Distinct changes in gene expression induced by A-Myb, B-Myb and c-Myb proteins.

abstract：:Signals received at the cell surface must be properly transmitted to critical targets within the cell to achieve the appropriate biological response. This process of signal transduction is often initiated by receptor tyrosine kinases (RTKs), which function as entry points for many extracellular cues and play a critica...

journal_title：Oncogene

authors： McKay MM,Morrison DK

更新日期：2007-05-14 00:00:00

abstract：:Heat shock protein 70 (HSP70) can inhibit apoptosis by neutralizing and interacting with apoptosis-inducing factor (AIF), a mitochondrial flavoprotein that translocates upon apoptosis induction to the nucleus, via the cytosol. Here, we show that only members of the HSP70 family interact with AIF. Systematic deletion m...

journal_title：Oncogene

authors： Gurbuxani S,Schmitt E,Cande C,Parcellier A,Hammann A,Daugas E,Kouranti I,Spahr C,Pance A,Kroemer G,Garrido C

更新日期：2003-10-02 00:00:00

abstract：:Although activation of the STAT3 pathway has been associated with tumor progression in a wide variety of cancer types (including ovarian cancer), the precise mechanism of invasion and metastasis due to STAT3 are not fully delineated in ovarian cancer. We found that pSTAT3 Tyr705 is constitutively activated in patient ...

journal_title：Oncogene

authors： Saini U,Naidu S,ElNaggar AC,Bid HK,Wallbillich JJ,Bixel K,Bolyard C,Suarez AA,Kaur B,Kuppusamy P,Hays J,Goodfellow PJ,Cohn DE,Selvendiran K

更新日期：2017-01-12 00:00:00

abstract：:RelA and RelB are two members of the NF-kappaB family that differ structurally and functionally. While RelA is regulated through its cytosolic localization by inhibitor proteins or IkappaB and not through transcriptional mechanisms, the regulation of RelB is poorly understood. In this study we demonstrate that stimuli...

journal_title：Oncogene

authors： Bren GD,Solan NJ,Miyoshi H,Pennington KN,Pobst LJ,Paya CV

更新日期：2001-11-22 00:00:00

abstract：:Fas-associated death domain (FADD) is an adaptor protein recruiting complexes of caspase 8 to death ligand receptors to induce extrinsic apoptotic cell death in response to a TNF superfamily member. Although, formation of the complex of FADD and caspase 8 upon death stimuli has been studied in detail, posttranslationa...

journal_title：Oncogene

authors： Seo J,Lee EW,Shin J,Seong D,Nam YW,Jeong M,Lee SH,Lee C,Song J

更新日期：2018-09-01 00:00:00

abstract：:Bcl-2 and Bcl-XL serve as critical inhibitors of apoptosis triggered by a broad range of stimuli, mainly acting on the mitochondria. We identified two members of the reticulon (RTN) family as Bcl-XL binding proteins, i.e., NSP-C (RTN1-C) and a new family member, RTN-XS, both of which did not belong to the Bcl-2 family...

journal_title：Oncogene

authors： Tagami S,Eguchi Y,Kinoshita M,Takeda M,Tsujimoto Y

更新日期：2000-11-23 00:00:00

abstract：:Synemin (SYNM) is a type IV intermediate filament that has recently been shown to interact with the LIM domain protein zyxin, thereby possibly modulating cell adhesion and cell motility. Owing to this multiplicity of potential functions relevant to cancer development, we initiated a study to decipher SYNM expression a...

journal_title：Oncogene

authors： Noetzel E,Rose M,Sevinc E,Hilgers RD,Hartmann A,Naami A,Knüchel R,Dahl E

更新日期：2010-08-26 00:00:00

abstract：:Our previous studies suggested that chromosome 8p deletion is associated with metastasis of hepatocellular carcinoma (HCC), in which some novel metastasis suppressor genes might be harbored. The present study aimed to identify the metastatic suppressor gene(s). A cDNA chip was constructed with the expressed sequence t...

