Cytokeratins in epithelia of odontogenic neoplasms.

Abstract:

:Neoplasms and tumours related to the odontogenic apparatus may be composed only of epithelial tissue or epithelial tissue associated with odontogenic ectomesenchyme. The immunohistochemical detection of different cytokeratins (CKs) polypeptides and vimentin has made it easier to explain the histogenesis of many epithelial diseases. The present study aimed to describe the immunohistochemical expression of cytokeratins 7, 8, 10, 13, 14, 18, 19 and vimentin in the epithelial components of the dental germ and of five types of odontogenic tumours. The results were compared and histogenesis discussed. All cells of the dental germ were positive for CK14, except for the preameloblasts and secreting ameloblasts, in which CK14 was gradually replaced by CK19. CK7 was especially expressed in the cells of the Hertwig root sheath and the stellate reticulum. The dental lamina was the only structure to express CK13. The reduced epithelium of the enamel organ contained CK14 and occasionally CK13. Cells similar to the stellate reticulum, present in the ameloblastoma and in the ameloblastic fibroma, were positive for CK13, which indicates a nature other than that of the stellate reticulum of the normal dental germ. The expression of CK14 and the ultrastructural aspects of the adenomatoid odontogenic tumour probably indicated its origin in the reduced dental epithelium. Calcifying odontogenic epithelial tumour is thought to be composed of primordial cells due to the expression of vimentin. Odontomas exhibited an immunohistochemical profile similar to that of the dental germ. In conclusion, the typical IF of odontogenic epithelium was CK14, while CK8, 10 and 18 were absent. Cytokeratins 13 and 19 labelled squamous differentiation or epithelial cells near the surface epithelium, and CK7 had variable expression.

journal_name

Oral Dis

journal_title

Oral diseases

authors

Crivelini MM,de Araújo VC,de Sousa SO,de Araújo NS

doi

10.1034/j.1601-0825.2003.00861.x

subject

Has Abstract

pub_date

2003-01-01 00:00:00

pages

1-6

issue

1

eissn

1354-523X

issn

1601-0825

journal_volume

9

pub_type

杂志文章
  • Cell synthesis, proliferation and apoptosis in human dental periapical lesions analysed by in situ hybridisation and immunohistochemistry.

    abstract:OBJECTIVE:The role of structural and host defensive cells in periapical lesions has been assessed previously by morphometric and immunohistochemical studies. The aim of this study was to investigate the function of peri- apical cells by employing molecular techniques to estimate the cell synthetic activity, proliferati...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/j.1601-0825.1999.tb00096.x

    authors: Takahashi K,MacDonald D,Murayama Y,Kinane D

    更新日期:1999-10-01 00:00:00

  • Salivary changes in oxidative stress related to inflammation in oral and gastrointestinal diseases.

    abstract:OBJECTIVES:The early diagnosis and monitoring of Crohn's disease (CD) and orofacial granulomatosis (OFG) might be facilitated by assaying potential disease biomarkers in saliva. Markers of oxidative stress and inflammation were assayed in salivas from patients with CD, OFG and concurrent OFG and CD (OFG + CD). SUBJECT...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.13537

    authors: Janšáková K,Escudier M,Tóthová Ľ,Proctor G

    更新日期:2021-03-01 00:00:00

  • Efficacy of hypermethylated DNA biomarkers in saliva and oral swabs for oral cancer diagnosis: Systematic review and meta-analysis.

    abstract:OBJECTIVES:This study aims to determine the diagnostic test accuracy (DTA) of hypermethylated DNA biomarkers in saliva and oral swabs for oral squamous cell carcinoma (OSCC) detection from the prevalidation studies available. MATERIALS AND METHODS:Electronic database searching of PubMed, EMBASE, Cochrane Library, Scop...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审

    doi:10.1111/odi.13773

    authors: Adeoye J,Alade AA,Zhu WY,Wang W,Choi SW,Thomson P

    更新日期:2021-01-10 00:00:00

  • Resource implications for oral care of patients with HIV.

