Abstract：
:This paper presents a novel method for validation of nonrigid medical image registration. This method is based on the simulation of physically plausible, biomechanical tissue deformations using finite-element methods. Applying a range of displacements to finite-element models of different patient anatomies generates model solutions which simulate gold standard deformations. From these solutions, deformed images are generated with a range of deformations typical of those likely to occur in vivo. The registration accuracy with respect to the finite-element simulations is quantified by co-registering the deformed images with the original images and comparing the recovered voxel displacements with the biomechanically simulated ones. The functionality of the validation method is demonstrated for a previously described nonrigid image registration technique based on free-form deformations using B-splines and normalized mutual information as a voxel similarity measure, with an application to contrast-enhanced magnetic resonance mammography image pairs. The exemplar nonrigid registration technique is shown to be of subvoxel accuracy on average for this particular application. The validation method presented here is an important step toward more generic simulations of biomechanically plausible tissue deformations and quantification of tissue motion recovery using nonrigid image registration. It will provide a basis for improving and comparing different nonrigid registration techniques for a diversity of medical applications, such as intrasubject tissue deformation or motion correction in the brain, liver or heart.
journal_name
IEEE Trans Med Imagingjournal_title
IEEE transactions on medical imagingauthors
Schnabel JA,Tanner C,Castellano-Smith AD,Degenhard A,Leach MO,Hose DR,Hill DL,Hawkes DJdoi
10.1109/TMI.2002.808367subject
Has Abstractpub_date
2003-02-01 00:00:00pages
238-47issue
2eissn
0278-0062issn
1558-254Xjournal_volume
22pub_type
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