Abstract：
:A limited number of antifungal agents including azoles, polyenes, pyrimidine analogues are used today to combat infections caused by yeast pathogens. While clinical factors can contribute to failures to antifungal treatments, yeast pathogens exposed to these agents can still limit their action either because they are intrinsically resistant or because they acquire specific resistance mechanisms. Microbiological methods are available to measure the susceptibility of yeast pathogens against the existing antifungal agents and to distinguish between antifungal susceptible and antifungal resistant organisms. This distinction can ideally predict the success or failure of a treatment in clinical situations and is available only for a limited number of antifungal agents, i.e. the azole antifungals fluconazole and itraconazole and the pyrimidine analogue 5-fluorocytosine. Cases of antifungal resistance have been reported for almost all classes of antifungal agents, but they have been mainly documented for the pyrimidine analogue 5-fluorocytosine and azole antifungals mainly in Candida species and less frequently in Cryptococcus species. This review summarizes the current knowledge on the different mechanisms of resistance to these agents in these yeast pathogens.
journal_name
Enferm Infecc Microbiol Clinjournal_title
Enfermedades infecciosas y microbiologia clinicaauthors
Sanglard Ddoi
10.1016/s0213-005x(02)72842-5subject
Has Abstractpub_date
2002-11-01 00:00:00pages
462-9; quiz 470, 479issue
9eissn
0213-005Xissn
1578-1852pii
13038501journal_volume
20pub_type
杂志文章,评审abstract：:The pathogenesis of arteriosclerosis in HIV-infected patients is complex. Both patient-related cardiovascular risk factors (CVRF) established for the general population and those related to highly-active antiretroviral therapy (HAART) and HIV infection per se are involved. Some traditional CVRF are more frequent in HI...
journal_title：Enfermedades infecciosas y microbiologia clinica
pub_type： 杂志文章,评审
doi：10.1016/S0213-005X(09)73440-8
更新日期：2009-09-01 00:00:00
abstract：:Chronic hepatitis B continues to be a serious problem worldwide. Because a high viral load is associated with greater progression to cirrhosis and hepatocarcinoma in these patients, new drugs that achieve rapid, potent and lasting suppression of viral replication must be sought. Entecavir is a new, highly potent antiv...
journal_title：Enfermedades infecciosas y microbiologia clinica
pub_type： 杂志文章,评审
doi：10.1016/s0213-005x(08)76518-2
更新日期：2008-05-01 00:00:00
abstract：INTRODUCTION:The aim of this study was to know, through a national survey, the methods and techniques used for the diagnosis of Helicobacter pylori (Hp) in the different Clinical Microbiology Services/Laboratories in Spain, as well as antibiotic resistance data. METHODS:The survey requested information about the diagn...
journal_title：Enfermedades infecciosas y microbiologia clinica
pub_type： 杂志文章
doi：10.1016/j.eimc.2019.11.008
更新日期：2020-11-01 00:00:00
abstract：:Antimicrobial prophylaxis in surgery refers to a very brief course of an antimicrobial agent initiated just before the start of the procedure. The efficacy of antimicrobials to prevent postoperative infection at the site of surgery (incisional superficial, incisional deep, or organ/space infection) has been demonstrat...
journal_title：Enfermedades infecciosas y microbiologia clinica
pub_type： 杂志文章
doi：
更新日期：2002-08-01 00:00:00
abstract：BACKGROUND:Reflex testing is necessary to achieve the objectives of hepatitis C elimination. However, in 2017 only 31% of Spanish hospitals performed reflex test. As a consequence of that finding, reflex testing was recommended by scientific societies involved in the diagnosis and treatment of hepatitis C. OBJECTIVE:T...
journal_title：Enfermedades infecciosas y microbiologia clinica
pub_type： 杂志文章
doi：10.1016/j.eimc.2020.03.004
更新日期：2020-05-22 00:00:00
abstract：BACKGROUND:Use of selective Clostridium difficile culture as a diagnostic method for C. difficile associated disease requires to prove the toxigenic ability of the isolates. Toxin B detection by cell culture assay after growing the microorganism in enriched broth is the standard method, but it delays the final diagnosi...