    abstract:OBJECTIVES:The aim was to investigate the attitudes of people with HIV infection towards their own dental care provision and the possible implications for future resource allocation. DESIGN:Sixty-nine HIV positive subjects attending support groups in London were interviewed. Past and current dental visiting behaviour,...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/j.1601-0825.1998.tb00250.x

    authors: Gallagher PD,Gealer M,Birnbaum W

    更新日期:1998-03-01 00:00:00

  • World Workshop on Oral Medicine VII: Relative frequency of oral mucosal lesions in children, a scoping review.

    abstract:OBJECTIVE:To detail a scoping review on the global and regional relative frequencies of oral mucosal disorders in the children based on both clinical studies and those reported from biopsy records. MATERIALS AND METHODS:A literature search was completed from 1 January 1990 to 31 December 2018 using PubMed and EMBASE. ...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审

    doi:10.1111/odi.13112

    authors: Hong CHL,Dean DR,Hull K,Hu SJ,Sim YF,Nadeau C,Gonçalves S,Lodi G,Hodgson TA

    更新日期:2019-06-01 00:00:00

  • Defining the genomic landscape of head and neck cancers through next-generation sequencing.

    abstract::Next-generation sequencing (NGS) has revolutionized the field of genomics and improved our understanding of cancer biology. Advances have been achieved by sequencing tumor DNA and using matched normal DNA to filter out germ line variants to identify cancer-specific changes. The identification of high incidences of act...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审

    doi:10.1111/odi.12246

    authors: Rizzo G,Black M,Mymryk JS,Barrett JW,Nichols AC

    更新日期:2015-01-01 00:00:00

  • Elevated leukocyte count is associated with periodontitis in Korean adults: the 2012-2014 KNHANES.

    abstract:OBJECTIVE:Both an elevated leukocyte count and periodontitis share well-recognized associations with cardiometabolic diseases. This cross-sectional study aimed to identify whether the leukocyte count is associated with periodontitis in a nationally representative Korean adult population. MATERIALS AND METHODS:Data fro...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.12601

    authors: Kwon YJ,Jeon KJ,Chung TH,Lee YJ

    更新日期:2017-03-01 00:00:00

  • A nomogram for predicting the risk of neck node metastasis in pathologically node-negative oral cavity carcinoma.

    abstract:OBJECTIVE:To generate a nomogram for predicting the risk of neck node metastasis in pathologically node-negative patients using a combination of variables comprising of protein expression, ultrastructural alterations and clinicopathological parameters. MATERIALS AND METHODS:Surgically removed oral tumours (n = 103) we...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.12696

    authors: Sawant SS,Dongre H,Ahire C,Sharma S,Kannan S,Mahadik S,Chaukar D,Lukmani F,Patil A,D'Cruz A,Vaidya MM,Dongre P

    更新日期:2017-11-01 00:00:00

  • Oral colonization by Candida species in AIDS pediatric patients.

    abstract::The aim of this study was to assess the prevalence of factors associated with oral colonization by Candida spp. in pediatric patients with AIDS. The sample comprised of 117 children. Clinical status, medicines in use, and laboratory findings were obtained from hospital records; sociodemographic data were given by rela...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/j.1601-0825.2010.01765.x

    authors: Domaneschi C,Massarente DB,de Freitas RS,de Sousa Marques HH,Paula CR,Migliari DA,Antunes JL

    更新日期:2011-05-01 00:00:00

  • Cyclin D1-induced proliferation is independent of beta-catenin in head and neck cancer.

    abstract:OBJECTIVE:Head and neck squamous cell carcinoma (HNSCC) progression and metastasis have previously been associated with the activation of phosphatidylinositol 3-kinase-protein kinase B (PI3K-Akt) and Wnt signalling pathways, which lead to the activation of pro-proliferative genes, such as cyclin D1. The current study a...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.12124

    authors: Sales KU,Giudice FS,Castilho RM,Salles FT,Squarize CH,Abrahao AC,Pinto DS Jr

    更新日期:2014-04-01 00:00:00

  • Sugars and beyond. The role of sugars and the other nutrients and their potential impact on caries.

