A novel c-fgr exon utilized in Epstein-Barr virus-infected B lymphocytes but not in normal monocytes.

abstract：:Kinase-negative mutants of S49 mouse lymphoma cells, which lack detectable catalytic (C) subunit of cyclic AMP-dependent protein kinase, nevertheless contain cytoplasmic mRNAs for the two major forms of C subunit, C alpha and C beta. Investigation of the metabolism of C subunits in wild-type and mutant cells was under...

journal_title：Molecular and cellular biology

authors： Steinberg RA

更新日期：1991-02-01 00:00:00

abstract：:In Saccharomyces cerevisiae, many amino acid biosynthetic pathways are coregulated by a complex general control system: starvation for a single amino acid results in the derepression of amino acid biosynthetic genes in multiple pathways. Derepression of these genes is mediated by positive (GCN) and negative (GCD) regu...

journal_title：Molecular and cellular biology

authors： Myers PL,Skvirsky RC,Greenberg ML,Greer H

更新日期：1986-09-01 00:00:00

abstract：:In yeast, the pheromone alpha-factor acts as an antiproliferative factor that induces G1 arrest and cellular differentiation. Previous data have indicated that Far1, a factor dedicated to pheromone-induced cell cycle arrest, is under positive and negative posttranslational regulation. Phosphorylation by the pheromone-...

journal_title：Molecular and cellular biology

authors： Gartner A,Jovanović A,Jeoung DI,Bourlat S,Cross FR,Ammerer G

更新日期：1998-07-01 00:00:00

abstract：:The serine/threonine kinase Akt is a component of many receptor signal transduction pathways and can prevent cell death following growth factor withdrawal. Here, we show that Akt inhibition of cell death is not dependent on new protein translation. Instead, Akt inhibition of cell death requires glucose hydrolysis thro...

journal_title：Molecular and cellular biology

authors： Rathmell JC,Fox CJ,Plas DR,Hammerman PS,Cinalli RM,Thompson CB

更新日期：2003-10-01 00:00:00

abstract：:The rad18 gene of Schizosaccharomyces pombe is an essential gene that is involved in several different DNA repair processes. Rad18 (Smc6) is a member of the structural maintenance of chromosomes (SMC) family and, together with its SMC partner Spr18 (Smc5), forms the core of a high-molecular-weight complex. We show her...

journal_title：Molecular and cellular biology

authors： Sergeant J,Taylor E,Palecek J,Fousteri M,Andrews EA,Sweeney S,Shinagawa H,Watts FZ,Lehmann AR

更新日期：2005-01-01 00:00:00

abstract：:In CBFbeta-SMMHC, core binding factor beta (CBFbeta) is fused to the alpha-helical rod domain of smooth muscle myosin heavy chain (SMMHC). We generated Ba/F3 hematopoietic cells expressing a CBFbeta-SMMHC variant lacking 28 amino acids homologous to the assembly competence domain (ACD) required for multimerization of ...

journal_title：Molecular and cellular biology

authors： Kummalue T,Lou J,Friedman AD

更新日期：2002-12-01 00:00:00

abstract：:Treatment of WEHI 231 immature B-lymphoma cells with an antibody against their surface immunoglobulin (anti-Ig) induces apoptosis and has been studied extensively as a model of B-cell tolerance. Anti-Ig treatment of exponentially growing WEHI 231 cells results in an early transient increase in c-myc expression that is...

journal_title：Molecular and cellular biology

authors： Wu M,Arsura M,Bellas RE,FitzGerald MJ,Lee H,Schauer SL,Sherr DH,Sonenshein GE

更新日期：1996-09-01 00:00:00

abstract：:Two alternative exons, BEK and K-SAM, code for part of the ligand binding site of fibroblast growth factor receptor 2. Splicing of these exons is mutually exclusive, and the choice between them is made in a tissue-specific manner. We identify here pre-mRNA sequences involved in controlling splicing of the K-SAM exon. ...

journal_title：Molecular and cellular biology

authors： Del Gatto F,Breathnach R

更新日期：1995-09-01 00:00:00

abstract：:The ubiquitin-proteasome pathway (UPP) is involved in regulation of multiple cellular processes. Hypoxia-inducible factor 1 alpha (HIF-1 alpha) is a prototypic target of the UPP and, as such, is stabilized under conditions of proteasomal inhibition. Using carbonic anhydrase IX (CAIX) and vascular endothelial growth fa...

journal_title：Molecular and cellular biology

authors： Kaluz S,Kaluzová M,Stanbridge EJ

更新日期：2006-08-01 00:00:00

abstract：:Irradiated mice reconstituted with bone marrow cells infected with a retrovirus carrying the bcr-abl oncogene of human chronic myeloid leukemia are subject to a range of neoplastic hematopoietic diseases, both myeloid and lymphoid. Comparison of DBA/2 and C57BL/6 mice has revealed a marked strain difference in suscept...

