Factor associated with neutral sphingomyelinase activation and its role in cardiac cell death.

abstract：:Disturbances in cardiac metabolism underlie most cardiovascular diseases. Metabolomics, one of the newer omics technologies, has emerged as a powerful tool for defining changes in both global and cardiac-specific metabolism that occur across a spectrum of cardiovascular disease states. Findings from metabolomics studi...

journal_title：Circulation research

authors： McGarrah RW,Crown SB,Zhang GF,Shah SH,Newgard CB

更新日期：2018-04-27 00:00:00

abstract：:Angiotensin (Ang) II is present inside vascular smooth muscle cells (VSMCs); however, its intracellular functions, if any, are unknown. We tested the hypothesis that intracellular Ang II exerts effects on cytosolic Ca2+ ([Ca2+]i) in VSMCs. Ang II was administered via microinjection. Intracellular Ang II localization w...

journal_title：Circulation research

authors： Haller H,Lindschau C,Erdmann B,Quass P,Luft FC

更新日期：1996-10-01 00:00:00

abstract：:The activity of the adrenergic system plays an important role in the genesis of malignant arrhythmias and the spreading of the infarcted zone in acute myocardial ischemia. Acute myocardial ischemia induces an increased activity of adenylyl cyclase. This sensitization at the enzyme level as shown in the isolated perfus...

journal_title：Circulation research

authors： Strasser RH,Braun-Dullaeus R,Walendzik H,Marquetant R

更新日期：1992-06-01 00:00:00

abstract：RATIONALE:Senescence of pulmonary artery smooth muscle cells (PA-SMCs) caused by telomere shortening or oxidative stress may contribute to pulmonary hypertension associated with chronic lung diseases. OBJECTIVE:To investigate whether cell senescence contributes to pulmonary vessel remodeling and pulmonary hypertension...

journal_title：Circulation research

authors： Noureddine H,Gary-Bobo G,Alifano M,Marcos E,Saker M,Vienney N,Amsellem V,Maitre B,Chaouat A,Chouaid C,Dubois-Rande JL,Damotte D,Adnot S

更新日期：2011-08-19 00:00:00

abstract：:Cardiac failure appears rapidly during severe hypoxia and precedes a substantial reduction in adenosine triphosphate content. Reduced adenosine triphosphate turnover, in the presence of nearly normal content, may be the metabolic basis for contractile failure during hypoxia. To measure both the myocardial content and ...

journal_title：Circulation research

authors： Bittl JA,Balschi JA,Ingwall JS

更新日期：1987-06-01 00:00:00

abstract：RATIONALE:Chronic inflammation in the myocardium is involved in the development of left ventricular (LV) remodeling and failure after myocardial infarction (MI). Invariant natural killer T (iNKT) cells have been shown to produce inflammatory cytokines and orchestrate tissue inflammation. However, no previous studies ha...

journal_title：Circulation research

authors： Sobirin MA,Kinugawa S,Takahashi M,Fukushima A,Homma T,Ono T,Hirabayashi K,Suga T,Azalia P,Takada S,Taniguchi M,Nakayama T,Ishimori N,Iwabuchi K,Tsutsui H

更新日期：2012-09-28 00:00:00

abstract：:Trimetazidine is a clinically effective antianginal agent that has no negative inotropic or vasodilator properties. Although it is thought to have direct cytoprotective actions on the myocardium, the mechanism(s) by which this occurs is as yet undefined. In this study, we determined what effects trimetazidine has on b...

journal_title：Circulation research

authors： Kantor PF,Lucien A,Kozak R,Lopaschuk GD

更新日期：2000-03-17 00:00:00

abstract：:Vascular remodeling, rather than vasoconstriction, is believed to account for high vascular resistance in severe pulmonary arterial hypertension (PAH). We have found previously that acute Rho kinase inhibition nearly normalizes PAH in chronically hypoxic rats that have no occlusive neointimal lesions. Here we examined...

journal_title：Circulation research

authors： Oka M,Homma N,Taraseviciene-Stewart L,Morris KG,Kraskauskas D,Burns N,Voelkel NF,McMurtry IF

更新日期：2007-03-30 00:00:00

abstract：:Adenosine, a vasodilator metabolite, is often produced in tissues where the demand for oxygen exceeds the supply. We have recently demonstrated in isolated cannulated arterioles that adenosine and its metabolite, inosine, can also cause vasoconstriction by stimulation of mast cells. Secondary release of histamine and ...

journal_title：Circulation research

authors： Shepherd RK,Linden J,Duling BR

更新日期：1996-04-01 00:00:00

abstract：:Insulin-like growth factor-I (IGF-I) plays an important role in regulating vascular smooth muscle cell (VSMC) proliferation and directed migration. The mitogenic and chemotactic actions of IGF-I are mediated through the IGF-I receptor, but how the activation of the IGF-I receptor leads to these biological responses is...

