The roles of alpha IIb beta 3-mediated outside-in signal transduction, thromboxane A2, and adenosine diphosphate in collagen-induced platelet aggregation.

abstract：:Time-lapse videotape recordings of polymorphonuclear leukocytes (PMNs) from clot preparations were used to quantify the locomotive behavior of individual PMNs from normal subjects. Tracings derived from the videotapes allow one to quantify multiple parameters of the locomotive behavior of PMNs--direction, distance, ra...

journal_title：Blood

authors： Howard TH

更新日期：1982-05-01 00:00:00

abstract：:Tissue inhibitor of metalloproteinases (TIMP)-1 and TIMP-2 are proteins with proteinase-inhibiting and cytokine properties. TIMP-1 is active primarily in B cells and B-cell lymphomas, whereas TIMP-2 expression is restricted to T cells. The expression of TIMP-1 and TIMP-2 in lymph nodes from patients with Hodgkin disea...

journal_title：Blood

authors： Oelmann E,Herbst H,Zühlsdorf M,Albrecht O,Nolte A,Schmitmann C,Manzke O,Diehl V,Stein H,Berdel WE

更新日期：2002-01-01 00:00:00

abstract：:To identify genes linked to normal plasma cell (PC) differentiation and to classify multiple myeloma (MM) with respect to the expression patterns of these genes, we analyzed global mRNA expression in CD19-enriched B cells (BCs) from 7 tonsils, CD138-enriched PCs from 11 tonsils, 31 normal bone marrow samples, and 74 M...

journal_title：Blood

authors： Zhan F,Tian E,Bumm K,Smith R,Barlogie B,Shaughnessy J Jr

更新日期：2003-02-01 00:00:00

abstract：:Heme biosynthesis was examined in erythroid tissue of a 4-yr-old girl with severe sideroblastic anemia since infancy, as documented by the presence of intramitochondrial deposits of iron in erythroblasts. Free red cell protoporphyrin, urinary porphyrins, and activities of erythrocyte porphobilinogen synthase, uroporph...

journal_title：Blood

authors： Buchanan GR,Bottomley SS,Nitschke R

更新日期：1980-01-01 00:00:00

abstract：:Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous disease with recognized variability in clinical outcome, genetic features, and cells of origin. To date, transcriptional profiling has been used to highlight similarities between DLBCL tumor cells and normal B-cell subtypes and associate genes and pathways with ...

journal_title：Blood

authors： Monti S,Savage KJ,Kutok JL,Feuerhake F,Kurtin P,Mihm M,Wu B,Pasqualucci L,Neuberg D,Aguiar RC,Dal Cin P,Ladd C,Pinkus GS,Salles G,Harris NL,Dalla-Favera R,Habermann TM,Aster JC,Golub TR,Shipp MA

更新日期：2005-03-01 00:00:00

abstract：:Immunosuppression resulting in impaired Epstein-Barr virus (EBV)-specific T-cell immunity is involved in the pathogenesis of EBV-positive post-transplantation lymphoproliferative disorder (EBV(+) PTLD). Restoration of EBV-specific T-cell immunity by adoptive immunotherapy can induce remission. EBV-nuclear antigen-1 (E...

journal_title：Blood

authors： Jones K,Nourse JP,Morrison L,Nguyen-Van D,Moss DJ,Burrows SR,Gandhi MK

更新日期：2010-09-30 00:00:00

abstract：:Wiskott-Aldrich syndrome (WAS) is an X-linked disease caused by mutations in the WAS gene, leading to thrombocytopenia, eczema, recurrent infections, autoimmune disease, and malignancy. Hematopoietic cell transplantation (HCT) is the primary curative approach, with the goal of correcting the underlying immunodeficienc...

journal_title：Blood

authors： Burroughs LM,Petrovic A,Brazauskas R,Liu X,Griffith LM,Ochs HD,Bleesing JJ,Edwards S,Dvorak CC,Chaudhury S,Prockop SE,Quinones R,Goldman FD,Quigg TC,Chandrakasan S,Smith AR,Parikh S,Dávila Saldaña BJ,Thakar MS,Phela

