Inheritance of extrachromosomal rDNA in Physarum polycephalum.

abstract：:Growth differentiation factor 15 (GDF15) is a secreted protein with pleotropic functions from the transforming growth factor β (TGF-β) family. GDF15 is synthesized as a precursor and undergoes proteolytic cleavage to generate mature GDF15. The strong appetite-suppressing effect of mature GDF15 makes it an attractive t...

journal_title：Molecular and cellular biology

authors： Li JJ,Liu J,Lupino K,Liu X,Zhang L,Pei L

更新日期：2018-10-15 00:00:00

abstract：:Endothelial cells differentiate from mesoderm-derived precursors to initiate the earliest events in vascular development. Although the signaling events that regulate the successive steps of vascular development are known in some detail, the transcriptional processes that regulate the first steps in vasculogenesis are ...

journal_title：Molecular and cellular biology

authors： Wu Y,Moser M,Bautch VL,Patterson C

更新日期：2003-08-01 00:00:00

abstract：:We report in vivo analysis of histone and RNA polymerase II (pol II) occupancy at the 601 element, which functions as a strong in vitro nucleosome-positioning element and transcriptional pause site. Surprisingly, nucleosomes were not strongly positioned over the 601 element inserted either within a yeast chromosomal o...

journal_title：Molecular and cellular biology

authors： Perales R,Zhang L,Bentley D

更新日期：2011-08-01 00:00:00

abstract：:The action of insulin to recruit the intracellular GLUT4 glucose transporter to the plasma membrane of 3T3-L1 adipocytes is mimicked by endothelin 1, which signals through trimeric G(alpha)q or G(alpha)11 proteins. Here we report that murine G(alpha)11 is most abundant in fat and that expression of the constitutively ...

journal_title：Molecular and cellular biology

authors： Bose A,Cherniack AD,Langille SE,Nicoloro SM,Buxton JM,Park JG,Chawla A,Czech MP

更新日期：2001-08-01 00:00:00

abstract：:The yeast Mcm1 protein is a member of the MADS box family of transcriptional regulatory factors, a class of DNA-binding proteins that control numerous cellular and developmental processes in yeast, Drosophila melanogaster, plants, and mammals. Although these proteins bind DNA on their own, they often combine with diff...

journal_title：Molecular and cellular biology

authors： Mead J,Bruning AR,Gill MK,Steiner AM,Acton TB,Vershon AK

更新日期：2002-07-01 00:00:00

abstract：:We evaluated the extent to which muscle-specific genes display identical patterns of mRNA accumulation during human myogenesis. Cloned satellite cells isolated from adult human skeletal muscle were expanded in culture, and RNA was isolated from low- and high-confluence cells and from fusing cultures over a 15-day time...

journal_title：Molecular and cellular biology

authors： Gunning P,Hardeman E,Wade R,Ponte P,Bains W,Blau HM,Kedes L

更新日期：1987-11-01 00:00:00

abstract：:The onc gene (v-fes) of the acutely transforming feline sarcoma virus (Snyder-Theilen strain) has homologous cellular sequences (c-fes) in all vertebrate species, including humans. We isolated from a human DNA library recombinant phages containing overlapping c-fes sequences. The human c-fes locus spans a region of 3....

journal_title：Molecular and cellular biology

authors： Franchini G,Gelmann EP,Dalla-Favera R,Gallo RC,Wong-Staal F

更新日期：1982-08-01 00:00:00

abstract：:In mast cells, antigen-mediated aggregation of the high-affinity receptor for immunoglobulin E, Fc epsilon RI, stimulates tyrosine phosphorylation and activation of multiple signaling pathways leading to the release of several classes of mediators of the allergic response. Early events induced upon cross-linking of Fc...

journal_title：Molecular and cellular biology

authors： Rivera VM,Brugge JS

更新日期：1995-03-01 00:00:00

abstract：:Several nonphotoautotrophic mutants of Chlamydomonas reinhardtii were generated by transforming strain nit1-305 (cw 15) with exogenous DNA. An enrichment for potential photophosphorylation mutants was performed on medium containing arsenate, and acetate-requiring auxotrophs were then identified by replica plating. Str...

journal_title：Molecular and cellular biology

authors： Smart EJ,Selman BR

更新日期：1991-10-01 00:00:00

abstract：:The human and murine MOK2 ortholog genes that are preferentially expressed in brain and testis tissues encode two different Krüppel-like zinc finger proteins. In this paper, we show that the MOK2 proteins are mainly associated with nuclear ribonucleoprotein components, including the nucleoli and extranucleolar structu...