journal_title：Oncogene

authors： Wu X,Jia HL,Wang YF,Ren N,Ye QH,Sun HC,Wang L,Liu YK,Tang ZY,Qin LX

更新日期：2006-03-16 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) is one of the most common and malignant carcinoma worldwide, and the incidence and mortality are increasing rapidly. Immunotherapy targeting programmed death 1/programmed death ligand 1 (PD-L1) signaling has shown prominent clinical effects in treating NSCLC; however, a poor understa...

journal_title：Oncogene

authors： Wang J,Jia Y,Zhao S,Zhang X,Wang X,Han X,Wang Y,Ma M,Shi J,Liu L

更新日期：2017-11-09 00:00:00

abstract：:MicroRNAs (miRNAs) have been shown to have an important role in various cellular processes, such as apoptosis, differentiation and development. Recent studies have shown that miRNAs are mis-expressed in human cancers where they can exert their effect as oncogenes or tumor suppressors. Here, we review the potential for...

journal_title：Oncogene

authors： Trang P,Weidhaas JB,Slack FJ

更新日期：2008-12-01 00:00:00

abstract：:The Rb protein is a tumor suppressor, which plays a pivotal role in the negative control of the cell cycle and in tumor progression. It has been shown that Rb protein (pRb) is responsible for a major G1 checkpoint, blocking S-phase entry and cell growth. The retinoblastoma family includes three members, Rb/p105, p107 ...

journal_title：Oncogene

authors： Giacinti C,Giordano A

更新日期：2006-08-28 00:00:00

abstract：:Various factors and cellular components in the tumor microenvironment are key drivers associated with drug resistance in many cancers. Here, we analyzed the factors and molecular mechanisms involved in chemoresistance in patients with esophageal squamous cell carcinoma (ESCC). We found that interleukin 6 (IL6) derived...

journal_title：Oncogene

authors： Qiao Y,Zhang C,Li A,Wang D,Luo Z,Ping Y,Zhou B,Liu S,Li H,Yue D,Zhang Z,Chen X,Shen Z,Lian J,Li Y,Wang S,Li F,Huang L,Wang L,Zhang B,Yu J,Qin Z,Zhang Y

更新日期：2018-02-15 00:00:00

abstract：:Clinical and epidemiological data support a role for human papilloma virus (HPV) type 16 in the pathogenesis of cervical carcinoma. The W12 cell line contains HPV16 sequences, predominantly as a high copy number episome, and is immortalised in vitro, but non-tumourigenic. A morphologically distinct sub-line of the par...

journal_title：Oncogene

authors： Crook T,Greenfield I,Howard J,Stanley M

更新日期：1990-04-01 00:00:00

abstract：:Early studies demonstrated that male melanoma patients have worse survival than female patients, yet the detailed mechanisms for this gender difference remain unclear. We analyzed around 100 cases of human melanoma and found that androgen receptor (AR) positive melanoma patients have worse survival outcomes compared w...

journal_title：Oncogene

authors： Wang Y,Ou Z,Sun Y,Yeh S,Wang X,Long J,Chang C

更新日期：2017-03-23 00:00:00

abstract：:DNA double-stranded breaks (DSBs) elicit a checkpoint response that causes a delay in cell cycle progression. Early in the checkpoint response, histone H2AX is phosphorylated in the chromatin region flanking the DSB by ATM/ATR and DNA-PK kinases. The resulting foci of phosphorylated H2AX (gamma-H2AX) serve as a platfo...

journal_title：Oncogene

authors： Macůrek L,Lindqvist A,Voets O,Kool J,Vos HR,Medema RH

更新日期：2010-04-15 00:00:00

abstract：:To investigate the possible role of the product of the retinoblastoma susceptibility gene, pRB, in leukemogenesis, we examined fresh leukemia cells from 56 cases of primary leukemia (AML, 32; ALL, 12; CML-BC, 9; CLL, 3) for expression of pRB by using an immunoblotting assay with anti-pRB monoclonal antibodies PMG 3-24...

