Abstract:
BACKGROUND:Endothelial injury plays a critical role in coronary artery disease (CAD), but the assessment of this injury has been problematical. Recently, it has been shown in vitro that endothelial cells (ECs) release endothelial microparticles (EMPs) on activation or apoptosis and that an assay of EMPs can provide useful information on EC status in patients with thrombotic disorders. This study is aimed at assessing possible correlations between EMPs, which are markers of endothelial injury, and clinical subgroups of patients with CAD. METHODS:A prospective, case-controlled study was conducted on 84 patients with CAD and 42 control subjects to investigate EMP profiles. Included were 64 patients with acute coronary syndromes ([ACS], 38 with myocardial infarction [MI] and 26 with unstable angina [UA]) and 20 patients with stable angina (SA). EMPs in platelet-poor plasma were measured flow cytometrically with combinations of fluorescent antibodies (anti-CD31, -51, -42), allowing distinction of EMPs from platelet microparticles (PMPs). Clinical subgroups of patients were correlated with EMP and PMP levels in blood. RESULTS:Two species of EMPs (CD31+ and CD51+) were evaluated. Both were significantly higher in patients with CAD than in control subjects. CD31+ EMP was higher in ACS than SA. Among patients with first MI, CD31+ EMP was higher in patients with MI than in patients with UA and was significantly higher than in patients with recurring MI. CD51+ EMP did not discriminate ACS from SA. A simultaneous assay of PMP showed correlation between EMPs and PMPs. However, PMPs did not discriminate patients with SA from control subjects. CONCLUSIONS:EMP assay appears promising for assessing EC injury in CAD.
journal_name
Am Heart Jjournal_title
American heart journalauthors
Bernal-Mizrachi L,Jy W,Jimenez JJ,Pastor J,Mauro LM,Horstman LL,de Marchena E,Ahn YSdoi
10.1016/S0002-8703(03)00103-0subject
Has Abstractpub_date
2003-06-01 00:00:00pages
962-70issue
6eissn
0002-8703issn
1097-6744pii
S0002870303001030journal_volume
145pub_type
杂志文章abstract:OBJECTIVES:The objective of this study is to assess trends in evidence-based therapy use and short- and long-term mortality over time among older patients with non-ST-segment elevation myocardial infarction (NSTEMI). BACKGROUND:With the prevalence of national quality improvement efforts, the use of evidence-based ther...
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pub_type: 杂志文章,多中心研究
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2015-07-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2008-08-01 00:00:00
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pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:1993-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:2008-08-01 00:00:00
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更新日期:2013-09-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:1991-03-01 00:00:00
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pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2011-07-01 00:00:00
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更新日期:2008-11-01 00:00:00