journal_title：Enfermedades infecciosas y microbiologia clinica
pub_type： 杂志文章
doi：
更新日期：2000-03-01 00:00:00
abstract：INTRODUCTION:A growing number of immigrants are using the public health services for HIV in Spain. We describe the sociodemographic, epidemiological, and clinical characteristics of a cohort of naïve HIV-infected subjects (CoRIS cohort) according to their place of origin. METHODS:CoRIS is an open, hospital-based cohor...
journal_title：Enfermedades infecciosas y microbiologia clinica
pub_type： 杂志文章,多中心研究
doi：10.1016/j.eimc.2008.10.007
更新日期：2009-08-01 00:00:00
abstract：:The imipenem and meropenem breakpoints for Enterobacteriaceae established by the Clinical and Laboratory Standards Institute (CLSI) are somewhat lower than those established by the European Committee on Antimicrobial Susceptibility Testing (EUCAST), but are identical for ertapenem and doripenem. The differences are pr...
journal_title：Enfermedades infecciosas y microbiologia clinica
pub_type： 杂志文章,评审
doi：10.1016/S0213-005X(14)70172-7
更新日期：2014-12-01 00:00:00
abstract：INTRODUCTION:Identification of yeasts is based on morphological, biochemical and nutritional characteristics, and using molecular methods. Matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry, a new method for the identification of microorganisms, has demonstrated to be very useful. ...
journal_title：Enfermedades infecciosas y microbiologia clinica
pub_type： 杂志文章
doi：10.1016/j.eimc.2014.10.003
更新日期：2015-06-01 00:00:00
abstract：BACKGROUND:The aim of this study was to evaluate the usefulness of colloidal gold probes widely used in histochemistry and electronic microscopy for the serologic diagnosis of syphilis. METHODS:One hundred eighty-nine sera which had been submitted to the traditional fluorescent trigenemic absorption (FTA-ABS) test and...
journal_title：Enfermedades infecciosas y microbiologia clinica
pub_type： 临床试验,杂志文章
doi：
更新日期：1996-05-01 00:00:00
abstract：OBJECTIVE:To provide an update of 2004 Guidelines from the Spanish AIDS Study Group (GESIDA) and the National AIDS Plan (PNS) committee on the prevention of opportunistic infections in adult and adolescent HIV-infected patients. METHODS:These consensus recommendations have been produced by a group of experts from GESI...
journal_title：Enfermedades infecciosas y microbiologia clinica
pub_type： 共识发展会议,杂志文章,实务指引
doi：10.1157/13125642
更新日期：2008-08-01 00:00:00
abstract：INTRODUCTION:Invasive pneumococcal disease (IPD) typically presents as bacterial pneumonia, meningitis or primary bacteraemia. However, Streptococcus pneumoniae can produce infection at any level of the body (endocarditis, arthritis, spontaneous bacterial peritonitis, etc.), which is also known as unusual IPD (uIPD). T...
journal_title：Enfermedades infecciosas y microbiologia clinica
pub_type： 杂志文章
doi：10.1016/j.eimc.2017.05.003
更新日期：2018-05-01 00:00:00
abstract：INTRODUCTION AND AIM:Immigration to Spain of Latin Americans with Chagas disease in its indeterminate phase could result in vertical transmission of the disease or transmission by transfusion or organ transplantation. To ascertain the magnitude of this problem, we investigated the prevalence of bearers among women who ...
journal_title：Enfermedades infecciosas y microbiologia clinica
pub_type： 杂志文章,多中心研究
doi：10.1016/s0213-005x(08)75276-5
更新日期：2008-12-01 00:00:00
abstract：:Interest in simplification arises from the need to dispense with nucleoside analogs due to their long-term toxicity. Since the first trials analyzing the safety and effectiveness of the strategy with lopinavir/ritonavir (LPV/r) emerged more than 10 years ago, simplification continues to arouse scientific, clinical and...
