Chromosomal elements regulate gene activity and chromatin structure of the human serpin gene cluster at 14q32.1.

abstract：:alpha 1-Antitrypsin (AT), the major elastase inhibitor in mammalian serum, is produced primarily in the liver. We have characterized AT gene structure and expression in the mouse species Mus caroli, which expresses high levels of AT in the kidneys as well as in the liver. Analysis of cDNA and genomic clones showed tha...

journal_title：Molecular and cellular biology

authors： Latimer JJ,Berger FG,Baumann H

更新日期：1990-02-01 00:00:00

abstract：:Yeast cells containing the recessive mas3 mutation display temperature-sensitive defects in both mitochondrial protein import and the cell division cycle. The import defect is characterized by two pools of mitochondrial precursors and a dramatically slower rate of posttranslational import. The effect of mas3 on cell c...

journal_title：Molecular and cellular biology

authors： Smith BJ,Yaffe MP

更新日期：1991-05-01 00:00:00

abstract：:Cell polarity plays a critical role in the development of all metazoans; however, the mechanisms of cell polarity and the specific role of cell polarity pathways in mammalian organisms are still poorly understood. Lethal giant larvae (Lgl) is an apical-basal polarity gene identified in Drosophila, where it functions a...

journal_title：Molecular and cellular biology

authors： Sripathy S,Lee M,Vasioukhin V

更新日期：2011-07-01 00:00:00

abstract：:The extracellular signal-regulated kinase 1 and 2 (ERK1/2) mitogen-activated protein (MAP) kinase signaling pathway plays an important role in the proliferative response of mammalian cells to mitogens. However, the individual contribution of the isoforms ERK1 and ERK2 to cell proliferation control is unclear. The two ...

journal_title：Molecular and cellular biology

authors： Voisin L,Saba-El-Leil MK,Julien C,Frémin C,Meloche S

更新日期：2010-06-01 00:00:00

abstract：:Oxygen radicals regulate many physiological processes, such as signaling, proliferation, and apoptosis, and thus play a pivotal role in pathophysiology and disease development. There are at least two thioredoxin reductase/thioredoxin/peroxiredoxin systems participating in the cellular defense against oxygen radicals. ...

journal_title：Molecular and cellular biology

authors： Conrad M,Jakupoglu C,Moreno SG,Lippl S,Banjac A,Schneider M,Beck H,Hatzopoulos AK,Just U,Sinowatz F,Schmahl W,Chien KR,Wurst W,Bornkamm GW,Brielmeier M

更新日期：2004-11-01 00:00:00

abstract：:Retinoic acid is known to have profound effects on developmental processes. It has been implicated as a putative morphogen in the developing chick limb bud and regenerating amphibian limb blastema and has been demonstrated to have powerful teratogenic effects in mammals, including humans. Recently, three specific reti...

journal_title：Molecular and cellular biology

authors： Giguère V,Shago M,Zirngibl R,Tate P,Rossant J,Varmuza S

更新日期：1990-05-01 00:00:00

abstract：:The c-abl protooncogene is unusual in two respects; it has multiple, widely space N-terminal coding exons transcribed by different promoters, and it is the target of the translocations that form the Philadelphia chromosome found in cells of chronic myelogenous leukemia patients. To understand the organization of the g...

journal_title：Molecular and cellular biology

authors： Bernards A,Rubin CM,Westbrook CA,Paskind M,Baltimore D

更新日期：1987-09-01 00:00:00

abstract：:The yeast alpha-factor pheromone receptor is a member of the G-protein-coupled receptor family. Limited trypsin digestion of yeast membranes was used to investigate ligand-induced conformational changes in this receptor. The agonist, alpha-factor, accelerated cleavage in the third intracellular loop, whereas the antag...

journal_title：Molecular and cellular biology

authors： Büküşoğlu G,Jenness DD

更新日期：1996-09-01 00:00:00

abstract：:Insulin stimulates glucose transport into fat and muscle cells by increasing the exocytic trafficking rate of the GLUT4 facilitative glucose transporter from intracellular stores to the plasma membrane. Delivery of GLUT4 to the plasma membrane is mediated by formation of functional SNARE complexes containing syntaxin4...

journal_title：Molecular and cellular biology

authors： Kioumourtzoglou D,Gould GW,Bryant NJ

更新日期：2014-04-01 00:00:00

abstract：:HMGN proteins promote chromatin unfolding, enhance access to nucleosomes, and modulate transcription from chromatin templates. It is not known whether they act indiscriminately as general modulators of transcription or whether they regulate specific gene expression. Here, we investigated the role of HMGN3, a recently ...