journal_title：Molecular and cellular biology

authors： Arranz V,Harper F,Florentin Y,Puvion E,Kress M,Ernoult-Lange M

更新日期：1997-04-01 00:00:00

abstract：:The murine int-1 proto-oncogene has been implicated in neural development and, when transcriptionally activated by mouse mammary tumor virus, contributes to the genesis of mammary tumors. To understand the function of the int-1 gene product in these processes, we have characterized the biochemical properties of int-1 ...

journal_title：Molecular and cellular biology

authors： Papkoff J,Schryver B

更新日期：1990-06-01 00:00:00

abstract：:To examine the functional role of the interaction between Munc18c and syntaxin 4 in the regulation of GLUT4 translocation in 3T3L1 adipocytes, we assessed the effects of introducing three different peptide fragments (20 to 24 amino acids) of Munc18c from evolutionarily conserved regions of the Sec1 protein family pred...

journal_title：Molecular and cellular biology

authors： Thurmond DC,Kanzaki M,Khan AH,Pessin JE

更新日期：2000-01-01 00:00:00

abstract：:Nutritional excess and/or obesity represent well-known predisposition factors for the development of non-insulin-dependent diabetes mellitus (NIDDM). However, molecular links between obesity and NIDDM are only beginning to emerge. Here, we demonstrate that nutrients suppress phosphatidylinositol 3 (PI3)-kinase/Akt sig...

journal_title：Molecular and cellular biology

authors： Tzatsos A,Kandror KV

更新日期：2006-01-01 00:00:00

abstract：:Considering the link between plasma high-density lipoprotein (HDL) cholesterol levels and a protective effect against coronary artery disease as well as the suggested beneficial effects of retinoids on the production of the major HDL apolipoprotein (apo), apo A-I, the goal of this study was to analyze the influence of...

journal_title：Molecular and cellular biology

authors： Vu-Dac N,Schoonjans K,Kosykh V,Dallongeville J,Heyman RA,Staels B,Auwerx J

更新日期：1996-07-01 00:00:00

abstract：:Microtubules in yeast are essential components of the mitotic and meiotic spindles and are essential for nuclear movement during cell division and mating. The relative importance in these processes of the two divergent alpha-tubulin genes of the budding yeast Saccharomyces cerevisiae, TUB1 and TUB3, was examined throu...

journal_title：Molecular and cellular biology

authors： Schatz PJ,Solomon F,Botstein D

更新日期：1986-11-01 00:00:00

abstract：:We have partially purified a nuclear protein (PPT) from Physarum polycephalum that binds to the extrachromosomal ribosomal DNA telomeres of this acellular slime mold. Binding is specific for the (T2AG3)n telomere repeats, as evidenced by nitrocellulose filter binding assays, by gel mobility shift assays with both DNA ...

journal_title：Molecular and cellular biology

authors： Coren JS,Epstein EM,Vogt VM

更新日期：1991-04-01 00:00:00

abstract：:Protein kinase GCN2 is a multidomain protein that contains a region homologous to histidyl-tRNA synthetases juxtaposed to the kinase catalytic moiety. Previous studies have shown that in response to histidine starvation, GCN2 phosphorylates eukaryotic initiation factor 2 (eIF-2), to induce the translational expression...

journal_title：Molecular and cellular biology

authors： Wek SA,Zhu S,Wek RC

更新日期：1995-08-01 00:00:00

abstract：:The nuclear factor of activated T cells (NFAT) regulates cytokine gene expression in T cells through cis-acting elements located in the promoters of cytokine genes. Here, we report the cDNA cloning, chromosomal localization, and initial characterization of a transcription factor related to NFATp and NFATc. The novel m...

journal_title：Molecular and cellular biology

authors： Masuda ES,Naito Y,Tokumitsu H,Campbell D,Saito F,Hannum C,Arai K,Arai N

更新日期：1995-05-01 00:00:00

abstract：:GCN4 encodes a transcriptional activator of amino acid biosynthetic genes in Saccharomyces cerevisiae. The GCN3 product is a positive regulator required for increased synthesis of GCN4 protein in amino acid-starved cells. GCN3 appears to act indirectly by antagonizing GCD-encoded negative regulators of GCN4 expression...

journal_title：Molecular and cellular biology

authors： Hannig EM,Hinnebusch AG

更新日期：1988-11-01 00:00:00

abstract：:Cellular senescence is an irreversible growth arrest and is presumed to be a natural barrier to tumor development. Like telomere shortening, certain defects in chromosome integrity can trigger senescence; however, the roles of centromere proteins in regulating commitment to the senescent state remains to be establishe...

journal_title：Molecular and cellular biology

authors： Maehara K,Takahashi K,Saitoh S

更新日期：2010-05-01 00:00:00

abstract：:Vascular smooth muscle cells (vSMCs) are key in the regulation of blood pressure and the engagement of vascular pathologies, such as hypertension, arterial remodeling, and neointima formation. The role of the Rac1 GTPase in these cells remains poorly characterized. To clarify this issue, we have utilized genetically e...