journal_title：Molecular and cellular biology

authors： Elefanty AG,Cory S

更新日期：1992-04-01 00:00:00

abstract：:The interaction of the retinoblastoma susceptibility gene product (Rb)-related p107 protein with the E2F transcription factor in S-phase cells facilitates the formation of a multicomponent complex also containing cyclin A and the p33cdk2 kinase. We have created a series of p107 mutants to assess the ability of p107 to...

journal_title：Molecular and cellular biology

authors： Smith EJ,Nevins JR

更新日期：1995-01-01 00:00:00

abstract：:The ribonucleoprotein enzyme telomerase is a specialized reverse transcriptase that synthesizes telomeric DNA by copying a template sequence within the telomerase RNA. Here we analyze the actions of telomerase from Tetrahymena thermophila assembled in vivo with mutated or wild-type telomerase RNA to define further the...

journal_title：Molecular and cellular biology

authors： Gilley D,Blackburn EH

更新日期：1996-01-01 00:00:00

abstract：:Inhibition of mitosis by antimitotic drugs is thought to occur by destruction of microtubules, causing cells to arrest through the action of one or more mitotic checkpoints. We have patterned experiments in the yeast Saccharomyces cerevisiae after recent studies in mammalian cells that demonstrate the effectiveness of...

journal_title：Molecular and cellular biology

authors： Wang Y,Burke DJ

更新日期：1995-12-01 00:00:00

abstract：:The DNA and protein complex known as chromatin is subject to posttranslational modifications (PTMs) that regulate cellular functions such that PTM dysregulation can lead to disease, including cancer. One critical PTM is acetylation/deacetylation, which is being investigated as a means to develop targeted cancer therap...

journal_title：Molecular and cellular biology

authors： Singh M,Bacolla A,Chaudhary S,Hunt CR,Pandita S,Chauhan R,Gupta A,Tainer JA,Pandita TK

更新日期：2020-08-28 00:00:00

abstract：:Calcineurin (Cn) is a calcium-activated serine/threonine protein phosphatase that is broadly implicated in diverse cellular processes, including the regulation of gene expression. During skeletal muscle differentiation, Cn activates the nuclear factor of activated T-cell (NFAT) transcription factor but also promotes d...

journal_title：Molecular and cellular biology

authors： Witwicka H,Nogami J,Syed SA,Maehara K,Padilla-Benavides T,Ohkawa Y,Imbalzano AN

更新日期：2019-09-11 00:00:00

abstract：:The transcriptional coactivator BOB.1/OBF.1 confers B-cell specificity on the transcription factors Oct1 and Oct2 at octamer site-containing promoters. A hallmark of the BOB.1/OBF.1 mutation in the mouse is the absence of germinal center development in secondary lymphoid organs, demonstrating the requirement for BOB.1...

journal_title：Molecular and cellular biology

authors： Hess J,Nielsen PJ,Fischer KD,Bujard H,Wirth T

更新日期：2001-03-01 00:00:00

abstract：:The ADP/ATP translocator, a transmembrane protein of the mitochondrial inner membrane, is coded in Saccharomyces cerevisiae by the nuclear gene PET9. DNA sequence analysis of the PET9 gene showed that it encoded a protein of 309 amino acids which exhibited a high degree of homology with mitochondrial translocator prot...

journal_title：Molecular and cellular biology

authors： Adrian GS,McCammon MT,Montgomery DL,Douglas MG

更新日期：1986-02-01 00:00:00

abstract：:The six human telomeric proteins TRF1, TRF2, RAP1, TIN2, POT1, and TPP1 can form a complex called the telosome/shelterin, which is required for telomere protection and length control. TPP1 has been shown to regulate both POT1 telomere localization and telosome assembly through its binding to TIN2. It remains to be det...

journal_title：Molecular and cellular biology

authors： Chen LY,Liu D,Songyang Z

更新日期：2007-08-01 00:00:00

abstract：:Cell lines established from the lepidopteran insect Spodoptera frugiperda (fall armyworm; Sf9) are used routinely as hosts for the expression of foreign proteins by recombinant baculovirus vectors. We have examined the pathway of protein glycosylation and secretion in these cells, using human tissue plasminogen activa...

journal_title：Molecular and cellular biology

authors： Jarvis DL,Summers MD

更新日期：1989-01-01 00:00:00

abstract：:Nucleoporins mediate transport of macromolecules across the nuclear pore complex, yet the function of many individual nucleoporins is largely unresolved. To address this question, we depleted cells of the cytoplasmic nucleoporins Nup214/CAN and Nup358/RanBP2 by RNA interference. Depletion of Nup214 resulted in codeple...

journal_title：Molecular and cellular biology

authors： Hutten S,Kehlenbach RH

更新日期：2006-09-01 00:00:00

abstract：:Previous analyses defined a proliferating cell nuclear antigen (PCNA) E1A-responsive element (PERE) in the PCNA promoter that is essential for transactivation by the 243-residue product of the adenovirus type 2 E1A 12S mRNA (E1A 243R). In this report, we show that the PERE activates a heterologous basal promoter and c...