journal_title：Circulation research

authors： Duan C,Bauchat JR,Hsieh T

更新日期：2000-01-07 00:00:00

abstract：:Gene transfer to blood vessels is a promising new approach to the treatment of the vascular diseases, but the feasibility of gene transfer to adult human vessels has not been explored. We introduced an adenovirus vector encoding a marker gene human placental alkaline phosphatase into normal and atherosclerotic human v...

journal_title：Circulation research

authors： Rekhter MD,Simari RD,Work CW,Nabel GJ,Nabel EG,Gordon D

更新日期：1998-06-29 00:00:00

abstract：:Epidermal fatty acid-binding protein (E-FABP), previously characterized in human keratinocytes, is a cytoplasmic protein of 15 kD that specifically binds fatty acids (FAs). Previous PAGE-immunoblotting studies indicated that several human tissues display an immunoreactive band with an electrophoretic mobility identica...

journal_title：Circulation research

authors： Masouyé I,Hagens G,Van Kuppevelt TH,Madsen P,Saurat JH,Veerkamp JH,Pepper MS,Siegenthaler G

更新日期：1997-09-01 00:00:00

abstract：:Three models of altered autonomic innervation of the chick heart have been developed in the last few years. These include sympathetically aneural heart, parasympathetically aneural heart, and heart with cholinergic innervation reconstituted from the nodose placodes. The neural status of these hearts has been assessed ...

journal_title：Circulation research

authors： Kirby ML,Creazzo TL,Christiansen JL

更新日期：1989-12-01 00:00:00

abstract：RATIONALE:Mechanisms of angiogenesis in skeletal muscle remain poorly understood. Efforts to induce physiological angiogenesis hold promise for the treatment of diabetic microvascular disease and peripheral artery disease but are hindered by the complexity of physiological angiogenesis and by the poor angiogenic respon...

journal_title：Circulation research

authors： Rowe GC,Raghuram S,Jang C,Nagy JA,Patten IS,Goyal A,Chan MC,Liu LX,Jiang A,Spokes KC,Beeler D,Dvorak H,Aird WC,Arany Z

更新日期：2014-08-15 00:00:00

abstract：:Although vascular endothelial growth factor (VEGF) has been described as a potent angiogenic stimulus, its application in therapy remains difficult: blood vessels formed by exposure to VEGF tend to be malformed and leaky. In nature, the principal form of VEGF possesses a binding site for ECM components that maintain i...

journal_title：Circulation research

authors： Ehrbar M,Djonov VG,Schnell C,Tschanz SA,Martiny-Baron G,Schenk U,Wood J,Burri PH,Hubbell JA,Zisch AH

更新日期：2004-04-30 00:00:00

abstract：:We hypothesized that a redox-sensitive transcription factor, redox factor-1 (Ref-1) (HAP1, APE, and APEX), was critical in the regulation of endothelial cell survival in response to hypoxia and cytokines, including tumor necrosis factor (TNF)-alpha. Hypoxia resulted in a significant decrease in Ref-1 protein expressio...

journal_title：Circulation research

authors： Hall JL,Wang X,Van Adamson,Zhao Y,Gibbons GH

更新日期：2001-06-22 00:00:00

abstract：:In newborn lambs, pulmonary prostacyclin (PGI2) production increases acutely in response to low oxygen. We tested the hypothesis that decreased oxygenation directly stimulates PGI2 synthesis in arterial segments and cultured endothelial cells from newborn lamb intrapulmonary arteries. In segments studied at PO2 of 680...

journal_title：Circulation research

authors： North AJ,Brannon TS,Wells LB,Campbell WB,Shaul PW

更新日期：1994-07-01 00:00:00

abstract：:To clarify the physiological role of calcium-activated neutral protease (CANP) in human platelets, we loaded the platelets with a Ca2+ -sensitive fluorescent dye, fura-2, and measured the degree of aggregation, cytosolic calcium ion concentration [( Ca2+]i), and proteolysis by sodium dodecyl sulfate-polyacrylamide gel...

journal_title：Circulation research

authors： Toyo-oka T,Shin WS,Okai Y,Dan Y,Morita M,Iizuka M,Sugimoto T

更新日期：1989-02-01 00:00:00

abstract：:Some statistical techniques for analyzing the kinds of studies typically reported in Circulation Research are described. Particular emphasis is given to the comparison of means from more than two populations, the joint effect of several experimentally controlled variables, and the analysis of studies with repeated mea...

journal_title：Circulation research

authors： Wallenstein S,Zucker CL,Fleiss JL

更新日期：1980-07-01 00:00:00

abstract：:Studies were performed to characterize the morphology and vascular reactivity of the allografted cerebral microcirculation. Cerebral cortical tissue was allografted into the cheek pouch of the hamster so that cerebral parenchymal vessels could be studied. The vascular morphology was characterized by a large number of ...