journal_title：Molecular and cellular biology

authors： Fabbiano S,Menacho-Márquez M,Sevilla MA,Albarrán-Juárez J,Zheng Y,Offermanns S,Montero MJ,Bustelo XR

更新日期：2014-12-01 00:00:00

abstract：:Trabecular myocardium accounts for the majority of the ventricles during early cardiogenesis, but compact myocardium is the primary component at later developmental stages. Elucidation of the genes regulating compact myocardium development is essential to increase our understanding of left ventricular noncompaction (L...

journal_title：Molecular and cellular biology

authors： Kosaka Y,Cieslik KA,Li L,Lezin G,Maguire CT,Saijoh Y,Toyo-oka K,Gambello MJ,Vatta M,Wynshaw-Boris A,Baldini A,Yost HJ,Brunelli L

更新日期：2012-12-01 00:00:00

abstract：:With v-yes DNA as the probe, a human cDNA library made from placental RNA was screened under relaxed conditions, and DNA clones derived from a novel genetic locus, termed lyn, were obtained. Nucleotide sequencing revealed that lyn could encode a novel tyrosine kinase that was very similar to mouse T-lymphocyte-specifi...

journal_title：Molecular and cellular biology

authors： Yamanashi Y,Fukushige S,Semba K,Sukegawa J,Miyajima N,Matsubara K,Yamamoto T,Toyoshima K

更新日期：1987-01-01 00:00:00

abstract：:Rad23 and Rpn10 play synergistic roles in the recognition of ubiquitinated proteins by the proteasome, and loss of both proteins causes growth and proteolytic defects. However, the physiological targets of Rad23 and Rpn10 have not been well defined. We report that rad23Delta rpn10Delta is unable to grow in the presenc...

journal_title：Molecular and cellular biology

authors： Chuang SM,Chen L,Lambertson D,Anand M,Kinzy TG,Madura K

更新日期：2005-01-01 00:00:00

abstract：:TFIID is a multiprotein complex consisting of the TATA box binding protein and multiple tightly associated proteins (TAFIIs) that are required for transcription by selected activators. We previously reported cloning and partial characterization of human TAFII130 (hTAFII130). The central domain of hTAFII130 contains fo...

journal_title：Molecular and cellular biology

authors： Saluja D,Vassallo MF,Tanese N

更新日期：1998-10-01 00:00:00

abstract：:Negative-feedback loops between transcription factors and repressors in responses to xenobiotics, oxidants, heat, hypoxia, DNA damage, and infection have been described. Although common, the function of feedback is largely unstudied. Here, we define a negative-feedback loop between the Caenorhabditis elegans detoxific...

journal_title：Molecular and cellular biology

authors： Leung CK,Wang Y,Deonarine A,Tang L,Prasse S,Choe KP

更新日期：2013-09-01 00:00:00

abstract：:Galanin is a neuropeptide implicated in the regulation of feeding, reproduction, cognition, nociception, and seizure susceptibility. There are three known galanin receptor (GALR) subtypes (GALR1, GALR2, and GALR3), which bind to galanin with different affinities and have their own unique distributions, signaling mecha...

journal_title：Molecular and cellular biology

authors： Gottsch ML,Zeng H,Hohmann JG,Weinshenker D,Clifton DK,Steiner RA

更新日期：2005-06-01 00:00:00

abstract：:An accumulation in cells of unfolded proteins is believed to be the common signal triggering the induction of heat shock proteins (hsps). Accordingly, in Saccharomyces cerevisiae, inhibition of protein breakdown at 30 degrees C with the proteasome inhibitor MG132 caused a coordinate induction of many heat shock protei...

journal_title：Molecular and cellular biology

authors： Lee DH,Goldberg AL

更新日期：1998-01-01 00:00:00

abstract：:Recognition of gene promoters by RNA polymerase II is mediated by general transcription factor IID (TFIID), which has been thought to be a static complex and to play a passive role in the regulation of gene expression under the instruction of gene-specific transcription factors. Here we show that transforming growth f...

journal_title：Molecular and cellular biology

authors： Nakagawa T,Hosogane M,Nakagawa M,Morohoshi A,Funayama R,Nakayama K

更新日期：2018-02-12 00:00:00

abstract：:Nonhistone chromosomal proteins HMG-14 and HMG-17 are closely related nucleosomal binding proteins that unfold the higher-order chromatin structure, thereby enhancing the transcription and replication potential of chromatin. Here we report that PCAF, a transcription coactivator with intrinsic histone acetyltransferase...

journal_title：Molecular and cellular biology

authors： Herrera JE,Sakaguchi K,Bergel M,Trieschmann L,Nakatani Y,Bustin M

更新日期：1999-05-01 00:00:00