Skeletal muscle plasticity: cellular and molecular responses to altered physical activity paradigms.

Abstract:

:The goal of this article is to examine our current understanding of the chain of events known to be involved in the adaptive process whereby specific genes and their protein products undergo altered expression; specifically, skeletal muscle adaptation in response to altered loading states will be discussed, with a special focus on the regulation of the contractile protein, myosin heavy chain gene expression. This protein, which is both an important structural and regulatory protein comprising the contractile apparatus, can be expressed as different isoforms, thereby having an impact on the functional diversity of the muscle. Because the regulation of the myosin gene family is under the control of a complex set of processes including, but not limited to, activity, hormonal, and metabolic factors, this protein will serve as a cellular "marker" for studies of muscle plasticity in response to various mechanical perturbations in which the quantity and type of myosin isoform, along with other important cellular proteins, are altered in expression.

journal_name

Am J Phys Med Rehabil

authors

Baldwin KM,Haddad F

doi

10.1097/01.PHM.0000029723.36419.0D

subject

Has Abstract

pub_date

2002-11-01 00:00:00

pages

S40-51

issue

11 Suppl

eissn

0894-9115

issn

1537-7385

journal_volume

81

pub_type

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