journal_title：Circulation research

authors： Joyner WL,Young R,Blank D,Eccleston-Joyner CA,Gilmore JP

更新日期：1988-10-01 00:00:00

abstract：:Multiple voltage-gated K+ channels contribute to the repolarization phases of the cardiac action potential and are targets of several antiarrhythmic drugs. The Kv1.5 K+ channel gene is expressed in the heart, and heterologous expression of this gene generates a slowly inactivating K+ current. Previously, we found that...

journal_title：Circulation research

authors： Takimoto K,Levitan ES

更新日期：1994-12-01 00:00:00

abstract：:Body surface electrocardiograms and electrograms recorded from the surfaces of the heart are the basis for diagnosis and treatment of cardiac electrophysiological disorders and arrhythmias. Given recent advances in understanding the molecular mechanisms of arrhythmia, it is important to relate these electrocardiograph...

journal_title：Circulation research

authors： Gima K,Rudy Y

更新日期：2002-05-03 00:00:00

abstract：:Rat myocardium expresses the 240- and 235-kD polypeptides antigenically related to alpha- and beta-subunits of brain calspectin (nonerythroid spectrin or fodrin), respectively. In the subcellular fractions of the myocardium, alpha-calspectin was found in the 600g, 10,000g, and 100,000g pellets, whereas beta-calspectin...

journal_title：Circulation research

authors： Yoshida K,Inui M,Harada K,Saido TC,Sorimachi Y,Ishihara T,Kawashima S,Sobue K

更新日期：1995-09-01 00:00:00

abstract：:In this study, anti-basic fibroblast growth factor (anti-bFGF) antibody was used to determine whether the mitogenic effect of angiotensin II in vivo could be blocked by neutralizing bFGF in the vessel wall. Animals, divided into six experimental groups, were given (1) angiotensin II, (2) angiotensin II + anti-bFGF ant...

journal_title：Circulation research

authors： Su EJ,Lombardi DM,Wiener J,Daemen MJ,Reidy MA,Schwartz SM

更新日期：1998-02-23 00:00:00

abstract：:Hypercholesterolemia induces atheroma formation, and the concentration of sphingomyelin is increased compared with that in the normal aortic intima-media. The aortic intima-media sphingomyelin concentration appears to increase exponentially with time on the cholesterol diet. Moreover, the entry rate of serum sphingomy...

journal_title：Circulation research

authors： Seth SK,Newman AI

更新日期：1975-02-01 00:00:00

abstract：:The hypothesis that neurally mediated coronary vasodilation occurs as part of the carotid baroreceptor reflex was investigated. The left main coronary artery was cannulated and perfused at constant pressure (100 mm Hg) in closed-chest, chloralose-anesthetized dogs. The heart was paced at a constant rate between 60 and...

journal_title：Circulation research

authors： Ito BR,Feigl EO

更新日期：1985-04-01 00:00:00

abstract：:The influence that the pressure-sensitive receptors in the cardiovascular system have on renal nerve activity and on heart rate was compared in normotensive rats (NTR) and spontaneously hypertensive rats (SHR). The cardiovascular receptors were stimulated by raising the blood pressure (BP) with intravenous phenylephri...

journal_title：Circulation research

authors： Coote JH,Sato Y

更新日期：1977-06-01 00:00:00

abstract：:To test the ability of regenerated endothelium to evoke endothelium-dependent relaxations, male Yorkshire pigs underwent balloon endothelial denudation of the proximal left anterior descending coronary artery. Endothelium-dependent responses were examined in vitro, in rings of coronary segments taken from the denuded ...

journal_title：Circulation research

authors： Shimokawa H,Aarhus LL,Vanhoutte PM

更新日期：1987-08-01 00:00:00

abstract：:Heart disease is often the end result of inherited genetic defects, which may potentially be treatable using a gene-transfer approach. Recombinant adeno-associated virus (rAAV)-mediated gene delivery has emerged as a realistic method for the treatment of such disorders. Here, we demonstrate and compare the natural aff...

journal_title：Circulation research

authors： Pacak CA,Mah CS,Thattaliyath BD,Conlon TJ,Lewis MA,Cloutier DE,Zolotukhin I,Tarantal AF,Byrne BJ

更新日期：2006-08-18 00:00:00

abstract：:Vascular endothelial growth factors (VEGFs) and their receptors have emerged as central regulators of the angiogenic process. However, involvement of VEGF-B, one of these factors, in angiogenesis remains obscure. Mice received subcutaneous injection of Matrigel alone or Matrigel with human recombinant protein rhVEGF-B...

journal_title：Circulation research

authors： Silvestre JS,Tamarat R,Ebrahimian TG,Le-Roux A,Clergue M,Emmanuel F,Duriez M,Schwartz B,Branellec D,Lévy BI

更新日期：2003-07-25 00:00:00