journal_title：Enfermedades infecciosas y microbiologia clinica
pub_type： 杂志文章
doi：10.1016/S0213-005X(14)70162-4
更新日期：2014-11-01 00:00:00
abstract：OBJECTIVES:China is the second high tuberculosis (TB) burden country in the world. This article was to determinate the molecular characteristic of drug resistance Mycobacterium tuberculosis (DRTB) strains from extra pulmonary tuberculosis (EPTB). METHODS:The medical records of patients with EPTB were reviewed and coll...
journal_title：Enfermedades infecciosas y microbiologia clinica
pub_type： 杂志文章
doi：10.1016/j.eimc.2020.04.007
更新日期：2020-06-27 00:00:00
abstract：:The recovery rate of Moraxella catarrhalis in a selective culture medium with acetazolamide and in a conventional blood-agar medium was compared from 1291 samples from the respiratory tract and conjunctivae of children and adults with respiratory and ocular symptomatology. M. catarrhalis was recovered in 215 samples o...
journal_title：Enfermedades infecciosas y microbiologia clinica
pub_type： 杂志文章
doi：
更新日期：1992-08-01 00:00:00
abstract：OBJECTIVES:To prospectively study the emergence and diagnostic problems of bronchiolitis caused by influenza A virus among children durign the 1999-2000 influenza epidemic. MATERIALS AND METHODS:Negative respiratory syncitial virus (RSV) specimens (ELISA dot-blot) were seeded in the MDCK cell line for the isolation of...
journal_title：Enfermedades infecciosas y microbiologia clinica
pub_type： 杂志文章
doi：10.1016/s0213-005x(01)72703-6
更新日期：2001-12-01 00:00:00
abstract：:Gonococcal infection is a current public health problem worldwide, being the second most prevalent bacterial sexually transmitted infection. The etiologic agent is Neisseria gonorrhoeae, a gram-negative diplococcus, and mainly causes urethritis in men. In women up to 50% of infections can be asymptomatic. N. gonorrhoe...
journal_title：Enfermedades infecciosas y microbiologia clinica
pub_type： 杂志文章,评审
doi：10.1016/j.eimc.2018.12.008
更新日期：2019-01-01 00:00:00
abstract：OBJECTIVE:The time to positivity (TTP) of blood cultures in patients with bloodstream infections (BSIs) has been considered to be a possible prognostic tool for some bacterial species. However, notable differences have been found between sampling designs and statistical methods in published studies to date, which makes...
journal_title：Enfermedades infecciosas y microbiologia clinica
pub_type： 杂志文章
doi：10.1016/j.eimc.2016.10.003
更新日期：2017-12-01 00:00:00
abstract：OBJECTIVE:To compare the incidence of severe hepatitis in HIV-infected patients receiving rifampicin plus pyrazinamide (RZ) for antituberculosis prophylaxis with that of patients receiving a conventional isoniazid-based regime for 6 to 12 months (6-12H). METHODS:Meta-analysis of randomized controlled trials, in which ...
journal_title：Enfermedades infecciosas y microbiologia clinica
pub_type： 杂志文章,meta分析
doi：10.1016/j.eimc.2009.04.003
更新日期：2010-04-01 00:00:00
abstract：:Urinary tract infections (UTI) are one of the most common infections in solid organ transplant (SOT) recipients. A systematic review was performed to assess the management of UTI in SOT recipients. Recommendations are provided on the management of asymptomatic bacteriuria, and prophylaxis and treatment of UTI in SOT r...
journal_title：Enfermedades infecciosas y microbiologia clinica
pub_type： 共识发展会议,杂志文章,实务指引
doi：10.1016/j.eimc.2015.03.020
更新日期：2015-12-01 00:00:00
abstract：OBJECTIVE:To study the possible viral etiology in 139 infants with lower respiratory tract infection who required hospitalization in the Infant Unit of our hospital, from October 1994 to June 1995. PATIENTS AND METHODS:139 patients were admitted, aged from 13 days to 14 months, during this period. The etiological agen...