更新日期：2020-06-04 00:00:00

abstract：:Natural killer (NK) cells participate in host defense by surveying for and ultimately killing virally infected or malignant target cells. NK cell cytotoxicity is a tightly regulated process that proceeds stepwise from adhesion and activation to the secretion of preformed lytic granule contents onto a diseased or stres...

journal_title：Blood

authors： James AM,Hsu HT,Dongre P,Uzel G,Mace EM,Banerjee PP,Orange JS

更新日期：2013-04-04 00:00:00

abstract：:As acute myeloid leukemia (AML) xenograft models improve, the potential for using them to evaluate novel therapeutic strategies becomes more appealing. Currently, there is little information on using standard chemotherapy regimens in AML xenografts. Here we have characterized the immunodeficient mouse response to comb...

journal_title：Blood

authors： Wunderlich M,Mizukawa B,Chou FS,Sexton C,Shrestha M,Saunthararajah Y,Mulloy JC

更新日期：2013-03-21 00:00:00

abstract：:Using the technique of differential cDNA library screening, we have molecularly cloned a gene that is highly expressed in an undifferentiated myeloid multipotent and growth factor-dependent stem cell line (FDCP-Mix) and that downregulates as these cells are induced to differentiate along monocytic, granulocytic, and e...

journal_title：Blood

authors： Hampson IN,Cross MA,Heyworth CM,Fairbairn L,Spooncer E,Cowling GJ,Dexter TM

更新日期：1992-12-15 00:00:00

abstract：:Chronic myelogenous leukemia (CML) is a malignant myeloproliferative disease arising from a hematopoietic stem cell expressing the BCR/ABL fusion protein. Leukemic and dendritic cells (DCs) develop from the same transformed hematopoietic progenitors. How BCR/ABL interferes with the immunoregulatory function of DCs in ...

journal_title：Blood

authors： Mumprecht S,Claus C,Schürch C,Pavelic V,Matter MS,Ochsenbein AF

更新日期：2009-05-07 00:00:00

abstract：:The erythroblastic island (EI), formed by a central macrophage and developing erythroblasts (EBs), was first described decades ago and was recently shown to play an in vivo role in homeostatic and pathological erythropoiesis. The exact molecular mechanisms, however, mediating the interactions between macrophages and E...

journal_title：Blood

authors： Wei Q,Boulais PE,Zhang D,Pinho S,Tanaka M,Frenette PS

更新日期：2019-03-14 00:00:00

abstract：:Non-Hodgkin lymphomas (NHLs) are the most common cancer to affect pet dogs. In contrast to the many genes whose mutation contributes to lymphomagenesis in humans, relatively little is known about the acquired genetic alterations that lead to canine B-cell lymphomas (cBCLs). We performed a survey of 84 canine NHL tumor...

journal_title：Blood

authors： Bushell KR,Kim Y,Chan FC,Ben-Neriah S,Jenks A,Alcaide M,Fornika D,Grande BM,Arthur S,Gascoyne RD,Steidl C,Morin RD

更新日期：2015-02-05 00:00:00

abstract：:To gain further insights in the pathogenesis of herpesvirus pneumonia in allogeneic bone marrow transplant recipients, transplanted mice (B10.BR --> CBA) with graft-versus-host disease (GVHD) and control mice (transplanted mice without GVHD and normal CBA mice) were infected intranasally with herpes simplex virus type...

journal_title：Blood

authors： Adler H,Beland JL,Kozlow W,Del-Pan NC,Kobzik L,Rimm IJ

更新日期：1998-10-01 00:00:00

abstract：:Allogeneic stem cell transplantation with umbilical cord blood (UCB) cells is limited by the cell dose a single unit provides recipients. Ex vivo expansion is one strategy to increase the number of cells available for transplantation. Aastrom Biosciences developed an automated continuous perfusion culture device for e...

journal_title：Blood

authors： Jaroscak J,Goltry K,Smith A,Waters-Pick B,Martin PL,Driscoll TA,Howrey R,Chao N,Douville J,Burhop S,Fu P,Kurtzberg J