journal_title：Oncogene

authors： Furukawa Y,DeCaprio JA,Belvin M,Griffin JD

更新日期：1991-08-01 00:00:00

abstract：:TCR-mediated activation of T cell hybridomas induces programmed cell death by a Fas-dependent pathway. We now show that costimulation of 2B4 cells, in the absence or presence of transgenic Bcl-2, with anti-CD3 epsilon and forskolin, an activator of cAMP signaling, resulted in antagonism of Fas-dependent activation-ind...

journal_title：Oncogene

authors： Ivanov VN,Lee RK,Podack ER,Malek TR

更新日期：1997-05-22 00:00:00

abstract：:Cyclooxygenase-2 (COX-2) is an inducible enzyme that contributes to the generation of chronic inflammation in response to chemical carcinogens and environmental stresses, including ultraviolet B (UVB) irradiation. Although post-translational histone modifications are believed to have an important role in modulating tr...

journal_title：Oncogene

authors： Keum YS,Kim HG,Bode AM,Surh YJ,Dong Z

更新日期：2013-01-24 00:00:00

abstract：:Breast cancer is a heterogeneous genetic disease driven by the accumulation of individual mutations per tumor. Whole-genome sequencing approaches have identified numerous genes with recurrent mutations in primary tumors. Although mutations in well characterized tumor suppressors and oncogenes are overrepresented in th...

journal_title：Oncogene

authors： Block I,Müller C,Sdogati D,Pedersen H,List M,Jaskot AM,Syse SD,Lund Hansen P,Schmidt S,Christiansen H,Casella C,Bering Olsen S,Blomstrøm MM,Riedel A,Thomassen M,Kruse TA,Karlskov Hansen SW,Kioschis P,Mollenhauer J

更新日期：2019-06-01 00:00:00

abstract：:Migration and invasion inhibitory protein (MIIP) is recently identified as an inhibitor in tumor development. However, the regulatory mechanism and biological contributions of MIIP in pancreatic cancer (PC) have been not elucidated. In this study, we demonstrated a negative feedback of MIIP and hypoxia-induced factor-...

journal_title：Oncogene

authors： Niu Y,Jin Y,Deng SC,Deng SJ,Zhu S,Liu Y,Li X,He C,Liu ML,Zeng Z,Chen HY,Zhong JX,Ye Z,Wang CY,Zhao G

更新日期：2018-03-01 00:00:00

abstract：:Angiogenesis is essential for tumor growth and blocking this process might be a valid tool for the control of cancer growth. We showed previously that tumor angiogenesis in integrin alpha1-null mice is reduced compared to that of wild type animals and that over-expression of matrix metalloproteinase 9 (MMP-9) in the a...

journal_title：Oncogene

authors： Pozzi A,LeVine WF,Gardner HA

更新日期：2002-01-10 00:00:00

abstract：:EZH2 (enhancer of zeste homolog 2) is a critical enzymatic subunit of the polycomb repressive complex 2 (PRC2), which trimethylates histone H3 (H3K27) to mediate gene repression. Somatic mutations, overexpression and hyperactivation of EZH2 have been implicated in the pathogenesis of several forms of cancer. In partic...

journal_title：Oncogene

authors： Sahasrabuddhe AA,Chen X,Chung F,Velusamy T,Lim MS,Elenitoba-Johnson KS

更新日期：2015-01-22 00:00:00

abstract：:Pancreatic cancer is characterized by early metastatic spread, but the process of tumor cell dissemination is largely unknown. In this study we show that the soluble protein pancreatic adenocarcinoma upregulated factor (PAUF) has an important role in the metastasis and progression of the disease. Variations in the lev...