    abstract::The traditional concept of caries as a multifactorial transmittable and infectious disease has been challenged. Novel conceptual ideas have come to add to the complexity of this highly prevalent disease worldwide. Current etiological understanding of the disease has emphasized the pivotal role of sugars in caries. In ...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审

    doi:10.1111/odi.12778

    authors: Giacaman RA

    更新日期:2018-10-01 00:00:00

  • Occupational COVID-19 risk to dental staff working in a public dental unit in the outbreak epicenter.

    abstract:OBJECTIVE:The management of the COVID-19 outbreak occurred in Lombardy (Italy) implied that non-COVID-19 health care was remodeled, limiting adequate resources in non-hospital public dental healthcare settings. This situation offered the opportunity to investigate the occupational COVID-19 risk to dental staff in publi...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.13632

    authors: Nardone M,Cordone A,Petti S

    更新日期:2020-09-03 00:00:00

  • siRNA-mediated gene silencing in the salivary gland using in vivo microbubble-enhanced sonoporation.

    abstract:OBJECTIVES:siRNA-induced gene silencing in the salivary gland using microbubble-enhanced sonoporation was used to develop an in vivo gene knockdown technique. METHODS:siRNA targeting rat glyceraldehyde-3-phosphate dehydrogenas (GAPDH) was mixed with echo-enhanced microbubbles and reverse-injected into rat parotid glan...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/j.1601-0825.2009.01579.x

    authors: Sakai T,Kawaguchi M,Kosuge Y

    更新日期:2009-10-01 00:00:00

  • The oral health status of dentate patients with chronic renal failure undergoing dialysis therapy.

    abstract:OBJECTIVE:The aim of this study was to compare the oral health status of chronic renal failure (CRF) patients on renal replacement therapy with a matched reference population. DESIGN:Cross-sectional study. SUBJECTS:Forty-two dentate CRF patients--aged 25-52 years old--were matched with a reference group of 808 dentat...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/j.1601-0825.2005.01183.x

    authors: Bots CP,Poorterman JH,Brand HS,Kalsbeek H,van Amerongen BM,Veerman EC,Nieuw Amerongen AV

    更新日期:2006-03-01 00:00:00

  • The use of tretinoin as oral mucositis prophylaxis in bone marrow transplantation patients: a preliminary study.

    abstract:OBJECTIVE:The examination of prophylactic efficacy of tretinoin on oral mucositis, post bone marrow transplantation (BMT). PATIENTS AND METHODS:The study population consisted of 11 patients undergoing BMT. Six tretinoin topically-treated patients (0.25 mg daily of 0.1% tretinoin cream) were matched with five non-treat...

    journal_title:Oral diseases

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1601-0825.1997.tb00049.x

    authors: Cohen G,Elad S,Or R,Galili D,Garfunkel AA

    更新日期:1997-12-01 00:00:00

  • The association between miR-499a polymorphism and oral squamous cell carcinoma progression.

    abstract:OBJECTIVE:To investigate the association of miR-499a genetic polymorphism with the risk of oral leukoplakia, oral submucous fibrosis (OSF), oral squamous cell carcinoma (OSCC), and clinicopathological outcomes of OSCC. METHODS:The genotyping of miR-499a T>C (rs3746444) using TagMan assay was conducted in two case-cont...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.12241

    authors: Hou YY,Lee JH,Chen HC,Yang CM,Huang SJ,Liou HH,Chi CC,Tsai KW,Ger LP

    更新日期:2015-03-01 00:00:00

  • Peripheral painful traumatic trigeminal neuropathies.

    abstract::The aim of this article is to review the clinical, pathophysiological, and therapeutic aspects of traumatically induced trigeminal nerve pain. We introduce a new and, in our view, more accurate terminology: peripheral painful traumatic trigeminal neuropathy (PPTTN) to define this patient group. The proposed pathophysi...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审

    doi:10.1111/j.1601-0825.2011.01883.x

    authors: Benoliel R,Kahn J,Eliav E

    更新日期:2012-05-01 00:00:00

  • Effect of a local anesthetic lozenge in relief of symptoms in burning mouth syndrome.