更新日期：2003-06-15 00:00:00

abstract：:A role for microRNA (miRNA) has been recognized in nearly every biologic system examined thus far. A complete delineation of their role must be preceded by the identification of all miRNAs present in any system. We elucidated the complete small RNA transcriptome of normal and malignant B cells through deep sequencing ...

journal_title：Blood

authors： Jima DD,Zhang J,Jacobs C,Richards KL,Dunphy CH,Choi WW,Au WY,Srivastava G,Czader MB,Rizzieri DA,Lagoo AS,Lugar PL,Mann KP,Flowers CR,Bernal-Mizrachi L,Naresh KN,Evens AM,Gordon LI,Luftig M,Friedman DR,Weinberg JB

更新日期：2010-12-02 00:00:00

abstract：:Familial hemophagocytic lymphohistiocytosis (FHL) is a frequently missed and almost uniformly fatal childhood disorder. It is characterized by fever, hepatosplenomegaly, cytopenia, coagulopathy, and hypertriglyceridemia. The pathogenesis of FHL is not known but the above clinical and laboratory findings are compatible...

journal_title：Blood

authors： Henter JI,Elinder G,Söder O,Hansson M,Andersson B,Andersson U

更新日期：1991-12-01 00:00:00

abstract：:Leukocyte extravasation involves interdependent signaling pathways underlying the complex dynamics of firm adhesion, crawling, and diapedesis. While signal transduction by agonist-bound chemokine receptors plays a central role in the above responses, it is unclear how it contributes to the sustained and concurrent nat...

journal_title：Blood

authors： Molteni R,Crespo CL,Feigelson S,Moser C,Fabbri M,Grabovsky V,Krombach F,Laudanna C,Alon R,Pardi R

更新日期：2009-07-30 00:00:00

abstract：:Adaptive immunity is triggered at the immune synapse, where peptide-major histocompatibility complexes and costimulatory molecules expressed by dendritic cells (DCs) are physically presented to T cells. Here we describe transmission of the inflammatory monoamine serotonin (5-hydroxytryptamine [5-HT]) between these cel...

journal_title：Blood

authors： O'Connell PJ,Wang X,Leon-Ponte M,Griffiths C,Pingle SC,Ahern GP

更新日期：2006-02-01 00:00:00

abstract：:In human immunodeficiency virus (HIV)-1 infection, decrease of telomere length is mainly found in CD8(+) T cells and not in CD4(+) T cells. Telomerase, a ribonucleoprotein enzyme that can synthesize telomeric sequence onto chromosomal ends, can compensate for telomere loss. Here, we investigated if telomerase activity...

journal_title：Blood

authors： Wolthers KC,Otto SA,Wisman GB,Fleury S,Reiss P,ten Kate RW,van der Zee AG,Miedema F

更新日期：1999-02-01 00:00:00

abstract：:Interferons (IFNs) initiate their effects by interacting with specific high-affinity cell surface receptors, but little is known about the physiology of IFN receptor interaction in vivo. Treatment of patients suffering from hairy cell leukemia (HCL) with human recombinant alpha IFN results in significant tumor regress...

journal_title：Blood

authors： Billard C,Sigaux F,Castaigne S,Valensi F,Flandrin G,Degos L,Falcoff E,Aguet M

更新日期：1986-03-01 00:00:00

abstract：:We evaluated spleen function in 193 children with sickle cell anemia 8 to 18 months of age by (99m)Tc sulfur-colloid liver-spleen scan and correlated results with clinical and laboratory parameters, including 2 splenic biomarkers: pitted cell counts (PIT) and quantitative Howell-Jolly bodies (HJB) enumerated by flow c...

journal_title：Blood

authors： Rogers ZR,Wang WC,Luo Z,Iyer RV,Shalaby-Rana E,Dertinger SD,Shulkin BL,Miller JH,Files B,Lane PA,Thompson BW,Miller ST,Ware RE,BABY HUG.