journal_title：Molecular and cellular biology

authors： Morris GF,Labrie C,Mathews MB

更新日期：1994-01-01 00:00:00

abstract：:We have investigated the mechanism underlying repression of calcitonin/calcitonin gene-related peptide (CT/CGRP) gene expression by retinoic acid. Retinoic acid treatment of the CA77 thyroid C-cell line decreased CT/CGRP promoter activity two- to threefold, which correlates well with the decrease in calcitonin and CGR...

journal_title：Molecular and cellular biology

authors： Lanigan TM,Tverberg LA,Russo AF

更新日期：1993-10-01 00:00:00

abstract：:The oxidation of methanol follows a well-defined pathway and is similar for several methylotrophic yeasts. The use of methanol as the sole carbon source for the growth of Pichia pastoris stimulates the expression of a family of genes. Three methanol-responsive genes have been isolated; cDNA copies have been made from ...

journal_title：Molecular and cellular biology

authors： Ellis SB,Brust PF,Koutz PJ,Waters AF,Harpold MM,Gingeras TR

更新日期：1985-05-01 00:00:00

abstract：:CD26 is a T-cell costimulatory molecule with dipeptidyl peptidase IV enzyme activity in its extracellular region. We have previously reported that the addition of recombinant soluble CD26 resulted in enhanced proliferation of human T lymphocytes induced by the recall antigen tetanus toxoid (TT) via upregulation of CD8...

journal_title：Molecular and cellular biology

authors： Ohnuma K,Yamochi T,Uchiyama M,Nishibashi K,Iwata S,Hosono O,Kawasaki H,Tanaka H,Dang NH,Morimoto C

更新日期：2005-09-01 00:00:00

abstract：:The Ace2p and Swi5p zinc finger proteins have nearly identical DNA-binding domains, yet in vivo they activate transcription of different genes, CTS1 and HO. We now demonstrate that Ace2p and Swi5p recognize sites in the CTS1 and HO promoters with the same affinities, raising the question of how promoter specificity is...

journal_title：Molecular and cellular biology

authors： Dohrmann PR,Voth WP,Stillman DJ

更新日期：1996-04-01 00:00:00

abstract：:Saccharomyces cerevisiae dbf4 and cdc7 cell cycle mutants block initiation of DNA synthesis (i.e., are iDS mutants) at 37 degrees C and arrest the cell cycle with a 1C DNA content. Surprisingly, certain dbf4 and cdc7 strains divide their chromatin at 37 degrees C. We found that the activation of the Cdc28 mitotic prot...

journal_title：Molecular and cellular biology

authors： Toyn JH,Johnson AL,Johnston LH

更新日期：1995-10-01 00:00:00

abstract：:NF-κB activation is a critical component in the transcriptional response to hypoxia. However, the underlying mechanisms that control its activity under these conditions are unknown. Here we report that under hypoxic conditions, IκB kinase (IKK) activity is induced through a calcium/calmodulin-dependent kinase 2 (CaMK2...

journal_title：Molecular and cellular biology

authors： Culver C,Sundqvist A,Mudie S,Melvin A,Xirodimas D,Rocha S

更新日期：2010-10-01 00:00:00

abstract：:Mutations in the spin gene are characterized by an extraordinarily strong rejection behavior of female flies in response to male courtship. They are also accompanied by decreases in the viability, adult life span, and oviposition rate of the flies. In spin mutants, some oocytes and adult neural cells undergo degenerat...

journal_title：Molecular and cellular biology

authors： Nakano Y,Fujitani K,Kurihara J,Ragan J,Usui-Aoki K,Shimoda L,Lukacsovich T,Suzuki K,Sezaki M,Sano Y,Ueda R,Awano W,Kaneda M,Umeda M,Yamamoto D

更新日期：2001-06-01 00:00:00

abstract：:Heterochromatin protein 1 (HP1) is a conserved chromosomal protein with important roles in chromatin packaging and gene silencing. In fission yeast, two HP1 family proteins, Swi6 and Chp2, are involved in transcriptional silencing at heterochromatic regions, but how they function and whether they act cooperatively or ...

journal_title：Molecular and cellular biology

authors： Sadaie M,Kawaguchi R,Ohtani Y,Arisaka F,Tanaka K,Shirahige K,Nakayama J

更新日期：2008-12-01 00:00:00

abstract：:Although phosphoinositide 3-kinase (PI 3-kinase) is essential for cell cycle progression, the molecular mechanisms that regulate its diverse biological effects are poorly understood. We demonstrate here that Rb, a key regulator of cell cycle progression, associates with p55 kDa (p55alpha and p55gamma) regulatory subun...

journal_title：Molecular and cellular biology

authors： Xia X,Cheng A,Akinmade D,Hamburger AW

更新日期：2003-03-01 00:00:00