    abstract:OBJECTIVE:Patients with burning mouth syndrome (BMS) often represent a clinical challenge as available agents for symptomatic treatment are few and often ineffective. The aim was to evaluate the effect of a bupivacaine lozenge on oral mucosal pain, xerostomia, and taste alterations in patients with BMS. METHODS:Eighte...

    journal_title:Oral diseases

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/odi.12386

    authors: Treldal C,Jacobsen CB,Mogensen S,Rasmussen M,Jacobsen J,Petersen J,Lynge Pedersen AM,Andersen O

    更新日期:2016-03-01 00:00:00

  • Intra-oral carcinomas in Maiduguri, north-eastern Nigeria.

    abstract:OBJECTIVE:To document the pattern of intra-oral carcinomas diagnosed in north-eastern Nigeria. DESIGN AND SETTING:A retrospective clinical and histopathological review seen in a tertiary care hospital (January 1987-December 2002). MATERIALS AND METHODS:Information on socio-demographic characteristics of patients and ...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审

    doi:10.1111/j.1601-0825.2005.01134.x

    authors: Otoh EC,Johnson NW,Olasoji HO,Danfillo IS,Adeleke OA

    更新日期:2005-11-01 00:00:00

  • Influence of gender and stress on the volatile sulfur compounds and stress biomarkers production.

    abstract:BACKGROUND:Stress and menstrual cycle have been described as factors influencing bad breath, as they can alter oral homeostasis and contribute to the production of volatile sulfur compounds (VSC). OBJECTIVE:Considering that the experimenter's and volunteer's gender may influence the volunteer's responses to stress, th...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.12011

    authors: Lima PO,Calil CM,Marcondes FK

    更新日期:2013-05-01 00:00:00

  • Marathon of eponyms: 6 Frey syndrome (Gustatory sweating).

    abstract::The use of eponyms has long been contentious, but many remain in common use, as discussed elsewhere (Editorial: Oral Diseases. 2009: 15; 185). The use of eponyms in diseases of the head and neck is found mainly in specialties dealing with medically compromised individuals (paediatric dentistry, special care dentistry,...

    journal_title:Oral diseases

    pub_type: 历史文章,杂志文章,评审

    doi:10.1111/j.1601-0825.2009.01538.x

    authors: Scully C,Langdon J,Evans J

    更新日期:2009-11-01 00:00:00

  • Impact of wearing an intra-oral lubricating device on oral health in dry mouth patients.

    abstract:OBJECTIVE:To establish whether an intra-oral lubricating device for dry mouth alters the oral environment. DESIGN:A single-blind randomized cross-over study. METHOD:Twenty-nine dentate subjects from the Sjogren's syndrome clinic attended on five occasions at 4-week intervals. They were randomized, having the device f...

    journal_title:Oral diseases

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1601-0825.2005.01161.x

    authors: Frost PM,Shirlaw PJ,Challacombe SJ,Fernandes-Naglik L,Walter JD,Ide M

    更新日期:2006-01-01 00:00:00

  • Prevalence of six periodontal pathogens detected by DNA probe method in HIV vs non-HIV periodontitis.

    abstract:OBJECTIVE:The aim of the study was to examine the prevalence of selected periodontal pathogens associated with HIV and non-HIV related periodontal lesions. METHODS:Subgingival plaque samples were obtained from both HIV-seropositive and HIV-seronegative patients affected with periodontal disease. DNA probes were used t...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/j.1601-0825.1997.tb00350.x

    authors: Tenenbaum H,Elkaim R,Cuisinier F,Dahan M,Zamanian P,Lang JM

    更新日期:1997-05-01 00:00:00

  • Palatal zygomycosis: experience of 21 cases.

    abstract:OBJECTIVE:To present a clinical report of palatal zygomycosis, its epidemiological, mycological features, and our treatment experience. DESIGN:Retrospective report. SUBJECTS AND METHODS:This is a 25-year long retrospective trial of clinically and mycologically proven cases of zygomycosis. Some patients underwent a bi...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/j.1601-0825.2007.01433.x

    authors: Bonifaz A,Macias B,Paredes-Farrera F,Arias P,Ponce RM,Araiza J

    更新日期:2008-09-01 00:00:00

  • Tooth ultrastructure of a novel COL1A2 mutation expanding its genotypic and phenotypic spectra.