journal_title：Oncogene

authors： Lee Y,Kim SJ,Park HD,Park EH,Huang SM,Jeon SB,Kim JM,Lim DS,Koh SS

更新日期：2010-01-07 00:00:00

abstract：:Pharmacological inactivation of cancer genes or products is being used as a strategy for therapy in oncology. To investigate the potential role of BCR-ABLp190 cessation in leukaemia development, we generated mice carrying a tetracycline-repressible BCR-ABLp190 transgene. These mice were morphologically normal at birth...

journal_title：Oncogene

authors： Pérez-Caro M,Gutierrez-Cianca N,González-Herrero I,López-Hernández I,Flores T,Orfao A,Sánchez-Martín M,Gutiérrez-Adán A,Pintado B,Sánchez-García I

更新日期：2007-03-15 00:00:00

abstract：:Selective inhibition of BCL-2 is expected to enhance therapeutic vulnerability in luminal estrogen receptor-positive breast cancers. We show here that the BCL-2 dependency of luminal tumor cells is nevertheless mitigated by breast cancer-associated fibroblasts (bCAFs) in a manner that defines MCL-1 as another critical...

journal_title：Oncogene

authors： Louault K,Bonneaud TL,Séveno C,Gomez-Bougie P,Nguyen F,Gautier F,Bourgeois N,Loussouarn D,Kerdraon O,Barillé-Nion S,Jézéquel P,Campone M,Amiot M,Juin PP,Souazé F

更新日期：2019-04-01 00:00:00

abstract：:Ubiquilin1 (UBQLN1) is a ubiquitin-like domain and a ubiquitin-associated domain containing protein that has been reported to be involved in shuttling proteins to the proteasome, especially during endoplasmic reticulum-associated protein degradation. Thus, UBQLN1 function has been shown to be critical for combating a ...

journal_title：Oncogene

authors： Shah PP,Lockwood WW,Saurabh K,Kurlawala Z,Shannon SP,Waigel S,Zacharias W,Beverly LJ

更新日期：2015-03-26 00:00:00

abstract：:The anti-p185(her2/neu) peptidomimetic (AHNP) is a small exo-cyclic peptide derived from the anti-p185(her2/neu) rhumAb 4D5 (h4D5). AHNP mimics many but not all of the antitumor characteristics exhibited by h4D5. However, the pharmacokinetic profiles of AHNP are less than optimal for therapeutic or diagnostic purposes...

journal_title：Oncogene

authors： Masuda K,Richter M,Song X,Berezov A,Masuda K,Murali R,Greene MI,Zhang H

更新日期：2006-12-14 00:00:00

abstract：:Scribble complex proteins maintain apicobasal polarity, regulate cell fate determination and function as tumour suppressors in epithelial tissue. Despite evidence that the function of Scribble is maintained in the lymphocyte lineage, we still understand little about its role as a tumour suppressor in haematological ma...

journal_title：Oncogene

authors： Hawkins ED,Oliaro J,Ramsbottom KM,Newbold A,Humbert PO,Johnstone RW,Russell SM

更新日期：2016-03-03 00:00:00

abstract：:Small cell lung cancer (SCLC) is a disease characterized by aggressive clinical behavior and lack of effective therapy. Owing to its tendency for early dissemination, only a third of patients have limited-stage disease at the time of diagnosis. SCLC is thought to derive from pulmonary neuroendocrine cells. Although se...

journal_title：Oncogene

authors： Kalari S,Jung M,Kernstine KH,Takahashi T,Pfeifer GP

更新日期：2013-07-25 00:00:00

abstract：:Hepatitis C virus (HCV) core has a pleiotropic effect on various promoters. In this study, we found that the expression of nucleolar phosphoprotein B23 was enhanced in HCV core-expressing cells and, moreover, HCV core interacts directly with the C-terminal end of B23. Using sucrose gradient centrifugation analysis and...

journal_title：Oncogene

authors： Mai RT,Yeh TS,Kao CF,Sun SK,Huang HH,Wu Lee YH

更新日期：2006-01-19 00:00:00