testis isozyme of angiotensin-converting enzyme (testis ACE) is one example of the many genes expressed uniquely during spermatogenesis. This protein is expressed by developing germ cells late in their development and results from the activation of a sperm-specific promoter that is located within...

journal_title：Molecular and cellular biology

authors： Howard T,Balogh R,Overbeek P,Bernstein KE

更新日期：1993-01-01 00:00:00

abstract：:In the current study, we were interested in exploring the molecular mechanism of circular RNA DLEU2 (circRNA-DLEU2) (hsa_circ_0000488) and microRNA 496 (miR-496), as well as PRKACB, in human acute myeloid leukemia (AML) cell activities. The RNA expression levels of circRNA-DLEU2, hsa-miR-496, and PRKACB were assessed ...

journal_title：Molecular and cellular biology

authors： Wu DM,Wen X,Han XR,Wang S,Wang YJ,Shen M,Fan SH,Zhang ZF,Shan Q,Li MQ,Hu B,Chen GQ,Lu J,Zheng YL

更新日期：2018-09-28 00:00:00

abstract：:Transcriptional activators interact with multisubunit coactivators that modify chromatin structure or recruit the general transcriptional machinery to their target genes. Budding yeast cells respond to amino acid starvation by inducing an activator of amino acid biosynthetic genes, Gcn4p. We conducted a comprehensive ...

journal_title：Molecular and cellular biology

authors： Swanson MJ,Qiu H,Sumibcay L,Krueger A,Kim SJ,Natarajan K,Yoon S,Hinnebusch AG

更新日期：2003-04-01 00:00:00

abstract：:To determine whether regulation of c-myc proteins occurs during the differentiation of murine erythroleukemia cells, we examined c-myc protein synthesis and accumulation throughout dimethyl sulfoxide (DMSO)- or hypoxanthine-induced differentiation. c-myc protein expression exhibited an overall biphasic reduction, with...

journal_title：Molecular and cellular biology

authors： Spotts GD,Hann SR

更新日期：1990-08-01 00:00:00

abstract：:Platelet-derived growth factor alpha receptor (PDGF alpha R) is a transmembrane tyrosine kinase receptor for all three existing PDGF isoforms, AA, AB, and BB. Transcripts of PDGF alpha R are detected as early as in fertilized mouse eggs and throughout adulthood in a time- and space-specific manner, thereby suggesting ...

journal_title：Molecular and cellular biology

authors： Wang C,Song B

更新日期：1996-02-01 00:00:00

abstract：:Fragments of African green monkey (Cercopithecus aethiops) DNA (3.5 to 18.0 kilobases) were inserted downstream from the thymidine kinase (TK, tk) coding region in pTK206/SV010, a gene construct which lacks both copies of the hexanucleotide 5'-AATAAA-3' and contains a simian virus 40 origin of replication, allowing it...

journal_title：Molecular and cellular biology

authors： Santangelo GM,Cole CN

更新日期：1983-04-01 00:00:00

abstract：:Thrombospondins are a family of stress-inducible secreted glycoproteins that underlie tissue remodeling. We recently reported that thrombospondin-4 (Thbs4) has a critical intracellular function, regulating the adaptive endoplasmic reticulum (ER) stress pathway through activating transcription factor 6α (Atf6α). In the...

journal_title：Molecular and cellular biology

authors： Brody MJ,Schips TG,Vanhoutte D,Kanisicak O,Karch J,Maliken BD,Blair NS,Sargent MA,Prasad V,Molkentin JD

更新日期：2015-10-12 00:00:00

abstract：:The role of the target cell in its own death mediated by cytotoxic T lymphocytes (CTL) has been controversial. The ability of the pore-forming granule components of CTL to induce target cell death directly has been taken to suggest an essentially passive role for the target. This view of CTL-mediated killing ascribes ...

journal_title：Molecular and cellular biology

authors： Ucker DS,Wilson JD,Hebshi LD

更新日期：1994-01-01 00:00:00

abstract：:Yeast metallothionein, encoded by the CUP1 gene, and its copper-dependent transcriptional activator ACE1 play a key role in mediating copper resistance in Saccharomyces cerevisiae. Using an ethyl methanesulfonate mutant of a yeast strain in which CUP1 and ACE1 were deleted, we isolated a gene, designated CUP9, which p...

journal_title：Molecular and cellular biology

authors： Knight SA,Tamai KT,Kosman DJ,Thiele DJ

更新日期：1994-12-01 00:00:00

abstract：:The cys-3+ gene of Neurospora crassa encodes a bZIP (basic region-leucine zipper) regulatory protein that is essential for sulfur structural gene expression (e.g., ars-1+). Nuclear transcription assays confirmed that cys-3+ was under sulfur-regulated transcriptional control and that cys-3+ transcription was constituti...

journal_title：Molecular and cellular biology

authors： Paietta JV

更新日期：1992-04-01 00:00:00

abstract：:Previously, we described a retrovirus vector that contained two genes: a 5' gene under transcriptional control of the viral long terminal repeat and a 3' gene under transcriptional control of the herpes simplex virus thymidine kinase promoter. By using a biological assay, we found that expression of the 5' gene is sup...

journal_title：Molecular and cellular biology

authors： Emerman M,Temin HM

更新日期：1986-03-01 00:00:00

abstract：:Recent studies showed that cyclophilin A (CypA) promotes NF-κB/p65 nuclear translocation, resulting in enhanced NF-κB activity and altered expression of its target genes, such as the Sox9 transcriptional factor, which plays a critical role in chondrogenic differentiation and endochondral ossification. In this report, ...