    abstract:OBJECTIVES:To investigate tooth ultrastructure and mutation of two patients in a family affected with osteogenesis imperfecta (OI) type IV and dentinogenesis imperfecta (DGI). METHODS:Mutations were detected by whole exome and Sanger sequencing. The permanent second molar obtained from the proband (DGI1) and the prima...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.13657

    authors: Intarak N,Budsamongkol T,Theerapanon T,Chanamuangkon T,Srijunbarl A,Boonprakong L,Porntaveetus T,Shotelersuk V

    更新日期:2020-09-29 00:00:00

  • The heme oxygenase system and oral diseases.

    abstract::Oral Diseases (2011) 17, 252-257 Heme oxygenase (HO) system catabolizes heme into three products: carbon monoxide (CO), biliverdin/bilirubin and free iron, which consists of three forms identified to date: the oxidative stress-inducible protein HO-1 and the constitutive isozymes HO-2 and HO-3. HO has been involved in ...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审

    doi:10.1111/j.1601-0825.2010.01732.x

    authors: Fan W,Huang F,Zhu X,Li D,Fu S,He H

    更新日期:2011-04-01 00:00:00

  • The PI3K/Akt/mTOR axis in head and neck cancer: functions, aberrations, cross-talk, and therapies.

    abstract::Head and neck squamous cell carcinoma (HNSCC) is one of the most morbid, mortal, and genetically diverse malignancies. Although HNSCC is heterogeneous in nature, alterations in major components of the PI3K/Akt/mTOR pathway are consistently observed throughout the majority of HNSCC cases. These alterations include gene...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审

    doi:10.1111/odi.12206

    authors: Vander Broek R,Mohan S,Eytan DF,Chen Z,Van Waes C

    更新日期:2015-10-01 00:00:00

  • Metalloproteinase 9 is the outer executioner of desmoglein 3 in apoptotic keratinocytes.

    abstract:OBJECTIVE:To investigate the specific matrix metalloproteinases (MMPs) targeting desmoglein 3 (Dsg3) in apoptotic keratinocytes. METHOD:Inhibitor studies on cultured keratinocytes and Western blot analysis. RESULTS:Blocking of MMP-9 activity strongly reduces shedding of Dsg3 from cell surface. MMP-2 has a less releva...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/j.1601-0825.2006.01287.x

    authors: Cirillo N,Femiano F,Gombos F,Lanza A

    更新日期:2007-05-01 00:00:00

  • Bacteremia after supragingival scaling and dental extraction: Culture and molecular analyses.

    abstract:OBJECTIVE:To study the incidence and magnitude of bacteremia after dental extraction and supragingival scaling. SUBJECTS AND METHODS:Blood samples were taken before and 5 and 30 min after dental extraction and supragingival scaling from individuals at high (n = 44) or negligible risk (n = 51) for infective endocarditi...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.12792

    authors: Reis LC,Rôças IN,Siqueira JF Jr,de Uzeda M,Lacerda VS,Domingues R,Miranda KR,Saraiva RM

    更新日期:2018-05-01 00:00:00

  • Osteomyelitis, osteoradionecrosis, or medication-related osteonecrosis of the jaws? Can CBCT enhance radiographic diagnosis?

    abstract:OBJECTIVE:To attempt defining differential radiographic diagnostic characteristics for osteonecrotic lesions using 2D as opposed to 3D images. MATERIALS AND METHODS:This was a cross-sectional study. Subjects presenting mandibular osteonecrotic lesions (osteomyelitis, osteoradionecrosis, and medication-related osteonec...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.13534

    authors: Gaêta-Araujo H,Vanderhaeghen O,Vasconcelos KF,Coucke W,Coropciuc R,Politis C,Jacobs R

    更新日期:2021-03-01 00:00:00