journal_title：Molecular and cellular biology

authors： West KL,Castellini MA,Duncan MK,Bustin M

更新日期：2004-05-01 00:00:00

abstract：:During the functional analysis of open reading frames (ORFs) identified during the sequencing of chromosome III of Saccharomyces cerevisiae, the previously uncharacterized ORF YCL031C (now designated RRP7) was deleted. RRP7 is essential for cell viability, and a conditional null allele was therefore constructed, by pl...

journal_title：Molecular and cellular biology

authors： Baudin-Baillieu A,Tollervey D,Cullin C,Lacroute F

更新日期：1997-09-01 00:00:00

abstract：:Hox11 is a homeobox gene essential for spleen formation in mice, since atrophy of the anlage of a developing spleen occurs in early embryonic development in Hox11 null mice. HOX11 is also expressed in a subset of T-cell acute leukemias after specific chromosomal translocations. Since the protein has a homeodomain and ...

journal_title：Molecular and cellular biology

authors： Greene WK,Bahn S,Masson N,Rabbitts TH

更新日期：1998-12-01 00:00:00

abstract：:The O-linked N-acetylglucosamine (O-GlcNAc) modification of proteins is dynamic and abundant in the nucleus and cytosol. Several transcription factors, including Sp1, have been shown to contain this modification; however, the functional role of O-GlcNAc in these proteins has not been determined. In this paper we descr...

journal_title：Molecular and cellular biology

authors： Roos MD,Su K,Baker JR,Kudlow JE

更新日期：1997-11-01 00:00:00

abstract：:Sphingolipid metabolism is implicated to play an important role in apoptosis. Here we show that dihydrosphingosine (DHS) and phytosphingosine (PHS), two major sphingoid bases of fungi, have potent fungicidal activity with remarkably high structural and stereochemical specificity against Aspergillus nidulans. In fact, ...

journal_title：Molecular and cellular biology

authors： Cheng J,Park TS,Chio LC,Fischl AS,Ye XS

更新日期：2003-01-01 00:00:00

abstract：:The human genome contains a number of methyl CpG binding proteins that translate DNA methylation into a physiological response. To gain insight into the function of MBD2 and MBD3, we first applied protein tagging and mass spectrometry. We show that MBD2 and MBD3 assemble into mutually exclusive distinct Mi-2/NuRD-like...

journal_title：Molecular and cellular biology

authors： Le Guezennec X,Vermeulen M,Brinkman AB,Hoeijmakers WA,Cohen A,Lasonder E,Stunnenberg HG

更新日期：2006-02-01 00:00:00

abstract：:The observation that transcriptionally active genes generally replicate early in S phase and observations of the interaction between transcription factors and replication proteins support the thesis that promoter elements may have a role in DNA replication. To test the relationship between transcription and replicatio...

journal_title：Molecular and cellular biology

authors： Ghosh M,Liu G,Randall G,Bevington J,Leffak M

更新日期：2004-12-01 00:00:00

abstract：:Chicken embryo fibroblast cells overexpressing activated mutant forms of human pp60c-src, but not those overexpressing normal human pp60c-src, exhibited high levels of type I phosphatidylinositol (PI) kinase activity associated with pp60c-src. Levels of PI kinase activity were positively correlated with src tyrosine p...

journal_title：Molecular and cellular biology

authors： Chan TO,Tanaka A,Bjorge JD,Fujita DJ

更新日期：1990-06-01 00:00:00

abstract：:The MyoD gene can orchestrate the expression of the skeletal muscle differentiation program. We have identified the regions of the gene necessary to reproduce transcription specific to skeletal myoblasts and myotubes. A proximal regulatory region (PRR) contains a conserved TATA box, a CCAAT box, and a GC-rich region t...

journal_title：Molecular and cellular biology

authors： Tapscott SJ,Lassar AB,Weintraub H

更新日期：1992-11-01 00:00:00

abstract：:Checkpoints prevent inaccurate chromosome segregation by inhibiting cell division when errors in mitotic processes are encountered. We used a temperature-sensitive mutation, dbf4, to examine the requirement for DNA replication in establishing mitotic checkpoint arrest. We used gamma-irradiation to induce DNA damage an...

journal_title：Molecular and cellular biology

authors： Tavormina PA,Wang Y,Burke DJ

更新日期：1997-06-01 00:00:00

abstract：:Plk is a mammalian serine/threonine protein kinase whose activity peaks at the onset of M phase. It is closely related to other mammalian kinases, Snk, Fnk, and Prk, as well as to Xenopus laevis Plx1, Drosophila melanogaster polo, Schizosaccharomyces pombe Plo1, and Saccharomyces cerevisiae Cdc5. The M phase of the ce...