更新日期：2011-03-03 00:00:00

abstract：:In 65 patients with hemophagocytic lymphohistiocytosis (HLH), we found an as yet undescribed heterogeneity of defects in cellular cytotoxicity when assay conditions were modified by the incubation time, the presence of mitogen, or interleukin-2 (IL-2). The standard 4-hour natural killer (NK) test against K562 targets ...

journal_title：Blood

authors： Schneider EM,Lorenz I,Müller-Rosenberger M,Steinbach G,Kron M,Janka-Schaub GE

更新日期：2002-10-15 00:00:00

abstract：:Glycogen storage disease type 1b (GSD1b) is a rare autosomal recessive disorder characterized by hypoglycemia, hepatomegaly, and growth retardation, and associated-for unknown reasons- with neutropenia and neutrophil dysfunction. In 5 GSD1b patients in whom nicotin-amide adenine dinucleotide phosphate-oxidase activity...

journal_title：Blood

authors： Kuijpers TW,Maianski NA,Tool AT,Smit GP,Rake JP,Roos D,Visser G

更新日期：2003-06-15 00:00:00

abstract：:The effect of cyclosporine A (CyA) on the ability of the human immunodeficiency virus type 1 (HIV-1) to infect the H-9 T-cell leukemic line, as well as interleukin-2 (IL-2)-grown human peripheral blood-derived lymphocytes, has been studied. Pretreatment of H-9 cells and human lymphocytes with CyA over 24 hours complet...

journal_title：Blood

authors： Wainberg MA,Dascal A,Blain N,Fitz-Gibbon L,Boulerice F,Numazaki K,Tremblay M

更新日期：1988-12-01 00:00:00

abstract：:Follicular lymphoma (FL) is the second most common non-Hodgkin lymphoma in the Western world. FL cell-intrinsic and cell-extrinsic factors influence FL biology and clinical outcome. To further our understanding of the genetic basis of FL, we performed whole-exome sequencing of 23 highly purified FL cases and 1 transfo...

journal_title：Blood

authors： Yildiz M,Li H,Bernard D,Amin NA,Ouillette P,Jones S,Saiya-Cork K,Parkin B,Jacobi K,Shedden K,Wang S,Chang AE,Kaminski MS,Malek SN

更新日期：2015-01-22 00:00:00

abstract：:Platelets are vital for hemostasis because they release their granule contents in response to vascular damage. Platelet exocytosis is mediated by soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs), whose interactions are governed by regulators, eg, Sec/Munc18 proteins. These proteins chape...

journal_title：Blood

authors： Al Hawas R,Ren Q,Ye S,Karim ZA,Filipovich AH,Whiteheart SW

更新日期：2012-09-20 00:00:00

abstract：:The oxygen transport function of hemoglobin (HB) is thought to have arisen ∼500 million years ago, roughly coinciding with the divergence between jawless (Agnatha) and jawed (Gnathostomata) vertebrates. Intriguingly, extant HBs of jawless and jawed vertebrates were shown to have evolved twice, and independently, from ...

journal_title：Blood

authors： Miyata M,Gillemans N,Hockman D,Demmers JAA,Cheng JF,Hou J,Salminen M,Fisher CA,Taylor S,Gibbons RJ,Ganis JJ,Zon LI,Grosveld F,Mulugeta E,Sauka-Spengler T,Higgs DR,Philipsen S

更新日期：2020-07-16 00:00:00

abstract：:Vascular tube morphogenesis requires the establishment of endothelial cell (EC) apical-basal polarity in three-dimensional (3D) extracellular matrices. To date, there is little understanding of how EC polarity is controlled during these highly dynamic and rapid morphogenic events. We show that the microtubule tip comp...

journal_title：Blood

authors： Kim DJ,Martinez-Lemus LA,Davis GE

更新日期：2013-04-25 00:00:00

abstract：:Granulocytic colonies grown in culture from marrow and peripheral blood from five patients with Ph1-positive CML and heterozygous at the G-6-PD locus were analyzed for G-6-PD in order to identify CFU-C that do not arise from the CML clone. The patients had both B and A enzymes in normal tissues, but their CML clones t...

journal_title：Blood

authors： Singer JW,Fialkow PJ,Steinmann L,Najfeld V,Stein SJ,Robinson WA

更新日期：1979-02-01 00:00:00