journal_title：Enfermedades infecciosas y microbiologia clinica
pub_type： 杂志文章
doi：
更新日期：1998-12-01 00:00:00
abstract：BACKGROUND:The aim of this study was to define the incidence of cervico-vaginal colonization by group B Streptococcus (SGB) in full term pregnancy as well as vertical and horizontal transmission in newborns attended in two public hospitals in Valencia, Venezuela. METHODS:An study cervico-vaginal exudates from 171 full...
journal_title：Enfermedades infecciosas y microbiologia clinica
pub_type： 杂志文章
doi：
更新日期：1993-06-01 00:00:00
abstract：:The disadvantages of the long-term administration of antiretroviral therapy as well as the huge number of affected persons have placed the cure of HIV as a primary goal of Public Health. HIV may persist in the organism by at least four mechanisms: a latently infected cellular reservoir, the persistent replication of H...
journal_title：Enfermedades infecciosas y microbiologia clinica
pub_type： 杂志文章,评审
doi：10.1016/j.eimc.2018.01.007
更新日期：2019-04-01 00:00:00
abstract：:Pharmacogenetics, the study of how individual genetic profiles influence the response to drugs, is an important topic. Results from pharmacogenetics studies in various clinical settings may lead to personalized medicine. Herein, we present the most important concepts of this discipline, as well as currently-used study...
journal_title：Enfermedades infecciosas y microbiologia clinica
pub_type： 杂志文章
doi：10.1016/s0213-005x(08)76506-6
更新日期：2008-05-01 00:00:00
abstract：:The morbidity and mortality rates associated with Streptococcus pneumoniae remain very high worldwide. The virulence of this bacterium is largely dependent on its polysaccharide capsule, which is quite heterogeneous and represents a serious obstacle for designing effective vaccines. However, it has been demonstrated t...
journal_title：Enfermedades infecciosas y microbiologia clinica
pub_type： 杂志文章,评审
doi：10.1157/13092469
更新日期：2006-10-01 00:00:00
abstract：:The guidelines on the treatment of invasive fungal disease by Aspergillus spp. and other fungi issued by the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC) are presented. These recommendations are focused on four clinical categories: oncology-haematology patients, solid organ transplant recip...
journal_title：Enfermedades infecciosas y microbiologia clinica
pub_type： 杂志文章,实务指引
doi：10.1016/j.eimc.2011.01.010
更新日期：2011-06-01 00:00:00
abstract：INTRODUCTION:Small colony variants of Staphylococcus aureus (SCVSA) are a sub-population with special features. METHODS:The phenotypic features and antibiotic susceptibility of four clinical isolates SCVSA were studied. RESULTS:Colonies grew in the usual culture media, except in Mueller Hinton. All isolates were resi...
journal_title：Enfermedades infecciosas y microbiologia clinica
pub_type： 杂志文章
doi：10.1016/j.eimc.2013.06.005
更新日期：2014-02-01 00:00:00
abstract：INTRODUCTION:The incidence of human immunodeficiency virus (HIV) and other sexually transmitted diseases increases in males who have sex with males (MSM), despite the knowledge on how to prevent them. To determine the mechanisms that are driving this lack of prevention is important to reverse the trend. PATIENTS AND M...
journal_title：Enfermedades infecciosas y microbiologia clinica
pub_type： 杂志文章
doi：10.1016/j.eimc.2013.04.017
更新日期：2014-04-01 00:00:00
abstract：:Dalbavancin is a semisynthetic lipoglycopeptide with two properties that distinguish it from other members of the antibiotic family from which it is derived: a greater intrinsic activity and a very prolonged mean half-life that allows weekly or twice-weekly dosing with a single 1000mg or 1500mg dose, respectively. Bec...
journal_title：Enfermedades infecciosas y microbiologia clinica
pub_type： 杂志文章
doi：10.1016/S0213-005X(17)30034-4
更新日期：2017-01-01 00:00:00