journal_title：Molecular and cellular biology

authors： Lee KS,Erikson RL

更新日期：1997-06-01 00:00:00

abstract：:The 3' poly(A) tail of eukaryotic mRNAs and the poly(A) binding protein (PABP) play important roles in the regulation of translation. Recently, a human PABP-interacting protein, Paip2, which disrupts the PABP-poly(A) interaction and consequently inhibits translation, was described. To gain insight into the biological ...

journal_title：Molecular and cellular biology

authors： Roy G,Miron M,Khaleghpour K,Lasko P,Sonenberg N

更新日期：2004-02-01 00:00:00

abstract：:To understand the function of SPT13, a gene encoding a trans-acting factor involved in regulation of Ty-mediated gene expression, we have cloned and sequenced the gene. Our analysis revealed that SPT13 is the same gene as GAL11, a gene in which mutations cause reduced expression of some GAL4-regulated genes. Further a...

journal_title：Molecular and cellular biology

authors： Fassler JS,Winston F

更新日期：1989-12-01 00:00:00

abstract：:Regulated transcription of class II genes of the yeast Saccharomyces cerevisiae requires the diverse functions of mediator complex. In particular, MED6 is essential for activated transcription from many class II promoters, suggesting that it functions as a key player in the relay of activator signals to the basal tran...

journal_title：Molecular and cellular biology

authors： Lee YC,Kim YJ

更新日期：1998-09-01 00:00:00

abstract：:We have characterized the role of YPR128cp, the orthologue of human PMP34, in fatty acid metabolism and peroxisomal proliferation in Saccharomyces cerevisiae. YPR128cp belongs to the mitochondrial carrier family (MCF) of solute transporters and is localized in the peroxisomal membrane. Disruption of the YPR128c gene r...

journal_title：Molecular and cellular biology

authors： van Roermund CW,Drissen R,van Den Berg M,Ijlst L,Hettema EH,Tabak HF,Waterham HR,Wanders RJ

更新日期：2001-07-01 00:00:00

abstract：:The TIS11 primary response gene is rapidly and transiently induced by both 12-O-tetradecanoylphorbol-13-acetate and growth factors. The predicted TIS11 protein contains a 6-amino-acid repeat, YKTELC. We cloned two additional cDNAs, TIS11b and TIS11d, that contain the YKTELC sequence. TIS11, TIS11b, and TIS11d proteins...

journal_title：Molecular and cellular biology

authors： Varnum BC,Ma QF,Chi TH,Fletcher B,Herschman HR

更新日期：1991-03-01 00:00:00

abstract：:Negative elongation factor (NELF) is a human transcription factor complex that cooperates with DRB sensitivity-inducing factor (DSIF)/hSpt4-hSpt5 to repress elongation by RNA polymerase II (RNAPII). NELF activity is associated with five polypeptides, including NELF-A, a candidate gene product for Wolf-Hirschhorn syndr...

journal_title：Molecular and cellular biology

authors： Yamaguchi Y,Inukai N,Narita T,Wada T,Handa H

更新日期：2002-05-01 00:00:00

abstract：:The upstream activating sequence of the adjacent and divergently transcribed GAL1 and GAL10 genes of Saccharomyces cerevisiae (UASG) contains at least three distinct classes of overlapping transcriptional control sites. The transcription activator GAL4 binds to four related sites in UASG and induces expression of GAL1...

journal_title：Molecular and cellular biology

authors： Finley RL Jr,West RW Jr

更新日期：1989-10-01 00:00:00

abstract：:We demonstrate that ATF3, a member of the ATF/CREB family of transcription factors, is induced in a variety of stressed tissues: mechanically injured liver, toxin-injured liver, blood-deprived heart, and postseizure brain. We also demonstrate that an ATF3-interacting protein, gadd153/Chop10, forms a nonfunctional hete...

journal_title：Molecular and cellular biology

authors： Chen BP,Wolfgang CD,Hai T

更新日期：1996-03-01 00:00:00

abstract：:E6-AP is a 100-kDa cellular protein that mediates the interaction of the human papillomavirus type 16 and 18 E6 proteins with p53. The association of p53 with E6 and E6-AP promotes the specific ubiquitination and subsequent proteolytic degradation of p53 in vitro. We recently isolated a cDNA encoding E6-AP and have no...

journal_title：Molecular and cellular biology

authors： Huibregtse JM,Scheffner M,Howley PM

更新日期：1993-08-01 00:00:00

abstract：:ICP4 of herpes simplex virus is responsible for the activation of viral transcription during infection. It also efficiently activates and represses transcription in vitro depending on the promoter context. The contacts made between ICP4 and the cellular proteins that result in activated transcription have not been ide...

journal_title：Molecular and cellular biology

authors： Carrozza MJ,DeLuca NA

更新日期：1996-06-01 00:00:00