journal_title：Molecular and cellular biology

authors： Guo M,Shen J,Kwak JH,Choi B,Lee M,Hu S,Zhang X,Ting K,Soo CB,Chiu RH

更新日期：2015-06-01 00:00:00

abstract：:Little is known about the posttranslational control of the cyclin-dependent protein kinase (CDK) inhibitor p21. We describe here a transient phosphorylation of p21 in the G2/M phase. G2/M-phosphorylated p21 is short-lived relative to hypophosphorylated p21. p21 becomes nuclear during S phase, prior to its phosphorylat...

journal_title：Molecular and cellular biology

authors： Dash BC,El-Deiry WS

更新日期：2005-04-01 00:00:00

abstract：:During Xenopus development, the synthesis of ribosomal proteins is regulated at the translational level. To identify the region of the ribosomal protein mRNAs responsible for their typical translational behavior, we constructed a fused gene in which the upstream sequences (promoter) and the 5' untranslated sequence (f...

journal_title：Molecular and cellular biology

authors： Mariottini P,Amaldi F

更新日期：1990-02-01 00:00:00

abstract：:Transcriptional activation by nuclear hormone receptors is mediated by the 160-kDa family of nuclear receptor coactivators. These coactivators associate with DNA-bound nuclear receptors and transmit activating signals to the transcription machinery through two activation domains. In screening for mammalian proteins th...

journal_title：Molecular and cellular biology

authors： Huang SM,Stallcup MR

更新日期：2000-03-01 00:00:00

abstract：:Activation of adult myoblasts called satellite cells during muscle degeneration is an important aspect of muscle regeneration. Satellite cells are believed to be the only myogenic stem cells in adult skeletal muscle and the source of regenerating muscle fibers. Upon activation, satellite cells proliferate, migrate to ...

journal_title：Molecular and cellular biology

authors： Taylor JM,Dupont-Versteegden EE,Davies JD,Hassell JA,Houlé JD,Gurley CM,Peterson CA

更新日期：1997-09-01 00:00:00

abstract：:First characterized in Trypanosoma brucei, the spliced leader-associated (SLA) RNA gene locus has now been isolated from the kinetoplastids Leishmania tarentolae and Trypanosoma cruzi. In addition to the T. brucei SLA RNA, both L. tarentolae and T. cruzi SLA RNA repeat units also yield RNAs of 75 or 76 nucleotides (nt...

journal_title：Molecular and cellular biology

authors： Roberts TG,Sturm NR,Yee BK,Yu MC,Hartshorne T,Agabian N,Campbell DA

更新日期：1998-08-01 00:00:00

abstract：:As a prominent characteristic of cell life, the regulation of cell quiescence is important for proper development, regeneration, and stress resistance and may play a role in certain degenerative diseases. However, the mechanism underlying quiescence remains largely unknown. Encysted embryos of Artemia are useful for s...

journal_title：Molecular and cellular biology

authors： Dai L,Ye S,Li HW,Chen DF,Wang HL,Jia SN,Lin C,Yang JS,Yang F,Nagasawa H,Yang WJ

更新日期：2017-03-17 00:00:00

abstract：:Kss1 and Fus3 are mitogen-activated protein kinases (MAPKs or ERKs), and Ste7 is their activating MAPK/ERK kinase (MEK), in the pheromone response pathway of Saccharomyces cerevisiae. To investigate the potential role of specific interactions between these enzymes during signaling, their ability to associate with each...

journal_title：Molecular and cellular biology

authors： Bardwell L,Cook JG,Chang EC,Cairns BR,Thorner J

更新日期：1996-07-01 00:00:00

abstract：:Viruses have developed numerous strategies to counteract the host cell defense. Kaposi's sarcoma-associated herpesvirus (KSHV) is a DNA tumor virus linked to the development of Kaposi's sarcoma, Castleman's disease, and primary effusion lymphoma (PEL). The virus-encoded viral interferon regulatory factor 3 (vIRF-3) ge...

journal_title：Molecular and cellular biology

authors： Baresova P,Musilova J,Pitha PM,Lubyova B

更新日期：2014-02-01 00:00:00

abstract：:Transcriptional silencing at the budding yeast silent mating type (HM) loci and telomeric DNA regions requires Sir2, a conserved NAD-dependent histone deacetylase, Sir3, Sir4, histones H3 and H4, and several DNA-binding proteins. Silencing at the yeast ribosomal DNA (rDNA) repeats requires a complex containing Sir2, N...

journal_title：Molecular and cellular biology

authors： Hoppe GJ,Tanny JC,Rudner AD,Gerber SA,Danaie S,Gygi SP,Moazed D

更新日期：2002-06-01 00:00:00

abstract：:The erythropoietin (Epo) gene is under tissue-specific inducible regulation. Because the kidney is the primary EPO-producing tissue in adults, impaired EPO production in chronic kidney disorders results in serious renal anemia. The Epo gene contains a liver-specific enhancer in the 3' region, but the kidney-specific e...

journal_title：Molecular and cellular biology

authors： Hirano I,Suzuki N,Yamazaki S,Sekine H,Minegishi N,Shimizu R,Yamamoto M

更新日期：2017-02-01 00:00:00